HUP0303432A2 - Szubsztituált piridoindolok mint szerotonin agonisták és antagonisták, és a vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Szubsztituált piridoindolok mint szerotonin agonisták és antagonisták, és a vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk

Info

Publication number
HUP0303432A2
HUP0303432A2 HU0303432A HUP0303432A HUP0303432A2 HU P0303432 A2 HUP0303432 A2 HU P0303432A2 HU 0303432 A HU0303432 A HU 0303432A HU P0303432 A HUP0303432 A HU P0303432A HU P0303432 A2 HUP0303432 A2 HU P0303432A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
alkenyl
alkynyl
substituted
Prior art date
Application number
HU0303432A
Other languages
English (en)
Inventor
Joseph Cacciola
Wenting Chen
John M. Fevig
Taekyu Lee
Ian S. Mitchell
Albert J. Robichaud
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HUP0303432A2 publication Critical patent/HUP0303432A2/hu
Publication of HUP0303432A3 publication Critical patent/HUP0303432A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

A találmány általános képletű új vegyületekre - amelyek képletében begyes kötés vagy kettős kötés; X oxi-, tio-, szulfinil-, szulfonil-vagy NRl0 csoport; R1 hidrogénatom, -C(=O)R2 , -C(=O)OR2 , adottesetben Z vagy legfeljebb két R2 csoporttal szubsztituált alkil-,alkenil-, alkinil-, cikloalkil-, aril-, heterociklilcsoport, adottesetben Y csoporttal szubsztituált alkil-, alkenil-, alkinilcsoport; YZ csoporttal vagy -alkil-Z csoporttal szubsztituált cikloalkil-,aril-, heterociklilcsoport; Z hidrogénatom, -CH(OH)R2, -C(etilén-dioxi)R2, -OR2, -SR2, -NR2R3, -C(O)R2, -C(O)NR2R3, -NR3C(O)R3, -C(O)OR2, -OC(O)R2, -CH(=NR4)NR2R3, -NHC(=NR4)NR2R3, -S(O)R2, -S(O)2R2,-S(O)2NR2R3 vagy -NR3S(O)2R2 csoport; R2 halogénatom, halogén-alkil-,alkil-, alkenil-, alkinil-; cikloalkil-, adott esetben R42 csoporttalszubsztituált arilcsoport, adott esetben R41 csoporttal szubsztituáltkarbociklusos vagy heterociklusos csoport; R3 hidrogénatom, alkil-,alkenil-, alkinil-, vagy alkoxicsoport; vagy R2 és R3 együtt egy adottesetben szubsztituált gyűrűt képez; R4, R5, R6, R14, R46 hidrogénatomvagy alkilcsoport; R7 és R9 hidrogén-, halogénatom, trifluor-metil-,trifluor-metoxi-, hidroxi-, ciano-, nitro-, -NR46R47, alkil-,alkenil-, alkinil-, halogén-alkil-, alkoxi-, halogén-alkoxi-, adottesetben R33 csoporttal cikloalkil-, alkil-, karbociklusos,arilcsoport, adott esetben R31 csoporttal szubsztituált heterociklusoscsoport; R8 hidrogén-, halogénatom, trifluor-metil-, trifluor-metoxi-,hidroxi-, ciano-, nitro-, alkil-, alkenil-, alkinil-, halogén-alkil-,alkoxi-, halogén-alkoxi-, adott esetben R33 csoporttal szubsztituáltcikloalkil- vagy karbociklusos csoport, adott esetben R11 csoporttalszubsztituált alkil-, alkenil-, alkinilcsoport, adott esetben R31csoporttal szubsztituált heterociklusos csoport, k és n értéke 1 vagy2; és m értéke 0 vagy 1; a leírásban meghatározott megkötésekkel -vagy gyógyszerészetileg elfogadható sóformáikra vonatkozik. Atalálmány kiterjed a találmány szerinti vegyületeket hatóanyagkénttartalmazó gyógyszerkészítményekre, valamint az új vegyületeknek éskészítményeiknek bizonyos rendellenességek kezelésére történőalkalmazására is. A találmány szerinti vegyületek szerotonin agonistákés antagonisták, így felhasználhatók központi idegrendszerirendellenességek kontrollálásra vagy megelőzésére. Ó
HU0303432A 2000-12-20 2001-12-19 Substituted pyridoindoles as serotonin agonists and antagonists and pharmaceutical compositions containing the compounds and their use HUP0303432A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25674000P 2000-12-20 2000-12-20
PCT/US2001/049371 WO2002059129A2 (en) 2000-12-20 2001-12-19 Substituted tetracyclic pyridoindoles as serotonin agonists and antagonists

Publications (2)

Publication Number Publication Date
HUP0303432A2 true HUP0303432A2 (hu) 2004-01-28
HUP0303432A3 HUP0303432A3 (en) 2012-09-28

Family

ID=22973405

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303432A HUP0303432A3 (en) 2000-12-20 2001-12-19 Substituted pyridoindoles as serotonin agonists and antagonists and pharmaceutical compositions containing the compounds and their use

Country Status (18)

Country Link
US (1) US6699852B2 (hu)
EP (1) EP1343791A2 (hu)
JP (1) JP4231290B2 (hu)
KR (1) KR20030070073A (hu)
BG (1) BG107865A (hu)
BR (1) BR0116429A (hu)
CA (1) CA2432185C (hu)
EE (1) EE200300296A (hu)
HU (1) HUP0303432A3 (hu)
IL (1) IL156354A0 (hu)
IS (1) IS6849A (hu)
MX (1) MXPA03005438A (hu)
NO (1) NO20032797L (hu)
PL (1) PL366233A1 (hu)
RU (1) RU2003121304A (hu)
SK (1) SK7042003A3 (hu)
WO (1) WO2002059129A2 (hu)
ZA (1) ZA200304305B (hu)

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NO20032797D0 (no) 2003-06-19
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BR0116429A (pt) 2006-05-09
EE200300296A (et) 2003-12-15
MXPA03005438A (es) 2004-05-05
KR20030070073A (ko) 2003-08-27
IS6849A (is) 2003-06-18
IL156354A0 (en) 2004-01-04
EP1343791A2 (en) 2003-09-17
CA2432185A1 (en) 2002-08-01
CA2432185C (en) 2011-11-08
WO2002059129A3 (en) 2003-01-30
SK7042003A3 (en) 2004-07-07
RU2003121304A (ru) 2005-01-27
WO2002059129A2 (en) 2002-08-01
ZA200304305B (en) 2004-09-02
HUP0303432A3 (en) 2012-09-28
PL366233A1 (en) 2005-01-24
US6699852B2 (en) 2004-03-02
JP2005506281A (ja) 2005-03-03
JP4231290B2 (ja) 2009-02-25

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