ZA200304530B - Substituted pyrrolidines as CCR-3 receptor antagonists. - Google Patents
Substituted pyrrolidines as CCR-3 receptor antagonists. Download PDFInfo
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- ZA200304530B ZA200304530B ZA200304530A ZA200304530A ZA200304530B ZA 200304530 B ZA200304530 B ZA 200304530B ZA 200304530 A ZA200304530 A ZA 200304530A ZA 200304530 A ZA200304530 A ZA 200304530A ZA 200304530 B ZA200304530 B ZA 200304530B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- compound
- formula
- hydrogen
- alk
- Prior art date
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- 102000004499 CCR3 Receptors Human genes 0.000 title claims description 14
- 108010017316 CCR3 Receptors Proteins 0.000 title claims description 14
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- 229940044551 receptor antagonist Drugs 0.000 title claims description 8
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 235000020183 skimmed milk Nutrition 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 description 1
- 229910001488 sodium perchlorate Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- IXGNPUSUVRTQGW-UHFFFAOYSA-M sodium;perchlorate;hydrate Chemical compound O.[Na+].[O-]Cl(=O)(=O)=O IXGNPUSUVRTQGW-UHFFFAOYSA-M 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
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- MDKGKXOCJGEUJW-UHFFFAOYSA-N suprofen Chemical compound C1=CC(C(C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-UHFFFAOYSA-N 0.000 description 1
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- 235000002906 tartaric acid Nutrition 0.000 description 1
- CAHOUDZKOBNBED-KGLIPLIRSA-N tert-butyl (2s,4r)-4-[(3,4-dichlorophenyl)methyl]-2-(methylsulfonyloxymethyl)pyrrolidine-1-carboxylate Chemical compound C1[C@@H](COS(C)(=O)=O)N(C(=O)OC(C)(C)C)C[C@@H]1CC1=CC=C(Cl)C(Cl)=C1 CAHOUDZKOBNBED-KGLIPLIRSA-N 0.000 description 1
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- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25658500P | 2000-12-19 | 2000-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200304530B true ZA200304530B (en) | 2004-09-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200304530A ZA200304530B (en) | 2000-12-19 | 2003-06-10 | Substituted pyrrolidines as CCR-3 receptor antagonists. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6552028B2 (ko) |
| EP (1) | EP1358181B1 (ko) |
| JP (1) | JP2004519443A (ko) |
| KR (1) | KR20030061455A (ko) |
| CN (1) | CN1239498C (ko) |
| AR (1) | AR035519A1 (ko) |
| AT (1) | ATE374198T1 (ko) |
| AU (1) | AU2002216107A1 (ko) |
| BR (1) | BR0116352A (ko) |
| CA (1) | CA2431767A1 (ko) |
| DE (1) | DE60130684T2 (ko) |
| ES (1) | ES2292530T3 (ko) |
| MX (1) | MXPA03005581A (ko) |
| WO (1) | WO2002050064A1 (ko) |
| ZA (1) | ZA200304530B (ko) |
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|---|---|---|---|---|
| KR20060061393A (ko) * | 2003-10-24 | 2006-06-07 | 에프. 호프만-라 로슈 아게 | Ｃｃｒ3 수용체 길항제 |
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| CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
| IL125658A0 (en) * | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| JP3593037B2 (ja) * | 1998-11-20 | 2004-11-24 | エフ．ホフマン−ラ ロシュ アーゲー | ピロリジン誘導体ｃｃｒ−３受容体アンタゴニスト |
| CA2351631A1 (en) * | 1998-11-20 | 2000-06-02 | F. Hoffmann-La Roche Ag | Piperidine quaternary salts-ccr-3 receptor antagonists |
| AU3126700A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| EP1158980B1 (en) | 1998-12-18 | 2005-08-24 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| US6441001B1 (en) | 1998-12-18 | 2002-08-27 | Bristol-Myers Squibb Pharma Company | 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity |
| EP1140834A1 (en) | 1998-12-18 | 2001-10-10 | Du Pont Pharmaceuticals Company | Heterocyclic piperidines as modulators of chemokine receptor activity |
| WO2000035451A1 (en) | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| CN1206219C (zh) | 1998-12-18 | 2005-06-15 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为趋化因子受体活性调节剂的n－脲基烷基－哌啶化合物 |
| AU2482100A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
-
2001
- 2001-12-13 MX MXPA03005581A patent/MXPA03005581A/es active IP Right Grant
- 2001-12-13 ES ES01271370T patent/ES2292530T3/es not_active Expired - Lifetime
- 2001-12-13 WO PCT/EP2001/014670 patent/WO2002050064A1/en active IP Right Grant
- 2001-12-13 DE DE60130684T patent/DE60130684T2/de not_active Expired - Fee Related
- 2001-12-13 CN CNB018208789A patent/CN1239498C/zh not_active Expired - Fee Related
- 2001-12-13 AT AT01271370T patent/ATE374198T1/de not_active IP Right Cessation
- 2001-12-13 JP JP2002551560A patent/JP2004519443A/ja active Pending
- 2001-12-13 KR KR10-2003-7008134A patent/KR20030061455A/ko not_active Application Discontinuation
- 2001-12-13 EP EP01271370A patent/EP1358181B1/en not_active Expired - Lifetime
- 2001-12-13 BR BR0116352-3A patent/BR0116352A/pt not_active IP Right Cessation
- 2001-12-13 CA CA002431767A patent/CA2431767A1/en not_active Abandoned
- 2001-12-13 AU AU2002216107A patent/AU2002216107A1/en not_active Abandoned
- 2001-12-17 AR ARP010105833A patent/AR035519A1/es not_active Application Discontinuation
- 2001-12-19 US US10/034,034 patent/US6552028B2/en not_active Expired - Fee Related
-
2003
- 2003-02-18 US US10/368,097 patent/US20030199532A1/en not_active Abandoned
- 2003-06-10 ZA ZA200304530A patent/ZA200304530B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6552028B2 (en) | 2003-04-22 |
| MXPA03005581A (es) | 2003-10-06 |
| WO2002050064A1 (en) | 2002-06-27 |
| EP1358181B1 (en) | 2007-09-26 |
| CN1481379A (zh) | 2004-03-10 |
| JP2004519443A (ja) | 2004-07-02 |
| CN1239498C (zh) | 2006-02-01 |
| AU2002216107A1 (en) | 2002-07-01 |
| AR035519A1 (es) | 2004-06-02 |
| ATE374198T1 (de) | 2007-10-15 |
| BR0116352A (pt) | 2003-12-02 |
| CA2431767A1 (en) | 2002-06-27 |
| DE60130684T2 (de) | 2008-08-14 |
| US20020198255A1 (en) | 2002-12-26 |
| US20030199532A1 (en) | 2003-10-23 |
| KR20030061455A (ko) | 2003-07-18 |
| ES2292530T3 (es) | 2008-03-16 |
| EP1358181A1 (en) | 2003-11-05 |
| DE60130684D1 (de) | 2007-11-08 |
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