BR0108064A - Compostos tendo atividade antitumoral, processo para sua preparação e composições farmacêuticas os contendo - Google Patents
Compostos tendo atividade antitumoral, processo para sua preparação e composições farmacêuticas os contendoInfo
- Publication number
- BR0108064A BR0108064A BR0108064-4A BR0108064A BR0108064A BR 0108064 A BR0108064 A BR 0108064A BR 0108064 A BR0108064 A BR 0108064A BR 0108064 A BR0108064 A BR 0108064A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- preparation
- pharmaceutical compositions
- compositions containing
- antitumor activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"COMPOSTOS TENDO ATIVIDADE ANTITUMORAL, PROCESSO PARA SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS OS CONTENDO". A presente invenção refere-se aos derivados de Andrografolida, seus estereoisómeros, seus polimorfos, seus sais farmaceuticamente aceitáveis, seus solvatos farmaceuticamente aceitáveis. Os derivados de Andrografolida têm a fórmula geral (I). Os derivados de andrografolida representados pela fórmula geral (I) como acima definidos da presente invenção são úteis para tratar câncer, HSV, HIV, psoríase, restenose, aterosclerose, outros distúrbios cardiovasculares, agentes antiviróticos, antimaláricos, antibacterianos, hepatoprotetores, imunomodulantes e para o tratamento de distúrbios metabólicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN89MA2000 | 2000-02-03 | ||
PCT/IB2001/000127 WO2001057026A1 (en) | 2000-02-03 | 2001-02-02 | Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0108064A true BR0108064A (pt) | 2002-10-29 |
Family
ID=11097156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0108064-4A BR0108064A (pt) | 2000-02-03 | 2001-02-02 | Compostos tendo atividade antitumoral, processo para sua preparação e composições farmacêuticas os contendo |
Country Status (18)
Country | Link |
---|---|
US (1) | US6410590B1 (pt) |
EP (1) | EP1261604A1 (pt) |
JP (1) | JP2003522166A (pt) |
KR (1) | KR20030004342A (pt) |
CN (1) | CN1416428A (pt) |
AU (1) | AU3043101A (pt) |
BG (1) | BG106985A (pt) |
BR (1) | BR0108064A (pt) |
CA (1) | CA2398996A1 (pt) |
CZ (1) | CZ20022655A3 (pt) |
HU (1) | HUP0204347A3 (pt) |
IL (1) | IL150905A0 (pt) |
MX (1) | MXPA02007513A (pt) |
NO (1) | NO20023643L (pt) |
NZ (1) | NZ520521A (pt) |
RU (1) | RU2002123576A (pt) |
WO (1) | WO2001057026A1 (pt) |
ZA (1) | ZA200206112B (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6576662B2 (en) * | 2000-05-05 | 2003-06-10 | Dr. Reddy's Laboratories Limited | Compounds having anticancer activity : process for their preparation and pharmaceutical compositions containing them |
CN100430054C (zh) * | 2002-12-31 | 2008-11-05 | 北京大学第一医院 | 穿心莲二萜内酯在制备抑制血管生成药物中的应用 |
CN100408571C (zh) * | 2003-02-25 | 2008-08-06 | 北京医工生物技术研究所 | 穿心莲内酯三马来酸半酯及其盐和它们的药物组合物 |
BRPI0418053A (pt) * | 2004-02-03 | 2007-04-17 | Univ Austral De Chile | composição de labdano diterpenos extraìdos a partir de andrographis paniculata, util para o tratamento de doenças autoimunes, e doença de alzheimer por ativação de receptores ppr-gama |
US8445533B2 (en) | 2004-11-08 | 2013-05-21 | Cornell Research Foundation, Inc. | Andrographolide derivatives to treat viral infections |
CN101129354B (zh) * | 2005-06-06 | 2011-02-02 | 河南大学 | 含有三乙酰穿心莲内酯的药物组合物及其医药用途 |
JP2007176934A (ja) * | 2005-11-30 | 2007-07-12 | Kose Corp | 血小板活性化因子アセチルヒドロラーゼ機能調整剤 |
CN101481375B (zh) * | 2005-12-07 | 2011-06-01 | 郑州大学 | 穿心莲内酯c15位取代系列衍生物及其制备方法 |
CN100999520B (zh) * | 2007-01-05 | 2010-12-01 | 郑州大学 | 异穿心莲内酯类似物及其制备方法 |
SG184715A1 (en) * | 2007-05-31 | 2012-10-30 | Suntory Holdings Ltd | Anti-fatigue agents and oral compositions containing andrographolide as active ingredient |
CN100584841C (zh) | 2007-08-08 | 2010-01-27 | 暨南大学 | 穿心莲内酯衍生物及其在制药中的应用 |
US20090117209A1 (en) * | 2007-11-02 | 2009-05-07 | Hutchison Medipharma Enterprises Limited | Andrographis paniculata extract |
JP5936707B2 (ja) | 2011-12-21 | 2016-06-22 | イノバイオサイエンス, エルエルシー | インターフェロンおよびアンドログラホリドを用いた多発性硬化症のための併用療法 |
CN102526026B (zh) * | 2012-02-10 | 2013-07-03 | 郑州大学 | 15-苄亚基-14-脱氧-11,12-脱氢穿心莲内酯衍生物在制备保肝药物中的用途 |
EP3209658A1 (en) * | 2014-10-24 | 2017-08-30 | Biogen MA Inc. | Diterpenoid derivatives and methods of use thereof |
CN106606506A (zh) * | 2015-10-21 | 2017-05-03 | 复旦大学 | 对映半日花烷型二萜在制备抗补体药物中的用途 |
CN105954457A (zh) * | 2016-06-24 | 2016-09-21 | 广西灵峰药业有限公司 | 一种金香胶囊的生产质量控制方法 |
CN109942520B (zh) * | 2019-04-10 | 2023-08-01 | 大理金明动物药业有限公司 | 穿心莲内酯磺化物及其制备方法与应用 |
CN116898841A (zh) * | 2023-09-11 | 2023-10-20 | 中国中医科学院广安门医院 | 一种穿心莲内酯改构化合物l8或其衍生物的用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6388124A (ja) | 1986-09-30 | 1988-04-19 | Toyo Jozo Co Ltd | 抗腫瘍剤 |
GB8917295D0 (en) | 1989-07-28 | 1989-09-13 | Ruffles Graham K | Anti-viral compositions |
AU4376396A (en) | 1994-12-06 | 1996-06-26 | Paracelsian, Inc. | Use of andrographolide compounds to treat or prevent pathogenicity of diseases |
-
2001
- 2001-02-01 US US09/775,533 patent/US6410590B1/en not_active Expired - Fee Related
- 2001-02-02 NZ NZ520521A patent/NZ520521A/en unknown
- 2001-02-02 HU HU0204347A patent/HUP0204347A3/hu unknown
- 2001-02-02 EP EP01902573A patent/EP1261604A1/en not_active Withdrawn
- 2001-02-02 BR BR0108064-4A patent/BR0108064A/pt not_active IP Right Cessation
- 2001-02-02 IL IL15090501A patent/IL150905A0/xx unknown
- 2001-02-02 AU AU30431/01A patent/AU3043101A/en not_active Abandoned
- 2001-02-02 CN CN01806413A patent/CN1416428A/zh active Pending
- 2001-02-02 JP JP2001557858A patent/JP2003522166A/ja active Pending
- 2001-02-02 WO PCT/IB2001/000127 patent/WO2001057026A1/en not_active Application Discontinuation
- 2001-02-02 CA CA002398996A patent/CA2398996A1/en not_active Abandoned
- 2001-02-02 RU RU2002123576/04A patent/RU2002123576A/ru not_active Application Discontinuation
- 2001-02-02 CZ CZ20022655A patent/CZ20022655A3/cs unknown
- 2001-02-02 KR KR1020027009978A patent/KR20030004342A/ko not_active Application Discontinuation
- 2001-02-02 MX MXPA02007513A patent/MXPA02007513A/es unknown
-
2002
- 2002-07-31 NO NO20023643A patent/NO20023643L/no not_active Application Discontinuation
- 2002-07-31 ZA ZA200206112A patent/ZA200206112B/en unknown
- 2002-08-07 BG BG106985A patent/BG106985A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CZ20022655A3 (cs) | 2003-04-16 |
JP2003522166A (ja) | 2003-07-22 |
EP1261604A1 (en) | 2002-12-04 |
AU3043101A (en) | 2001-08-14 |
US20020032229A1 (en) | 2002-03-14 |
HUP0204347A3 (en) | 2005-04-28 |
CA2398996A1 (en) | 2001-08-09 |
IL150905A0 (en) | 2003-02-12 |
MXPA02007513A (es) | 2004-08-23 |
NO20023643D0 (no) | 2002-07-31 |
CN1416428A (zh) | 2003-05-07 |
NZ520521A (en) | 2004-05-28 |
BG106985A (en) | 2003-04-30 |
US6410590B1 (en) | 2002-06-25 |
ZA200206112B (en) | 2003-10-31 |
HUP0204347A2 (en) | 2003-05-28 |
WO2001057026A1 (en) | 2001-08-09 |
RU2002123576A (ru) | 2004-01-10 |
KR20030004342A (ko) | 2003-01-14 |
NO20023643L (no) | 2002-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009 |