ZA200308857B - Ligands of integrin avbeta6. - Google Patents

Ligands of integrin avbeta6. Download PDF

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Publication number
ZA200308857B
ZA200308857B ZA200308857A ZA200308857A ZA200308857B ZA 200308857 B ZA200308857 B ZA 200308857B ZA 200308857 A ZA200308857 A ZA 200308857A ZA 200308857 A ZA200308857 A ZA 200308857A ZA 200308857 B ZA200308857 B ZA 200308857B
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South Africa
Prior art keywords
biphenyl
propionic acid
ethanoylamino
ureido
amino
Prior art date
Application number
ZA200308857A
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English (en)
Inventor
Oliver Schadt
Wolfgang Staehle
Alfred Jonczyk
Simon Goodman
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Merck Patent Gmbh
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Publication of ZA200308857B publication Critical patent/ZA200308857B/en

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ZA200308857A 2001-04-14 2003-11-13 Ligands of integrin avbeta6. ZA200308857B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10118550A DE10118550A1 (de) 2001-04-14 2001-04-14 Liganden des Integrins alpha¶nu¶beta¶6¶

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ZA200308857B true ZA200308857B (en) 2004-09-13

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ZA200308857A ZA200308857B (en) 2001-04-14 2003-11-13 Ligands of integrin avbeta6.

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US (1) US20040142877A1 (fr)
EP (1) EP1379495A2 (fr)
JP (1) JP2004528325A (fr)
KR (1) KR20030090739A (fr)
CN (1) CN1501827A (fr)
BR (1) BR0208885A (fr)
CA (1) CA2444247A1 (fr)
CZ (1) CZ20033000A3 (fr)
DE (1) DE10118550A1 (fr)
HU (1) HUP0303804A3 (fr)
MX (1) MXPA03009318A (fr)
PL (1) PL363328A1 (fr)
RU (1) RU2003130639A (fr)
SK (1) SK13732003A3 (fr)
WO (1) WO2002083627A2 (fr)
ZA (1) ZA200308857B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ535425A (en) 2002-03-13 2008-05-30 Biogen Idec Inc Anti-alphavbeta6 antibodies
US20090028853A1 (en) * 2006-10-19 2009-01-29 The Regents Of The University Of California, A California Corporation TREATMENT AND PREVENTION OF CHRONIC ASTHMA USING ANTAGONISTS OF INTEGRIN ALPHAvBETA6
US7838252B2 (en) * 2005-02-17 2010-11-23 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating a subject having an anthrax toxin mediated condition
CN102875681A (zh) 2005-07-08 2013-01-16 拜奥根Idec马萨诸塞公司 抗-αvβ6抗体及其用途
AU2007272995B2 (en) 2006-07-10 2013-02-07 Biogen Idec Ma Inc. Compositions and methods for inhibiting growth of smad4-deficient cancers
WO2014018913A2 (fr) * 2012-07-27 2014-01-30 University Of Connecticut Compositions de santacruzamate a et analogues et procédés d'utilisation
WO2014144466A1 (fr) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anticorps anti-alpha ν bêta 6 et leurs utilisations
WO2014143739A2 (fr) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anticorps anti-alpha ν bêta 6 et leurs utilisations
KR102634762B1 (ko) * 2016-11-01 2024-02-06 애로우헤드 파마슈티컬스 인코포레이티드 알파-v 베타-6 인테그린 리간드 및 그의 용도

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0378167B1 (fr) * 1989-01-10 1994-12-28 Sumitomo Chemical Company Limited Composition de colorants dispersés utile pour la teinture ou l'impression de matériaux en fibres hydrophobes
DE3927069A1 (de) * 1989-08-16 1991-02-21 Basf Ag Phenonazofarbstoffe und verfahren zum thermischen transfer dieser farbstoffe
US5550098A (en) * 1991-11-14 1996-08-27 Dai Nippon Printing Co., Ltd. Thermal transfer sheet
CN1146541C (zh) * 1999-02-20 2004-04-21 默克专利股份有限公司 β-丙氨酸衍生物
DE19933173A1 (de) * 1999-07-15 2001-01-18 Merck Patent Gmbh Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶

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HUP0303804A2 (hu) 2004-03-29
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MXPA03009318A (es) 2004-02-12
RU2003130639A (ru) 2005-04-10
CN1501827A (zh) 2004-06-02
DE10118550A1 (de) 2002-10-17
CZ20033000A3 (cs) 2004-02-18
PL363328A1 (en) 2004-11-15
EP1379495A2 (fr) 2004-01-14
JP2004528325A (ja) 2004-09-16
HUP0303804A3 (en) 2005-09-28
SK13732003A3 (sk) 2004-02-03
WO2002083627A2 (fr) 2002-10-24
KR20030090739A (ko) 2003-11-28
US20040142877A1 (en) 2004-07-22

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