ZA200203252B - Process for preparing 4"-substituted-9-deoxo-9A-AZA-9A-homoerythromycina derivatives. - Google Patents
Process for preparing 4"-substituted-9-deoxo-9A-AZA-9A-homoerythromycina derivatives.Info
- Publication number
- ZA200203252B ZA200203252B ZA200203252A ZA200203252A ZA200203252B ZA 200203252 B ZA200203252 B ZA 200203252B ZA 200203252 A ZA200203252 A ZA 200203252A ZA 200203252 A ZA200203252 A ZA 200203252A ZA 200203252 B ZA200203252 B ZA 200203252B
- Authority
- ZA
- South Africa
- Prior art keywords
- homoerythromycina
- deoxo
- aza
- derivatives
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28720301P | 2001-04-27 | 2001-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200203252B true ZA200203252B (en) | 2003-10-24 |
Family
ID=23101880
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200203252A ZA200203252B (en) | 2001-04-27 | 2002-04-24 | Process for preparing 4"-substituted-9-deoxo-9A-AZA-9A-homoerythromycina derivatives. |
ZA200307506A ZA200307506B (en) | 2001-04-27 | 2003-09-26 | Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200307506A ZA200307506B (en) | 2001-04-27 | 2003-09-26 | Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives. |
Country Status (23)
Country | Link |
---|---|
US (1) | US6825327B2 (he) |
EP (2) | EP1383780A1 (he) |
JP (3) | JP4104463B2 (he) |
KR (1) | KR100474225B1 (he) |
CN (4) | CN100413879C (he) |
AR (1) | AR035871A1 (he) |
AU (1) | AU784362B2 (he) |
BR (2) | BR0209241A (he) |
CA (2) | CA2445306C (he) |
CZ (1) | CZ303716B6 (he) |
DK (1) | DK1253153T3 (he) |
ES (1) | ES2608848T3 (he) |
HK (2) | HK1050370A1 (he) |
HU (1) | HU230717B1 (he) |
IL (3) | IL158059A0 (he) |
MX (2) | MXPA03009786A (he) |
PL (2) | PL371766A1 (he) |
PT (1) | PT1253153T (he) |
RU (2) | RU2263117C2 (he) |
SG (1) | SG100789A1 (he) |
WO (1) | WO2002088158A1 (he) |
YU (1) | YU29502A (he) |
ZA (2) | ZA200203252B (he) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA82359C2 (uk) * | 2003-04-03 | 2008-04-10 | Schering Plough Ltd | Композиція (варіанти) і спосіб лікування мікробних і паразитних інфекцій у великої рогатої худоби і інших тварин |
US7384921B2 (en) * | 2004-02-20 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | Polymorphic forms of 6-11 bicyclic ketolide derivatives |
US7468428B2 (en) | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
DK1776109T3 (da) | 2004-08-13 | 2009-05-04 | Schering Plough Ltd | Farmaceutisk formulering omfattende et antibiotikum, en triazol og et cortocosteroid |
US7312248B2 (en) | 2004-09-23 | 2007-12-25 | Schering-Plough Animal Health Corporation | Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives |
ATE446677T1 (de) | 2004-11-19 | 2009-11-15 | Schering Plough Ltd | Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h- pyrrol-2-yl) acrylonitril-derivaten |
ATE429921T1 (de) * | 2005-01-14 | 2009-05-15 | Glaxosmithkline Zagreb | 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung |
EP1890547A2 (en) * | 2005-06-09 | 2008-02-27 | Schering-Plough Ltd. | Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives |
US20070238700A1 (en) * | 2006-04-10 | 2007-10-11 | Winzenberg Kevin N | N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites |
US8044230B2 (en) * | 2006-12-13 | 2011-10-25 | Intervet Inc. | Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof |
EP2091909A1 (en) * | 2006-12-13 | 2009-08-26 | Schering-Plough Ltd. | Water-soluble prodrugs of florfenicol and its analogs |
TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
MX2009013748A (es) | 2007-06-27 | 2010-01-26 | Du Pont | Metodo de control de plagas en animales. |
TWI468407B (zh) | 2008-02-06 | 2015-01-11 | Du Pont | 中離子農藥 |
EP2321269B1 (en) * | 2008-07-30 | 2018-09-19 | Intervet International B.V. | Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol |
WO2010086351A1 (en) * | 2009-01-30 | 2010-08-05 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | 3'-n-substituted 9-deoxo-9a-methyl-9a-aza-homoerythromycin having antimalarial activity |
EP2462125A2 (en) | 2009-08-05 | 2012-06-13 | E. I. du Pont de Nemours and Company | Mesoionic pesticides |
UA107804C2 (en) | 2009-08-05 | 2015-02-25 | Du Pont | Mixtures of pesticides mezoionnyh |
UA110924C2 (uk) | 2009-08-05 | 2016-03-10 | Е. І. Дю Пон Де Немур Енд Компані | Мезоіонні пестициди |
CN102686570A (zh) | 2009-08-05 | 2012-09-19 | 杜邦公司 | 介离子杀虫剂 |
UA108881C2 (xx) | 2010-05-27 | 2015-06-25 | Кристалічна форма 4-$5-$3-хлор-5-(трифторметил)феніл]-4,5-дигідро-5-(трифторметил)-3-ізоксазоліл]-n-$2-оксо-2-$(2,2,2-трифторетил)аміно]етил]-1-нафталінкарбоксаміду | |
EP4324524A2 (en) * | 2010-07-01 | 2024-02-21 | Elanco Tiergesundheit AG | Antibiotic compositions |
JP5908479B2 (ja) * | 2010-09-20 | 2016-04-26 | ノバルティス ティーアゲズントハイト アーゲー | クラジノース環のC−4”をエポキシド基で修飾した9−デオキソ−9a−アザ−9a−ホモエリスロマイシンAの新規製造方法 |
WO2012087630A1 (en) | 2010-12-20 | 2012-06-28 | E.I. Du Pont De Nemours And Company | Pyridine and pyrimidine compounds for controlling invertebrate |
CN102295672B (zh) * | 2011-07-13 | 2014-06-04 | 武汉回盛生物科技有限公司 | 一种泰拉菌素的合成方法 |
CN102260306B (zh) * | 2011-07-22 | 2012-07-18 | 山东鲁抗舍里乐药业有限公司 | 一种制备泰拉霉素的方法 |
EP2736915A1 (en) * | 2011-07-27 | 2014-06-04 | Farma GRS, d.o.o. | New crystalline forms of tulathromycin |
WO2013158422A1 (en) | 2012-04-17 | 2013-10-24 | E. I. Du Pont De Nemours And Company | Heterocyclic compounds for controlling invertebrate pests |
CN103965273B (zh) | 2013-08-23 | 2016-05-25 | 普莱柯生物工程股份有限公司 | 一种大环内酯类化合物 |
CN103497227B (zh) * | 2013-09-13 | 2015-09-30 | 青岛科技大学 | 一种泰拉菌素中间体的制备方法 |
EP3406619B1 (en) * | 2016-01-18 | 2020-11-25 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Method and intermediate for preparing tulathromycin |
CN106046077B (zh) * | 2016-08-04 | 2019-07-26 | 湖北美天生物科技股份有限公司 | 一种泰拉霉素a的合成方法 |
CN106434797A (zh) * | 2016-08-25 | 2017-02-22 | 艾美科健(中国)生物医药有限公司 | 一种酶法合成泰拉霉素的工艺 |
CN106939029B (zh) * | 2017-04-28 | 2020-10-13 | 艾美科健(中国)生物医药有限公司 | 一种泰拉霉素的制备方法 |
CN107400152B (zh) * | 2017-08-29 | 2019-10-15 | 博瑞生物医药(苏州)股份有限公司 | 泰拉菌素草酸盐 |
CN107556351B (zh) * | 2017-08-29 | 2019-10-18 | 博瑞生物医药(苏州)股份有限公司 | 一种泰拉菌素的制备方法 |
CN109535210A (zh) * | 2018-12-19 | 2019-03-29 | 江苏威凌生化科技有限公司 | 一种合成纯化泰拉霉素杂质e的方法 |
WO2020212760A2 (en) * | 2019-04-18 | 2020-10-22 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
CN111072730B (zh) * | 2019-12-16 | 2021-01-12 | 浙江国邦药业有限公司 | 一种泰拉霉素中间体盐的制备方法及应用 |
CN112225769A (zh) * | 2020-09-21 | 2021-01-15 | 江苏威凌生化科技有限公司 | 一种合成纯化泰拉霉素杂质e的方法 |
CN113493483A (zh) * | 2021-07-05 | 2021-10-12 | 上海应用技术大学 | 一种泰拉霉素的合成方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI7910768A8 (en) | 1979-04-02 | 1996-06-30 | Pliva Pharm & Chem Works | Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives |
SI8110592A8 (en) | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
US4474768A (en) | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
US4512982A (en) | 1984-04-13 | 1985-04-23 | Pfizer Inc. | 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method |
US4518590A (en) | 1984-04-13 | 1985-05-21 | Pfizer Inc. | 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method |
CA2064634C (en) | 1991-04-04 | 1998-08-04 | James V. Heck | 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions |
EP0549040A1 (en) | 1991-12-20 | 1993-06-30 | Merck & Co. Inc. | Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A |
US5441939A (en) | 1994-03-04 | 1995-08-15 | Pfizer Inc. | 3"-desmethoxy derivatives of erythromycin and azithromycin |
ES2122905B1 (es) * | 1996-07-11 | 1999-11-16 | Astur Pharma Sa | Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato). |
HN1998000074A (es) * | 1997-06-11 | 1999-01-08 | Pfizer Prod Inc | Derivados de macrolidos c-4 sustituidos |
HN1998000086A (es) * | 1997-06-11 | 1999-03-08 | Pfizer Prod Inc | Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos. |
UA70972C2 (uk) * | 1998-11-20 | 2004-11-15 | Пфайзер Продактс Інк. | 13-членні азаліди і їх застосування як антибіотиків |
OA11876A (en) * | 1999-05-18 | 2006-03-27 | Pfizer Prod Inc | Novel crystalline forms of a macrolide antibiotic. |
-
2002
- 2002-04-11 RU RU2003131351/04A patent/RU2263117C2/ru not_active IP Right Cessation
- 2002-04-11 PL PL02371766A patent/PL371766A1/xx not_active Application Discontinuation
- 2002-04-11 CN CNB028086961A patent/CN100413879C/zh not_active Expired - Fee Related
- 2002-04-11 WO PCT/IB2002/001252 patent/WO2002088158A1/en active Search and Examination
- 2002-04-11 CN CNB2005100820637A patent/CN1297564C/zh not_active Expired - Fee Related
- 2002-04-11 IL IL15805902A patent/IL158059A0/xx unknown
- 2002-04-11 JP JP2002585456A patent/JP4104463B2/ja not_active Expired - Fee Related
- 2002-04-11 BR BR0209241-7A patent/BR0209241A/pt not_active IP Right Cessation
- 2002-04-11 CA CA002445306A patent/CA2445306C/en not_active Expired - Fee Related
- 2002-04-11 MX MXPA03009786A patent/MXPA03009786A/es active IP Right Grant
- 2002-04-11 EP EP02722578A patent/EP1383780A1/en not_active Withdrawn
- 2002-04-17 EP EP02252730.3A patent/EP1253153B1/en not_active Expired - Lifetime
- 2002-04-17 ES ES02252730.3T patent/ES2608848T3/es not_active Expired - Lifetime
- 2002-04-17 PT PT2252730T patent/PT1253153T/pt unknown
- 2002-04-17 DK DK02252730.3T patent/DK1253153T3/da active
- 2002-04-19 YU YU29502A patent/YU29502A/sh unknown
- 2002-04-19 IL IL149226A patent/IL149226A/he active IP Right Grant
- 2002-04-19 IL IL182418A patent/IL182418A/he active IP Right Grant
- 2002-04-23 CZ CZ20021417A patent/CZ303716B6/cs not_active IP Right Cessation
- 2002-04-24 SG SG200202485A patent/SG100789A1/en unknown
- 2002-04-24 JP JP2002122346A patent/JP4100955B2/ja not_active Expired - Lifetime
- 2002-04-24 AU AU35630/02A patent/AU784362B2/en not_active Expired
- 2002-04-24 ZA ZA200203252A patent/ZA200203252B/xx unknown
- 2002-04-25 CN CNB021184356A patent/CN1167708C/zh not_active Expired - Lifetime
- 2002-04-25 PL PL353633A patent/PL213731B1/pl unknown
- 2002-04-25 US US10/133,472 patent/US6825327B2/en not_active Expired - Lifetime
- 2002-04-25 CN CNB2004100396880A patent/CN1295240C/zh not_active Expired - Lifetime
- 2002-04-25 CA CA002383409A patent/CA2383409C/en not_active Expired - Lifetime
- 2002-04-26 HU HU0201385A patent/HU230717B1/hu unknown
- 2002-04-26 AR ARP020101536A patent/AR035871A1/es active IP Right Grant
- 2002-04-26 RU RU2002111333/04A patent/RU2233287C2/ru active
- 2002-04-26 MX MXPA02004231A patent/MXPA02004231A/es active IP Right Grant
- 2002-04-26 KR KR10-2002-0022902A patent/KR100474225B1/ko active IP Right Grant
- 2002-04-26 BR BR0201437-8 patent/BRPI0201437B8/pt not_active IP Right Cessation
-
2003
- 2003-04-10 HK HK03102597A patent/HK1050370A1/xx not_active IP Right Cessation
- 2003-09-26 ZA ZA200307506A patent/ZA200307506B/xx unknown
-
2004
- 2004-11-03 HK HK04108627A patent/HK1065803A1/xx not_active IP Right Cessation
-
2007
- 2007-01-09 JP JP2007001229A patent/JP2007091754A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA200203252B (en) | Process for preparing 4"-substituted-9-deoxo-9A-AZA-9A-homoerythromycina derivatives. | |
IL157478A0 (en) | Method for the synthesis of 2', 3'-didehydronucleosides | |
HUP0004884A3 (en) | Process for preparing 1,4-dihydropyridine derivatives | |
ZA200108623B (en) | Process for preparing imidachloprid. | |
IL139023A0 (en) | Process for the preparation of 2,3,5-trimethyl-p- benzoquinone | |
IL162188A0 (en) | Process for the preparation of Ä1,4,5Ü-oxadiazepine derivatives | |
EG23417A (en) | Process for the preparation 7 a-methylsteroids. | |
IL146573A0 (en) | Method for producing 2,2,4,4-tetra-substituted 1,3,5-cyclohexanetriones | |
EP1295864A4 (en) | PROCESS FOR THE PREPARATION OF 1,5-DIAMINONAPHTHALINES | |
HUP0103778A3 (en) | Process for preparing 1,5-diaryl-3-substituted pyrazoles | |
IL146810A0 (en) | Process for preparing 10, 11-methanobenzosuberane derivatives | |
HUP0302821A2 (hu) | Eljárás szubsztituált 5-amino-N-fenil-1,2,4-triazol-3-szulfonamid-származékok előállítására | |
IL137364A (en) | Process for the preparation of 6,6-dimethylhept-1-en-4-yn-3-ol | |
HUP0401989A3 (en) | A process for the preparation of the 14 beta-hydroxy-baccatin iii-1,14-carbonate | |
IL153935A0 (en) | Process for the preparation of chiral 1,4-diaryl-2-fluoro-2-butenes | |
HK1041606B (zh) | N,n'-羰基雙內酰胺的製備方法 | |
EP1451178A4 (en) | PROCESS FOR PREPARING BEAT D RIBOFURANOSE DERIVATIVES | |
IL159965A0 (en) | Novel 2,4-diaminothiazole derivatives | |
HUP0204401A3 (en) | Process for producing 2,6-dichlorophenol derivatives | |
HUP0204443A3 (en) | Process for preparing fluoroformates | |
AU2001234795A1 (en) | Process for obtaining 1, 2, 3, 5, 6, 7, 8, 8a-oltahydro-1, 2, 8, 8tetramethylnaphthalen-2-yl!etan-1-one | |
HK1062678A1 (en) | Process for preparing 8-cyclopentyl-6-ethyl-3-ÄsubstitutedÜ-5,8-dihydro-4H 7,8-pentaaza-as-indacenesand intermediates useful therein | |
HUP0300259A3 (en) | Process for preparing 5'-acetylstavudine | |
HK1087414A1 (en) | Process for preparing 4"-substituted-9-deoxo-9A-aza-9A-homoerythromycin a derivatives | |
HUP0004154A3 (en) | Process for the preparation of 1,5-disubstituted-3-amino-1,2,4-triazole derivatives |