ZA200300403B - Fused azepine derivatives and their use as antidiuretic agents. - Google Patents

Fused azepine derivatives and their use as antidiuretic agents.

Info

Publication number
ZA200300403B
ZA200300403B ZA200300403A ZA200300403A ZA200300403B ZA 200300403 B ZA200300403 B ZA 200300403B ZA 200300403 A ZA200300403 A ZA 200300403A ZA 200300403 A ZA200300403 A ZA 200300403A ZA 200300403 B ZA200300403 B ZA 200300403B
Authority
ZA
South Africa
Prior art keywords
sup
antidiuretic agents
azepine derivatives
fused azepine
fused
Prior art date
Application number
ZA200300403A
Other languages
English (en)
Inventor
Ashworth Doreen Mary
Peter Hudson
Franklin Richard Jeremy
Jenkins David Paul
Pitt Gary Robert William
Yea Christopher Martyn
Graeme Semple
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of ZA200300403B publication Critical patent/ZA200300403B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200300403A 2000-06-26 2003-01-15 Fused azepine derivatives and their use as antidiuretic agents. ZA200300403B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0015601.8A GB0015601D0 (en) 2000-06-26 2000-06-26 Novel antidiuretic agents

Publications (1)

Publication Number Publication Date
ZA200300403B true ZA200300403B (en) 2004-04-02

Family

ID=9894399

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200300403A ZA200300403B (en) 2000-06-26 2003-01-15 Fused azepine derivatives and their use as antidiuretic agents.

Country Status (22)

Country Link
US (1) US7176195B2 (fr)
EP (1) EP1294698B1 (fr)
JP (2) JP3935071B2 (fr)
KR (1) KR100805808B1 (fr)
CN (1) CN1308313C (fr)
AT (1) ATE368650T1 (fr)
AU (2) AU2001274290B9 (fr)
CA (1) CA2412555A1 (fr)
CZ (1) CZ304037B6 (fr)
DE (1) DE60129697T2 (fr)
GB (1) GB0015601D0 (fr)
HK (1) HK1059780A1 (fr)
HU (1) HU229315B1 (fr)
IL (1) IL153358A0 (fr)
MX (1) MXPA02012779A (fr)
NO (1) NO324217B1 (fr)
NZ (1) NZ523066A (fr)
PL (1) PL359187A1 (fr)
RU (1) RU2269517C2 (fr)
UA (1) UA73177C2 (fr)
WO (1) WO2002000626A1 (fr)
ZA (1) ZA200300403B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
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US7138393B2 (en) 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
GB0000079D0 (en) 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0115515D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Oxytocin agonisys
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
EP2426122A1 (fr) * 2002-10-24 2012-03-07 Merck Patent GmbH Dérivés d'urée de méthylène comme inhibteurs de RAF kinase
KR20050100615A (ko) 2003-01-14 2005-10-19 싸이토키네틱스, 인코포레이티드 화합물, 조성물 및 방법
JP4629657B2 (ja) * 2003-04-11 2011-02-09 ハイ・ポイント・ファーマスーティカルズ、エルエルシー １１β−ヒドロキシステロイドデヒドロゲナーゼ１型化活性化合物
US7700583B2 (en) 2003-04-11 2010-04-20 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
EP1622698B1 (fr) * 2003-05-02 2010-01-06 Worcester Polytechnic Institute Modules composites de separation de gaz dotes de couches intermediaires a temperature de tamman elevee
EP1512687A1 (fr) * 2003-09-05 2005-03-09 Ferring B.V. Piperazines comme agonistes d'oxytocin
DE60305043T2 (de) * 2003-11-13 2006-11-30 Ferring B.V. Blisterverpackung und feste Dosierungsform enthaltend Desmopressin
MXPA06014495A (es) * 2004-06-17 2007-03-01 Cytokinetics Inc Compuestos, composiciones y metodos.
US7176222B2 (en) 2004-07-27 2007-02-13 Cytokinetics, Inc. Syntheses of ureas
EP1627876A1 (fr) * 2004-08-20 2006-02-22 Ferring B.V. Composés hétérocycliques condensés et leur usage et leur utilisation comme anti-diurétiques
EP1632494A1 (fr) * 2004-08-24 2006-03-08 Ferring B.V. Antagonistes de la v1a vasopressine
WO2006054560A1 (fr) * 2004-11-17 2006-05-26 Kissei Pharmaceutical Co., Ltd. Derives d’amides aromatiques, compositions medicinales contenant ces derniers et utilisations medicales de ces deux elements
US7538223B2 (en) 2005-08-04 2009-05-26 Cytokinetics, Inc. Compounds, compositions and methods
US7825120B2 (en) 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
US20070161617A1 (en) * 2005-12-15 2007-07-12 Morgan Bradley P Certain chemical entities, compositions and methods
WO2007078815A2 (fr) 2005-12-16 2007-07-12 Cytokinetics, Inc. Entites chimiques, compositions et methodes
WO2007078839A2 (fr) 2005-12-19 2007-07-12 Cytokinetics, Inc. Composes, compositions et methodes
SE0600482L (sv) * 2006-03-02 2006-11-14 Ferring Int Ct Sa Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse
WO2008141081A1 (fr) * 2007-05-10 2008-11-20 Amr Technology, Inc. Tétrahydrobenzo-l,4-diazépines substituées par un aryle ou un hétéroaryle et utilisation desdites dans le blocage de la réassimilation de la norépinéphrine, de la dopamine et de la sérotonine
CA2988753A1 (fr) 2007-08-06 2009-02-12 Serenity Pharmaceuticals, Llc Procedes et dispositifs pour l'administration de medicament desmopressine
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
ES2462465T5 (es) * 2008-05-21 2018-02-28 Ferring B.V. Desmopresina bucodispersable para aumentar el periodo inicial del sueño no alterado por nocturia
GB201005623D0 (en) 2010-04-01 2010-05-19 Vantia Ltd New polymorph
WO2012121973A1 (fr) * 2011-03-04 2012-09-13 Life Technologies Corporation Composés et procédés de conjugaison de biomolécules
GB201105537D0 (en) 2011-03-31 2011-05-18 Vantia Ltd New process
CN103159641A (zh) * 2011-12-14 2013-06-19 天津泰普药品科技发展有限公司 托伐普坦中间体2-甲酸-5-(2-甲基苯甲酰氨基)甲苯的制备方法
RU2480468C1 (ru) * 2012-02-16 2013-04-27 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" КРИСТАЛЛИЧЕСКАЯ МОДИФИКАЦИЯ ПАРА-МЕТОКСИАНИЛИДА 6-ГИДРОКСИ-4-ОКСО-2,4-ДИГИДРО-1Н-ПИРРОЛО[3,2,1-ij]ХИНОЛИН-5-КАРБОНОВОЙ КИСЛОТЫ
CN103373960B (zh) * 2012-04-24 2017-03-01 江苏康缘药业股份有限公司 一种托伐普坦中间体及其制备方法
WO2020154581A1 (fr) * 2019-01-24 2020-07-30 Assia Chemical Industries Ltd Formes à l'état solide d'un co-cristal de fédovapagon-acide salicylique

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Publication number Priority date Publication date Assignee Title
US5516774A (en) 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
DE69530690T2 (de) * 1994-06-15 2004-03-18 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclische derivate verwendbar als vasopressin- oder oxytocin-modulatoren
CN1183134C (zh) 1997-07-30 2005-01-05 惠氏公司 三环后叶加压素激动剂
NZ502448A (en) * 1997-07-30 2002-12-20 Wyeth Corp Tricyclic vasopressin agonists and medicaments containing these compounds
GB2355454A (en) * 1999-10-20 2001-04-25 Ferring Bv Antidiuretic agents
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents

Also Published As

Publication number Publication date
GB0015601D0 (en) 2000-08-16
RU2269517C2 (ru) 2006-02-10
AU2001274290B9 (en) 2006-06-29
ATE368650T1 (de) 2007-08-15
KR20030010738A (ko) 2003-02-05
HUP0301339A3 (en) 2004-10-28
NO20026094L (no) 2003-02-24
NO324217B1 (no) 2007-09-10
UA73177C2 (en) 2005-06-15
AU2001274290B2 (en) 2006-06-01
HUP0301339A2 (hu) 2003-08-28
JP2004501899A (ja) 2004-01-22
MXPA02012779A (es) 2003-09-22
AU7429001A (en) 2002-01-08
CA2412555A1 (fr) 2002-01-03
US7176195B2 (en) 2007-02-13
WO2002000626A1 (fr) 2002-01-03
HU229315B1 (en) 2013-10-28
NZ523066A (en) 2004-03-26
KR100805808B1 (ko) 2008-02-22
JP3935071B2 (ja) 2007-06-20
NO20026094D0 (no) 2002-12-18
PL359187A1 (en) 2004-08-23
EP1294698B1 (fr) 2007-08-01
US20040038962A1 (en) 2004-02-26
CN1308313C (zh) 2007-04-04
DE60129697T2 (de) 2008-06-05
JP2005104990A (ja) 2005-04-21
CZ304037B6 (cs) 2013-09-04
HK1059780A1 (en) 2004-07-16
DE60129697D1 (de) 2007-09-13
CN1462269A (zh) 2003-12-17
IL153358A0 (en) 2003-07-06
EP1294698A1 (fr) 2003-03-26

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