ZA200205902B - Azacyclic compounds for use in the treatment of serotonin related diseases. - Google Patents
Azacyclic compounds for use in the treatment of serotonin related diseases. Download PDFInfo
- Publication number
- ZA200205902B ZA200205902B ZA200205902A ZA200205902A ZA200205902B ZA 200205902 B ZA200205902 B ZA 200205902B ZA 200205902 A ZA200205902 A ZA 200205902A ZA 200205902 A ZA200205902 A ZA 200205902A ZA 200205902 B ZA200205902 B ZA 200205902B
- Authority
- ZA
- South Africa
- Prior art keywords
- acetamide
- methylpiperidin
- methyl
- piperidin
- methylphenyl
- Prior art date
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- 238000011282 treatment Methods 0.000 title claims abstract description 63
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 51
- 201000010099 disease Diseases 0.000 title claims abstract description 46
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title claims description 48
- 229940076279 serotonin Drugs 0.000 title description 10
- 150000004030 azacyclic compounds Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 255
- 238000000034 method Methods 0.000 claims abstract description 213
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- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 claims description 77
- -1 methylene, vinylene Chemical group 0.000 claims description 67
- 125000000217 alkyl group Chemical group 0.000 claims description 44
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 37
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- 101710138091 5-hydroxytryptamine receptor 2A Proteins 0.000 claims description 27
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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