MXPA03009318A - Ligandos de integrina alfa v beta 6. - Google Patents

Ligandos de integrina alfa v beta 6.

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Publication number
MXPA03009318A
MXPA03009318A MXPA03009318A MXPA03009318A MXPA03009318A MX PA03009318 A MXPA03009318 A MX PA03009318A MX PA03009318 A MXPA03009318 A MX PA03009318A MX PA03009318 A MXPA03009318 A MX PA03009318A MX PA03009318 A MXPA03009318 A MX PA03009318A
Authority
MX
Mexico
Prior art keywords
dollar
integrin
ligands
Prior art date
Application number
MXPA03009318A
Other languages
English (en)
Inventor
Alfred Jonczyk
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MXPA03009318A publication Critical patent/MXPA03009318A/es

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    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
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    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
MXPA03009318A 2001-04-14 2002-03-13 Ligandos de integrina alfa v beta 6. MXPA03009318A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10118550A DE10118550A1 (de) 2001-04-14 2001-04-14 Liganden des Integrins alpha¶nu¶beta¶6¶
PCT/EP2002/002728 WO2002083627A2 (de) 2001-04-14 2002-03-13 Liganden des integrins alpha-v-beta-6

Publications (1)

Publication Number Publication Date
MXPA03009318A true MXPA03009318A (es) 2004-02-12

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MXPA03009318A MXPA03009318A (es) 2001-04-14 2002-03-13 Ligandos de integrina alfa v beta 6.

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US (1) US20040142877A1 (es)
EP (1) EP1379495A2 (es)
JP (1) JP2004528325A (es)
KR (1) KR20030090739A (es)
CN (1) CN1501827A (es)
BR (1) BR0208885A (es)
CA (1) CA2444247A1 (es)
CZ (1) CZ20033000A3 (es)
DE (1) DE10118550A1 (es)
HU (1) HUP0303804A3 (es)
MX (1) MXPA03009318A (es)
PL (1) PL363328A1 (es)
RU (1) RU2003130639A (es)
SK (1) SK13732003A3 (es)
WO (1) WO2002083627A2 (es)
ZA (1) ZA200308857B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102659946A (zh) 2002-03-13 2012-09-12 拜奥根Idec马萨诸塞公司 抗αvβ6抗体
US7838252B2 (en) * 2005-02-17 2010-11-23 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating a subject having an anthrax toxin mediated condition
CN104072614B (zh) 2005-07-08 2017-04-26 生物基因Ma公司 抗-αvβ6 抗体及其用途
BRPI0714381A2 (pt) 2006-07-10 2013-03-05 Biogen Idec Inc composiÇÕes e mÉtodos para inibir crescimento de cÂnceres deficientes em smad4
AU2007354317A1 (en) * 2006-10-19 2008-12-04 Biogen Idec Ma Inc. Treatment and prevention of chronic asthma using antagonists of integrin alphaVbeta6
WO2014018913A2 (en) * 2012-07-27 2014-01-30 University Of Connecticut Santacruzamate a compositions and analogs and methods of use
US10035859B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
WO2014143739A2 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
CA3039618A1 (en) * 2016-11-01 2018-05-11 Arrowhead Pharmaceuticals, Inc. Alpha-v beta-6 integrin ligands and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5038415A (en) * 1989-01-10 1991-08-13 Sumitomo Chemical Company, Limited Disperse dye composition useful for dyeing of printing hydrophobic fiber materials: mixture of pyridone mono-azo dyes and optionally a quino-phthalone
DE3927069A1 (de) * 1989-08-16 1991-02-21 Basf Ag Phenonazofarbstoffe und verfahren zum thermischen transfer dieser farbstoffe
US5550098A (en) * 1991-11-14 1996-08-27 Dai Nippon Printing Co., Ltd. Thermal transfer sheet
HUP0105479A3 (en) * 1999-02-20 2002-06-28 Merck Patent Gmbh Betha-alanine derivatives, process for producing them and pharmaceutical compositions containing them
DE19933173A1 (de) * 1999-07-15 2001-01-18 Merck Patent Gmbh Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶

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US20040142877A1 (en) 2004-07-22
EP1379495A2 (de) 2004-01-14
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CA2444247A1 (en) 2002-10-24
CN1501827A (zh) 2004-06-02
RU2003130639A (ru) 2005-04-10
SK13732003A3 (sk) 2004-02-03
HUP0303804A3 (en) 2005-09-28
DE10118550A1 (de) 2002-10-17
BR0208885A (pt) 2004-06-29
WO2002083627A2 (de) 2002-10-24
PL363328A1 (en) 2004-11-15
KR20030090739A (ko) 2003-11-28
ZA200308857B (en) 2004-09-13
JP2004528325A (ja) 2004-09-16
WO2002083627A3 (de) 2003-10-09

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