DE60216128D1 - Thienoä2,3-düpyrimidine mit kombinierter lh und fsh agonistischen wirkung - Google Patents

Thienoä2,3-düpyrimidine mit kombinierter lh und fsh agonistischen wirkung

Info

Publication number
DE60216128D1
DE60216128D1 DE60216128T DE60216128T DE60216128D1 DE 60216128 D1 DE60216128 D1 DE 60216128D1 DE 60216128 T DE60216128 T DE 60216128T DE 60216128 T DE60216128 T DE 60216128T DE 60216128 D1 DE60216128 D1 DE 60216128D1
Authority
DE
Germany
Prior art keywords
thienoä2
düpyrimidine
combined
agonistic effect
fsh agonistic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60216128T
Other languages
English (en)
Other versions
DE60216128T2 (de
Inventor
Robert Gerard Jules Ma Hanssen
Cornelis Marius Timmers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon NV filed Critical Organon NV
Publication of DE60216128D1 publication Critical patent/DE60216128D1/de
Application granted granted Critical
Publication of DE60216128T2 publication Critical patent/DE60216128T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60216128T 2001-09-04 2002-08-29 Thieno[2,3-D]Pyrimidine mit kombinierter LH und FSH agonistischen Wirkung Expired - Lifetime DE60216128T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01203327 2001-09-04
EP01203327 2001-09-04
PCT/EP2002/009647 WO2003020726A1 (en) 2001-09-04 2002-08-29 Thieno[2,3-d]pyrimidines with combined lh and fsh agonistic activity

Publications (2)

Publication Number Publication Date
DE60216128D1 true DE60216128D1 (de) 2006-12-28
DE60216128T2 DE60216128T2 (de) 2007-09-27

Family

ID=8180876

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60216128T Expired - Lifetime DE60216128T2 (de) 2001-09-04 2002-08-29 Thieno[2,3-D]Pyrimidine mit kombinierter LH und FSH agonistischen Wirkung

Country Status (28)

Country Link
US (1) US7317006B2 (de)
EP (1) EP1427733B1 (de)
JP (1) JP4262092B2 (de)
KR (1) KR100900018B1 (de)
CN (1) CN1246324C (de)
AR (1) AR036407A1 (de)
AT (1) ATE345345T1 (de)
AU (1) AU2002337035B2 (de)
BR (1) BR0211938A (de)
CA (1) CA2456901C (de)
CY (1) CY1106012T1 (de)
DE (1) DE60216128T2 (de)
DK (1) DK1427733T3 (de)
ES (1) ES2275005T3 (de)
HR (1) HRP20040202A2 (de)
HU (1) HUP0401444A3 (de)
IL (1) IL160084A0 (de)
IS (1) IS2424B (de)
MX (1) MXPA04002045A (de)
NO (1) NO20040927L (de)
NZ (1) NZ531340A (de)
PE (1) PE20030439A1 (de)
PL (1) PL368502A1 (de)
PT (1) PT1427733E (de)
RU (1) RU2298011C2 (de)
TW (1) TWI228508B (de)
WO (1) WO2003020726A1 (de)
ZA (1) ZA200401455B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890923B2 (en) * 2002-12-16 2005-05-10 Astrazeneca Ab Compounds
GB0315950D0 (en) * 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
GB0525164D0 (en) * 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
CN100430403C (zh) * 2006-10-13 2008-11-05 中国科学院上海有机化学研究所 3-芳基-5,6-取代噻吩并嘧啶-4-羰基-2-巯基乙腈、合成方法和用途
US20090118276A1 (en) * 2007-11-02 2009-05-07 Wyeth Thienopyrimidines, thienopyridines, and pyrrolopyrimidines as b-raf inhibitors
TWI389913B (zh) * 2008-09-08 2013-03-21 Lg Life Sciences Ltd 并合雜環化合物
US8741259B2 (en) * 2008-10-20 2014-06-03 Marvin C. Gershengorn Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists
GB0905525D0 (en) 2009-03-31 2009-05-13 Univ Leiden Compounds and uses
EA022553B1 (ru) 2010-01-22 2016-01-29 Байер Интеллектуэль Проперти Гмбх Применение комбинации биологически активных веществ, набор и средство, содержащие комбинацию биологически активных веществ, для борьбы с вредителями животного происхождения и способ улучшения использования продукционного потенциала трансгенного растения
CN102791705B (zh) 2010-04-08 2016-08-03 美国政府(由卫生和人类服务部的部长所代表) 用于tsh受体的反向激动剂和中性拮抗剂
RU2619091C2 (ru) * 2015-10-13 2017-05-11 Министерство Промышленности И Торговли Рф Цилиндрический термоэмиссионный катод
WO2023239854A2 (en) * 2022-06-08 2023-12-14 Icahn School Of Medicine At Mount Sinai Method of treating obesity with a luteinizing hormone receptor agonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2054784T3 (es) 1987-08-08 1994-08-16 Akzo Nv Un metodo para la fabricacion de un implante.
TW564247B (en) 1999-04-08 2003-12-01 Akzo Nobel Nv Bicyclic heteraromatic compound

Also Published As

Publication number Publication date
RU2004110042A (ru) 2005-08-20
HUP0401444A3 (en) 2008-05-28
AU2002337035B2 (en) 2008-04-24
NO20040927L (no) 2004-03-03
CA2456901A1 (en) 2003-03-13
IS2424B (is) 2008-10-15
HRP20040202A2 (en) 2004-08-31
EP1427733A1 (de) 2004-06-16
PT1427733E (pt) 2007-02-28
NZ531340A (en) 2005-08-26
ZA200401455B (en) 2004-11-19
ES2275005T3 (es) 2007-06-01
WO2003020726A1 (en) 2003-03-13
KR20040029134A (ko) 2004-04-03
JP2005505555A (ja) 2005-02-24
MXPA04002045A (es) 2004-07-08
CY1106012T1 (el) 2011-04-06
US20040180873A1 (en) 2004-09-16
TWI228508B (en) 2005-03-01
PL368502A1 (en) 2005-04-04
ATE345345T1 (de) 2006-12-15
KR100900018B1 (ko) 2009-06-01
RU2298011C2 (ru) 2007-04-27
HUP0401444A2 (hu) 2004-11-29
PE20030439A1 (es) 2003-05-17
AR036407A1 (es) 2004-09-08
JP4262092B2 (ja) 2009-05-13
DE60216128T2 (de) 2007-09-27
IL160084A0 (en) 2004-06-20
IS7130A (is) 2004-01-29
CA2456901C (en) 2011-01-04
CN1551884A (zh) 2004-12-01
DK1427733T3 (da) 2007-03-19
US7317006B2 (en) 2008-01-08
BR0211938A (pt) 2004-09-21
EP1427733B1 (de) 2006-11-15
CN1246324C (zh) 2006-03-22

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