ZA200204390B - Caspase inhibitors and uses thereof. - Google Patents
Caspase inhibitors and uses thereof.Info
- Publication number
- ZA200204390B ZA200204390B ZA200204390A ZA200204390A ZA200204390B ZA 200204390 B ZA200204390 B ZA 200204390B ZA 200204390 A ZA200204390 A ZA 200204390A ZA 200204390 A ZA200204390 A ZA 200204390A ZA 200204390 B ZA200204390 B ZA 200204390B
- Authority
- ZA
- South Africa
- Prior art keywords
- caspase inhibitors
- caspase
- inhibitors
- Prior art date
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US16981299P | 1999-12-08 | 1999-12-08 |
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ZA200204390B true ZA200204390B (en) | 2003-08-27 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200204390A ZA200204390B (en) | 1999-12-08 | 2002-05-31 | Caspase inhibitors and uses thereof. |
Country Status (24)
Country | Link |
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US (4) | US7517987B2 (fr) |
EP (4) | EP2308846A3 (fr) |
JP (3) | JP5021131B2 (fr) |
KR (3) | KR100904697B1 (fr) |
CN (2) | CN101348455A (fr) |
AP (1) | AP2002002535A0 (fr) |
AR (1) | AR026748A1 (fr) |
AU (3) | AU2428301A (fr) |
BR (1) | BR0016282A (fr) |
CA (2) | CA2733434A1 (fr) |
CO (1) | CO5261609A1 (fr) |
CZ (1) | CZ20021970A3 (fr) |
EA (1) | EA200200645A1 (fr) |
HU (1) | HUP0300782A3 (fr) |
IL (1) | IL150077A0 (fr) |
IS (1) | IS6411A (fr) |
MX (1) | MXPA02005779A (fr) |
NO (2) | NO324776B1 (fr) |
NZ (2) | NZ530485A (fr) |
PL (1) | PL356066A1 (fr) |
SK (1) | SK8072002A3 (fr) |
TW (1) | TWI275586B (fr) |
WO (1) | WO2001042216A2 (fr) |
ZA (1) | ZA200204390B (fr) |
Families Citing this family (46)
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US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
AR026748A1 (es) * | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
WO2002094263A2 (fr) * | 2001-05-23 | 2002-11-28 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de caspase et leurs utilisations |
WO2003088917A2 (fr) * | 2002-04-19 | 2003-10-30 | Vertex Pharmaceuticals Incorporated | Regulation du tnf alpha |
JP4616643B2 (ja) * | 2002-06-28 | 2011-01-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼインヒビターおよびそれらの用途 |
US7612091B2 (en) * | 2002-12-20 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
US7465738B2 (en) | 2003-06-16 | 2008-12-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as promoters of SMN2 |
EP2399916B1 (fr) | 2004-03-12 | 2014-12-10 | Vertex Pharmaceuticals Incorporated | Procédé et intermédiaires pour la préparation d'acétals de l'acide aspartique, inhibiteurs de la caspase |
AU2005247409B2 (en) * | 2004-05-15 | 2011-11-10 | Vertex Pharmaceuticals Incorporated | Treating seizures using ICE inhibitors |
EP1778221A2 (fr) | 2004-05-27 | 2007-05-02 | Vertex Pharmaceuticals Incorporated | Traitement de maladies autoinflammatopires a l'aide d'inhibiteurs de l'ice |
EP1833794B1 (fr) * | 2004-11-24 | 2012-02-01 | Vertex Pharmceuticals Incorporated | Derives de l'acide 3-[2-(3-acylamino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pentanoique et leur utilisation comme inhibiteurs des caspases |
JP2009502922A (ja) * | 2005-07-28 | 2009-01-29 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼ阻害剤プロドラッグ |
EP2001875A2 (fr) * | 2006-03-08 | 2008-12-17 | Takeda San Diego, Inc. | Activateurs de la glucokinase |
TW200823225A (en) * | 2006-11-01 | 2008-06-01 | Astrazeneca Ab | New compounds |
JP5419706B2 (ja) * | 2006-12-20 | 2014-02-19 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼアクチベーター |
US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
ES2640814T3 (es) | 2008-05-21 | 2017-11-06 | Genesis Technologies Limited | Inhibidores selectivos de caspasa y usos de los mismos |
US8518942B2 (en) | 2008-08-06 | 2013-08-27 | Buck Institute For Research On Aging | Caspase inhibitors and uses thereof |
CA2738314C (fr) | 2008-09-23 | 2017-01-10 | Georgetown University | Derives de 1,2-benzisothiazolinone et d'isoindolinone |
EP2344481B9 (fr) * | 2008-09-23 | 2014-12-31 | Georgetown University | Inhibiteurs viraux et fongiques |
US9045524B2 (en) | 2009-05-21 | 2015-06-02 | Novagenesis Foundation | Selective caspase inhibitors and uses thereof |
WO2010138585A1 (fr) * | 2009-05-29 | 2010-12-02 | Merck Sharp & Dohme Corp. | Pyrimidinones constituant des inhibiteurs de pde10 |
WO2011031486A1 (fr) | 2009-08-25 | 2011-03-17 | Lasermax Roll Systems, Inc. | Système et procédé pour coupe et empilement en ligne de feuilles pour formation de livres |
US8882099B2 (en) | 2009-08-25 | 2014-11-11 | Lasermax Roll Systems, Inc. | System and method for inline cutting and stacking of sheets for formation of books |
US9365612B2 (en) | 2010-01-29 | 2016-06-14 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Caspase inhibitors |
EP2635906A4 (fr) | 2010-11-05 | 2014-04-02 | Univ Brandeis | Composés inhibiteurs de ice et leurs utilisations |
AU2012236655B2 (en) | 2011-03-28 | 2016-09-22 | Deuterx, Llc, | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
ES2665301T3 (es) | 2011-04-15 | 2018-04-25 | Genesis Technologies Limited | Inhibidores selectivos de cisteína proreasa y usos de los mismos |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
WO2013025897A1 (fr) | 2011-08-16 | 2013-02-21 | Georgetown University | Méthodes de traitement d'infections bactériennes au moyen de dérivés de 1,2-benzisothiazolinone et d'isoindolinone |
US9540340B2 (en) | 2013-01-14 | 2017-01-10 | Deuterx, Llc | 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same |
EP2968334A4 (fr) * | 2013-03-14 | 2016-08-03 | Deuterx Llc | Dérivés de 3-(oxoquinazolin-3(4h)-yl-4 substitué)-3-deutéro-pipéridine-2,6-dione et des compositions les comprenant et des procédés les utilisant |
WO2014160592A2 (fr) * | 2013-03-27 | 2014-10-02 | Merck Sharp & Dohme Corp. | Inhibiteurs du facteur xia |
US9809603B1 (en) | 2015-08-18 | 2017-11-07 | Deuterx, Llc | Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same |
TWI764977B (zh) | 2017-01-23 | 2022-05-21 | 大陸商正大天晴藥業集團股份有限公司 | 作爲caspase抑制劑的聯環化合物、含有其的藥物組合物及其應用 |
CN106749045B (zh) * | 2017-03-03 | 2020-02-14 | 上海交通大学 | 一种d-氨基酸氧化酶抑制剂及其制法和应用 |
KR20200067855A (ko) * | 2017-10-04 | 2020-06-12 | 바텔리 메모리얼 인스티튜트 | 제노바이오틱(xenobiotic) 대사에 관련되는 효소들을 선택적으로 규명하기 위한 탐침 (probe) 및 이들을 제조하는 방법 및 사용 방법 |
CA3171430A1 (fr) * | 2020-03-13 | 2021-09-16 | Brent R. Stockwell | Composes gpx4 et compositions et procedes de traitement les utilisant |
BR112022026725A2 (pt) * | 2020-08-05 | 2023-02-14 | Lg Chemical Ltd | Composição farmacêutica para aliviar ou tratar osteoartrite |
KR102670554B1 (ko) | 2022-01-04 | 2024-05-30 | 주식회사 이노보테라퓨틱스 | 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물 |
WO2024073426A1 (fr) * | 2022-09-26 | 2024-04-04 | Edgewise Therapeutics, Inc. | Composés de 1,4-dihydroquinazolinone et utilisations associées |
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US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
FR2582514B1 (fr) | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
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US5714484A (en) * | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
GB2292149A (en) | 1994-08-09 | 1996-02-14 | Ferring Res Ltd | Peptide inhibitors of pro-interleukin-1beta converting enzyme |
US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
US5981491A (en) * | 1995-05-10 | 1999-11-09 | Darwin Discovery Limited | Peptidyl compounds and their therapeutic use |
US6252076B1 (en) * | 1996-05-04 | 2001-06-26 | Yuhan Corporation | Process for preparation of pyrimidine derivatives |
US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
JP2001508404A (ja) * | 1996-10-11 | 2001-06-26 | ワーナー―ランバート・コンパニー | スルホンアミドインターロイキン―1β変換酵素阻害剤 |
AU738341B2 (en) * | 1996-10-11 | 2001-09-13 | Abbott Gmbh & Co. Kg | Asparate ester inhibitors of interleukin-1beta converting enzyme |
WO1998018781A2 (fr) * | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Banques combinatoires de 2,4-pyrimidinediones fusionnes et 2,4-pyrimidinediones fusionnes actifs biologiquement |
KR100767199B1 (ko) * | 1999-05-07 | 2007-10-17 | 엔싸이시브 파마슈티칼즈 인코퍼레이티드 | 인테그린이 이의 수용체에 결합하는 것을 억제하는프로판산 유도체 |
US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
WO2000067746A1 (fr) | 1999-05-07 | 2000-11-16 | Texas Biotechnology Corporation | Derives d'acide carboxylique inhibant la liaison entre des integrines et leurs recepteurs |
AR026748A1 (es) * | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
US7410956B2 (en) * | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
WO2003088917A2 (fr) * | 2002-04-19 | 2003-10-30 | Vertex Pharmaceuticals Incorporated | Regulation du tnf alpha |
-
2000
- 2000-12-06 AR ARP000106476A patent/AR026748A1/es unknown
- 2000-12-07 CO CO00093694A patent/CO5261609A1/es not_active Application Discontinuation
- 2000-12-07 TW TWCASPASEIA patent/TWI275586B/zh not_active IP Right Cessation
- 2000-12-08 PL PL00356066A patent/PL356066A1/xx not_active Application Discontinuation
- 2000-12-08 AU AU24283/01A patent/AU2428301A/en not_active Abandoned
- 2000-12-08 KR KR1020027007337A patent/KR100904697B1/ko not_active IP Right Cessation
- 2000-12-08 WO PCT/US2000/033260 patent/WO2001042216A2/fr active IP Right Grant
- 2000-12-08 SK SK807-2002A patent/SK8072002A3/sk not_active Application Discontinuation
- 2000-12-08 CA CA2733434A patent/CA2733434A1/fr not_active Abandoned
- 2000-12-08 EA EA200200645A patent/EA200200645A1/ru unknown
- 2000-12-08 CZ CZ20021970A patent/CZ20021970A3/cs unknown
- 2000-12-08 HU HU0300782A patent/HUP0300782A3/hu unknown
- 2000-12-08 CA CA2393710A patent/CA2393710C/fr not_active Expired - Fee Related
- 2000-12-08 MX MXPA02005779A patent/MXPA02005779A/es active IP Right Grant
- 2000-12-08 NZ NZ530485A patent/NZ530485A/en unknown
- 2000-12-08 IL IL15007700A patent/IL150077A0/xx unknown
- 2000-12-08 EP EP10196409A patent/EP2308846A3/fr not_active Withdrawn
- 2000-12-08 JP JP2001543517A patent/JP5021131B2/ja not_active Expired - Fee Related
- 2000-12-08 EP EP00988026A patent/EP1244626A2/fr not_active Withdrawn
- 2000-12-08 AP APAP/P/2002/002535A patent/AP2002002535A0/en unknown
- 2000-12-08 EP EP10196405A patent/EP2308845A3/fr not_active Withdrawn
- 2000-12-08 EP EP10196401A patent/EP2308844A3/fr not_active Withdrawn
- 2000-12-08 CN CNA2008101443995A patent/CN101348455A/zh active Pending
- 2000-12-08 CN CNB008182558A patent/CN100415718C/zh not_active Expired - Fee Related
- 2000-12-08 BR BR0016282-5A patent/BR0016282A/pt not_active Application Discontinuation
- 2000-12-08 NZ NZ519424A patent/NZ519424A/en not_active IP Right Cessation
-
2002
- 2002-05-31 ZA ZA200204390A patent/ZA200204390B/xx unknown
- 2002-06-05 NO NO20022656A patent/NO324776B1/no not_active IP Right Cessation
- 2002-06-06 IS IS6411A patent/IS6411A/is unknown
- 2002-06-10 US US10/166,437 patent/US7517987B2/en not_active Expired - Fee Related
-
2006
- 2006-10-10 AU AU2006225317A patent/AU2006225317A1/en not_active Abandoned
-
2007
- 2007-09-19 NO NO20074773A patent/NO20074773L/no not_active Application Discontinuation
- 2007-12-05 JP JP2007315252A patent/JP2008101019A/ja not_active Withdrawn
-
2008
- 2008-02-18 KR KR1020087003852A patent/KR100910195B1/ko not_active IP Right Cessation
-
2009
- 2009-01-26 US US12/359,749 patent/US7906650B2/en not_active Expired - Fee Related
- 2009-03-12 KR KR1020097005203A patent/KR100919654B1/ko not_active IP Right Cessation
-
2010
- 2010-05-21 AU AU2010202075A patent/AU2010202075B2/en not_active Ceased
-
2011
- 2011-02-08 US US13/022,820 patent/US8093392B2/en not_active Expired - Fee Related
- 2011-10-25 JP JP2011234386A patent/JP2012021032A/ja not_active Withdrawn
- 2011-12-01 US US13/309,117 patent/US8288537B2/en not_active Expired - Fee Related
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