ZA200304348B - Heteroaryl urea neuropeptide Y Y5 receptor antagonists. - Google Patents
Heteroaryl urea neuropeptide Y Y5 receptor antagonists. Download PDFInfo
- Publication number
- ZA200304348B ZA200304348B ZA200304348A ZA200304348A ZA200304348B ZA 200304348 B ZA200304348 B ZA 200304348B ZA 200304348 A ZA200304348 A ZA 200304348A ZA 200304348 A ZA200304348 A ZA 200304348A ZA 200304348 B ZA200304348 B ZA 200304348B
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- ZA
- South Africa
- Prior art keywords
- compound
- alkyl
- prodrug
- cycloalkyl
- pharmaceutically acceptable
- Prior art date
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- 125000001072 heteroaryl group Chemical group 0.000 title claims description 42
- 101710151321 Melanostatin Proteins 0.000 title description 18
- URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 title description 18
- 102100029549 Neuropeptide Y receptor type 5 Human genes 0.000 title description 7
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- 239000002464 receptor antagonist Substances 0.000 title description 6
- 229940044551 receptor antagonist Drugs 0.000 title description 6
- 239000004202 carbamide Substances 0.000 title description 4
- 102400000064 Neuropeptide Y Human genes 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims description 147
- 150000001875 compounds Chemical class 0.000 claims description 144
- 229940002612 prodrug Drugs 0.000 claims description 80
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- 125000003118 aryl group Chemical group 0.000 claims description 43
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- 238000000034 method Methods 0.000 claims description 27
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
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- 125000003282 alkyl amino group Chemical group 0.000 claims description 5
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims description 5
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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US (1) | US6982267B2 (hu) |
EP (1) | EP1343503B1 (hu) |
JP (1) | JP4226326B2 (hu) |
KR (1) | KR20030061458A (hu) |
CN (2) | CN1807426A (hu) |
AR (1) | AR035520A1 (hu) |
AT (1) | ATE413880T1 (hu) |
AU (2) | AU2002234056B2 (hu) |
BR (1) | BR0116379A (hu) |
CA (1) | CA2432809C (hu) |
DE (1) | DE60136562D1 (hu) |
ES (1) | ES2316486T3 (hu) |
HK (1) | HK1054333A1 (hu) |
HU (1) | HUP0303339A3 (hu) |
IL (1) | IL156157A0 (hu) |
MX (1) | MXPA03005745A (hu) |
NO (1) | NO20032861L (hu) |
NZ (1) | NZ526174A (hu) |
PE (1) | PE20020761A1 (hu) |
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US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
EP1601666A2 (en) | 2002-07-02 | 2005-12-07 | Schering Corporation | New neuropeptide y y5 receptor antagonists |
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CA2551037A1 (en) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivative |
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DE2928485A1 (de) * | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
US4623662A (en) | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
US5602024A (en) | 1994-12-02 | 1997-02-11 | Synaptic Pharmaceutical Corporation | DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof |
US6043246A (en) * | 1996-12-03 | 2000-03-28 | Banyu Pharmaceutical Co., Ltd. | Urea derivatives |
AR016817A1 (es) * | 1997-08-14 | 2001-08-01 | Smithkline Beecham Plc | Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento |
ES2154253T3 (es) * | 1997-12-22 | 2012-01-27 | Bayer Healthcare Llc | Inhibición de la actividad de p38 cinasa usando ureas heterocíclicas sustituidas. |
WO2000027845A1 (en) | 1998-11-10 | 2000-05-18 | Merck & Co., Inc. | Spiro-indolines as y5 receptor antagonists |
EP1184373A4 (en) * | 1999-04-20 | 2004-10-20 | Meiji Seika Kaisha | TRICYCLIC CONNECTIONS |
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EP2014285B1 (en) | 1999-11-26 | 2010-05-05 | Shionogi&Co., Ltd. | NPYY5 antagonists |
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2001
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- 2001-12-17 CN CNA2006100050504A patent/CN1807426A/zh active Pending
- 2001-12-17 NZ NZ526174A patent/NZ526174A/xx unknown
- 2001-12-17 CA CA2432809A patent/CA2432809C/en not_active Expired - Fee Related
- 2001-12-17 CN CNA018211720A patent/CN1482912A/zh active Pending
- 2001-12-17 IL IL15615701A patent/IL156157A0/xx unknown
- 2001-12-17 WO PCT/US2001/049302 patent/WO2002049648A1/en active IP Right Grant
- 2001-12-17 BR BR0116379-5A patent/BR0116379A/pt not_active Application Discontinuation
- 2001-12-17 AU AU3405602A patent/AU3405602A/xx active Pending
- 2001-12-17 SG SG200503925-0A patent/SG138463A1/en unknown
- 2001-12-17 HU HU0303339A patent/HUP0303339A3/hu unknown
- 2001-12-17 AR ARP010105841A patent/AR035520A1/es not_active Application Discontinuation
- 2001-12-17 MX MXPA03005745A patent/MXPA03005745A/es active IP Right Grant
- 2001-12-17 AT AT01985069T patent/ATE413880T1/de not_active IP Right Cessation
- 2001-12-17 ES ES01985069T patent/ES2316486T3/es not_active Expired - Lifetime
- 2001-12-17 KR KR10-2003-7008229A patent/KR20030061458A/ko not_active Application Discontinuation
- 2001-12-17 EP EP01985069A patent/EP1343503B1/en not_active Expired - Lifetime
- 2001-12-17 DE DE60136562T patent/DE60136562D1/de not_active Expired - Lifetime
- 2001-12-17 JP JP2002550988A patent/JP4226326B2/ja not_active Expired - Fee Related
- 2001-12-18 US US10/026,651 patent/US6982267B2/en not_active Expired - Lifetime
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- 2003-06-03 ZA ZA200304348A patent/ZA200304348B/en unknown
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- 2003-09-19 HK HK03106723.8A patent/HK1054333A1/zh unknown
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ES2316486T3 (es) | 2009-04-16 |
MXPA03005745A (es) | 2003-09-05 |
US6982267B2 (en) | 2006-01-03 |
AU3405602A (en) | 2002-07-01 |
CA2432809C (en) | 2010-11-30 |
BR0116379A (pt) | 2003-09-30 |
JP2004516267A (ja) | 2004-06-03 |
CA2432809A1 (en) | 2002-06-27 |
DE60136562D1 (de) | 2008-12-24 |
HUP0303339A3 (en) | 2004-04-28 |
JP4226326B2 (ja) | 2009-02-18 |
PE20020761A1 (es) | 2002-08-22 |
EP1343503A1 (en) | 2003-09-17 |
WO2002049648A1 (en) | 2002-06-27 |
HK1054333A1 (zh) | 2003-11-28 |
US20030055062A1 (en) | 2003-03-20 |
EP1343503A4 (en) | 2004-03-17 |
ATE413880T1 (de) | 2008-11-15 |
KR20030061458A (ko) | 2003-07-18 |
IL156157A0 (en) | 2003-12-23 |
EP1343503B1 (en) | 2008-11-12 |
SG138463A1 (en) | 2008-01-28 |
CN1807426A (zh) | 2006-07-26 |
NO20032861D0 (no) | 2003-06-20 |
AR035520A1 (es) | 2004-06-02 |
HUP0303339A2 (hu) | 2004-01-28 |
NO20032861L (no) | 2003-08-21 |
NZ526174A (en) | 2004-12-24 |
CN1482912A (zh) | 2004-03-17 |
AU2002234056B2 (en) | 2005-04-07 |
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