ZA200201136B - Rapidly disintegrating pellets based on chitosan. - Google Patents
Rapidly disintegrating pellets based on chitosan. Download PDFInfo
- Publication number
- ZA200201136B ZA200201136B ZA200201136A ZA200201136A ZA200201136B ZA 200201136 B ZA200201136 B ZA 200201136B ZA 200201136 A ZA200201136 A ZA 200201136A ZA 200201136 A ZA200201136 A ZA 200201136A ZA 200201136 B ZA200201136 B ZA 200201136B
- Authority
- ZA
- South Africa
- Prior art keywords
- porous
- active substance
- chitosan
- containing pellets
- rapidly
- Prior art date
Links
- 239000008188 pellet Substances 0.000 title claims description 67
- 229920001661 Chitosan Polymers 0.000 title claims description 42
- 238000000034 method Methods 0.000 claims description 35
- 230000008569 process Effects 0.000 claims description 28
- 239000013543 active substance Substances 0.000 claims description 25
- 238000004519 manufacturing process Methods 0.000 claims description 20
- 239000000126 substance Substances 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 10
- 239000000110 cooling liquid Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 239000006185 dispersion Substances 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 239000007789 gas Substances 0.000 claims description 5
- 230000021736 acetylation Effects 0.000 claims description 4
- 238000006640 acetylation reaction Methods 0.000 claims description 4
- 239000000032 diagnostic agent Substances 0.000 claims description 4
- 229940039227 diagnostic agent Drugs 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 4
- 239000007902 hard capsule Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 239000000243 solution Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 description 10
- 239000001828 Gelatine Substances 0.000 description 9
- 229920000159 gelatin Polymers 0.000 description 9
- 235000019322 gelatine Nutrition 0.000 description 9
- 239000000047 product Substances 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 239000012876 carrier material Substances 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 229920002101 Chitin Polymers 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 229920001222 biopolymer Polymers 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 239000004129 EU approved improving agent Substances 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- USDJGQLNFPZEON-UHFFFAOYSA-N [[4,6-bis(hydroxymethylamino)-1,3,5-triazin-2-yl]amino]methanol Chemical compound OCNC1=NC(NCO)=NC(NCO)=N1 USDJGQLNFPZEON-UHFFFAOYSA-N 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000014104 aloe vera supplement Nutrition 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 239000000924 antiasthmatic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000003434 antitussive agent Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000012809 cooling fluid Substances 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 125000004925 dihydropyridyl group Chemical class N1(CC=CC=C1)* 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940097879 mumpsvax Drugs 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19940795A DE19940795A1 (de) | 1999-08-27 | 1999-08-27 | Schnellzerfallende Pellets auf der Basis von Chitosan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200201136B true ZA200201136B (en) | 2002-08-28 |
Family
ID=7919872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200201136A ZA200201136B (en) | 1999-08-27 | 2002-02-11 | Rapidly disintegrating pellets based on chitosan. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6770300B1 (es) |
| EP (1) | EP1208140B1 (es) |
| JP (1) | JP4944327B2 (es) |
| KR (1) | KR100610176B1 (es) |
| CN (1) | CN1208381C (es) |
| AR (1) | AR025393A1 (es) |
| AT (1) | ATE331755T1 (es) |
| AU (1) | AU768328B2 (es) |
| BR (1) | BR0013562A (es) |
| CA (1) | CA2382902C (es) |
| CZ (1) | CZ300123B6 (es) |
| DE (2) | DE19940795A1 (es) |
| DK (1) | DK1208140T3 (es) |
| ES (1) | ES2267562T3 (es) |
| HK (1) | HK1047122A1 (es) |
| HU (1) | HUP0203079A3 (es) |
| IL (1) | IL148221A (es) |
| MX (1) | MXPA02002047A (es) |
| NZ (1) | NZ517542A (es) |
| PL (1) | PL203820B1 (es) |
| PT (1) | PT1208140E (es) |
| RU (1) | RU2248790C2 (es) |
| TR (1) | TR200200519T2 (es) |
| TW (1) | TW477697B (es) |
| WO (1) | WO2001016218A1 (es) |
| ZA (1) | ZA200201136B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE387487T1 (de) * | 2003-05-23 | 2008-03-15 | Procter & Gamble | Waschmittelzusammensetzung zum gebrauch in einer textilwasch- oder geschirrspülmaschine |
| EP1627573A1 (en) * | 2004-08-20 | 2006-02-22 | Firmenich Sa | A process for the incorporation of a flavor or fragrance ingredient or composition into a carbohydrate matrix |
| EP1993637A2 (en) * | 2006-02-15 | 2008-11-26 | Medingo Ltd. | Systems and methods for sensing analyte and dispensing therapeutic fluid |
| EP2306981A1 (en) | 2008-06-19 | 2011-04-13 | University Of The Witwatersrand, Johannesburg | A transmucosal delivery system |
| WO2011053959A1 (en) * | 2009-11-02 | 2011-05-05 | Mannkind Corporation | Apparatus and method for cryogranulating a pharmaceutical composition |
| JP6392907B2 (ja) * | 2016-04-14 | 2018-09-19 | 株式会社新菱 | ガス含有基材およびその製造方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE14047T1 (de) | 1981-12-11 | 1985-07-15 | Wyeth John & Brother Ltd | Verfahren und vorrichtung zum gefrieren einer fluessigkeit. |
| DE3711169A1 (de) | 1987-04-02 | 1988-10-20 | Messer Griesheim Gmbh | Vorrichtung zum kontrollierten einfrieren von zaehfliessenden fluessigkeiten |
| JPH01152104A (ja) * | 1987-12-08 | 1989-06-14 | Hokkaido Soda Kk | 水溶性キトサン塩粉末の製造方法 |
| ES2081384T3 (es) * | 1990-04-25 | 1996-03-01 | Hoechst Ag | Preparado farmaceutico que contiene complejos de polielectrolitos en forma de microparticulas y por lo menos una sustancia activa. |
| DE4201172C1 (en) | 1992-01-17 | 1993-07-22 | Alfatec-Pharma Gmbh, 6900 Heidelberg, De | Pellets contg. Aloe vera extract - useful, e.g. as antiinflammatory of antibiotic agents, or for treating gastric ulcers |
| DE4201173C2 (de) | 1992-01-17 | 1998-10-29 | Alfatec Pharma Gmbh | Akutarzneimittel in Form von Dihydropyridinderivaten enthaltenden Pellets und ihre Herstellung |
| DE4201179A1 (de) * | 1992-01-17 | 1993-07-22 | Alfatec Pharma Gmbh | Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung |
| GB2311027B (en) * | 1996-03-15 | 1999-10-27 | Johnson & Johnson Medical | Coated bioabsorbable beads for wound treatment |
| ES2175433T3 (es) * | 1996-07-10 | 2002-11-16 | West Pharm Serv Drug Res Ltd | Composiciones indicadas para la administracion de genes en celulas epiteliales. |
| JP3879018B2 (ja) * | 1996-07-19 | 2007-02-07 | アステラス製薬株式会社 | 生体適合性物質の水不溶化多孔性粒子及びその製造法 |
| US5976577A (en) * | 1997-07-11 | 1999-11-02 | Rp Scherer Corporation | Process for preparing fast dispersing solid oral dosage form |
| DE19756314C2 (de) * | 1997-12-12 | 2000-06-29 | Roland Bodmeier | Zubereitung mit verlängerter Verweildauer am Applikationsort |
| DE19845246A1 (de) * | 1997-12-18 | 1999-06-24 | Henkel Kgaa | Vitaminhaltige Zubereitungen |
-
1999
- 1999-08-27 DE DE19940795A patent/DE19940795A1/de not_active Withdrawn
-
2000
- 2000-08-14 IL IL14822100A patent/IL148221A/xx not_active IP Right Cessation
- 2000-08-14 TR TR2002/00519T patent/TR200200519T2/xx unknown
- 2000-08-14 MX MXPA02002047A patent/MXPA02002047A/es unknown
- 2000-08-14 DK DK00960450T patent/DK1208140T3/da active
- 2000-08-14 CZ CZ20020654A patent/CZ300123B6/cs not_active IP Right Cessation
- 2000-08-14 BR BR0013562-3A patent/BR0013562A/pt not_active IP Right Cessation
- 2000-08-14 AU AU72755/00A patent/AU768328B2/en not_active Ceased
- 2000-08-14 EP EP00960450A patent/EP1208140B1/de not_active Expired - Lifetime
- 2000-08-14 WO PCT/EP2000/007897 patent/WO2001016218A1/de active IP Right Grant
- 2000-08-14 HU HU0203079A patent/HUP0203079A3/hu unknown
- 2000-08-14 NZ NZ517542A patent/NZ517542A/xx not_active IP Right Cessation
- 2000-08-14 PT PT00960450T patent/PT1208140E/pt unknown
- 2000-08-14 US US10/069,399 patent/US6770300B1/en not_active Expired - Fee Related
- 2000-08-14 RU RU2002103514/15A patent/RU2248790C2/ru not_active IP Right Cessation
- 2000-08-14 DE DE50013092T patent/DE50013092D1/de not_active Expired - Lifetime
- 2000-08-14 KR KR1020027002508A patent/KR100610176B1/ko not_active IP Right Cessation
- 2000-08-14 PL PL353890A patent/PL203820B1/pl not_active IP Right Cessation
- 2000-08-14 ES ES00960450T patent/ES2267562T3/es not_active Expired - Lifetime
- 2000-08-14 CA CA002382902A patent/CA2382902C/en not_active Expired - Fee Related
- 2000-08-14 AT AT00960450T patent/ATE331755T1/de active
- 2000-08-14 JP JP2001520769A patent/JP4944327B2/ja not_active Expired - Fee Related
- 2000-08-14 CN CNB008119023A patent/CN1208381C/zh not_active Expired - Fee Related
- 2000-08-25 TW TW089117148A patent/TW477697B/zh not_active IP Right Cessation
- 2000-08-25 AR ARP000104417A patent/AR025393A1/es not_active Application Discontinuation
-
2002
- 2002-02-11 ZA ZA200201136A patent/ZA200201136B/en unknown
- 2002-11-25 HK HK02108511.1A patent/HK1047122A1/zh unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5827541A (en) | Process for preparing solid pharmaceutical dosage forms of hydrophobic substances | |
| US5738875A (en) | Process for preparing solid pharmaceutical dosage forms | |
| JP2641620B2 (ja) | 経口導入製品に味付けする方法及び組成物 | |
| JP4943581B2 (ja) | 迅速分散性固形経口投与用剤形の製造方法 | |
| AU722289B2 (en) | Taste-masked microcapsule compositions and methods of manufacture | |
| JP3509105B2 (ja) | 活性物質をポリマーで被覆したマイクロカプセルの製法と特にこの方法で得られる新規マイクロカプセル | |
| DK175095B1 (da) | Produkter indeholdende mikro- eller nanopartikler samt fremgangsmåde til deres fremstilling | |
| JP2550362B2 (ja) | スプレードライしたアセトアミノフェン | |
| EP0910345A1 (en) | Biconvex rapidly disintegrating dosage forms | |
| KR970007899B1 (ko) | 맛 은폐를 위한 수단을 포함하는 저작가능한 의약 정제 | |
| US5837287A (en) | Process for preparing solid pharmaceutical dosage forms | |
| EP2827843B1 (en) | Method for producing enteric alginate microcapsules via ionic gelation containing diclofenac or one of the salts thereof and multiparticled pharmaceutical composition containing them | |
| AU768328B2 (en) | Rapidly decomposing chitosan-based pellets | |
| WO2000074656A1 (en) | Microencapsulated and controlled-release herbal formulations | |
| JP2002511404A (ja) | コーティングされたデンプンカプセル、およびこれらの製造方法 | |
| KR20020031416A (ko) | 나노졸을 함유한 의약제제 | |
| Borin | New product formulations and pharmacokinetics of acetaminophen |