ZA200402306B - Keratinocytes which may be used as biologically active substances for the treatment of wounds - Google Patents
Keratinocytes which may be used as biologically active substances for the treatment of wounds Download PDFInfo
- Publication number
- ZA200402306B ZA200402306B ZA200402306A ZA200402306A ZA200402306B ZA 200402306 B ZA200402306 B ZA 200402306B ZA 200402306 A ZA200402306 A ZA 200402306A ZA 200402306 A ZA200402306 A ZA 200402306A ZA 200402306 B ZA200402306 B ZA 200402306B
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- South Africa
- Prior art keywords
- keratinocytes
- cells
- wounds
- product
- carrier
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/11—Epidermal growth factor [EGF]
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- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/30—Hormones
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- C12N2501/395—Thyroid hormones
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- C12N2502/00—Coculture with; Conditioned medium produced by
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- Dermatology (AREA)
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- Botany (AREA)
- Hematology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10151296A DE10151296A1 (de) | 2001-10-17 | 2001-10-17 | Keratinozyten verwendbar als biologisch aktive Substanz bei der Behandlung von Wunden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200402306B true ZA200402306B (en) | 2006-05-31 |
Family
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Family Applications (1)
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| ZA200402306A ZA200402306B (en) | 2001-10-17 | 2004-03-24 | Keratinocytes which may be used as biologically active substances for the treatment of wounds |
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| EP (1) | EP1440148B1 (es) |
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| EC (1) | ECSP045065A (es) |
| ES (1) | ES2345767T3 (es) |
| HR (1) | HRP20040347B1 (es) |
| HU (1) | HU228887B1 (es) |
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| MX (1) | MXPA04003487A (es) |
| MY (1) | MY137828A (es) |
| NO (1) | NO334974B1 (es) |
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| PE (1) | PE20030627A1 (es) |
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| UY (1) | UY27486A1 (es) |
| WO (1) | WO2003033686A2 (es) |
| ZA (1) | ZA200402306B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| EP3100611B1 (en) | 2003-08-01 | 2018-09-12 | Stratatech Corporation | Human skin equivalents expressing exogenous polypeptides |
| WO2006010161A2 (en) * | 2004-07-20 | 2006-01-26 | The Regents Of The University Of California | In vitro wound healing assay and device |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| EA030606B1 (ru) | 2006-05-04 | 2018-08-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Способы приготовления лекарственного средства, содержащего полиморфы |
| CN101878324B (zh) * | 2007-10-19 | 2013-04-03 | 比奥因特费斯公司 | 新颖组合物和相关方法、涂料和物件 |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| CN102123717A (zh) | 2008-05-27 | 2011-07-13 | 普拉里斯坦有限公司 | 治疗炎性结肠疾病的方法 |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| JP2012512848A (ja) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 有機化合物の塩の形態 |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| BR112012012641A2 (pt) | 2009-11-27 | 2020-08-11 | Boehringer Ingelheim International Gmbh | TRATAMENTO DE PACIENTES DIABÉTICOS GENOTIPADOS COM INIBIDORES DE DPP-lVTAL COMO LINAGLIPTINA |
| WO2011138421A1 (en) | 2010-05-05 | 2011-11-10 | Boehringer Ingelheim International Gmbh | Combination therapy |
| ES2459143T3 (es) * | 2010-06-09 | 2014-05-08 | Chanel Parfums Beauté | Inhibidores de varios microARN para usar en la prevención y/o atenuación del envejecimiento cutáneo y/o para hidratar la piel |
| EP3366304B1 (en) | 2010-06-24 | 2020-05-13 | Boehringer Ingelheim International GmbH | Diabetes therapy |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| WO2013010964A1 (en) | 2011-07-15 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| WO2013171167A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| WO2013174769A1 (en) | 2012-05-25 | 2013-11-28 | Boehringer Ingelheim International Gmbh | Use of keratinocytes as a biologically active substance in the treatment of wounds, such as diabetic wounds, optionally in combination with a dpp-4 inhibitor |
| ES2950384T3 (es) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Uso médico de un inhibidor de DPP-4 |
| CN105219697A (zh) * | 2014-07-04 | 2016-01-06 | 赫柏慧康生物科技无锡有限公司 | 一种人原代角质细胞分离制备的方法 |
| EP3132809A1 (en) | 2015-08-21 | 2017-02-22 | Bioskinco GmbH | Composition and products comprising senescent cells for use in tissue regeneration |
| US10668259B2 (en) | 2015-10-21 | 2020-06-02 | Materials Science Associates, LLC | Metal oxide and polymer controlled delivery systems, sunscreens, treatments, and topical coating applicators |
| JP2019518428A (ja) * | 2016-04-12 | 2019-07-04 | ユニシテ エーファウ アクチェンゲゼルシャフト | 体液試料からの細胞外小胞（ｅｖ）の単離 |
| EP3468562A1 (en) | 2016-06-10 | 2019-04-17 | Boehringer Ingelheim International GmbH | Combinations of linagliptin and metformin |
| CN109055303A (zh) * | 2018-09-12 | 2018-12-21 | 山东麦德克斯生物科技有限公司 | 一种皮肤组织的构建方法 |
| RU2731065C1 (ru) * | 2019-12-24 | 2020-08-28 | Федеральное государственное бюджетное учреждение науки Институт биологии развития им. Н.К. Кольцова РАН (ИБР РАН) | Состав криоконсерванта для длительного хранения первичных кератиноцитов |
Family Cites Families (12)
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|---|---|---|---|---|
| US4016038A (en) * | 1968-04-01 | 1977-04-05 | Hayashibara Company | Process for preparing maltoses from starches |
| US4016036A (en) | 1975-11-14 | 1977-04-05 | Massachusetts Institute Of Technology | Process for serially culturing keratinocytes |
| IT1207525B (it) | 1987-06-23 | 1989-05-25 | Ist Naz Ric Sul Cancro | Metodo per la preservazione difogli trapiantabili di epitelio coltivato in vitro vitale. |
| US5292655A (en) * | 1990-01-29 | 1994-03-08 | Wille Jr John J | Method for the formation of a histologically-complete skin substitute |
| IT1248934B (it) | 1990-06-01 | 1995-02-11 | Fidia Spa | Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle |
| US6585969B1 (en) | 1991-11-20 | 2003-07-01 | N. V. Innogenetics S.A. | Non-viable keratinocyte cell composition or lysate for promoting wound healing |
| DK0615545T3 (da) | 1991-11-20 | 2000-10-30 | Innogenetics Nv | Lysater hidrørende fra keratinocytter til brug som sårhelingsmidler |
| US5518878A (en) | 1993-09-15 | 1996-05-21 | Organogenesis Inc. | Cryopreservation of cultured skin or cornea equivalents with agitation |
| US5891617A (en) * | 1993-09-15 | 1999-04-06 | Organogenesis Inc. | Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing |
| US5693332C1 (en) | 1995-08-11 | 2001-01-09 | Univ California | Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure |
| AUPP244498A0 (en) | 1998-03-18 | 1998-04-09 | Medvet Science Pty. Ltd. | Keratinocyte stem cells |
| DE19917532A1 (de) | 1999-04-19 | 2000-10-26 | Christian Toloczyki | Trägergebundene kultivierte Stamm-bzw. Vorläuferzellen von Keratinozyten |
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2001
- 2001-10-17 DE DE10151296A patent/DE10151296A1/de not_active Withdrawn
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2002
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- 2002-10-14 CN CNB028207874A patent/CN100432220C/zh not_active Expired - Fee Related
- 2002-10-14 EP EP02781248A patent/EP1440148B1/de not_active Expired - Lifetime
- 2002-10-14 DE DE50214540T patent/DE50214540D1/de not_active Expired - Lifetime
- 2002-10-14 HU HU0600341A patent/HU228887B1/hu not_active IP Right Cessation
- 2002-10-14 DK DK02781248.6T patent/DK1440148T3/da active
- 2002-10-14 EA EA200400482A patent/EA009073B1/ru not_active IP Right Cessation
- 2002-10-14 PL PL02367338A patent/PL367338A1/xx unknown
- 2002-10-14 NZ NZ532899A patent/NZ532899A/en not_active IP Right Cessation
- 2002-10-14 UA UA20040503620A patent/UA81398C2/xx unknown
- 2002-10-14 WO PCT/EP2002/011459 patent/WO2003033686A2/de active Application Filing
- 2002-10-14 RS YU30104A patent/RS30104A/sr unknown
- 2002-10-14 ES ES02781248T patent/ES2345767T3/es not_active Expired - Lifetime
- 2002-10-14 IL IL16144202A patent/IL161442A0/xx unknown
- 2002-10-14 BR BR0213282-6A patent/BR0213282A/pt active Pending
- 2002-10-14 AT AT02781248T patent/ATE474039T1/de active
- 2002-10-14 KR KR1020047005677A patent/KR101019916B1/ko not_active IP Right Cessation
- 2002-10-14 AU AU2002349352A patent/AU2002349352B2/en not_active Ceased
- 2002-10-14 CA CA2461141A patent/CA2461141C/en not_active Expired - Fee Related
- 2002-10-14 UY UY27486A patent/UY27486A1/es not_active Application Discontinuation
- 2002-10-14 JP JP2003536415A patent/JP4476625B2/ja not_active Expired - Fee Related
- 2002-10-15 MY MYPI20023849A patent/MY137828A/en unknown
- 2002-10-15 PE PE2002001015A patent/PE20030627A1/es not_active Application Discontinuation
- 2002-10-16 AR ARP020103870A patent/AR036827A1/es not_active Suspension/Interruption
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2004
- 2004-03-24 ZA ZA200402306A patent/ZA200402306B/en unknown
- 2004-04-14 MX MXPA04003487A patent/MXPA04003487A/es active IP Right Grant
- 2004-04-15 IL IL161442A patent/IL161442A/en not_active IP Right Cessation
- 2004-04-15 EC EC2004005065A patent/ECSP045065A/es unknown
- 2004-04-16 CO CO04035176A patent/CO5580844A2/es not_active Application Discontinuation
- 2004-04-16 NO NO20041570A patent/NO334974B1/no not_active IP Right Cessation
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2006
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2007
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