ZA200300750B - 7-substituted tetracycline compounds. - Google Patents
7-substituted tetracycline compounds.Info
- Publication number
- ZA200300750B ZA200300750B ZA200300750A ZA200300750A ZA200300750B ZA 200300750 B ZA200300750 B ZA 200300750B ZA 200300750 A ZA200300750 A ZA 200300750A ZA 200300750 A ZA200300750 A ZA 200300750A ZA 200300750 B ZA200300750 B ZA 200300750B
- Authority
- ZA
- South Africa
- Prior art keywords
- tetracycline compounds
- substituted tetracycline
- substituted
- compounds
- tetracycline
- Prior art date
Links
- 239000004098 Tetracycline Substances 0.000 title 1
- 229960002180 tetracycline Drugs 0.000 title 1
- 229930101283 tetracycline Natural products 0.000 title 1
- 235000019364 tetracycline Nutrition 0.000 title 1
- -1 tetracycline compounds Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61P35/00—Antineoplastic agents
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- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
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- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2475—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aralkylamines
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- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
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- C07C2601/14—The ring being saturated
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- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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ZA200300750A ZA200300750B (en) | 2000-07-07 | 2003-01-27 | 7-substituted tetracycline compounds. |
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US (3) | US6818635B2 (fr) |
EP (2) | EP2289871A1 (fr) |
JP (2) | JP5044084B2 (fr) |
KR (4) | KR100619637B1 (fr) |
CN (2) | CN102336679A (fr) |
AU (3) | AU2001271642B2 (fr) |
BR (1) | BR0112265A (fr) |
CA (1) | CA2415718C (fr) |
CZ (1) | CZ2003343A3 (fr) |
EA (1) | EA006170B1 (fr) |
HR (1) | HRP20030090A2 (fr) |
HU (1) | HUP0301163A3 (fr) |
IL (3) | IL153672A0 (fr) |
MX (1) | MXPA03000056A (fr) |
WO (1) | WO2002004407A2 (fr) |
ZA (1) | ZA200300750B (fr) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
AU2466099A (en) * | 1998-01-23 | 1999-08-09 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
DE60027465T2 (de) * | 1999-09-14 | 2007-02-01 | The Trustees Of Tufts College, Medford | Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien |
JP2003523963A (ja) | 2000-01-24 | 2003-08-12 | トラスティーズ・オブ・タフツ・カレッジ | クリプトスポリジウム・パルヴム関連疾患の治療のためのテトラサイクリン化合物 |
BR0109725A (pt) * | 2000-03-31 | 2003-02-04 | Tufts College | Composto de tetraciclina substituìdo, método para tratar um estado responsivo a tetraciclina em um mamìfero, composição farmacêutica, método para sintetizar um composto de tetraciclina 7- ou 9-substituìdo, e, intermediário reativo |
AU2001259701A1 (en) | 2000-05-15 | 2001-11-26 | Paratek Pharmaceuticals, Inc | 7-substituted fused ring tetracycline compounds |
US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
AU2001268475A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
HUP0301163A3 (en) * | 2000-07-07 | 2008-08-28 | Tufts College | 7-substituted tetracycline dervatives, pharmaceutical compositions containing them and their use |
WO2002004406A2 (fr) | 2000-07-07 | 2002-01-17 | Trustees Of Tufts College | Composes de monocycline 9-substitues |
AU2002250331A1 (en) | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
EP1241160A1 (fr) | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Dérivés de tétracyclines et leur utilisation comme agents antibiotiques |
CZ20032780A3 (cs) * | 2001-03-13 | 2004-01-14 | Paratek Pharmaceuticals, Inc. | 7,9- Substituované tetracyklinové sloučeniny |
US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
WO2002072031A2 (fr) * | 2001-03-14 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques |
CA2457234A1 (fr) * | 2001-03-14 | 2002-09-19 | Mark L. Nelson | Composes de tetracycline substitues, en tant qu'agents antifongiques |
EP1399414B1 (fr) * | 2001-04-24 | 2010-01-13 | Paratek Pharmaceuticals, Inc. | Composes de tetracycline substitues destines au traitement de la malaria |
US8088820B2 (en) | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
WO2003005971A2 (fr) | 2001-07-13 | 2003-01-23 | Paratek Pharmaceuticals, Inc. | Composes de tetracycline a activites therapeutiques cibles |
AU2002365120A1 (en) * | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
EP2322501B1 (fr) * | 2002-01-08 | 2015-08-05 | Paratek Pharmaceuticals, Inc. | Composés de tétracycline 4-dedimethylamino |
KR101093842B1 (ko) * | 2002-03-08 | 2011-12-13 | 파라테크 파마슈티컬스, 인크. | 아미노-메틸 치환된 테트라시클린 화합물 |
AU2003218242A1 (en) * | 2002-03-21 | 2003-10-08 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
CN1653037A (zh) * | 2002-03-21 | 2005-08-10 | 帕拉特克药品公司 | 取代的四环素化合物 |
KR101089429B1 (ko) * | 2002-07-12 | 2011-12-07 | 파라테크 파마슈티컬스, 인크. | 3, 10, 및 12a 치환된 테트라시클린 화합물 |
WO2004038001A2 (fr) * | 2002-10-24 | 2004-05-06 | Paratek Pharmaceuticals, Inc. | Composes tetracycline substituee servant au traitement du paludisme |
JP4686189B2 (ja) * | 2002-10-24 | 2011-05-18 | パラテック ファーマシューティカルズ インコーポレイテッド | Rnaを調節するための置換テトラサイクリン化合物の使用方法 |
CA2517256C (fr) | 2003-02-26 | 2013-04-30 | Sugen, Inc. | Composes d'aminoheteroaryle utilises en tant qu'inhibiteurs de proteine kinase |
EA201001081A1 (ru) * | 2003-07-09 | 2011-02-28 | Пэрэтек Фамэсьютикэлс, Инк. | Соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
EP1716101A1 (fr) * | 2004-01-15 | 2006-11-02 | Paratek Pharmaceuticals, Inc. | Derives a cycle aromatique a provenant de composes de tetracycline |
AU2012202559B2 (en) * | 2004-05-21 | 2014-07-17 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
DK1753713T3 (en) * | 2004-05-21 | 2016-11-28 | Harvard College | SYNTHESIS OF TETRACYCLINES AND ANALOGS THEREOF |
TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
EP1805134B1 (fr) | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines et procedes d'utilisation |
JP2008518035A (ja) | 2004-10-25 | 2008-05-29 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換テトラサイクリン化合物 |
EP1848685A1 (fr) | 2005-02-04 | 2007-10-31 | Paratek Pharmaceuticals, Inc. | Derives 11a, 12 de composes de tetracycline |
AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
AR057034A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Metodos para purificar tigeciclina |
CA2631632A1 (fr) * | 2005-12-22 | 2007-07-05 | Wyeth | Methodes de traitement d'infections du tractus gastro-intestinal a l'aide de tigecycline |
WO2007075794A2 (fr) * | 2005-12-22 | 2007-07-05 | Wyeth | Formulations orales contenant de la tigecycline |
EP1991236A2 (fr) * | 2006-01-24 | 2008-11-19 | Paratek Pharmaceuticals, Inc. | Procede permettant d'accroitre la biodisponibilite orale de tetracyclines |
WO2007117639A2 (fr) * | 2006-04-07 | 2007-10-18 | The President And Fellows Of Harvard College | Synthèse de tétracyclines et d'analogues de celles-ci |
US20080118979A1 (en) | 2006-05-15 | 2008-05-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
US7763735B2 (en) * | 2006-10-11 | 2010-07-27 | President And Fellows Of Harvard College | Synthesis of enone intermediate |
US8440646B1 (en) | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
LT2120963T (lt) * | 2006-12-21 | 2019-01-10 | Paratek Pharmaceuticals, Inc. | Pakeistieji tetraciklino junginiai uždegiminių odos ligų gydymui |
CA2673466C (fr) * | 2006-12-21 | 2016-06-14 | Paratek Pharmaceuticals, Inc. | Composes de tetracycline substituee |
AU2008239606A1 (en) * | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
AU2008246119A1 (en) * | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
EA201070233A1 (ru) | 2007-07-06 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Способы синтеза замещённых соединений тетрациклина (варианты) |
WO2009111064A2 (fr) | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Composés de minocycline et procédés d’utilisation de ceux-ci |
WO2009128913A1 (fr) * | 2008-04-14 | 2009-10-22 | Paratek Pharmaceuticals, Inc. | Composés à base de tétracyclines substituées |
TWI585071B (zh) * | 2008-05-23 | 2017-06-01 | 派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
EP2341771A4 (fr) * | 2008-09-19 | 2012-08-15 | Paratek Pharm Innc | Composés de tétracycline utilisés dans le traitement de la polyarthrite rhumatoïde et méthodes thérapeutiques associées |
EP2424834B1 (fr) | 2009-04-30 | 2018-07-11 | President and Fellows of Harvard College | Synthèse de tétracyclines et intermédiaires de celles-ci |
CA2761241C (fr) | 2009-05-08 | 2018-02-27 | Tetraphase Pharmaceuticals, Inc. | Composes de tetracycline |
CN105622496B (zh) * | 2009-08-28 | 2019-03-05 | 四相制药公司 | 四环素类化合物 |
US9889129B2 (en) | 2012-03-21 | 2018-02-13 | Case Western Reserve University | Method of modulating ribonucleotide reductase |
BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
EP3180335B1 (fr) | 2014-08-11 | 2021-05-05 | Angion Biomedica Corporation | Inhibiteurs de cytochrome p450 et leurs utilisations |
CA2970819A1 (fr) | 2014-12-31 | 2016-07-07 | Angion Biomedica Corp. | Methodes et agents pour traiter une maladie |
US10961190B2 (en) | 2016-10-19 | 2021-03-30 | Tetraphase Pharmaceuticals, Inc. | Crystalline forms of eravacycline |
SG10201913599RA (en) | 2016-11-01 | 2020-02-27 | Paratek Pharm Innc | 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp) |
CN113717073B (zh) * | 2021-08-26 | 2023-11-14 | 河北圣雪大成制药有限责任公司 | 一种合成盐酸米诺环素的新方法 |
Family Cites Families (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE26271E (en) * | 1967-09-26 | Reductive alkylation process | ||
US2990331A (en) | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
US2980584A (en) | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
US3062717A (en) | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
US3219671A (en) | 1961-04-14 | 1965-11-23 | American Cyanamid Co | Substituted 6-deoxytetracyclines and 6-demethyl-6-deoxytetracyclines |
US3165531A (en) | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
US3148212A (en) * | 1961-12-22 | 1964-09-08 | American Cyanamid Co | Reductive alkylation process |
USRE26253E (en) * | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
NL6408922A (fr) | 1963-08-08 | 1965-02-09 | ||
US3338983A (en) * | 1964-01-24 | 1967-08-29 | Exxon Research Engineering Co | Purification of alkyl aryl hydrocarbons |
US3609188A (en) * | 1964-10-29 | 1971-09-28 | American Cyanamid Co | 4-dedimethylamino-4-substituted-amino-6-demethyltetracyclines |
US3345379A (en) * | 1965-02-26 | 1967-10-03 | American Cyanamid Co | 7-imidomethyl-6-demethyl-6-deoxytetracyclines |
US3454697A (en) | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
US3350557A (en) * | 1965-06-09 | 1967-10-31 | Szymanski Ronald | Fog lens attachments for vehicle headlights |
US3397230A (en) * | 1966-03-14 | 1968-08-13 | American Cyanamid Co | Nitration of tetracyclines |
US3433834A (en) * | 1966-03-14 | 1969-03-18 | American Cyanamid Co | Nitration of 11a-chloro tetracyclines |
US3341585A (en) | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
NL6607516A (fr) | 1966-05-31 | 1967-12-01 | ||
US3345410A (en) | 1966-12-01 | 1967-10-03 | American Cyanamid Co | Substituted 7- and/or 9-amino tetracyclines |
US3403179A (en) | 1967-01-10 | 1968-09-24 | American Cyanamid Co | Novel 7-(1, 2-bis-substituted-hydrazino)-tetracyclines and methods of preparing same |
US3483251A (en) * | 1967-03-03 | 1969-12-09 | American Cyanamid Co | Reductive alkylation process |
US3373196A (en) | 1967-03-21 | 1968-03-12 | American Cyanamid Co | 7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines |
US3360561A (en) * | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
US3518306A (en) * | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
US3579579A (en) * | 1968-04-18 | 1971-05-18 | American Cyanamid Co | Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines |
DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
NL158172B (nl) * | 1972-09-18 | 1978-10-16 | Farmaceutici Italia | Werkwijze voor het bereiden van tetracyclinederivaten met een substituent op de 7-plaats. |
US3957980A (en) | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
JPS5119757A (ja) * | 1974-06-25 | 1976-02-17 | Farmaceutici Italia | Arukirutetorasaikurinjudotainoseizoho |
DE2437487A1 (de) * | 1974-08-03 | 1976-02-19 | Merck Patent Gmbh | 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung |
DE2442829A1 (de) | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
US4018889A (en) | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
US4126680A (en) | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
JPH0737433B2 (ja) * | 1987-06-11 | 1995-04-26 | 協和醗酵工業株式会社 | 7−アミノ−6−デメチル−6−デオキシテトラサイクリンの製造法 |
JPS6429346A (en) * | 1987-07-24 | 1989-01-31 | Nippon Kayaku Kk | Production of 7-nitro-6-demethyl-6-deoxytetracycline |
US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5281628A (en) * | 1991-10-04 | 1994-01-25 | American Cyanamid Company | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines |
US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
US5248797A (en) * | 1992-08-13 | 1993-09-28 | American Cyanamid Company | Method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5328902A (en) * | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
CA2103189C (fr) | 1992-11-17 | 2005-05-03 | Lorne M. Golub | Inhibition des liaisons croisees du collagene en exces au cours du diabete par des tetracyclines, y compris par des tetracyclines non antimicrobiennes chimiquement modifiees |
US5371076A (en) * | 1993-04-02 | 1994-12-06 | American Cyanamid Company | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines |
MX9603508A (es) | 1994-02-17 | 1997-03-29 | Pfizer | Analogos de la doxiciclina. |
US5675030A (en) * | 1994-11-16 | 1997-10-07 | American Cyanamid Company | Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound |
US5567693A (en) * | 1994-12-13 | 1996-10-22 | American Cyanamid Company | Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
US5843925A (en) * | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
US5789395A (en) | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
AU2466099A (en) * | 1998-01-23 | 1999-08-09 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
KR100701635B1 (ko) | 1998-11-18 | 2007-03-30 | 콜라제넥스 파마슈티칼스, 인크 | 신규한 4-데디메틸아미노테트라시클린 유도체 |
US6946453B2 (en) * | 1998-11-18 | 2005-09-20 | Collagenex Pharmaceuticals, Inc. | 4-dedimethylaminotracycline derivatives |
US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
DE60027465T2 (de) * | 1999-09-14 | 2007-02-01 | The Trustees Of Tufts College, Medford | Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
JP2003523963A (ja) | 2000-01-24 | 2003-08-12 | トラスティーズ・オブ・タフツ・カレッジ | クリプトスポリジウム・パルヴム関連疾患の治療のためのテトラサイクリン化合物 |
BR0109725A (pt) * | 2000-03-31 | 2003-02-04 | Tufts College | Composto de tetraciclina substituìdo, método para tratar um estado responsivo a tetraciclina em um mamìfero, composição farmacêutica, método para sintetizar um composto de tetraciclina 7- ou 9-substituìdo, e, intermediário reativo |
AU2001259701A1 (en) * | 2000-05-15 | 2001-11-26 | Paratek Pharmaceuticals, Inc | 7-substituted fused ring tetracycline compounds |
US20020128237A1 (en) | 2000-06-16 | 2002-09-12 | Nelson Mark L. | 7-N-substituted phenyl tetracycline compounds |
US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
AU2001268475A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
WO2001098259A1 (fr) | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | Composes de tetracycline 7-phenyl-substituee |
HUP0301163A3 (en) * | 2000-07-07 | 2008-08-28 | Tufts College | 7-substituted tetracycline dervatives, pharmaceutical compositions containing them and their use |
US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
DE60144375D1 (de) * | 2000-07-07 | 2011-05-19 | Trustees Of Tufts College Medford | 7-, 8- und 9-substitutierte tetracyclinverbindungen |
US20050143353A1 (en) * | 2000-07-07 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | 13-Substituted methacycline compounds |
CZ20032780A3 (cs) * | 2001-03-13 | 2004-01-14 | Paratek Pharmaceuticals, Inc. | 7,9- Substituované tetracyklinové sloučeniny |
US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
AU2002250331A1 (en) * | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
WO2002072031A2 (fr) * | 2001-03-14 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques |
CA2457234A1 (fr) * | 2001-03-14 | 2002-09-19 | Mark L. Nelson | Composes de tetracycline substitues, en tant qu'agents antifongiques |
US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
AU2002365120A1 (en) * | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
KR100816340B1 (ko) * | 2001-08-27 | 2008-03-24 | 삼성전자주식회사 | 액정 표시 장치 제조용 노광 마스크와 이를 이용한 액정표시 장치 제조에서의 기판의 노광 방법 |
EP2322501B1 (fr) * | 2002-01-08 | 2015-08-05 | Paratek Pharmaceuticals, Inc. | Composés de tétracycline 4-dedimethylamino |
KR101093842B1 (ko) * | 2002-03-08 | 2011-12-13 | 파라테크 파마슈티컬스, 인크. | 아미노-메틸 치환된 테트라시클린 화합물 |
CN1653037A (zh) * | 2002-03-21 | 2005-08-10 | 帕拉特克药品公司 | 取代的四环素化合物 |
KR101089429B1 (ko) * | 2002-07-12 | 2011-12-07 | 파라테크 파마슈티컬스, 인크. | 3, 10, 및 12a 치환된 테트라시클린 화합물 |
JP4686189B2 (ja) * | 2002-10-24 | 2011-05-18 | パラテック ファーマシューティカルズ インコーポレイテッド | Rnaを調節するための置換テトラサイクリン化合物の使用方法 |
US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
EA201001081A1 (ru) * | 2003-07-09 | 2011-02-28 | Пэрэтек Фамэсьютикэлс, Инк. | Соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
EP1716101A1 (fr) * | 2004-01-15 | 2006-11-02 | Paratek Pharmaceuticals, Inc. | Derives a cycle aromatique a provenant de composes de tetracycline |
EP1805134B1 (fr) * | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines et procedes d'utilisation |
JP2008518035A (ja) * | 2004-10-25 | 2008-05-29 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換テトラサイクリン化合物 |
EP1848685A1 (fr) * | 2005-02-04 | 2007-10-31 | Paratek Pharmaceuticals, Inc. | Derives 11a, 12 de composes de tetracycline |
US20080118979A1 (en) * | 2006-05-15 | 2008-05-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
AU2008239606A1 (en) * | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
-
2001
- 2001-06-29 HU HU0301163A patent/HUP0301163A3/hu unknown
- 2001-06-29 US US09/895,812 patent/US6818635B2/en not_active Expired - Lifetime
- 2001-06-29 MX MXPA03000056A patent/MXPA03000056A/es unknown
- 2001-06-29 JP JP2002509075A patent/JP5044084B2/ja not_active Expired - Fee Related
- 2001-06-29 EP EP10183426A patent/EP2289871A1/fr not_active Withdrawn
- 2001-06-29 EP EP01950674A patent/EP1301466A2/fr not_active Withdrawn
- 2001-06-29 BR BR0112265-7A patent/BR0112265A/pt not_active Application Discontinuation
- 2001-06-29 KR KR1020037000156A patent/KR100619637B1/ko not_active IP Right Cessation
- 2001-06-29 IL IL15367201A patent/IL153672A0/xx unknown
- 2001-06-29 KR KR1020107009085A patent/KR101083571B1/ko not_active IP Right Cessation
- 2001-06-29 AU AU2001271642A patent/AU2001271642B2/en not_active Ceased
- 2001-06-29 WO PCT/US2001/020766 patent/WO2002004407A2/fr active IP Right Grant
- 2001-06-29 EA EA200300134A patent/EA006170B1/ru not_active IP Right Cessation
- 2001-06-29 CN CN2011102225383A patent/CN102336679A/zh active Pending
- 2001-06-29 CZ CZ2003343A patent/CZ2003343A3/cs unknown
- 2001-06-29 CN CN01815094A patent/CN1450989A/zh active Pending
- 2001-06-29 KR KR1020097020272A patent/KR101027625B1/ko not_active IP Right Cessation
- 2001-06-29 KR KR1020067009612A patent/KR100997596B1/ko not_active IP Right Cessation
- 2001-06-29 AU AU7164201A patent/AU7164201A/xx active Pending
- 2001-06-29 CA CA2415718A patent/CA2415718C/fr not_active Expired - Fee Related
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2002
- 2002-12-25 IL IL153672A patent/IL153672A/en not_active IP Right Cessation
-
2003
- 2003-01-27 ZA ZA200300750A patent/ZA200300750B/xx unknown
- 2003-02-07 HR HR20030090A patent/HRP20030090A2/xx not_active Application Discontinuation
-
2004
- 2004-05-24 US US10/853,635 patent/US7595309B2/en not_active Expired - Fee Related
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2009
- 2009-06-09 US US12/481,368 patent/US8492365B2/en not_active Expired - Lifetime
- 2009-10-08 AU AU2009222638A patent/AU2009222638A1/en not_active Abandoned
- 2009-11-26 IL IL202385A patent/IL202385A/en not_active IP Right Cessation
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- 2012-02-17 JP JP2012032850A patent/JP2012140438A/ja active Pending
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