ZA200402499B - New bacterium causing poultry disease and vaccine derived thereof. - Google Patents
New bacterium causing poultry disease and vaccine derived thereof. Download PDFInfo
- Publication number
- ZA200402499B ZA200402499B ZA200402499A ZA200402499A ZA200402499B ZA 200402499 B ZA200402499 B ZA 200402499B ZA 200402499 A ZA200402499 A ZA 200402499A ZA 200402499 A ZA200402499 A ZA 200402499A ZA 200402499 B ZA200402499 B ZA 200402499B
- Authority
- ZA
- South Africa
- Prior art keywords
- mannheimia haemolytica
- pasteurella
- pasteurella trehalosi
- atcc
- pta
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims description 61
- 241000894006 Bacteria Species 0.000 title claims description 56
- 208000027954 Poultry disease Diseases 0.000 title description 5
- 241000218561 Bibersteinia trehalosi Species 0.000 claims description 141
- 241001293418 Mannheimia haemolytica Species 0.000 claims description 128
- 238000000034 method Methods 0.000 claims description 71
- 238000012360 testing method Methods 0.000 claims description 41
- 201000010099 disease Diseases 0.000 claims description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
- 239000012634 fragment Substances 0.000 claims description 24
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 23
- 230000002238 attenuated effect Effects 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 22
- 244000005700 microbiome Species 0.000 claims description 19
- 241000287828 Gallus gallus Species 0.000 claims description 18
- 239000000427 antigen Substances 0.000 claims description 17
- 102000036639 antigens Human genes 0.000 claims description 17
- 108091007433 antigens Proteins 0.000 claims description 17
- 244000144977 poultry Species 0.000 claims description 17
- 241000606860 Pasteurella Species 0.000 claims description 16
- 241000700605 Viruses Species 0.000 claims description 13
- 239000002671 adjuvant Substances 0.000 claims description 12
- 241001293415 Mannheimia Species 0.000 claims description 11
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 10
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 10
- 208000015181 infectious disease Diseases 0.000 claims description 9
- 210000001519 tissue Anatomy 0.000 claims description 8
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 6
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 6
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 6
- 230000001717 pathogenic effect Effects 0.000 claims description 6
- 230000000241 respiratory effect Effects 0.000 claims description 6
- 241000606767 Avibacterium paragallinarum Species 0.000 claims description 5
- 238000003745 diagnosis Methods 0.000 claims description 5
- 238000002405 diagnostic procedure Methods 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 210000002345 respiratory system Anatomy 0.000 claims description 5
- 208000024891 symptom Diseases 0.000 claims description 5
- 108010053835 Catalase Proteins 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- 229910002651 NO3 Inorganic materials 0.000 claims description 4
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 4
- 241000606856 Pasteurella multocida Species 0.000 claims description 4
- 230000002779 inactivation Effects 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- 229940051027 pasteurella multocida Drugs 0.000 claims description 4
- 210000005000 reproductive tract Anatomy 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 241001519465 Avian metapneumovirus Species 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 230000003053 immunization Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 230000009467 reduction Effects 0.000 claims description 3
- 241000272525 Anas platyrhynchos Species 0.000 claims description 2
- 241000272814 Anser sp. Species 0.000 claims description 2
- 241001516406 Avian orthoreovirus Species 0.000 claims description 2
- 241000272201 Columbiformes Species 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 241000711450 Infectious bronchitis virus Species 0.000 claims description 2
- 241000702626 Infectious bursal disease virus Species 0.000 claims description 2
- 241000286209 Phasianidae Species 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 241001223089 Tremovirus A Species 0.000 claims description 2
- 208000007502 anemia Diseases 0.000 claims description 2
- 108010005774 beta-Galactosidase Proteins 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims description 2
- 238000007790 scraping Methods 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims 2
- 241000711404 Avian avulavirus 1 Species 0.000 claims 1
- 102100026189 Beta-galactosidase Human genes 0.000 claims 1
- 102100035882 Catalase Human genes 0.000 claims 1
- 241000271566 Aves Species 0.000 description 32
- 208000032843 Hemorrhage Diseases 0.000 description 28
- 210000004027 cell Anatomy 0.000 description 28
- 241001465754 Metazoa Species 0.000 description 27
- 230000001580 bacterial effect Effects 0.000 description 25
- 239000006161 blood agar Substances 0.000 description 25
- 241001494479 Pecora Species 0.000 description 19
- 210000002216 heart Anatomy 0.000 description 18
- 108090000623 proteins and genes Proteins 0.000 description 18
- 239000000463 material Substances 0.000 description 17
- 238000006243 chemical reaction Methods 0.000 description 15
- 102000004169 proteins and genes Human genes 0.000 description 15
- 230000035899 viability Effects 0.000 description 15
- 238000010790 dilution Methods 0.000 description 13
- 239000012895 dilution Substances 0.000 description 13
- 238000002955 isolation Methods 0.000 description 12
- 206010018910 Haemolysis Diseases 0.000 description 11
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 11
- 230000012010 growth Effects 0.000 description 11
- 210000004556 brain Anatomy 0.000 description 10
- 230000008588 hemolysis Effects 0.000 description 10
- 241000894007 species Species 0.000 description 10
- 239000013598 vector Substances 0.000 description 10
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 9
- 238000001802 infusion Methods 0.000 description 9
- 230000003902 lesion Effects 0.000 description 9
- 238000009826 distribution Methods 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 102000004196 processed proteins & peptides Human genes 0.000 description 8
- 239000003381 stabilizer Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 108020004414 DNA Proteins 0.000 description 7
- 241000196324 Embryophyta Species 0.000 description 7
- 239000003242 anti bacterial agent Substances 0.000 description 7
- 229940088710 antibiotic agent Drugs 0.000 description 7
- 231100000676 disease causative agent Toxicity 0.000 description 7
- 210000002149 gonad Anatomy 0.000 description 7
- 239000002054 inoculum Substances 0.000 description 7
- 244000052769 pathogen Species 0.000 description 7
- 210000002257 embryonic structure Anatomy 0.000 description 6
- 238000011534 incubation Methods 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 238000010186 staining Methods 0.000 description 6
- 239000008174 sterile solution Substances 0.000 description 6
- 108010046334 Urease Proteins 0.000 description 5
- 230000000890 antigenic effect Effects 0.000 description 5
- 239000003925 fat Substances 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 5
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 238000001990 intravenous administration Methods 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 239000013612 plasmid Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 230000003612 virological effect Effects 0.000 description 5
- 108010077805 Bacterial Proteins Proteins 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- 102000002464 Galactosidases Human genes 0.000 description 4
- 108010093031 Galactosidases Proteins 0.000 description 4
- 206010039101 Rhinorrhoea Diseases 0.000 description 4
- 230000004520 agglutination Effects 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 235000013601 eggs Nutrition 0.000 description 4
- 239000002158 endotoxin Substances 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 238000003306 harvesting Methods 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 239000002480 mineral oil Substances 0.000 description 4
- 235000010446 mineral oil Nutrition 0.000 description 4
- 208000010753 nasal discharge Diseases 0.000 description 4
- 210000003101 oviduct Anatomy 0.000 description 4
- 206010039083 rhinitis Diseases 0.000 description 4
- 235000020183 skimmed milk Nutrition 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 239000007762 w/o emulsion Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000001262 western blot Methods 0.000 description 4
- 241001600407 Aphis <genus> Species 0.000 description 3
- 102000016938 Catalase Human genes 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 206010019842 Hepatomegaly Diseases 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 3
- 239000000020 Nitrocellulose Substances 0.000 description 3
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 3
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 102000004316 Oxidoreductases Human genes 0.000 description 3
- 108090000854 Oxidoreductases Proteins 0.000 description 3
- NGFMICBWJRZIBI-JZRPKSSGSA-N Salicin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O1)c1c(CO)cccc1 NGFMICBWJRZIBI-JZRPKSSGSA-N 0.000 description 3
- NGFMICBWJRZIBI-UHFFFAOYSA-N alpha-salicin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000010876 biochemical test Methods 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 206010016256 fatigue Diseases 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 231100001261 hazardous Toxicity 0.000 description 3
- 230000002949 hemolytic effect Effects 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 3
- 230000000521 hyperimmunizing effect Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000036512 infertility Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000002906 microbiologic effect Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 201000008383 nephritis Diseases 0.000 description 3
- 229920001220 nitrocellulos Polymers 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 229960003104 ornithine Drugs 0.000 description 3
- 238000003752 polymerase chain reaction Methods 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 208000018299 prostration Diseases 0.000 description 3
- 238000013094 purity test Methods 0.000 description 3
- 238000003127 radioimmunoassay Methods 0.000 description 3
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 3
- 229940120668 salicin Drugs 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 210000000115 thoracic cavity Anatomy 0.000 description 3
- 210000003437 trachea Anatomy 0.000 description 3
- 238000002255 vaccination Methods 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 206010008631 Cholera Diseases 0.000 description 2
- 206010011703 Cyanosis Diseases 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 102000004366 Glucosidases Human genes 0.000 description 2
- 108010056771 Glucosidases Proteins 0.000 description 2
- 208000010359 Newcastle Disease Diseases 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 241000606752 Pasteurellaceae Species 0.000 description 2
- 241000613130 Tima Species 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 230000001332 colony forming effect Effects 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 229960001760 dimethyl sulfoxide Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 230000000415 inactivating effect Effects 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 238000002803 maceration Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 210000002394 ovarian follicle Anatomy 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000012809 post-inoculation Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 208000012331 ruffled feather Diseases 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
- PLXMOAALOJOTIY-FPTXNFDTSA-N Aesculin Natural products OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1Oc2cc3C=CC(=O)Oc3cc2O PLXMOAALOJOTIY-FPTXNFDTSA-N 0.000 description 1
- 244000105975 Antidesma platyphyllum Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 1
- 241000588851 Bordetella avium Species 0.000 description 1
- 208000027312 Bursal disease Diseases 0.000 description 1
- 101710188973 Catalase-4 Proteins 0.000 description 1
- 241000497233 Chlorella coloniales Species 0.000 description 1
- WNBCMONIPIJTSB-BGNCJLHMSA-N Cichoriin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1)c1c(O)cc2c(OC(=O)C=C2)c1 WNBCMONIPIJTSB-BGNCJLHMSA-N 0.000 description 1
- 241000237970 Conus <genus> Species 0.000 description 1
- 241000689227 Cora <basidiomycete fungus> Species 0.000 description 1
- 238000007900 DNA-DNA hybridization Methods 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 241000288140 Gruiformes Species 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 241000976416 Isatis tinctoria subsp. canescens Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241000286819 Malo Species 0.000 description 1
- 101100328463 Mus musculus Cmya5 gene Proteins 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- RSPISYXLHRIGJD-UHFFFAOYSA-N OOOO Chemical compound OOOO RSPISYXLHRIGJD-UHFFFAOYSA-N 0.000 description 1
- 241001135620 Ornithobacterium rhinotracheale Species 0.000 description 1
- 101710116435 Outer membrane protein Proteins 0.000 description 1
- 206010033122 Ovarian atrophy Diseases 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 241000577218 Phenes Species 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 238000010240 RT-PCR analysis Methods 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- 206010039438 Salmonella Infections Diseases 0.000 description 1
- SZKKRCSOSQAJDE-UHFFFAOYSA-N Schradan Chemical compound CN(C)P(=O)(N(C)C)OP(=O)(N(C)C)N(C)C SZKKRCSOSQAJDE-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 206010041660 Splenomegaly Diseases 0.000 description 1
- 101710136739 Teichoic acid poly(glycerol phosphate) polymerase Proteins 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 description 1
- 210000000579 abdominal fat Anatomy 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 229910001569 aluminium mineral Inorganic materials 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 230000002141 anti-parasite Effects 0.000 description 1
- 239000003096 antiparasitic agent Substances 0.000 description 1
- 229940125687 antiparasitic agent Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007688 edging Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000009585 enzyme analysis Methods 0.000 description 1
- XHCADAYNFIFUHF-TVKJYDDYSA-N esculin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC2=C1OC(=O)C=C2 XHCADAYNFIFUHF-TVKJYDDYSA-N 0.000 description 1
- 229940093496 esculin Drugs 0.000 description 1
- AWRMZKLXZLNBBK-UHFFFAOYSA-N esculin Natural products OC1OC(COc2cc3C=CC(=O)Oc3cc2O)C(O)C(O)C1O AWRMZKLXZLNBBK-UHFFFAOYSA-N 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 210000004317 gizzard Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 235000009424 haa Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 210000004754 hybrid cell Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 230000001965 increasing effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 208000030175 lameness Diseases 0.000 description 1
- 230000003137 locomotive effect Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 231100001043 ovarian atrophy Toxicity 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000009374 poultry farming Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229960000380 propiolactone Drugs 0.000 description 1
- 210000000253 proventriculus Anatomy 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 206010039447 salmonellosis Diseases 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- 238000009589 serological test Methods 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 102000009816 urokinase plasminogen activator receptor activity proteins Human genes 0.000 description 1
- 108040001269 urokinase plasminogen activator receptor activity proteins Proteins 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10152307A DE10152307A1 (de) | 2001-10-26 | 2001-10-26 | Neue bakterielle Geflügelkrankheit |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200402499B true ZA200402499B (en) | 2005-06-08 |
Family
ID=7703460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200402499A ZA200402499B (en) | 2001-10-26 | 2004-03-30 | New bacterium causing poultry disease and vaccine derived thereof. |
Country Status (32)
Country | Link |
---|---|
US (3) | US7794735B2 (fr) |
EP (2) | EP1942181A1 (fr) |
JP (2) | JP4447319B2 (fr) |
KR (2) | KR100954175B1 (fr) |
CN (1) | CN100471945C (fr) |
AR (3) | AR037020A1 (fr) |
AT (1) | ATE391767T1 (fr) |
AU (1) | AU2002363173B2 (fr) |
BR (1) | BR0213538A (fr) |
CA (1) | CA2462652A1 (fr) |
CO (1) | CO5580796A2 (fr) |
CY (1) | CY1108178T1 (fr) |
DE (2) | DE10152307A1 (fr) |
DK (1) | DK1442114T3 (fr) |
EC (1) | ECSP045083A (fr) |
ES (1) | ES2304466T3 (fr) |
HK (1) | HK1073862A1 (fr) |
HR (1) | HRP20040366B1 (fr) |
HU (1) | HU228692B1 (fr) |
IL (1) | IL161223A0 (fr) |
MA (1) | MA26293A1 (fr) |
MX (1) | MXPA04003941A (fr) |
MY (1) | MY138203A (fr) |
NO (1) | NO333635B1 (fr) |
NZ (1) | NZ532805A (fr) |
PL (1) | PL206589B1 (fr) |
PT (1) | PT1442114E (fr) |
RU (4) | RU2334792C2 (fr) |
SI (1) | SI1442114T1 (fr) |
UA (2) | UA89607C2 (fr) |
WO (1) | WO2003037367A2 (fr) |
ZA (1) | ZA200402499B (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10152307A1 (de) * | 2001-10-26 | 2003-05-08 | Boehringer Ingelheim Vetmed | Neue bakterielle Geflügelkrankheit |
RU2012118977A (ru) * | 2009-10-09 | 2013-11-20 | Кобенхавнс Университет (Юниверсити Оф Копенгаген) | Цитолитический rtx-токсин gallibacterium anatis |
CN102406936A (zh) * | 2011-11-22 | 2012-04-11 | 青岛易邦生物工程有限公司 | 一种鸡传染性鼻炎灭活疫苗佐剂 |
CN102380092A (zh) * | 2011-11-22 | 2012-03-21 | 青岛易邦生物工程有限公司 | 一种鸡传染性鼻炎灭活疫苗 |
AU2014234452B2 (en) | 2013-03-18 | 2018-02-22 | Intervet International B.V. | Vaccine to protect a ruminant against pneumonia caused by Mannheimia haemolytica |
RU2563885C1 (ru) * | 2014-06-03 | 2015-09-27 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | Способ определения антител к бактериальным антигенам |
CN104491856A (zh) * | 2014-12-07 | 2015-04-08 | 青岛易邦生物工程有限公司 | 一种禽肺病毒病灭活疫苗的生产方法 |
CN108728558A (zh) * | 2018-05-31 | 2018-11-02 | 广西壮族自治区兽医研究所 | 一种快速检测溶血性曼氏杆菌的pcr扩增引物及其应用 |
CN111621450B (zh) * | 2020-07-10 | 2022-07-05 | 青岛易邦生物工程有限公司 | 一种鸭源鸡杆菌及其应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5855894A (en) * | 1992-03-30 | 1999-01-05 | Pfizer Inc. | Pasteurella haemolytica type A-1 bacterin-toxoid vaccine |
EP0625190B1 (fr) * | 1992-10-14 | 1996-12-27 | Akzo Nobel N.V. | Nouvelle bacterie provoquant des maladies chez les volailles et vaccin derive de cette bacterie |
US5587305A (en) * | 1993-12-06 | 1996-12-24 | The United States Of America As Represented By The Department Of Agriculture | Pasteurella haemolytica transformants |
RU94023126A (ru) * | 1994-06-16 | 1997-04-10 | Всероссийский научно-исследовательский институт экспериментальной ветеринарии им.Я.Р.Коваленко | Вакцина против пастереллеза свиней |
RU2103355C1 (ru) * | 1995-11-23 | 1998-01-27 | Государственное Федеральное предприятие Государственный научный центр прикладной микробиологии | Способ получения аттенуированных иммуногенных штаммов pasteurella multocida |
FR2760640B1 (fr) | 1997-03-17 | 1999-05-28 | Vetoquinol Sa | Utilisation d'une souche de pasteurella haemolytica serotype a6 pour la preparation d'un vaccin contre la pasteurellose bovine due a pasteurella haemolytica |
WO2001044289A2 (fr) * | 1999-12-17 | 2001-06-21 | University Of Guelph Office Of The Vice President Of Research | Gene et proteine de leucotoxine modifiee |
DE10152307A1 (de) * | 2001-10-26 | 2003-05-08 | Boehringer Ingelheim Vetmed | Neue bakterielle Geflügelkrankheit |
US7521060B2 (en) * | 2001-10-26 | 2009-04-21 | Boehringer Ingelheim Vetmedica S.A. De C.V. | Pathogen for bacterial poultry disease |
-
2001
- 2001-10-26 DE DE10152307A patent/DE10152307A1/de not_active Withdrawn
-
2002
- 2002-10-24 EP EP08150505A patent/EP1942181A1/fr not_active Withdrawn
- 2002-10-24 KR KR1020047005166A patent/KR100954175B1/ko not_active IP Right Cessation
- 2002-10-24 AU AU2002363173A patent/AU2002363173B2/en not_active Ceased
- 2002-10-24 PL PL369963A patent/PL206589B1/pl not_active IP Right Cessation
- 2002-10-24 RU RU2004116134/13A patent/RU2334792C2/ru not_active IP Right Cessation
- 2002-10-24 DE DE60226057T patent/DE60226057T2/de not_active Expired - Lifetime
- 2002-10-24 MX MXPA04003941A patent/MXPA04003941A/es active IP Right Grant
- 2002-10-24 PT PT02802303T patent/PT1442114E/pt unknown
- 2002-10-24 BR BR0213538-8A patent/BR0213538A/pt active Pending
- 2002-10-24 ES ES02802303T patent/ES2304466T3/es not_active Expired - Lifetime
- 2002-10-24 JP JP2003539709A patent/JP4447319B2/ja not_active Expired - Fee Related
- 2002-10-24 MY MYPI20023986A patent/MY138203A/en unknown
- 2002-10-24 AT AT02802303T patent/ATE391767T1/de active
- 2002-10-24 SI SI200230699T patent/SI1442114T1/sl unknown
- 2002-10-24 DK DK02802303T patent/DK1442114T3/da active
- 2002-10-24 UA UA20040503962A patent/UA89607C2/ru unknown
- 2002-10-24 UA UAA200900431A patent/UA96948C2/ru unknown
- 2002-10-24 NZ NZ532805A patent/NZ532805A/en not_active IP Right Cessation
- 2002-10-24 CA CA002462652A patent/CA2462652A1/fr not_active Abandoned
- 2002-10-24 RU RU2007129099/15A patent/RU2456343C2/ru not_active IP Right Cessation
- 2002-10-24 KR KR1020097012926A patent/KR101024887B1/ko not_active IP Right Cessation
- 2002-10-24 HU HU0402098A patent/HU228692B1/hu not_active IP Right Cessation
- 2002-10-24 WO PCT/EP2002/011899 patent/WO2003037367A2/fr active Application Filing
- 2002-10-24 EP EP02802303A patent/EP1442114B1/fr not_active Expired - Lifetime
- 2002-10-24 CN CNB028212517A patent/CN100471945C/zh not_active Expired - Fee Related
- 2002-10-24 RU RU2007148219/15A patent/RU2430967C2/ru not_active IP Right Cessation
- 2002-10-24 IL IL16122302A patent/IL161223A0/xx unknown
- 2002-10-25 AR ARP020104046A patent/AR037020A1/es active IP Right Grant
-
2004
- 2004-03-30 ZA ZA200402499A patent/ZA200402499B/en unknown
- 2004-04-22 CO CO04037170A patent/CO5580796A2/es active IP Right Grant
- 2004-04-23 EC EC2004005083A patent/ECSP045083A/es unknown
- 2004-04-23 NO NO20041675A patent/NO333635B1/no not_active IP Right Cessation
- 2004-04-23 HR HRP20040366AA patent/HRP20040366B1/xx not_active IP Right Cessation
- 2004-05-25 MA MA27700A patent/MA26293A1/fr unknown
-
2005
- 2005-07-26 HK HK05106369.5A patent/HK1073862A1/xx not_active IP Right Cessation
-
2008
- 2008-07-07 CY CY20081100706T patent/CY1108178T1/el unknown
- 2008-07-30 AR ARP080103284A patent/AR067732A2/es unknown
- 2008-09-10 RU RU2008136404/15A patent/RU2481393C2/ru not_active IP Right Cessation
-
2009
- 2009-02-25 US US12/392,594 patent/US7794735B2/en not_active Expired - Lifetime
- 2009-08-26 US US12/548,210 patent/US7964197B2/en not_active Expired - Fee Related
- 2009-09-02 AR ARP090103365A patent/AR073482A2/es not_active Application Discontinuation
- 2009-12-03 JP JP2009275445A patent/JP5087604B2/ja not_active Expired - Fee Related
-
2011
- 2011-05-09 US US13/103,987 patent/US20110212132A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7794735B2 (en) | Pathogen for bacterial poultry disease | |
EP3200820B1 (fr) | Vaccin à large spectre contre un réovirus aviaire | |
CA2656032C (fr) | Procede de culture de bacteries du genrepiscirickettsia | |
AU2002363173A1 (en) | New bacterium causing poultry disease and vaccine derived thereof | |
CN109609468A (zh) | 一种六基因缺失的猪伪狂犬病毒、猪伪狂犬病疫苗以及制备方法 | |
CN112546210A (zh) | 一种沙门菌灭活疫苗的制备方法及应用 | |
CN104059134A (zh) | 败血性巴氏杆菌毒素重组蛋白及其应用 | |
JP2005511032A5 (fr) | ||
US7521060B2 (en) | Pathogen for bacterial poultry disease | |
Fernández et al. | Protection conferred by bivalent and trivalent infectious coryza bacterins against prevalent serovars of Avibacterium (Haemophilus) paragallinarum in Mexico | |
Molaee et al. | Isolation of the various serotypes of Mannheimia haemolytica and preparation of the first vaccine candidate in Iran | |
CN108276499B (zh) | 融合牛抗菌肽fbap重组酵母菌制剂的制备及应用 |