BR0116429A - piridoindóis substituìdos como agonistas e antagonistas da serotonina - Google Patents
piridoindóis substituìdos como agonistas e antagonistas da serotoninaInfo
- Publication number
- BR0116429A BR0116429A BRPI0116429-5A BR0116429A BR0116429A BR 0116429 A BR0116429 A BR 0116429A BR 0116429 A BR0116429 A BR 0116429A BR 0116429 A BR0116429 A BR 0116429A
- Authority
- BR
- Brazil
- Prior art keywords
- disorders
- antagonists
- serotonin agonists
- novel compounds
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/16—Peri-condensed systems
Abstract
"PIRIDOINDóIS SUBSTITUìDOS COMO AGONISTAS E ANTAGONISTAS DA SEROTONINA". A presente invenção está direcionada para certos compostos novos representados pela Fórmula (I) estrutural ou suas formas de sal farmaceuticamente aceitáveis, onde R¬ 1¬, R¬ 5¬, R¬ 6¬, R¬ 7¬, R¬ 8¬, R¬ 9¬, X, b, k, e n, e as linhas traçadas estão descritas na presente invenção. A invenção está também relacionada com formulações farmacêuticas compreendendo esses compostos novos como componentes ativos e o uso dos compostos novos e suas formulações no tratamento de certos distúrbios. Os compostos dessa invenção são agonistas e antagonistas da serotonina e são úteis no controle e prevenção de distúrbios do sistema nervoso central incluindo obesidade, ansiedade, depressão, psicose, esquizofrenia, distúrbios do sono, distúrbios sexuais, cefaléia, condições associadas com dor cefálica, fobias sociais, e distúrbios gastrintestinais, tais como disfunção da motilidade do trato gastrintestinal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25674000P | 2000-12-20 | 2000-12-20 | |
PCT/US2001/049371 WO2002059129A2 (en) | 2000-12-20 | 2001-12-19 | Substituted tetracyclic pyridoindoles as serotonin agonists and antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0116429A true BR0116429A (pt) | 2006-05-09 |
Family
ID=22973405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0116429-5A BR0116429A (pt) | 2000-12-20 | 2001-12-19 | piridoindóis substituìdos como agonistas e antagonistas da serotonina |
Country Status (18)
Country | Link |
---|---|
US (1) | US6699852B2 (pt) |
EP (1) | EP1343791A2 (pt) |
JP (1) | JP4231290B2 (pt) |
KR (1) | KR20030070073A (pt) |
BG (1) | BG107865A (pt) |
BR (1) | BR0116429A (pt) |
CA (1) | CA2432185C (pt) |
EE (1) | EE200300296A (pt) |
HU (1) | HUP0303432A3 (pt) |
IL (1) | IL156354A0 (pt) |
IS (1) | IS6849A (pt) |
MX (1) | MXPA03005438A (pt) |
NO (1) | NO20032797L (pt) |
PL (1) | PL366233A1 (pt) |
RU (1) | RU2003121304A (pt) |
SK (1) | SK7042003A3 (pt) |
WO (1) | WO2002059129A2 (pt) |
ZA (1) | ZA200304305B (pt) |
Families Citing this family (68)
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US6858604B2 (en) * | 2000-11-03 | 2005-02-22 | Wyeth | Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
US6759405B2 (en) | 2000-11-03 | 2004-07-06 | Wyeth | Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
TW200307682A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
TW200307540A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
TWI312781B (en) * | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
IL166593A0 (en) * | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
ATE509929T1 (de) | 2002-12-19 | 2011-06-15 | Bristol Myers Squibb Co | Substituierte tricyclische gamma-carbolineals serotonin-rezeptor-agonisten und antagonisten |
US8598219B2 (en) | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
GB0306604D0 (en) * | 2003-03-21 | 2003-04-30 | Curidium Ltd | Second medical use |
CL2004000826A1 (es) | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
US7767689B2 (en) * | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
KR20120073287A (ko) | 2004-03-15 | 2012-07-04 | 피티씨 테라퓨틱스, 인크. | 혈관형성을 억제하는데 유용한 카르볼린 유도체 |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
JP5173190B2 (ja) | 2004-08-25 | 2013-03-27 | 武田薬品工業株式会社 | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
AR051946A1 (es) * | 2004-11-05 | 2007-02-21 | Wyeth Corp | Formulaciones de derivados de [1,4] diazepina [6,7,1-ij] quinolina |
GT200500317A (es) * | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
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AT502251B1 (de) * | 2005-05-06 | 2007-12-15 | Puchegger U Beisteiner Parkett | Fussbodenschleifmaschine |
AR054849A1 (es) * | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
AU2006275694A1 (en) * | 2005-07-28 | 2007-02-08 | Bristol-Myers Squibb Company | Substituted tetrahydro-1H-pyrido(4,3,b)indoles as serotonin receptor agonists and antagonists |
TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
CA2644656A1 (en) * | 2006-03-24 | 2007-10-04 | Wyeth | Treatment of pain |
CL2007000774A1 (es) * | 2006-03-24 | 2008-03-07 | Wyeth Corp | Uso de compuestos derivados de diazepina condensada para tratar la incontinencia urinaria. |
AR060087A1 (es) * | 2006-03-24 | 2008-05-21 | Wyeth Corp | Nuevas combinaciones terapeuticas para el tratamiento de la depresion |
CL2007000773A1 (es) * | 2006-03-24 | 2008-01-25 | Wyeth Corp | Uso de compuestos derivados de diazepina condensada para el tratamiento de un desorden cognitivo como add o adhd;o su uso para tratar spm o pmdd. |
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US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
MX2010007430A (es) | 2008-01-11 | 2010-12-21 | Albany Molecular Res Inc | Piridoindoles (1-azinona)-sustituidos como antagonistas de la hormona de concentracion melanina humana. |
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EP3931189A4 (en) | 2019-02-27 | 2022-11-30 | The Regents Of The University Of California | AZEPINO-INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS |
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US3299078A (en) | 1962-10-01 | 1967-01-17 | Smith Kline French Lab | Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines |
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FR2213283A1 (en) | 1973-11-15 | 1974-08-02 | Inst Im Ordzhonikidze | Pyrazino(1,2,3-ab)beta carbolines and homologues - antidepressants not acting by MAO inhibition |
US4088647A (en) | 1976-02-04 | 1978-05-09 | Glushkov Robert Georgievich | Pyrazino (1,2,3-ab)-β-carboline derivatives and salts thereof and method of preparing same |
US4219550A (en) | 1978-11-09 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Cis- and trans- octahydropyridopyrrolobenzheterocycles |
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ATE136032T1 (de) | 1987-07-20 | 1996-04-15 | Duphar Int Res | 8,9-anellierte 1,2,3,4-tetrahydro-beta-carbolin- derivate |
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-
2001
- 2001-12-19 EP EP01994316A patent/EP1343791A2/en not_active Withdrawn
- 2001-12-19 JP JP2002559431A patent/JP4231290B2/ja not_active Expired - Lifetime
- 2001-12-19 HU HU0303432A patent/HUP0303432A3/hu not_active Application Discontinuation
- 2001-12-19 MX MXPA03005438A patent/MXPA03005438A/es unknown
- 2001-12-19 IL IL15635401A patent/IL156354A0/xx unknown
- 2001-12-19 SK SK704-2003A patent/SK7042003A3/sk unknown
- 2001-12-19 RU RU2003121304/04A patent/RU2003121304A/ru not_active Application Discontinuation
- 2001-12-19 WO PCT/US2001/049371 patent/WO2002059129A2/en active IP Right Grant
- 2001-12-19 CA CA2432185A patent/CA2432185C/en not_active Expired - Lifetime
- 2001-12-19 PL PL01366233A patent/PL366233A1/xx unknown
- 2001-12-19 US US10/026,611 patent/US6699852B2/en not_active Expired - Lifetime
- 2001-12-19 BR BRPI0116429-5A patent/BR0116429A/pt unknown
- 2001-12-19 KR KR10-2003-7008272A patent/KR20030070073A/ko not_active Application Discontinuation
- 2001-12-19 EE EEP200300296A patent/EE200300296A/xx unknown
-
2003
- 2003-05-30 BG BG107865A patent/BG107865A/xx unknown
- 2003-06-02 ZA ZA200304305A patent/ZA200304305B/en unknown
- 2003-06-18 IS IS6849A patent/IS6849A/is unknown
- 2003-06-19 NO NO20032797A patent/NO20032797L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2002059129A2 (en) | 2002-08-01 |
US20020173503A1 (en) | 2002-11-21 |
JP2005506281A (ja) | 2005-03-03 |
EE200300296A (et) | 2003-12-15 |
EP1343791A2 (en) | 2003-09-17 |
MXPA03005438A (es) | 2004-05-05 |
KR20030070073A (ko) | 2003-08-27 |
HUP0303432A2 (hu) | 2004-01-28 |
JP4231290B2 (ja) | 2009-02-25 |
WO2002059129A3 (en) | 2003-01-30 |
RU2003121304A (ru) | 2005-01-27 |
BG107865A (en) | 2004-07-30 |
ZA200304305B (en) | 2004-09-02 |
NO20032797D0 (no) | 2003-06-19 |
CA2432185A1 (en) | 2002-08-01 |
CA2432185C (en) | 2011-11-08 |
SK7042003A3 (en) | 2004-07-07 |
NO20032797L (no) | 2003-08-19 |
IS6849A (is) | 2003-06-18 |
PL366233A1 (en) | 2005-01-24 |
IL156354A0 (en) | 2004-01-04 |
HUP0303432A3 (en) | 2012-09-28 |
US6699852B2 (en) | 2004-03-02 |
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