ZA200402856B - 4-(4-Akoxy-3-hydroxyphenyl)-2-poyrrolidone derivatives as PDE-4 inhibitors for the treatment of neurogical syndromes. - Google Patents

4-(4-Akoxy-3-hydroxyphenyl)-2-poyrrolidone derivatives as PDE-4 inhibitors for the treatment of neurogical syndromes. Download PDF

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Publication number
ZA200402856B
ZA200402856B ZA200402856A ZA200402856A ZA200402856B ZA 200402856 B ZA200402856 B ZA 200402856B ZA 200402856 A ZA200402856 A ZA 200402856A ZA 200402856 A ZA200402856 A ZA 200402856A ZA 200402856 B ZA200402856 B ZA 200402856B
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alkyl
substituted
halogen
combinations
carbon atoms
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ZA200402856A
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English (en)
Inventor
Ruiping Liu
Hans-Jurgen Ernst Hess
Erik Kuester
Michael De Vivo
Allen Hopper
Ashok Tehim
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Memory Pharm Corp
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Publication of ZA200402856B publication Critical patent/ZA200402856B/en

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/26—2-Pyrrolidones
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
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ZA200402856A 2001-10-16 2004-04-15 4-(4-Akoxy-3-hydroxyphenyl)-2-poyrrolidone derivatives as PDE-4 inhibitors for the treatment of neurogical syndromes. ZA200402856B (en)

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US32931401P 2001-10-16 2001-10-16

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ZA200402856B true ZA200402856B (en) 2005-01-25

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US (3) US7235579B2 (ko)
EP (1) EP1435944B1 (ko)
JP (2) JP4484515B2 (ko)
KR (2) KR20090080573A (ko)
CN (1) CN1604776A (ko)
AT (1) ATE444065T1 (ko)
AU (1) AU2002335015B8 (ko)
BR (1) BR0213660A (ko)
CA (1) CA2463469A1 (ko)
CO (1) CO5570674A2 (ko)
DE (1) DE60233884D1 (ko)
ES (1) ES2334650T3 (ko)
HR (1) HRP20040409A2 (ko)
IL (1) IL161317A0 (ko)
MX (1) MXPA04003516A (ko)
NO (1) NO20042024L (ko)
NZ (1) NZ532288A (ko)
RU (2) RU2340600C2 (ko)
WO (1) WO2003032981A1 (ko)
ZA (1) ZA200402856B (ko)

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