BR0208885A - Inibidores de integrina alfavbeta6 - Google Patents
Inibidores de integrina alfavbeta6Info
- Publication number
- BR0208885A BR0208885A BR0208885-1A BR0208885A BR0208885A BR 0208885 A BR0208885 A BR 0208885A BR 0208885 A BR0208885 A BR 0208885A BR 0208885 A BR0208885 A BR 0208885A
- Authority
- BR
- Brazil
- Prior art keywords
- alphabeta6
- novel
- integrin inhibitors
- integrin
- inhibitors
- Prior art date
Links
- 102000006495 integrins Human genes 0.000 title abstract 3
- 108010044426 integrins Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
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- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
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Abstract
"INIBIDORES DE INTEGRINA ALFA~ v~BETA~ 6~". A presente invenção refere-se a derivados de bifenila novos da fórmula geral 1 na qual R^ 1^, R^ 1<39>^, R^ 1"^, R^ 2^ e n são como definido na Reivindicação 1, seus estereoisómeros e seus sais ou solvatos fisiologicamente aceitáveis são novos ligandos de integrina, em particular do receptor de integrina <244>~ v~<225>~ 6~. Os novos compostos podem ser empregados como medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10118550A DE10118550A1 (de) | 2001-04-14 | 2001-04-14 | Liganden des Integrins alpha¶nu¶beta¶6¶ |
PCT/EP2002/002728 WO2002083627A2 (de) | 2001-04-14 | 2002-03-13 | Liganden des integrins alpha-v-beta-6 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0208885A true BR0208885A (pt) | 2004-06-29 |
Family
ID=7681550
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0208885-1A BR0208885A (pt) | 2001-04-14 | 2002-03-13 | Inibidores de integrina alfavbeta6 |
Country Status (16)
Country | Link |
---|---|
US (1) | US20040142877A1 (pt) |
EP (1) | EP1379495A2 (pt) |
JP (1) | JP2004528325A (pt) |
KR (1) | KR20030090739A (pt) |
CN (1) | CN1501827A (pt) |
BR (1) | BR0208885A (pt) |
CA (1) | CA2444247A1 (pt) |
CZ (1) | CZ20033000A3 (pt) |
DE (1) | DE10118550A1 (pt) |
HU (1) | HUP0303804A3 (pt) |
MX (1) | MXPA03009318A (pt) |
PL (1) | PL363328A1 (pt) |
RU (1) | RU2003130639A (pt) |
SK (1) | SK13732003A3 (pt) |
WO (1) | WO2002083627A2 (pt) |
ZA (1) | ZA200308857B (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2478833C (en) | 2002-03-13 | 2015-11-10 | Biogen, Inc. | Anti-.alpha.v.beta.6 antibodies |
WO2006089114A2 (en) * | 2005-02-17 | 2006-08-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating an anthrax toxin mediated condition |
CN102875681A (zh) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
KR20090027241A (ko) | 2006-07-10 | 2009-03-16 | 바이오겐 아이덱 엠에이 인코포레이티드 | Smad4-결핍 암의 성장을 억제하기 위한 조성물 및 방법 |
AU2007354317A1 (en) * | 2006-10-19 | 2008-12-04 | Biogen Idec Ma Inc. | Treatment and prevention of chronic asthma using antagonists of integrin alphaVbeta6 |
WO2014018913A2 (en) * | 2012-07-27 | 2014-01-30 | University Of Connecticut | Santacruzamate a compositions and analogs and methods of use |
WO2014144466A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
WO2014143739A2 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
ES2906109T3 (es) * | 2016-11-01 | 2022-04-13 | Arrowhead Pharmaceuticals Inc | Ligandos de la integrina alfa- v beta-6 y usos de los mismos |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69015374T2 (de) * | 1989-01-10 | 1995-05-04 | Sumitomo Chemical Co | Dispersionsfarbstoffzubereitung zum Färben oder Bedrucken von hydrophoben Fasermaterialien. |
DE3927069A1 (de) * | 1989-08-16 | 1991-02-21 | Basf Ag | Phenonazofarbstoffe und verfahren zum thermischen transfer dieser farbstoffe |
US5550098A (en) * | 1991-11-14 | 1996-08-27 | Dai Nippon Printing Co., Ltd. | Thermal transfer sheet |
US6576637B1 (en) * | 1999-02-20 | 2003-06-10 | Merck Patent Gmbh | β-alanine derivatives |
DE19933173A1 (de) * | 1999-07-15 | 2001-01-18 | Merck Patent Gmbh | Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶ |
-
2001
- 2001-04-14 DE DE10118550A patent/DE10118550A1/de not_active Withdrawn
-
2002
- 2002-03-13 SK SK1373-2003A patent/SK13732003A3/sk unknown
- 2002-03-13 CA CA002444247A patent/CA2444247A1/en not_active Abandoned
- 2002-03-13 MX MXPA03009318A patent/MXPA03009318A/es unknown
- 2002-03-13 JP JP2002581384A patent/JP2004528325A/ja active Pending
- 2002-03-13 BR BR0208885-1A patent/BR0208885A/pt not_active Application Discontinuation
- 2002-03-13 US US10/474,802 patent/US20040142877A1/en not_active Abandoned
- 2002-03-13 KR KR10-2003-7013447A patent/KR20030090739A/ko not_active Application Discontinuation
- 2002-03-13 CZ CZ20033000A patent/CZ20033000A3/cs unknown
- 2002-03-13 RU RU2003130639/04A patent/RU2003130639A/ru not_active Application Discontinuation
- 2002-03-13 WO PCT/EP2002/002728 patent/WO2002083627A2/de not_active Application Discontinuation
- 2002-03-13 CN CNA028081722A patent/CN1501827A/zh active Pending
- 2002-03-13 PL PL02363328A patent/PL363328A1/xx unknown
- 2002-03-13 HU HU0303804A patent/HUP0303804A3/hu unknown
- 2002-03-13 EP EP02747260A patent/EP1379495A2/de not_active Withdrawn
-
2003
- 2003-11-13 ZA ZA200308857A patent/ZA200308857B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE10118550A1 (de) | 2002-10-17 |
WO2002083627A3 (de) | 2003-10-09 |
WO2002083627A2 (de) | 2002-10-24 |
HUP0303804A3 (en) | 2005-09-28 |
SK13732003A3 (sk) | 2004-02-03 |
CZ20033000A3 (cs) | 2004-02-18 |
MXPA03009318A (es) | 2004-02-12 |
RU2003130639A (ru) | 2005-04-10 |
ZA200308857B (en) | 2004-09-13 |
CA2444247A1 (en) | 2002-10-24 |
KR20030090739A (ko) | 2003-11-28 |
EP1379495A2 (de) | 2004-01-14 |
JP2004528325A (ja) | 2004-09-16 |
PL363328A1 (en) | 2004-11-15 |
CN1501827A (zh) | 2004-06-02 |
US20040142877A1 (en) | 2004-07-22 |
HUP0303804A2 (hu) | 2004-03-29 |
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