ZA200104321B - 2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-hydroxamic acid as matrix metalloproteinase inhibitors. - Google Patents
2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-hydroxamic acid as matrix metalloproteinase inhibitors. Download PDFInfo
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- ZA200104321B ZA200104321B ZA200104321A ZA200104321A ZA200104321B ZA 200104321 B ZA200104321 B ZA 200104321B ZA 200104321 A ZA200104321 A ZA 200104321A ZA 200104321 A ZA200104321 A ZA 200104321A ZA 200104321 B ZA200104321 B ZA 200104321B
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- alkyl
- hydrogen
- alkylco
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- tetrahydro
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- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 title description 4
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 title description 4
- YWCKAVNWINYYFA-UHFFFAOYSA-N n-hydroxy-2,3,4,5-tetrahydro-1h-1,4-benzodiazepine-3-carboxamide Chemical compound C1NC(C(=O)NO)CNC2=CC=CC=C21 YWCKAVNWINYYFA-UHFFFAOYSA-N 0.000 title description 2
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 37
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- UQPUONNXJVWHRM-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 UQPUONNXJVWHRM-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Hospice & Palliative Care (AREA)
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Applications Claiming Priority (1)
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| US23908099A | 1999-01-27 | 1999-01-27 |
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| CA2357110A1 (en) * | 2001-04-11 | 2002-10-11 | American Cyanamid Company | Method for the treatment of polycystic kidney disease |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| AU2002324716A1 (en) | 2001-08-17 | 2003-03-03 | Bristol-Myers Squibb Company Patent Department | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace) |
| WO2003037852A1 (en) | 2001-11-01 | 2003-05-08 | Wyeth Holdings Corporation | Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| PE20030701A1 (es) | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| US7488754B2 (en) | 2002-04-05 | 2009-02-10 | Wyeth | Method for the treatment of polycystic kidney disease |
| CA2494014A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Monocyclic derivatives as matrix metalloproteinase inhibitors |
| US7199155B2 (en) | 2002-12-23 | 2007-04-03 | Wyeth Holdings Corporation | Acetylenic aryl sulfonate hydroxamic acid TACE and matrix metalloproteinase inhibitors |
| ATE520935T1 (de) | 2003-05-21 | 2011-09-15 | Alexza Pharmaceuticals Inc | Verwendung einer schicht aus festem brennstoff, verfahren zum erstellen einer solchen schicht und zugehörige heizvorrichtung |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| DE602005023874D1 (de) | 2004-07-21 | 2010-11-11 | Merck Serono Sa | Octahydropyrroloä2, 3, cüpyridinderivative und pharmazeutische verwendung damit |
| WO2006022714A1 (en) | 2004-08-12 | 2006-03-02 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| EP1865001A1 (en) * | 2006-06-08 | 2007-12-12 | Gsf-Forschungszentrum Für Umwelt Und Gesundheit, Gmbh | Specific protease inhibitors and their use in cancer therapy |
| WO2007141029A1 (en) * | 2006-06-08 | 2007-12-13 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Specific protease inhibitors and their use in cancer therapy |
| WO2008112661A2 (en) | 2007-03-09 | 2008-09-18 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| FR2950057B1 (fr) | 2009-09-17 | 2011-08-26 | Galderma Res & Dev | Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique |
| FR2950056B1 (fr) | 2009-09-17 | 2011-08-26 | Galderma Res & Dev | Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique |
| ES2592154T3 (es) | 2010-07-08 | 2016-11-28 | Kaken Pharmaceutical Co., Ltd. | Derivado de N-hidroxiformamida y medicamento que contiene el mismo |
| RU2578607C2 (ru) | 2010-09-17 | 2016-03-27 | Дзе Юниверсити Оф Токио | Композиция для поддержания функции тромбоцитов |
| EP3746138A4 (en) | 2018-02-02 | 2021-11-03 | Alexza Pharmaceuticals, Inc. | ELECTRIC CONDENSING AEROSOL DEVICE |
| JP2022512584A (ja) | 2018-10-04 | 2022-02-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 角皮症を処置するためのｅｇｆｒインヒビター |
| WO2021055817A1 (en) * | 2019-09-19 | 2021-03-25 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Stabilized c-fms intracellular fragments (ficd) promote osteoclast differentiation and arthritic bone erosion |
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| US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| DE69519751T2 (de) * | 1995-04-20 | 2001-04-19 | Pfizer Inc., New York | Arylsulfonamido-substituierte hydroxamsäure derivate als inhibitoren von mmp und tnf |
| CN1131215C (zh) * | 1995-11-13 | 2003-12-17 | 赫彻斯特股份公司 | 环和杂环N－取代的α－亚氨基异羟肟酸和羧酸 |
| US5753653A (en) * | 1995-12-08 | 1998-05-19 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| AU725831C (en) * | 1995-12-08 | 2002-10-17 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation |
| CN1228773A (zh) * | 1996-08-28 | 1999-09-15 | 普罗克特和甘保尔公司 | 杂环金属蛋白酶抑制剂 |
| EP0927168B1 (en) * | 1996-08-28 | 2002-11-06 | The Procter & Gamble Company | 1,3-diheterocyclic metalloprotease inhibitors |
| DK0923561T3 (da) * | 1996-08-28 | 2003-02-24 | Procter & Gamble | Heterocykliske metalloproteaseinhibitorer |
| JP2002501056A (ja) * | 1998-01-27 | 2002-01-15 | アメリカン・サイアナミド・カンパニー | マトリクス金属プロテイナーゼ阻害薬としての２，３，４，５−テトラヒドロ−１ｈ−［１，４］−ベンゾジアゼピン−３−ヒドロキサム酸 |
-
2000
- 2000-01-26 AR ARP000100323A patent/AR022423A1/es not_active Application Discontinuation
- 2000-01-27 IL IL14416800A patent/IL144168A0/xx unknown
- 2000-01-27 ES ES00909990T patent/ES2223470T3/es not_active Expired - Lifetime
- 2000-01-27 CA CA002356267A patent/CA2356267A1/en not_active Abandoned
- 2000-01-27 JP JP2000595986A patent/JP2002535392A/ja active Pending
- 2000-01-27 HU HU0105302A patent/HUP0105302A3/hu unknown
- 2000-01-27 SK SK1042-2001A patent/SK10422001A3/sk unknown
- 2000-01-27 EP EP00909990A patent/EP1147095B1/en not_active Expired - Lifetime
- 2000-01-27 WO PCT/US2000/001991 patent/WO2000044730A1/en active IP Right Grant
- 2000-01-27 ID IDW00200101465A patent/ID29046A/id unknown
- 2000-01-27 AU AU32160/00A patent/AU767039B2/en not_active Ceased
- 2000-01-27 CN CNB008031355A patent/CN1197849C/zh not_active Expired - Fee Related
- 2000-01-27 NZ NZ511885A patent/NZ511885A/xx unknown
- 2000-01-27 CZ CZ20012637A patent/CZ20012637A3/cs unknown
- 2000-01-27 EA EA200100809A patent/EA200100809A1/ru unknown
- 2000-01-27 TR TR2001/02131T patent/TR200102131T2/xx unknown
- 2000-01-27 AT AT00909990T patent/ATE273288T1/de not_active IP Right Cessation
- 2000-01-27 KR KR1020017009430A patent/KR20010101730A/ko not_active Withdrawn
- 2000-01-27 PL PL00349025A patent/PL349025A1/xx not_active Application Discontinuation
- 2000-01-27 BR BR0007759-3A patent/BR0007759A/pt not_active IP Right Cessation
- 2000-01-27 PT PT00909990T patent/PT1147095E/pt unknown
- 2000-01-27 DE DE60012883T patent/DE60012883T2/de not_active Expired - Fee Related
-
2001
- 2001-05-25 ZA ZA200104321A patent/ZA200104321B/en unknown
- 2001-07-26 NO NO20013675A patent/NO20013675L/no not_active Application Discontinuation
- 2001-07-26 BG BG105736A patent/BG105736A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ID29046A (id) | 2001-07-26 |
| CZ20012637A3 (cs) | 2002-04-17 |
| AU767039B2 (en) | 2003-10-30 |
| JP2002535392A (ja) | 2002-10-22 |
| AU3216000A (en) | 2000-08-18 |
| TR200102131T2 (tr) | 2001-12-21 |
| NO20013675D0 (no) | 2001-07-26 |
| NZ511885A (en) | 2003-06-30 |
| PL349025A1 (en) | 2002-07-01 |
| AR022423A1 (es) | 2002-09-04 |
| BR0007759A (pt) | 2001-11-13 |
| HUP0105302A3 (en) | 2002-09-30 |
| DE60012883D1 (de) | 2004-09-16 |
| DE60012883T2 (de) | 2005-08-25 |
| NO20013675L (no) | 2001-09-21 |
| ES2223470T3 (es) | 2005-03-01 |
| BG105736A (en) | 2002-05-31 |
| CN1337952A (zh) | 2002-02-27 |
| CN1197849C (zh) | 2005-04-20 |
| EP1147095B1 (en) | 2004-08-11 |
| PT1147095E (pt) | 2004-12-31 |
| SK10422001A3 (sk) | 2002-09-10 |
| ATE273288T1 (de) | 2004-08-15 |
| CA2356267A1 (en) | 2000-08-03 |
| HUP0105302A2 (hu) | 2002-07-29 |
| WO2000044730A1 (en) | 2000-08-03 |
| EP1147095A1 (en) | 2001-10-24 |
| EA200100809A1 (ru) | 2002-02-28 |
| IL144168A0 (en) | 2002-05-23 |
| KR20010101730A (ko) | 2001-11-14 |
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