HRP20010414A2 - METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY - Google Patents
METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY Download PDFInfo
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- HRP20010414A2 HRP20010414A2 HR20010414A HRP20010414A HRP20010414A2 HR P20010414 A2 HRP20010414 A2 HR P20010414A2 HR 20010414 A HR20010414 A HR 20010414A HR P20010414 A HRP20010414 A HR P20010414A HR P20010414 A2 HRP20010414 A2 HR P20010414A2
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- alkyl
- protein
- phenyl
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- hydroxy
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
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- A—HUMAN NECESSITIES
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Landscapes
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- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US11054298P | 1998-12-02 | 1998-12-02 | |
PCT/IB1999/001916 WO2000032175A2 (fr) | 1998-12-02 | 1999-12-01 | PROCEDES ET COMPOSITIONS POUR RETABLIR LA STABILITE DE CONFORMATION D'UNE PROTEINE DE LA FAMILLE p53 |
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HRP20010414A2 true HRP20010414A2 (en) | 2002-06-30 |
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HR20010414A HRP20010414A2 (en) | 1998-12-02 | 2001-05-29 | METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY |
Country Status (25)
Country | Link |
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US (1) | US20020048271A1 (fr) |
EP (1) | EP1137418A2 (fr) |
JP (2) | JP2002531396A (fr) |
KR (1) | KR20010086073A (fr) |
CN (1) | CN1329493A (fr) |
AP (1) | AP2001002153A0 (fr) |
AU (1) | AU1290700A (fr) |
BG (1) | BG105599A (fr) |
BR (1) | BR9915940A (fr) |
CA (1) | CA2350597A1 (fr) |
EA (1) | EA003326B1 (fr) |
EE (1) | EE200100302A (fr) |
HK (1) | HK1041644A1 (fr) |
HR (1) | HRP20010414A2 (fr) |
HU (1) | HUP0201215A2 (fr) |
ID (1) | ID29061A (fr) |
IL (1) | IL143094A0 (fr) |
IS (1) | IS5943A (fr) |
NO (1) | NO20012737L (fr) |
OA (1) | OA11722A (fr) |
PL (1) | PL348310A1 (fr) |
TR (1) | TR200101549T2 (fr) |
WO (1) | WO2000032175A2 (fr) |
YU (1) | YU35401A (fr) |
ZA (1) | ZA200104210B (fr) |
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EP1414846A2 (fr) * | 2001-08-10 | 2004-05-06 | Medical Research Council | Molecule |
AU2003298512A1 (en) * | 2002-05-06 | 2004-05-04 | Colorado State University Research Foundation | Genotoxicity analysis |
WO2004030671A2 (fr) * | 2002-10-02 | 2004-04-15 | Merck Patent Gmbh | Utilisation de 4-amino-quinazolines comme agents anticancereux |
DE60307049T2 (de) * | 2003-04-25 | 2007-02-08 | Neuro3D | Verwendung von Piperazin- Phenothiazin- Derivaten zur Herstellung eines Arzneimittels mit neuroprotektiven und/oder neurotropischen Wirkungen auf das ZNS und/oder PNS |
US6970791B1 (en) * | 2003-05-23 | 2005-11-29 | Verachem, Llc | Tailored user interfaces for molecular modeling |
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EP1687275A4 (fr) * | 2003-11-21 | 2009-01-14 | Merck & Co Inc | Composes de pyridin-4-ylamine convenant pour le traitement de la douleur neuropathique |
JPWO2005061007A1 (ja) * | 2003-12-24 | 2007-07-12 | 学校法人 聖マリアンナ医科大学 | 癌の抑制方法 |
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CA2592900A1 (fr) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Composes et utilisation therapeutique associee |
US20070021433A1 (en) * | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
MX2008000744A (es) * | 2005-07-15 | 2008-03-10 | Schering Corp | Derivados de quinazolina utiles en el tratamiento del cancer. |
US7790474B1 (en) | 2005-07-15 | 2010-09-07 | Schering Corporation | p53 modulators |
US8232298B2 (en) | 2006-03-22 | 2012-07-31 | Janssen Pharmaceutica N.V. | Inhibitors of the interaction between MDM2 and P53 |
CA2644649C (fr) | 2006-03-22 | 2014-06-17 | Janssen Pharmaceutica N.V. | Derives d'alkylamine cyclique en tant qu'inhibiteurs de l'interaction entre mdm2 et p53 |
NZ546477A (en) * | 2006-04-07 | 2009-04-30 | Auckland Uniservices Ltd | 4-Alkylamino-2-(heterocyclic)quinazolines and their use in cancer therapy |
MY162844A (en) | 2006-07-10 | 2017-07-31 | The Trustee Of Columbia Univ In The City Of New York | Anti-cocaine compositions and treatment |
WO2008155441A1 (fr) * | 2007-06-20 | 2008-12-24 | Marikki Laiho | Activateurs et leurs applications thérapeutiques |
ES2510551T3 (es) | 2007-07-10 | 2014-10-21 | The Trustees Of Columbia University In The City Of New York | Termoestabilización de proteínas |
ES2534899T3 (es) | 2007-08-06 | 2015-04-30 | Janssen Pharmaceutica, N.V. | Fenilendiaminas sustituidas como inhibidores de la interacción entre MDM2 y p53 |
AU2010210178B2 (en) | 2009-02-04 | 2014-06-05 | Janssen Pharmaceutica Nv | Indole derivatives as anticancer agents |
US20130102627A1 (en) * | 2010-04-09 | 2013-04-25 | The Brigham And Women's Hospital, Inc. | Acridines As Inhibitors Of Haspin And DYRK Kinases |
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LT3201234T (lt) * | 2014-09-30 | 2019-03-12 | Diadem S.R.L. | Antikūnas, surišantis linijinį žmogaus p53 epitopą, ir jo panaudojimas diagnostikai |
CN105399670B (zh) * | 2015-12-02 | 2018-04-17 | 广西中医药大学 | 一种苯并(c)吖啶酰胺基硫脲衍生物及其制备方法和用途 |
CN105418501B (zh) * | 2015-12-02 | 2018-04-17 | 广西中医药大学 | 7‑对甲氧苯氨基苯并[c]吖啶盐酸盐及其制备方法和用途 |
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CN109694358B (zh) * | 2019-01-23 | 2022-02-08 | 广西师范大学 | 2-对硝苯乙烯基-4-取代氨基喹唑啉衍生物及其制备方法和应用 |
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US5981564A (en) * | 1998-07-01 | 1999-11-09 | Universite Laval | Water-soluble derivatives of paclitaxel, method for producing same and uses thereof |
AU5197599A (en) * | 1998-08-12 | 2000-03-06 | Daiichi Pure Chemicals Co., Ltd. | Fluorescent labelling reagents |
SE9900941D0 (sv) * | 1998-12-23 | 1999-03-16 | Nomet Management Serv Bv | Novel retinoic acid derivatives and their use |
US6207700B1 (en) * | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
FR2788696B1 (fr) * | 1999-01-26 | 2004-03-05 | Synthelabo | Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central |
WO2000066125A1 (fr) * | 1999-04-29 | 2000-11-09 | Aventis Pharma S.A. | Procede de traitement du cancer a l'aide de derives de la camptothecine et de 5-fluorouracil |
US6406699B1 (en) * | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
WO2001028550A1 (fr) * | 1999-10-15 | 2001-04-26 | Mayo Foundation For Medical Education And Research | Anesthesiques topiques employes dans le traitement du cancer, les affections auto-immunes et l'ischemie |
US6372785B1 (en) * | 2000-05-04 | 2002-04-16 | Keith Chan, President Globoasia, Llc | Synthesis of 1,8-dichloro-anthracene analogues and pharmaceutical compositions based thereon |
US6384049B1 (en) * | 2000-05-25 | 2002-05-07 | The Procter & Gamble Company | Cancer treatment |
US6395771B1 (en) * | 2000-05-31 | 2002-05-28 | Dabur Research Foundation | Paclitaxel derivatives for the treatment of cancer |
US6391916B1 (en) * | 2000-07-21 | 2002-05-21 | The Hong Kong University Of Science And Technology | Enediyne derivatives |
-
1999
- 1999-12-01 CA CA002350597A patent/CA2350597A1/fr not_active Abandoned
- 1999-12-01 AP APAP/P/2001/002153A patent/AP2001002153A0/en unknown
- 1999-12-01 EE EEP200100302A patent/EE200100302A/xx unknown
- 1999-12-01 JP JP2000584871A patent/JP2002531396A/ja active Pending
- 1999-12-01 CN CN99814010A patent/CN1329493A/zh active Pending
- 1999-12-01 PL PL99348310A patent/PL348310A1/xx unknown
- 1999-12-01 HU HU0201215A patent/HUP0201215A2/hu unknown
- 1999-12-01 TR TR2001/01549T patent/TR200101549T2/xx unknown
- 1999-12-01 IL IL14309499A patent/IL143094A0/xx unknown
- 1999-12-01 AU AU12907/00A patent/AU1290700A/en not_active Abandoned
- 1999-12-01 WO PCT/IB1999/001916 patent/WO2000032175A2/fr not_active Application Discontinuation
- 1999-12-01 YU YU35401A patent/YU35401A/sh unknown
- 1999-12-01 ID IDW00200101178A patent/ID29061A/id unknown
- 1999-12-01 OA OA1200100136A patent/OA11722A/en unknown
- 1999-12-01 BR BR9915940-6A patent/BR9915940A/pt not_active IP Right Cessation
- 1999-12-01 KR KR1020017006830A patent/KR20010086073A/ko not_active Application Discontinuation
- 1999-12-01 EA EA200100502A patent/EA003326B1/ru not_active IP Right Cessation
- 1999-12-01 EP EP99956270A patent/EP1137418A2/fr not_active Withdrawn
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2001
- 2001-05-15 IS IS5943A patent/IS5943A/is unknown
- 2001-05-23 ZA ZA200104210A patent/ZA200104210B/en unknown
- 2001-05-23 US US09/863,976 patent/US20020048271A1/en not_active Abandoned
- 2001-05-29 HR HR20010414A patent/HRP20010414A2/hr not_active Application Discontinuation
- 2001-06-01 NO NO20012737A patent/NO20012737L/no not_active Application Discontinuation
- 2001-06-14 BG BG105599A patent/BG105599A/xx unknown
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2002
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Also Published As
Publication number | Publication date |
---|---|
TR200101549T2 (tr) | 2001-11-21 |
CA2350597A1 (fr) | 2000-06-08 |
AU1290700A (en) | 2000-06-19 |
HK1041644A1 (zh) | 2002-07-19 |
NO20012737L (no) | 2001-07-09 |
AP2001002153A0 (en) | 2001-06-30 |
KR20010086073A (ko) | 2001-09-07 |
ZA200104210B (en) | 2003-02-24 |
US20020048271A1 (en) | 2002-04-25 |
NO20012737D0 (no) | 2001-06-01 |
HUP0201215A2 (en) | 2002-08-28 |
CN1329493A (zh) | 2002-01-02 |
JP2002531396A (ja) | 2002-09-24 |
ID29061A (id) | 2001-07-26 |
YU35401A (sh) | 2005-07-19 |
BR9915940A (pt) | 2001-09-11 |
PL348310A1 (en) | 2002-05-20 |
OA11722A (en) | 2005-01-25 |
EP1137418A2 (fr) | 2001-10-04 |
IL143094A0 (en) | 2002-04-21 |
EA003326B1 (ru) | 2003-04-24 |
WO2000032175A2 (fr) | 2000-06-08 |
EE200100302A (et) | 2002-08-15 |
JP2006166920A (ja) | 2006-06-29 |
BG105599A (en) | 2002-02-28 |
WO2000032175A3 (fr) | 2000-08-03 |
IS5943A (is) | 2001-05-15 |
EA200100502A1 (ru) | 2001-12-24 |
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