ZA200401455B - Thienol[2,3-d]pyrimidines with combined LH and FSH agonistic activity. - Google Patents
Thienol[2,3-d]pyrimidines with combined LH and FSH agonistic activity. Download PDFInfo
- Publication number
- ZA200401455B ZA200401455B ZA200401455A ZA200401455A ZA200401455B ZA 200401455 B ZA200401455 B ZA 200401455B ZA 200401455 A ZA200401455 A ZA 200401455A ZA 200401455 A ZA200401455 A ZA 200401455A ZA 200401455 B ZA200401455 B ZA 200401455B
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- ZA
- South Africa
- Prior art keywords
- composition
- thieno
- pyrimidine
- substance
- tert
- Prior art date
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- 150000003230 pyrimidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 11
- -1 (pyrrolidin-1-yl)-acetamido Chemical group 0.000 claims description 9
- 230000035558 fertility Effects 0.000 claims description 7
- DDWBRNXDKNIQDY-UHFFFAOYSA-N thieno[2,3-d]pyrimidine Chemical class N1=CN=C2SC=CC2=C1 DDWBRNXDKNIQDY-UHFFFAOYSA-N 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 5
- 208000021267 infertility disease Diseases 0.000 claims description 3
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- YIPQZUTVMXEUDX-UHFFFAOYSA-N 5-amino-n-tert-butyl-2-methylsulfanyl-4-[3-[(2-piperidin-1-ylacetyl)amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide Chemical compound C=12C(N)=C(C(=O)NC(C)(C)C)SC2=NC(SC)=NC=1C(C=1)=CC=CC=1NC(=O)CN1CCCCC1 YIPQZUTVMXEUDX-UHFFFAOYSA-N 0.000 claims description 2
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- WSAPCUMOHOWCGR-UHFFFAOYSA-N 5-amino-n-tert-butyl-2-methylsulfanyl-4-[3-[(2-thiomorpholin-4-ylacetyl)amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide Chemical compound C=12C(N)=C(C(=O)NC(C)(C)C)SC2=NC(SC)=NC=1C(C=1)=CC=CC=1NC(=O)CN1CCSCC1 WSAPCUMOHOWCGR-UHFFFAOYSA-N 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203327 | 2001-09-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200401455B true ZA200401455B (en) | 2004-11-19 |
Family
ID=8180876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200401455A ZA200401455B (en) | 2001-09-04 | 2004-02-23 | Thienol[2,3-d]pyrimidines with combined LH and FSH agonistic activity. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7317006B2 (ko) |
| EP (1) | EP1427733B1 (ko) |
| JP (1) | JP4262092B2 (ko) |
| KR (1) | KR100900018B1 (ko) |
| CN (1) | CN1246324C (ko) |
| AR (1) | AR036407A1 (ko) |
| AT (1) | ATE345345T1 (ko) |
| AU (1) | AU2002337035B2 (ko) |
| BR (1) | BR0211938A (ko) |
| CA (1) | CA2456901C (ko) |
| CY (1) | CY1106012T1 (ko) |
| DE (1) | DE60216128T2 (ko) |
| DK (1) | DK1427733T3 (ko) |
| ES (1) | ES2275005T3 (ko) |
| HR (1) | HRP20040202A2 (ko) |
| HU (1) | HUP0401444A3 (ko) |
| IL (1) | IL160084A0 (ko) |
| IS (1) | IS2424B (ko) |
| MX (1) | MXPA04002045A (ko) |
| NO (1) | NO20040927L (ko) |
| NZ (1) | NZ531340A (ko) |
| PE (1) | PE20030439A1 (ko) |
| PL (1) | PL368502A1 (ko) |
| PT (1) | PT1427733E (ko) |
| RU (1) | RU2298011C2 (ko) |
| TW (1) | TWI228508B (ko) |
| WO (1) | WO2003020726A1 (ko) |
| ZA (1) | ZA200401455B (ko) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6890923B2 (en) * | 2002-12-16 | 2005-05-10 | Astrazeneca Ab | Compounds |
| GB0315950D0 (en) * | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| GB0525164D0 (en) * | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| CN100430403C (zh) * | 2006-10-13 | 2008-11-05 | 中国科学院上海有机化学研究所 | 3-芳基-5,6-取代噻吩并嘧啶-4-羰基-2-巯基乙腈、合成方法和用途 |
| US20090118276A1 (en) * | 2007-11-02 | 2009-05-07 | Wyeth | Thienopyrimidines, thienopyridines, and pyrrolopyrimidines as b-raf inhibitors |
| TWI389913B (zh) * | 2008-09-08 | 2013-03-21 | Lg Life Sciences Ltd | 并合雜環化合物 |
| CA2741030A1 (en) | 2008-10-20 | 2010-04-29 | Marvin C. Gershengorn | Low molecular weight thyroid stimulating hormone receptor (tshr) agonists |
| GB0905525D0 (en) | 2009-03-31 | 2009-05-13 | Univ Leiden | Compounds and uses |
| EP2525658B1 (de) | 2010-01-22 | 2017-03-01 | Bayer Intellectual Property GmbH | Akarizide und/oder insektizide wirkstoffkombinationen |
| EP2563777A4 (en) | 2010-04-08 | 2013-09-04 | Us Health | INVERSE AGONISTS AND NEUTRAL AGONISTS FOR THE TSH RECEPTOR |
| RU2619091C2 (ru) * | 2015-10-13 | 2017-05-11 | Министерство Промышленности И Торговли Рф | Цилиндрический термоэмиссионный катод |
| WO2023239854A2 (en) * | 2022-06-08 | 2023-12-14 | Icahn School Of Medicine At Mount Sinai | Method of treating obesity with a luteinizing hormone receptor agonist |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19975054I2 (de) | 1987-08-08 | 2000-04-13 | Akzo Nobel Nv | Kontrazeptives Implantat |
| TW564247B (en) * | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
-
2002
- 2002-07-22 TW TW091116284A patent/TWI228508B/zh not_active IP Right Cessation
- 2002-08-29 DE DE60216128T patent/DE60216128T2/de not_active Expired - Lifetime
- 2002-08-29 IL IL16008402A patent/IL160084A0/xx not_active IP Right Cessation
- 2002-08-29 BR BR0211938-2A patent/BR0211938A/pt not_active IP Right Cessation
- 2002-08-29 AU AU2002337035A patent/AU2002337035B2/en not_active Ceased
- 2002-08-29 NZ NZ531340A patent/NZ531340A/en unknown
- 2002-08-29 AT AT02772230T patent/ATE345345T1/de not_active IP Right Cessation
- 2002-08-29 ES ES02772230T patent/ES2275005T3/es not_active Expired - Lifetime
- 2002-08-29 CN CNB028172604A patent/CN1246324C/zh not_active Expired - Fee Related
- 2002-08-29 HU HU0401444A patent/HUP0401444A3/hu unknown
- 2002-08-29 PL PL02368502A patent/PL368502A1/xx not_active Application Discontinuation
- 2002-08-29 EP EP02772230A patent/EP1427733B1/en not_active Expired - Lifetime
- 2002-08-29 RU RU2004110042/04A patent/RU2298011C2/ru not_active IP Right Cessation
- 2002-08-29 WO PCT/EP2002/009647 patent/WO2003020726A1/en active IP Right Grant
- 2002-08-29 PT PT02772230T patent/PT1427733E/pt unknown
- 2002-08-29 JP JP2003524996A patent/JP4262092B2/ja not_active Expired - Fee Related
- 2002-08-29 CA CA2456901A patent/CA2456901C/en not_active Expired - Fee Related
- 2002-08-29 KR KR1020047003095A patent/KR100900018B1/ko not_active IP Right Cessation
- 2002-08-29 DK DK02772230T patent/DK1427733T3/da active
- 2002-08-29 US US10/488,482 patent/US7317006B2/en not_active Expired - Lifetime
- 2002-08-29 MX MXPA04002045A patent/MXPA04002045A/es active IP Right Grant
- 2002-09-02 AR ARP020103309A patent/AR036407A1/es unknown
- 2002-09-03 PE PE2002000840A patent/PE20030439A1/es not_active Application Discontinuation
-
2004
- 2004-01-29 IS IS7130A patent/IS2424B/is unknown
- 2004-02-23 ZA ZA200401455A patent/ZA200401455B/en unknown
- 2004-03-01 HR HR20040202A patent/HRP20040202A2/hr not_active Application Discontinuation
- 2004-03-03 NO NO20040927A patent/NO20040927L/no not_active Application Discontinuation
-
2007
- 2007-02-13 CY CY20071100189T patent/CY1106012T1/el unknown
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