ZA200203255B - Hydroxamic acid derivative as inhibitor of the formation of soluble human CD23. - Google Patents

Hydroxamic acid derivative as inhibitor of the formation of soluble human CD23. Download PDF

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Publication number
ZA200203255B
ZA200203255B ZA200203255A ZA200203255A ZA200203255B ZA 200203255 B ZA200203255 B ZA 200203255B ZA 200203255 A ZA200203255 A ZA 200203255A ZA 200203255 A ZA200203255 A ZA 200203255A ZA 200203255 B ZA200203255 B ZA 200203255B
Authority
ZA
South Africa
Prior art keywords
compound
formula
disorders
dose
naphthylmethyl
Prior art date
Application number
ZA200203255A
Other languages
English (en)
Inventor
Andrew Faller
Ward John Gerard
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of ZA200203255B publication Critical patent/ZA200203255B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
ZA200203255A 1999-10-27 2002-04-24 Hydroxamic acid derivative as inhibitor of the formation of soluble human CD23. ZA200203255B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9925470.8A GB9925470D0 (en) 1999-10-27 1999-10-27 Novel compounds

Publications (1)

Publication Number Publication Date
ZA200203255B true ZA200203255B (en) 2003-03-20

Family

ID=10863507

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200203255A ZA200203255B (en) 1999-10-27 2002-04-24 Hydroxamic acid derivative as inhibitor of the formation of soluble human CD23.

Country Status (32)

Country Link
US (2) US6673965B1 (zh)
EP (1) EP1224164B1 (zh)
JP (1) JP3922431B2 (zh)
KR (1) KR20020044578A (zh)
CN (1) CN1182107C (zh)
AR (1) AR026244A1 (zh)
AT (1) ATE284382T1 (zh)
AU (1) AU766072B2 (zh)
BR (1) BR0015082A (zh)
CA (1) CA2389319A1 (zh)
CO (1) CO5261576A1 (zh)
CZ (1) CZ20021424A3 (zh)
DE (1) DE60016622T2 (zh)
DK (1) DK1224164T3 (zh)
ES (1) ES2233474T3 (zh)
GB (1) GB9925470D0 (zh)
GC (1) GC0000142A (zh)
HK (1) HK1049146A1 (zh)
HU (1) HUP0203270A3 (zh)
IL (1) IL149364A0 (zh)
MX (1) MXPA02004228A (zh)
MY (1) MY133601A (zh)
NO (1) NO20021965L (zh)
NZ (1) NZ518566A (zh)
PE (1) PE20010898A1 (zh)
PL (1) PL356524A1 (zh)
PT (1) PT1224164E (zh)
SI (1) SI1224164T1 (zh)
TW (1) TW561141B (zh)
UY (1) UY26416A1 (zh)
WO (1) WO2001030747A1 (zh)
ZA (1) ZA200203255B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8722686B2 (en) * 2008-09-19 2014-05-13 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
US8945575B2 (en) 2009-12-01 2015-02-03 Trustees Of Boston University Treatment of IgE-mediated disease
US8664401B2 (en) 2009-12-16 2014-03-04 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
CN104529883A (zh) 2011-03-07 2015-04-22 辉瑞大药厂 可用作抗菌剂的氟吡啶酮衍生物
CA2830866A1 (en) 2011-04-08 2012-10-11 Pfizer Inc. Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
US8748466B2 (en) 2011-04-08 2014-06-10 Pfizer Inc. Isoxazole derivatives useful as antibacterial agents
EP2525213A1 (en) * 2011-05-16 2012-11-21 Renishaw plc Spectroscopic apparatus and methods for determining components present in a sample

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9513331D0 (en) 1995-06-30 1995-09-06 British Biotech Pharm Matrix metalloproteinase inhibitors
GB9813451D0 (en) * 1998-06-22 1998-08-19 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
KR20020044578A (ko) 2002-06-15
TW561141B (en) 2003-11-11
CN1182107C (zh) 2004-12-29
GB9925470D0 (en) 1999-12-29
DE60016622D1 (de) 2005-01-13
MXPA02004228A (es) 2002-10-17
UY26416A1 (es) 2001-05-31
ES2233474T3 (es) 2005-06-16
JP2003512450A (ja) 2003-04-02
WO2001030747A1 (en) 2001-05-03
CN1411436A (zh) 2003-04-16
AR026244A1 (es) 2003-02-05
CO5261576A1 (es) 2003-03-31
HUP0203270A3 (en) 2003-11-28
SI1224164T1 (en) 2005-06-30
IL149364A0 (en) 2002-11-10
EP1224164B1 (en) 2004-12-08
MY133601A (en) 2007-11-30
CZ20021424A3 (cs) 2002-09-11
CA2389319A1 (en) 2001-05-03
NZ518566A (en) 2004-02-27
PL356524A1 (en) 2004-06-28
ATE284382T1 (de) 2004-12-15
AU766072B2 (en) 2003-10-09
NO20021965L (no) 2002-06-13
HUP0203270A2 (hu) 2003-02-28
PT1224164E (pt) 2005-04-29
US20040077727A1 (en) 2004-04-22
AU1389501A (en) 2001-05-08
US6673965B1 (en) 2004-01-06
PE20010898A1 (es) 2001-10-13
DK1224164T3 (da) 2005-03-29
NO20021965D0 (no) 2002-04-25
HK1049146A1 (en) 2003-05-02
GC0000142A (en) 2005-06-29
DE60016622T2 (de) 2005-11-03
BR0015082A (pt) 2003-04-15
EP1224164A1 (en) 2002-07-24
JP3922431B2 (ja) 2007-05-30

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