ZA200104128B - Non-peptide antagonists of GLP-1 receptor and methods of use. - Google Patents
Non-peptide antagonists of GLP-1 receptor and methods of use. Download PDFInfo
- Publication number
- ZA200104128B ZA200104128B ZA200104128A ZA200104128A ZA200104128B ZA 200104128 B ZA200104128 B ZA 200104128B ZA 200104128 A ZA200104128 A ZA 200104128A ZA 200104128 A ZA200104128 A ZA 200104128A ZA 200104128 B ZA200104128 B ZA 200104128B
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- ZA
- South Africa
- Prior art keywords
- pharmaceutically acceptable
- group
- compound
- prodrug
- glp
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- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 title claims description 17
- 238000000034 method Methods 0.000 title claims description 13
- 239000005557 antagonist Substances 0.000 title description 16
- 229910052799 carbon Inorganic materials 0.000 claims description 36
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- 125000000217 alkyl group Chemical group 0.000 claims description 25
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 17
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- 229940002612 prodrug Drugs 0.000 claims description 16
- 239000000651 prodrug Substances 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 239000012453 solvate Substances 0.000 claims description 16
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11173698P | 1998-12-10 | 1998-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200104128B true ZA200104128B (en) | 2002-05-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200104128A ZA200104128B (en) | 1998-12-10 | 2001-05-21 | Non-peptide antagonists of GLP-1 receptor and methods of use. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6469021B1 (ja) |
| EP (1) | EP1137413B1 (ja) |
| JP (1) | JP2002531501A (ja) |
| KR (1) | KR20010089563A (ja) |
| AT (1) | ATE288268T1 (ja) |
| AU (1) | AU758968B2 (ja) |
| BR (1) | BR9916965A (ja) |
| CA (1) | CA2350887A1 (ja) |
| DE (1) | DE69923587T2 (ja) |
| ES (1) | ES2233089T3 (ja) |
| NZ (1) | NZ511698A (ja) |
| PT (1) | PT1137413E (ja) |
| WO (1) | WO2000033839A1 (ja) |
| ZA (1) | ZA200104128B (ja) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003532691A (ja) | 2000-05-05 | 2003-11-05 | ノボ ノルディスク アクティーゼルスカブ | 重症疾患神経障害 |
| AU2002221222A1 (en) * | 2000-12-04 | 2002-06-18 | Biovitrum Ab | Novel method and use |
| WO2003066084A1 (en) * | 2002-02-07 | 2003-08-14 | Novo Nordisk A/S | Use of glp-1 compound for treatment of critically ill patients |
| US20030199445A1 (en) | 2002-02-07 | 2003-10-23 | Knudsen Lotte Bjerre | Use of GLP-1 compound for treatment of critically ill patients |
| CA2474460C (en) * | 2002-02-13 | 2009-12-22 | F. Hoffmann-La Roche Ag | Pyridine- and quinoline-derivatives |
| CN100503607C (zh) | 2003-06-02 | 2009-06-24 | 新疆华世丹药物研究有限责任公司 | 去氢骆驼蓬碱衍生物类化合物及其应用 |
| DK3456340T3 (da) | 2007-01-08 | 2022-03-21 | Univ Pennsylvania | Glp-1-receptorantagonist til brug ved behandling af medfødt hyperinsulisme |
| US20090221627A1 (en) * | 2007-09-20 | 2009-09-03 | Alexey Aksinenko | Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use |
| WO2009067233A1 (en) * | 2007-11-20 | 2009-05-28 | Millennium Pharmaceuticals, Inc. | Beta carbolines and uses thereof |
| US10639354B2 (en) | 2015-05-22 | 2020-05-05 | The Bot Of The Leland Stanford Junior University | Treatment of hyperinsulinemic hypoglycemia with exendin (9-39) |
| WO2017152014A1 (en) | 2016-03-04 | 2017-09-08 | Eiger Biopharmaceuticals, Inc. | Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives |
| US11020484B2 (en) | 2016-11-21 | 2021-06-01 | Eiger Biopharmaceuticals, Inc. | Buffered formulations of exendin (9-39) |
| CN111362937B (zh) * | 2020-03-06 | 2021-06-22 | 贵州医科大学 | N-芳基-β-卡波林类衍生物及其用途 |
| CN116134016A (zh) * | 2020-07-23 | 2023-05-16 | 默克专利股份公司 | 三环杂环 |
| CA3195925A1 (en) * | 2020-10-30 | 2022-05-05 | Robin Elaine DUNCAN | Modulation of glucagon-like peptide 1 and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE223915T1 (de) | 1995-05-05 | 2002-09-15 | British Tech Group Int | Neue heterozyklische chemie |
-
1999
- 1999-12-08 KR KR1020017007173A patent/KR20010089563A/ko not_active Application Discontinuation
- 1999-12-08 PT PT99960663T patent/PT1137413E/pt unknown
- 1999-12-08 US US09/831,572 patent/US6469021B1/en not_active Expired - Fee Related
- 1999-12-08 WO PCT/US1999/029065 patent/WO2000033839A1/en active IP Right Grant
- 1999-12-08 AT AT99960663T patent/ATE288268T1/de not_active IP Right Cessation
- 1999-12-08 CA CA002350887A patent/CA2350887A1/en not_active Abandoned
- 1999-12-08 DE DE69923587T patent/DE69923587T2/de not_active Expired - Fee Related
- 1999-12-08 NZ NZ511698A patent/NZ511698A/en unknown
- 1999-12-08 JP JP2000586331A patent/JP2002531501A/ja active Pending
- 1999-12-08 EP EP99960663A patent/EP1137413B1/en not_active Expired - Lifetime
- 1999-12-08 AU AU17518/00A patent/AU758968B2/en not_active Ceased
- 1999-12-08 BR BR9916965-7A patent/BR9916965A/pt not_active IP Right Cessation
- 1999-12-08 ES ES99960663T patent/ES2233089T3/es not_active Expired - Lifetime
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2001
- 2001-05-21 ZA ZA200104128A patent/ZA200104128B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010089563A (ko) | 2001-10-06 |
| US6469021B1 (en) | 2002-10-22 |
| AU758968B2 (en) | 2003-04-03 |
| DE69923587T2 (de) | 2005-06-23 |
| EP1137413A4 (en) | 2002-06-26 |
| EP1137413A2 (en) | 2001-10-04 |
| AU1751800A (en) | 2000-06-26 |
| ATE288268T1 (de) | 2005-02-15 |
| ES2233089T3 (es) | 2005-06-01 |
| EP1137413B1 (en) | 2005-02-02 |
| BR9916965A (pt) | 2001-11-06 |
| WO2000033839B1 (en) | 2000-09-28 |
| CA2350887A1 (en) | 2000-06-15 |
| DE69923587D1 (de) | 2005-03-10 |
| JP2002531501A (ja) | 2002-09-24 |
| WO2000033839A1 (en) | 2000-06-15 |
| PT1137413E (pt) | 2005-05-31 |
| NZ511698A (en) | 2003-09-26 |
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