ZA200104210B - Methods and compositions for restoring conformational stability of a protein of the p53 family. - Google Patents
Methods and compositions for restoring conformational stability of a protein of the p53 family. Download PDFInfo
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- ZA200104210B ZA200104210B ZA200104210A ZA200104210A ZA200104210B ZA 200104210 B ZA200104210 B ZA 200104210B ZA 200104210 A ZA200104210 A ZA 200104210A ZA 200104210 A ZA200104210 A ZA 200104210A ZA 200104210 B ZA200104210 B ZA 200104210B
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- ZA
- South Africa
- Prior art keywords
- alkyl
- protein
- phenyl
- hydroxy
- cycloalkyl
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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Landscapes
- Health & Medical Sciences (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Country Status (25)
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| EP (1) | EP1137418A2 (fr) |
| JP (2) | JP2002531396A (fr) |
| KR (1) | KR20010086073A (fr) |
| CN (1) | CN1329493A (fr) |
| AP (1) | AP2001002153A0 (fr) |
| AU (1) | AU1290700A (fr) |
| BG (1) | BG105599A (fr) |
| BR (1) | BR9915940A (fr) |
| CA (1) | CA2350597A1 (fr) |
| EA (1) | EA003326B1 (fr) |
| EE (1) | EE200100302A (fr) |
| HK (1) | HK1041644A1 (fr) |
| HR (1) | HRP20010414A2 (fr) |
| HU (1) | HUP0201215A2 (fr) |
| ID (1) | ID29061A (fr) |
| IL (1) | IL143094A0 (fr) |
| IS (1) | IS5943A (fr) |
| NO (1) | NO20012737L (fr) |
| OA (1) | OA11722A (fr) |
| PL (1) | PL348310A1 (fr) |
| TR (1) | TR200101549T2 (fr) |
| WO (1) | WO2000032175A2 (fr) |
| YU (1) | YU35401A (fr) |
| ZA (1) | ZA200104210B (fr) |
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| US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
| WO2003000853A2 (fr) * | 2001-06-20 | 2003-01-03 | Caprion Pharmaceuticals Inc. | Essais pour agregation de proteines, et utilisations |
| CA2454768A1 (fr) * | 2001-08-10 | 2003-02-20 | Medical Research Council | Molecule |
| US20050221324A1 (en) * | 2002-05-06 | 2005-10-06 | Fox Michael H | Genotoxicity analysis |
| AU2003258662A1 (en) * | 2002-10-02 | 2004-04-23 | Merck Patent Gmbh | Use of 4-amino-quinazolines as anti cancer agents |
| DE60307049T2 (de) * | 2003-04-25 | 2007-02-08 | Neuro3D | Verwendung von Piperazin- Phenothiazin- Derivaten zur Herstellung eines Arzneimittels mit neuroprotektiven und/oder neurotropischen Wirkungen auf das ZNS und/oder PNS |
| US6970791B1 (en) * | 2003-05-23 | 2005-11-29 | Verachem, Llc | Tailored user interfaces for molecular modeling |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| CN1984660B (zh) * | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
| US20070099950A1 (en) * | 2003-11-21 | 2007-05-03 | Jongwon Lim | Pyridin-4-ylamine compounds useful in the treatment of neuropathic pain |
| US20080039409A1 (en) * | 2003-12-24 | 2008-02-14 | Locomogene, Inc. | Method of Suppressing Cancer |
| JPWO2005061007A1 (ja) * | 2003-12-24 | 2007-07-12 | 学校法人 聖マリアンナ医科大学 | 癌の抑制方法 |
| AU2005251735A1 (en) * | 2004-06-04 | 2005-12-22 | Amphora Discovery Corporation | Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| EP1833482A4 (fr) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | Composés bicycliques azotés et utilisation thérapeutique associée |
| US20070021433A1 (en) * | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| US7790474B1 (en) | 2005-07-15 | 2010-09-07 | Schering Corporation | p53 modulators |
| MX2008000744A (es) * | 2005-07-15 | 2008-03-10 | Schering Corp | Derivados de quinazolina utiles en el tratamiento del cancer. |
| JP5162574B2 (ja) | 2006-03-22 | 2013-03-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｍｄｍ２及びｐ５３間の相互作用のインヒビターとしての環式アルキルアミン誘導体 |
| CA2644643C (fr) | 2006-03-22 | 2015-05-19 | Janssen Pharmaceutica N.V. | Inhibiteurs de l'interaction entre mdm2 et p53 |
| NZ546477A (en) * | 2006-04-07 | 2009-04-30 | Auckland Uniservices Ltd | 4-Alkylamino-2-(heterocyclic)quinazolines and their use in cancer therapy |
| WO2008008358A2 (fr) | 2006-07-10 | 2008-01-17 | Columbia University | Compositions anti-cocaïne et traitement |
| WO2008155441A1 (fr) * | 2007-06-20 | 2008-12-24 | Marikki Laiho | Activateurs et leurs applications thérapeutiques |
| DK2170373T3 (da) * | 2007-07-10 | 2014-10-13 | Univ Columbia | Termostabilisering af proteiner |
| WO2009019274A1 (fr) | 2007-08-06 | 2009-02-12 | Janssen Pharmaceutica Nv | Phénylènediamines substituées utilisables en tant qu'inhibiteurs de l'interaction entre mdm2 et p53 |
| ES2639752T3 (es) | 2009-02-04 | 2017-10-30 | Janssen Pharmaceutica N.V. | Inhibidores de la interacción entre MDM2 y p53 |
| WO2011127406A2 (fr) * | 2010-04-09 | 2011-10-13 | The Brigham And Women's Hospital, Inc. | Acridines en tant qu'inhibiteurs des kinases haspine et dyrk |
| US9221760B2 (en) | 2011-05-09 | 2015-12-29 | Van Andel Research Institute | Autophagy inhibitors |
| EP2758403B1 (fr) | 2011-09-21 | 2016-04-27 | Inception Orion, Inc. | Composés tricycliques utiles comme agents neurogènes et neuroprotecteurs |
| CN102660257B (zh) * | 2012-05-22 | 2013-11-27 | 南京邮电大学 | 吩噻嗪基喹唑啉类荧光离子探针及其应用 |
| SI3201234T1 (sl) | 2014-09-30 | 2019-03-29 | Diadem S.R.L. | Protitelo, ki veže linearni epitop humanega P53 in njegove diagnostične aplikacije |
| CN105399670B (zh) * | 2015-12-02 | 2018-04-17 | 广西中医药大学 | 一种苯并(c)吖啶酰胺基硫脲衍生物及其制备方法和用途 |
| CN105418501B (zh) * | 2015-12-02 | 2018-04-17 | 广西中医药大学 | 7‑对甲氧苯氨基苯并[c]吖啶盐酸盐及其制备方法和用途 |
| CN105399671B (zh) * | 2015-12-02 | 2018-04-17 | 广西中医药大学 | 7‑对甲苯氨基苯并[c]吖啶盐酸盐及其制备方法和用途 |
| US11230578B2 (en) | 2016-02-04 | 2022-01-25 | Yeda Research And Development Co. Ltd. | Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant P53 |
| CA3215564A1 (fr) * | 2016-02-19 | 2017-08-24 | Pmv Pharmaceuticals, Inc. | Methodes et composes pour la restauration de la fonction du p53 mutant |
| CN109694358B (zh) * | 2019-01-23 | 2022-02-08 | 广西师范大学 | 2-对硝苯乙烯基-4-取代氨基喹唑啉衍生物及其制备方法和应用 |
| WO2021061643A1 (fr) * | 2019-09-23 | 2021-04-01 | Pmv Pharmaceuticals, Inc. | Méthodes et composés pour la restauration de la fonction du p53 mutant |
| US20210405056A1 (en) * | 2020-06-24 | 2021-12-30 | Pmv Pharmaceuticals, Inc. | Methods for detecting mutant p53 function |
| US11938124B2 (en) | 2020-06-24 | 2024-03-26 | Pmv Pharmaceuticals, Inc. | Combination therapy for treatment of cancer |
| GB202111035D0 (en) * | 2021-07-30 | 2021-09-15 | Vestlandets Innovasjonsselskap As | Therapy |
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| ATE354638T1 (de) * | 1994-12-13 | 2007-03-15 | Human Genome Sciences Inc | Menschlicher gewebsinhibitor von metalloproteinase-4 |
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| EP0959877A4 (fr) * | 1996-04-10 | 2000-08-23 | Univ California | Correction des defaillances genetiques a l'aide de chaperons chimiques |
| US6270954B1 (en) * | 1996-04-10 | 2001-08-07 | The Regents Of The University Of California | Correction of genetic defects using chemical chaperones |
| DE19624154A1 (de) * | 1996-06-18 | 1998-01-08 | Hoechst Ag | Ringannelierte Dihydropyrane, Verfahren zur Herstellung sowie deren Verwendung |
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| US6406699B1 (en) * | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
| AU7847800A (en) * | 1999-10-15 | 2001-04-30 | Mayo Foundation For Medical Education And Research | Topical anesthetics useful for treating cancer, autoimmune diseases and ischemia |
| US6372785B1 (en) * | 2000-05-04 | 2002-04-16 | Keith Chan, President Globoasia, Llc | Synthesis of 1,8-dichloro-anthracene analogues and pharmaceutical compositions based thereon |
| US6384049B1 (en) * | 2000-05-25 | 2002-05-07 | The Procter & Gamble Company | Cancer treatment |
| US6395771B1 (en) * | 2000-05-31 | 2002-05-28 | Dabur Research Foundation | Paclitaxel derivatives for the treatment of cancer |
| US6391916B1 (en) * | 2000-07-21 | 2002-05-21 | The Hong Kong University Of Science And Technology | Enediyne derivatives |
-
1999
- 1999-12-01 CN CN99814010A patent/CN1329493A/zh active Pending
- 1999-12-01 WO PCT/IB1999/001916 patent/WO2000032175A2/fr not_active Application Discontinuation
- 1999-12-01 AU AU12907/00A patent/AU1290700A/en not_active Abandoned
- 1999-12-01 ID IDW00200101178A patent/ID29061A/id unknown
- 1999-12-01 AP APAP/P/2001/002153A patent/AP2001002153A0/en unknown
- 1999-12-01 PL PL99348310A patent/PL348310A1/xx unknown
- 1999-12-01 EE EEP200100302A patent/EE200100302A/xx unknown
- 1999-12-01 TR TR2001/01549T patent/TR200101549T2/xx unknown
- 1999-12-01 IL IL14309499A patent/IL143094A0/xx unknown
- 1999-12-01 EA EA200100502A patent/EA003326B1/ru not_active IP Right Cessation
- 1999-12-01 BR BR9915940-6A patent/BR9915940A/pt not_active IP Right Cessation
- 1999-12-01 OA OA1200100136A patent/OA11722A/en unknown
- 1999-12-01 CA CA002350597A patent/CA2350597A1/fr not_active Abandoned
- 1999-12-01 YU YU35401A patent/YU35401A/sh unknown
- 1999-12-01 HU HU0201215A patent/HUP0201215A2/hu unknown
- 1999-12-01 KR KR1020017006830A patent/KR20010086073A/ko not_active Application Discontinuation
- 1999-12-01 JP JP2000584871A patent/JP2002531396A/ja active Pending
- 1999-12-01 EP EP99956270A patent/EP1137418A2/fr not_active Withdrawn
-
2001
- 2001-05-15 IS IS5943A patent/IS5943A/is unknown
- 2001-05-23 US US09/863,976 patent/US20020048271A1/en not_active Abandoned
- 2001-05-23 ZA ZA200104210A patent/ZA200104210B/en unknown
- 2001-05-29 HR HR20010414A patent/HRP20010414A2/hr not_active Application Discontinuation
- 2001-06-01 NO NO20012737A patent/NO20012737L/no not_active Application Discontinuation
- 2001-06-14 BG BG105599A patent/BG105599A/xx unknown
-
2002
- 2002-05-04 HK HK02103378.4A patent/HK1041644A1/zh unknown
-
2006
- 2006-01-06 JP JP2006001475A patent/JP2006166920A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ID29061A (id) | 2001-07-26 |
| JP2002531396A (ja) | 2002-09-24 |
| HUP0201215A2 (en) | 2002-08-28 |
| EE200100302A (et) | 2002-08-15 |
| AU1290700A (en) | 2000-06-19 |
| KR20010086073A (ko) | 2001-09-07 |
| TR200101549T2 (tr) | 2001-11-21 |
| HRP20010414A2 (en) | 2002-06-30 |
| PL348310A1 (en) | 2002-05-20 |
| EP1137418A2 (fr) | 2001-10-04 |
| HK1041644A1 (zh) | 2002-07-19 |
| WO2000032175A2 (fr) | 2000-06-08 |
| NO20012737D0 (no) | 2001-06-01 |
| YU35401A (sh) | 2005-07-19 |
| AP2001002153A0 (en) | 2001-06-30 |
| WO2000032175A3 (fr) | 2000-08-03 |
| IS5943A (is) | 2001-05-15 |
| BR9915940A (pt) | 2001-09-11 |
| NO20012737L (no) | 2001-07-09 |
| OA11722A (en) | 2005-01-25 |
| CN1329493A (zh) | 2002-01-02 |
| CA2350597A1 (fr) | 2000-06-08 |
| EA200100502A1 (ru) | 2001-12-24 |
| IL143094A0 (en) | 2002-04-21 |
| US20020048271A1 (en) | 2002-04-25 |
| EA003326B1 (ru) | 2003-04-24 |
| BG105599A (en) | 2002-02-28 |
| JP2006166920A (ja) | 2006-06-29 |
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