ZA200108636B - Tetracyclic azepinoindole compounds as 5-HT receptor ligands. - Google Patents
Tetracyclic azepinoindole compounds as 5-HT receptor ligands. Download PDFInfo
- Publication number
- ZA200108636B ZA200108636B ZA200108636A ZA200108636A ZA200108636B ZA 200108636 B ZA200108636 B ZA 200108636B ZA 200108636 A ZA200108636 A ZA 200108636A ZA 200108636 A ZA200108636 A ZA 200108636A ZA 200108636 B ZA200108636 B ZA 200108636B
- Authority
- ZA
- South Africa
- Prior art keywords
- azepino
- hexahydro
- pyrrolo
- disorder
- alkyl
- Prior art date
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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Landscapes
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- Immunology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Otolaryngology (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US13081199P | 1999-04-23 | 1999-04-23 |
Publications (1)
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ZA200108636B true ZA200108636B (en) | 2003-02-19 |
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ZA200108636A ZA200108636B (en) | 1999-04-23 | 2001-10-19 | Tetracyclic azepinoindole compounds as 5-HT receptor ligands. |
Country Status (20)
Country | Link |
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EP (1) | EP1173440B1 (zh) |
JP (1) | JP2002543080A (zh) |
KR (1) | KR20020005708A (zh) |
CN (1) | CN1183132C (zh) |
AR (1) | AR023574A1 (zh) |
AT (1) | ATE276255T1 (zh) |
AU (1) | AU760943C (zh) |
BR (1) | BR0009983A (zh) |
CA (1) | CA2367682A1 (zh) |
DE (1) | DE60013803T2 (zh) |
DK (1) | DK1173440T3 (zh) |
EC (1) | ECSP003426A (zh) |
ES (1) | ES2226822T3 (zh) |
HK (1) | HK1045512B (zh) |
NZ (1) | NZ514553A (zh) |
PE (1) | PE20010052A1 (zh) |
PT (1) | PT1173440E (zh) |
SI (1) | SI1173440T1 (zh) |
WO (1) | WO2000064899A1 (zh) |
ZA (1) | ZA200108636B (zh) |
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US6777407B2 (en) | 2000-11-03 | 2004-08-17 | Wyeth | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
AR031200A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados |
US6858604B2 (en) | 2000-11-03 | 2005-02-22 | Wyeth | Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
US6849619B2 (en) | 2000-12-20 | 2005-02-01 | Bristol-Myers Squibb Company | Substituted pyridoindoles as serotonin agonists and antagonists |
BR0116429A (pt) * | 2000-12-20 | 2006-05-09 | Bristol Myers Squibb Co | piridoindóis substituìdos como agonistas e antagonistas da serotonina |
US20020160999A1 (en) * | 2001-01-08 | 2002-10-31 | Jacobsen Susan Fox | Substituted indolines |
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WO2003014125A1 (en) * | 2001-08-06 | 2003-02-20 | Pharmacia & Upjohn Company | Therapeutically useful tetracyclic ligands |
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MXPA04003594A (es) * | 2001-10-18 | 2004-07-30 | Upjohn Co | Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2. |
TWI312781B (en) | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
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TW200307540A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
WO2006022420A1 (ja) | 2004-08-25 | 2006-03-02 | Takeda Pharmaceutical Company Limited | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
GT200500317A (es) | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
AR054849A1 (es) | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
CA2636992C (en) * | 2006-01-19 | 2015-10-06 | Athersys, Inc. | Thiophenyl and pyrrolyl azepines as serotonin 5-ht2c receptor ligands and uses thereof |
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CN101796051B (zh) | 2007-03-12 | 2013-11-06 | 细胞内治疗公司 | 与取代的杂环稠合的γ-咔啉的合成 |
US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
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CN102482292B (zh) * | 2009-04-23 | 2017-07-18 | Abbvie 公司 | 5‑ht受体的调节剂和其使用方法 |
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JP2012532144A (ja) | 2009-07-01 | 2012-12-13 | アルバニー モレキュラー リサーチ, インコーポレイテッド | アジノン置換アゼピノ[b]インドールおよびピリド−ピロロ−アゼピンmch−1拮抗薬、ならびにその作製方法および使用 |
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JP2017509677A (ja) | 2014-04-04 | 2017-04-06 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
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CN105837571A (zh) * | 2016-04-23 | 2016-08-10 | 何华琼 | 盐酸倍他司汀的药物组合物及其在生物医药中的应用 |
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US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
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US3839357A (en) * | 1966-05-10 | 1974-10-01 | Upjohn Co | 1,2,3,4,5,6-hexahydroazepino(4,5-b)indoles |
US3676558A (en) * | 1970-08-28 | 1972-07-11 | Upjohn Co | Anorexigenic compositions comprising 6-alkyl-1,2,3,4,5,6-hexahydroazepino 4,5-indoles as active ingredient and process of treatment |
EP0377238A1 (en) * | 1988-12-22 | 1990-07-11 | Duphar International Research B.V | New annelated indolo (3,2-c)-lactams |
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2000
- 2000-04-19 PE PE2000000368A patent/PE20010052A1/es not_active Application Discontinuation
- 2000-04-19 AR ARP000101881A patent/AR023574A1/es unknown
- 2000-04-20 CA CA002367682A patent/CA2367682A1/en not_active Abandoned
- 2000-04-20 WO PCT/US2000/010600 patent/WO2000064899A1/en not_active Application Discontinuation
- 2000-04-20 CN CNB008066639A patent/CN1183132C/zh not_active Expired - Fee Related
- 2000-04-20 DK DK00923532T patent/DK1173440T3/da active
- 2000-04-20 AU AU43637/00A patent/AU760943C/en not_active Ceased
- 2000-04-20 ES ES00923532T patent/ES2226822T3/es not_active Expired - Lifetime
- 2000-04-20 DE DE60013803T patent/DE60013803T2/de not_active Expired - Fee Related
- 2000-04-20 EP EP00923532A patent/EP1173440B1/en not_active Expired - Lifetime
- 2000-04-20 SI SI200030516T patent/SI1173440T1/xx unknown
- 2000-04-20 AT AT00923532T patent/ATE276255T1/de not_active IP Right Cessation
- 2000-04-20 JP JP2000614251A patent/JP2002543080A/ja active Pending
- 2000-04-20 KR KR1020017013458A patent/KR20020005708A/ko not_active Application Discontinuation
- 2000-04-20 NZ NZ514553A patent/NZ514553A/en unknown
- 2000-04-20 BR BR0009983-0A patent/BR0009983A/pt not_active IP Right Cessation
- 2000-04-20 PT PT00923532T patent/PT1173440E/pt unknown
- 2000-04-27 EC EC2000003426A patent/ECSP003426A/es unknown
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2001
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Also Published As
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CN1183132C (zh) | 2005-01-05 |
CA2367682A1 (en) | 2000-11-02 |
AU760943B2 (en) | 2003-05-22 |
DE60013803D1 (de) | 2004-10-21 |
EP1173440A1 (en) | 2002-01-23 |
EP1173440B1 (en) | 2004-09-15 |
NZ514553A (en) | 2003-10-31 |
PE20010052A1 (es) | 2001-01-27 |
HK1045512A1 (en) | 2004-10-15 |
PT1173440E (pt) | 2004-12-31 |
DE60013803T2 (de) | 2005-11-17 |
ECSP003426A (es) | 2000-10-24 |
CN1348454A (zh) | 2002-05-08 |
KR20020005708A (ko) | 2002-01-17 |
AR023574A1 (es) | 2002-09-04 |
HK1045512B (zh) | 2005-09-02 |
BR0009983A (pt) | 2002-04-16 |
JP2002543080A (ja) | 2002-12-17 |
SI1173440T1 (en) | 2005-02-28 |
ES2226822T3 (es) | 2005-04-01 |
DK1173440T3 (da) | 2004-12-20 |
WO2000064899A1 (en) | 2000-11-02 |
ATE276255T1 (de) | 2004-10-15 |
AU4363700A (en) | 2000-11-10 |
AU760943C (en) | 2003-12-04 |
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