ZA200206112B - Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them. - Google Patents
Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them. Download PDFInfo
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- ZA200206112B ZA200206112B ZA200206112A ZA200206112A ZA200206112B ZA 200206112 B ZA200206112 B ZA 200206112B ZA 200206112 A ZA200206112 A ZA 200206112A ZA 200206112 A ZA200206112 A ZA 200206112A ZA 200206112 B ZA200206112 B ZA 200206112B
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- 230000001256 tonic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- AIDS & HIV (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN89MA2000 | 2000-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200206112B true ZA200206112B (en) | 2003-10-31 |
Family
ID=11097156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200206112A ZA200206112B (en) | 2000-02-03 | 2002-07-31 | Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6410590B1 (zh) |
| EP (1) | EP1261604A1 (zh) |
| JP (1) | JP2003522166A (zh) |
| KR (1) | KR20030004342A (zh) |
| CN (1) | CN1416428A (zh) |
| AU (1) | AU3043101A (zh) |
| BG (1) | BG106985A (zh) |
| BR (1) | BR0108064A (zh) |
| CA (1) | CA2398996A1 (zh) |
| CZ (1) | CZ20022655A3 (zh) |
| HU (1) | HUP0204347A3 (zh) |
| IL (1) | IL150905A0 (zh) |
| MX (1) | MXPA02007513A (zh) |
| NO (1) | NO20023643L (zh) |
| NZ (1) | NZ520521A (zh) |
| RU (1) | RU2002123576A (zh) |
| WO (1) | WO2001057026A1 (zh) |
| ZA (1) | ZA200206112B (zh) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6576662B2 (en) * | 2000-05-05 | 2003-06-10 | Dr. Reddy's Laboratories Limited | Compounds having anticancer activity : process for their preparation and pharmaceutical compositions containing them |
| CN100430054C (zh) * | 2002-12-31 | 2008-11-05 | 北京大学第一医院 | 穿心莲二萜内酯在制备抑制血管生成药物中的应用 |
| CN100408571C (zh) * | 2003-02-25 | 2008-08-06 | 北京医工生物技术研究所 | 穿心莲内酯三马来酸半酯及其盐和它们的药物组合物 |
| BRPI0418053A (pt) * | 2004-02-03 | 2007-04-17 | Univ Austral De Chile | composição de labdano diterpenos extraìdos a partir de andrographis paniculata, util para o tratamento de doenças autoimunes, e doença de alzheimer por ativação de receptores ppr-gama |
| US8445533B2 (en) | 2004-11-08 | 2013-05-21 | Cornell Research Foundation, Inc. | Andrographolide derivatives to treat viral infections |
| CN101129354B (zh) * | 2005-06-06 | 2011-02-02 | 河南大学 | 含有三乙酰穿心莲内酯的药物组合物及其医药用途 |
| JP2007176934A (ja) * | 2005-11-30 | 2007-07-12 | Kose Corp | 血小板活性化因子アセチルヒドロラーゼ機能調整剤 |
| CN101481375B (zh) * | 2005-12-07 | 2011-06-01 | 郑州大学 | 穿心莲内酯c15位取代系列衍生物及其制备方法 |
| CN100999520B (zh) * | 2007-01-05 | 2010-12-01 | 郑州大学 | 异穿心莲内酯类似物及其制备方法 |
| SG184715A1 (en) * | 2007-05-31 | 2012-10-30 | Suntory Holdings Ltd | Anti-fatigue agents and oral compositions containing andrographolide as active ingredient |
| CN100584841C (zh) | 2007-08-08 | 2010-01-27 | 暨南大学 | 穿心莲内酯衍生物及其在制药中的应用 |
| US20090117209A1 (en) * | 2007-11-02 | 2009-05-07 | Hutchison Medipharma Enterprises Limited | Andrographis paniculata extract |
| JP5936707B2 (ja) | 2011-12-21 | 2016-06-22 | イノバイオサイエンス， エルエルシー | インターフェロンおよびアンドログラホリドを用いた多発性硬化症のための併用療法 |
| CN102526026B (zh) * | 2012-02-10 | 2013-07-03 | 郑州大学 | 15-苄亚基-14-脱氧-11,12-脱氢穿心莲内酯衍生物在制备保肝药物中的用途 |
| EP3209658A1 (en) * | 2014-10-24 | 2017-08-30 | Biogen MA Inc. | Diterpenoid derivatives and methods of use thereof |
| CN106606506A (zh) * | 2015-10-21 | 2017-05-03 | 复旦大学 | 对映半日花烷型二萜在制备抗补体药物中的用途 |
| CN105954457A (zh) * | 2016-06-24 | 2016-09-21 | 广西灵峰药业有限公司 | 一种金香胶囊的生产质量控制方法 |
| CN109942520B (zh) * | 2019-04-10 | 2023-08-01 | 大理金明动物药业有限公司 | 穿心莲内酯磺化物及其制备方法与应用 |
| CN116898841A (zh) * | 2023-09-11 | 2023-10-20 | 中国中医科学院广安门医院 | 一种穿心莲内酯改构化合物l8或其衍生物的用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6388124A (ja) | 1986-09-30 | 1988-04-19 | Toyo Jozo Co Ltd | 抗腫瘍剤 |
| GB8917295D0 (en) | 1989-07-28 | 1989-09-13 | Ruffles Graham K | Anti-viral compositions |
| AU4376396A (en) | 1994-12-06 | 1996-06-26 | Paracelsian, Inc. | Use of andrographolide compounds to treat or prevent pathogenicity of diseases |
-
2001
- 2001-02-01 US US09/775,533 patent/US6410590B1/en not_active Expired - Fee Related
- 2001-02-02 NZ NZ520521A patent/NZ520521A/en unknown
- 2001-02-02 HU HU0204347A patent/HUP0204347A3/hu unknown
- 2001-02-02 EP EP01902573A patent/EP1261604A1/en not_active Withdrawn
- 2001-02-02 BR BR0108064-4A patent/BR0108064A/pt not_active IP Right Cessation
- 2001-02-02 IL IL15090501A patent/IL150905A0/xx unknown
- 2001-02-02 AU AU30431/01A patent/AU3043101A/en not_active Abandoned
- 2001-02-02 CN CN01806413A patent/CN1416428A/zh active Pending
- 2001-02-02 JP JP2001557858A patent/JP2003522166A/ja active Pending
- 2001-02-02 WO PCT/IB2001/000127 patent/WO2001057026A1/en not_active Application Discontinuation
- 2001-02-02 CA CA002398996A patent/CA2398996A1/en not_active Abandoned
- 2001-02-02 RU RU2002123576/04A patent/RU2002123576A/ru not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| CZ20022655A3 (cs) | 2003-04-16 |
| JP2003522166A (ja) | 2003-07-22 |
| EP1261604A1 (en) | 2002-12-04 |
| AU3043101A (en) | 2001-08-14 |
| US20020032229A1 (en) | 2002-03-14 |
| HUP0204347A3 (en) | 2005-04-28 |
| CA2398996A1 (en) | 2001-08-09 |
| IL150905A0 (en) | 2003-02-12 |
| MXPA02007513A (es) | 2004-08-23 |
| NO20023643D0 (no) | 2002-07-31 |
| CN1416428A (zh) | 2003-05-07 |
| NZ520521A (en) | 2004-05-28 |
| BG106985A (en) | 2003-04-30 |
| US6410590B1 (en) | 2002-06-25 |
| BR0108064A (pt) | 2002-10-29 |
| HUP0204347A2 (en) | 2003-05-28 |
| WO2001057026A1 (en) | 2001-08-09 |
| RU2002123576A (ru) | 2004-01-10 |
| KR20030004342A (ko) | 2003-01-14 |
| NO20023643L (no) | 2002-09-30 |
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