YU35401A - POSTUPCI I PREPARATI ZA USPOSTAVLJANJE UJEDNAČENE STABILNOSTI PROTEINA IZ p53 FAMILIJE - Google Patents

POSTUPCI I PREPARATI ZA USPOSTAVLJANJE UJEDNAČENE STABILNOSTI PROTEINA IZ p53 FAMILIJE

Info

Publication number
YU35401A
YU35401A YU35401A YU35401A YU35401A YU 35401 A YU35401 A YU 35401A YU 35401 A YU35401 A YU 35401A YU 35401 A YU35401 A YU 35401A YU 35401 A YU35401 A YU 35401A
Authority
YU
Yugoslavia
Prior art keywords
protein
family
methods
compositions
restoring
Prior art date
Application number
YU35401A
Other languages
English (en)
Inventor
Anne Coffey Heather
Damian Connell Richard
Ann Foster Barbara
Rastinejad Farzan
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of YU35401A publication Critical patent/YU35401A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Pronalazak je iz oblasti tretmana raka. Naročito, ovaj pronalazak obezbedjuje farmaceutska jedinjenje sposobna da medjusobno deluju sa mutant i ne-mutant oblicima proteina koji se odnose na rak tako da mutant protein pojačava kapacitet za ispravno medjusobno delovanje sa drugim makromolekulima, čime se uspostavljaju ili stabilišu svi ili deo njihovih aktivnosti neobradjenog tipa. Regulacioni proteini uključuju članove iz p53 protein familije takve kao, na primer p53, p63 i p73. Jedinjenja iz pronalaska su korisna za tretman raka. Postupci za ekranizovanje takvih farmakoloških jedinjenja su takodje obezbedjeni.[The invention provides pharmaceutical non-peptidic organic compounds capable of interacting with a functionally defective form of a mutant or a wild-type tumor suppressor protein of the p53 family (such as p53, p63 or p73). The interaction allows stabilization or folding of the protein in a functional conformation, thereby restoring all or part of its wild-type normal activity. More particularly said compounds interact with the DNA binding domain of p53 family proteins, are acridine, quinoline, quinazoline or phenothiazine derivatives, and are used in cancer therapy. Also provided are methods for screening such pharmacological compounds.
YU35401A 1998-12-02 1999-12-01 POSTUPCI I PREPARATI ZA USPOSTAVLJANJE UJEDNAČENE STABILNOSTI PROTEINA IZ p53 FAMILIJE YU35401A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11054298P 1998-12-02 1998-12-02

Publications (1)

Publication Number Publication Date
YU35401A true YU35401A (sh) 2005-07-19

Family

ID=22333594

Family Applications (1)

Application Number Title Priority Date Filing Date
YU35401A YU35401A (sh) 1998-12-02 1999-12-01 POSTUPCI I PREPARATI ZA USPOSTAVLJANJE UJEDNAČENE STABILNOSTI PROTEINA IZ p53 FAMILIJE

Country Status (25)

Country Link
US (1) US20020048271A1 (sh)
EP (1) EP1137418A2 (sh)
JP (2) JP2002531396A (sh)
KR (1) KR20010086073A (sh)
CN (1) CN1329493A (sh)
AP (1) AP2001002153A0 (sh)
AU (1) AU1290700A (sh)
BG (1) BG105599A (sh)
BR (1) BR9915940A (sh)
CA (1) CA2350597A1 (sh)
EA (1) EA003326B1 (sh)
EE (1) EE200100302A (sh)
HK (1) HK1041644A1 (sh)
HR (1) HRP20010414A2 (sh)
HU (1) HUP0201215A2 (sh)
ID (1) ID29061A (sh)
IL (1) IL143094A0 (sh)
IS (1) IS5943A (sh)
NO (1) NO20012737L (sh)
OA (1) OA11722A (sh)
PL (1) PL348310A1 (sh)
TR (1) TR200101549T2 (sh)
WO (1) WO2000032175A2 (sh)
YU (1) YU35401A (sh)
ZA (1) ZA200104210B (sh)

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CA2644643C (en) 2006-03-22 2015-05-19 Janssen Pharmaceutica N.V. Inhibitors of the interaction between mdm2 and p53
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PL3201234T3 (pl) 2014-09-30 2019-04-30 Diadem S R L Przeciwciało wiążące liniowy epitop ludzkiego p53 i zastosowania diagnostyczne tego przeciwciała
CN105418501B (zh) * 2015-12-02 2018-04-17 广西中医药大学 7‑对甲氧苯氨基苯并[c]吖啶盐酸盐及其制备方法和用途
CN105399671B (zh) * 2015-12-02 2018-04-17 广西中医药大学 7‑对甲苯氨基苯并[c]吖啶盐酸盐及其制备方法和用途
CN105399670B (zh) * 2015-12-02 2018-04-17 广西中医药大学 一种苯并(c)吖啶酰胺基硫脲衍生物及其制备方法和用途
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CN109694358B (zh) * 2019-01-23 2022-02-08 广西师范大学 2-对硝苯乙烯基-4-取代氨基喹唑啉衍生物及其制备方法和应用
KR20220070255A (ko) * 2019-09-23 2022-05-30 피엠브이 파마슈티컬스 인코포레이티드 돌연변이체 p53 기능을 회복시키기 위한 방법 및 화합물
CN116096704A (zh) 2020-06-24 2023-05-09 皮姆维制药公司 用于治疗癌症的组合疗法
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Also Published As

Publication number Publication date
WO2000032175A2 (en) 2000-06-08
HRP20010414A2 (en) 2002-06-30
EP1137418A2 (en) 2001-10-04
EE200100302A (et) 2002-08-15
ID29061A (id) 2001-07-26
US20020048271A1 (en) 2002-04-25
AP2001002153A0 (en) 2001-06-30
WO2000032175A3 (en) 2000-08-03
EA003326B1 (ru) 2003-04-24
BR9915940A (pt) 2001-09-11
HUP0201215A2 (en) 2002-08-28
NO20012737D0 (no) 2001-06-01
IS5943A (is) 2001-05-15
IL143094A0 (en) 2002-04-21
JP2006166920A (ja) 2006-06-29
BG105599A (en) 2002-02-28
CA2350597A1 (en) 2000-06-08
NO20012737L (no) 2001-07-09
PL348310A1 (en) 2002-05-20
CN1329493A (zh) 2002-01-02
ZA200104210B (en) 2003-02-24
AU1290700A (en) 2000-06-19
JP2002531396A (ja) 2002-09-24
HK1041644A1 (zh) 2002-07-19
KR20010086073A (ko) 2001-09-07
OA11722A (en) 2005-01-25
EA200100502A1 (ru) 2001-12-24
TR200101549T2 (tr) 2001-11-21

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