ZA200106677B - Spontaneously dispersible n-benzoyl staurosporine compositions. - Google Patents
Spontaneously dispersible n-benzoyl staurosporine compositions. Download PDFInfo
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- ZA200106677B ZA200106677B ZA200106677A ZA200106677A ZA200106677B ZA 200106677 B ZA200106677 B ZA 200106677B ZA 200106677 A ZA200106677 A ZA 200106677A ZA 200106677 A ZA200106677 A ZA 200106677A ZA 200106677 B ZA200106677 B ZA 200106677B
- Authority
- ZA
- South Africa
- Prior art keywords
- composition
- surfactant
- benzoylstaurosporine
- pharmaceutical composition
- bioavailability
- Prior art date
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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Landscapes
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- Communicable Diseases (AREA)
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- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| GBGB9903547.9A GB9903547D0 (en) | 1999-02-16 | 1999-02-16 | Organic compounds |
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| ZA200106677B true ZA200106677B (en) | 2003-01-14 |
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| ZA200106677A ZA200106677B (en) | 1999-02-16 | 2001-02-14 | Spontaneously dispersible n-benzoyl staurosporine compositions. |
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| US7795246B2 (en) | 1998-08-06 | 2010-09-14 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| US6200968B1 (en) * | 1998-08-06 | 2001-03-13 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| CA2439097C (en) * | 2001-03-26 | 2010-10-12 | Novartis Ag | Pharmaceutical compositions |
| HUP0400038A3 (en) | 2001-05-16 | 2007-05-29 | Novartis Ag | Combination comprising n-{5-[4-{-methyl-piperazino-methyl)-benzoylamino]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent |
| CN1582150B (zh) * | 2001-10-30 | 2011-09-07 | 诺瓦提斯公司 | 作为flt3受体酪氨酸激酶活性抑制剂的星形孢菌素衍生物 |
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| US7842791B2 (en) * | 2002-12-19 | 2010-11-30 | Nancy Jean Britten | Dispersible pharmaceutical compositions |
| TWI324604B (en) * | 2003-06-18 | 2010-05-11 | Novartis Ag | New use of staurosporine derivatives |
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| BRPI0714963A2 (pt) * | 2006-08-16 | 2013-07-30 | Novartis Ag | processo de fabricaÇço de dispersÕes sàlidas de compostos terapÊuticos altamente cristalinos |
| FR2918566B1 (fr) | 2007-07-11 | 2009-10-09 | Pierre Fabre Medicament Sa | Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine. |
| US20090155352A1 (en) * | 2007-11-20 | 2009-06-18 | Cephalon, Inc. | Microemulsion containing indolocarbazole compound and dosage forms containing the same |
| EP2229936B1 (en) * | 2009-03-09 | 2015-05-06 | PharmaSol GmbH | Nanonized testosterone formulations for improved bioavailability |
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| CN102781425B (zh) * | 2009-12-22 | 2014-08-13 | 利奥制药有限公司 | 含有维生素d类似物以及溶剂和表面活性剂混合物的皮肤用组合物 |
| JO3337B1 (ar) | 2010-12-13 | 2019-03-13 | Debiopharm Sa | تركيبات صيدلية تشمل أليسبوريفير |
| US9387446B2 (en) * | 2011-09-22 | 2016-07-12 | Ariel-University Research And Development Company Ltd. | Emulsions and methods of making emulsions |
| RU2742650C2 (ru) * | 2015-12-09 | 2021-02-09 | Фосфейдженикс Лимитед | Фармацевтический состав |
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| EP4058465A1 (en) | 2019-11-14 | 2022-09-21 | Cohbar Inc. | Cxcr4 antagonist peptides |
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| JPH10501527A (ja) * | 1994-06-01 | 1998-02-10 | チバ−ガイギー アクチェンゲゼルシャフト | 多重薬剤耐性細胞を抗腫瘍剤に対して感受性にするためのインドロカルバゾール誘導体 |
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| GB2308545B (en) | 1994-10-26 | 1999-06-02 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
| EP0711557A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Pharmazeutische Formulierungsgrundlage |
| EP0733372A3 (de) * | 1995-03-21 | 1998-05-20 | Ciba-Geigy Ag | Pharmazeutische Formulierungsgrundlage für Nanosuspensionen |
| AU4491697A (en) | 1996-09-27 | 1998-04-17 | Trega Biosciences, Inc. | Compositions of therapeutic agents suitable for oral administration |
| DE19641672A1 (de) | 1996-10-10 | 1998-04-16 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen auf der Basis von ethylenoxidfreien und propylenoxidfreien Emulgatoren zur Herstellung von Mikroemulsionsgelen |
| US5827522A (en) | 1996-10-30 | 1998-10-27 | Troy Corporation | Microemulsion and method |
| NZ314060A (en) | 1997-01-13 | 1997-08-22 | Bernard Charles Sherman | Pharmaceutical microemulsion preconcentrate comprising cyclosporin dissolved in a solvent system comprising hydrophobic solvent(s) and surfactant(s) |
| GB2355195B (en) * | 1997-01-30 | 2001-09-12 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin A |
| CA2294032A1 (en) | 1997-07-29 | 1999-02-11 | Pharmacia & Upjohn Company | Self-emulsifying formulation for lipophilic compounds |
| DE69823663T2 (de) | 1997-07-29 | 2005-05-19 | Pharmacia & Upjohn Co., Kalamazoo | Selbstemulgierbare formulierung enthaltend lipophile verbindungen |
| US6346511B1 (en) * | 1997-09-08 | 2002-02-12 | Panacea Biotec Limited | Pharmaceutical composition comprising cyclosporin |
| US6979456B1 (en) * | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| GB9814527D0 (en) * | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
| AR013276A1 (es) | 1998-07-31 | 2000-12-13 | Panacea Biotec Ltd | Composicion de ciclosporina transparente |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
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1999
- 1999-02-16 GB GBGB9903547.9A patent/GB9903547D0/en not_active Ceased
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2000
- 2000-02-14 BR BRPI0008228A patent/BRPI0008228B8/pt not_active IP Right Cessation
- 2000-02-14 WO PCT/EP2000/001196 patent/WO2000048571A1/en active Application Filing
- 2000-02-14 EP EP00909165A patent/EP1152750B1/en not_active Expired - Lifetime
- 2000-02-14 AT AT00909165T patent/ATE430554T1/de active
- 2000-02-14 PE PE2000000113A patent/PE20001499A1/es not_active Application Discontinuation
- 2000-02-14 ES ES00909165T patent/ES2326783T3/es not_active Expired - Lifetime
- 2000-02-14 CA CA2362277A patent/CA2362277C/en not_active Expired - Lifetime
- 2000-02-14 TR TR2001/02385T patent/TR200102385T2/xx unknown
- 2000-02-14 DE DE60042151T patent/DE60042151D1/de not_active Expired - Lifetime
- 2000-02-14 ID IDW00200101649A patent/ID30504A/id unknown
- 2000-02-14 IL IL14451200A patent/IL144512A0/xx active IP Right Grant
- 2000-02-14 AU AU31542/00A patent/AU765776B2/en active Active
- 2000-02-14 PT PT00909165T patent/PT1152750E/pt unknown
- 2000-02-14 SK SK1172-2001A patent/SK286967B6/sk not_active IP Right Cessation
- 2000-02-14 SI SI200031035T patent/SI1152750T1/sl unknown
- 2000-02-14 KR KR1020017009391A patent/KR100880859B1/ko active Protection Beyond IP Right Term
- 2000-02-14 AR ARP000100627A patent/AR022589A1/es not_active Application Discontinuation
- 2000-02-14 CZ CZ20012931A patent/CZ303979B6/cs not_active IP Right Cessation
- 2000-02-14 JP JP2000599363A patent/JP5057610B2/ja not_active Expired - Fee Related
- 2000-02-14 DK DK00909165T patent/DK1152750T3/da active
- 2000-02-14 PL PL350556A patent/PL198330B1/pl unknown
- 2000-02-14 KR KR1020087015449A patent/KR20080064914A/ko not_active Application Discontinuation
- 2000-02-14 NZ NZ513529A patent/NZ513529A/en not_active IP Right Cessation
- 2000-02-14 RU RU2001124597/15A patent/RU2266121C2/ru active
- 2000-02-14 CN CNB008038244A patent/CN100367930C/zh not_active Expired - Lifetime
- 2000-02-14 HU HU0105364A patent/HUP0105364A3/hu unknown
- 2000-02-15 MY MYPI20000530A patent/MY128362A/en unknown
- 2000-03-13 TW TW089104503A patent/TWI240636B/zh not_active IP Right Cessation
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2001
- 2001-02-14 ZA ZA200106677A patent/ZA200106677B/en unknown
- 2001-07-23 IL IL144512A patent/IL144512A/en not_active IP Right Cessation
- 2001-08-15 NO NO20013964A patent/NO331232B1/no not_active IP Right Cessation
- 2001-08-15 US US09/930,335 patent/US20020061873A1/en not_active Abandoned
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2002
- 2002-09-13 HK HK02106758.7A patent/HK1045807B/zh not_active IP Right Cessation
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2007
- 2007-09-21 US US11/859,077 patent/US8575147B2/en not_active Expired - Fee Related
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2008
- 2008-07-04 EC EC2008003351A patent/ECSP083351A/es unknown
- 2008-07-07 IL IL192666A patent/IL192666A0/en unknown
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2009
- 2009-07-31 CL CL2009001682A patent/CL2009001682A1/es unknown
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2011
- 2011-08-05 AR ARP110102851A patent/AR082579A2/es not_active Application Discontinuation
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2012
- 2012-01-05 JP JP2012000816A patent/JP2012111763A/ja active Pending
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2013
- 2013-10-15 US US14/053,661 patent/US8722664B2/en not_active Expired - Fee Related
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