ZA200101829B - Immunogenic liposome compositions. - Google Patents

Immunogenic liposome compositions. Download PDF

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Publication number
ZA200101829B
ZA200101829B ZA200101829A ZA200101829A ZA200101829B ZA 200101829 B ZA200101829 B ZA 200101829B ZA 200101829 A ZA200101829 A ZA 200101829A ZA 200101829 A ZA200101829 A ZA 200101829A ZA 200101829 B ZA200101829 B ZA 200101829B
Authority
ZA
South Africa
Prior art keywords
composition
immunogenic
antigenic
liposome composition
fusion protein
Prior art date
Application number
ZA200101829A
Other languages
English (en)
Inventor
Gary Fujii
Donald V Cramer
William A Ernst
Jill Adler-Moore
L Jeanne Perry
Original Assignee
Molecular Express Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Express Inc filed Critical Molecular Express Inc
Publication of ZA200101829B publication Critical patent/ZA200101829B/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
ZA200101829A 1998-09-22 2001-03-05 Immunogenic liposome compositions. ZA200101829B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10135198P 1998-09-22 1998-09-22
US40072399A 1999-09-21 1999-09-21

Publications (1)

Publication Number Publication Date
ZA200101829B true ZA200101829B (en) 2002-06-05

Family

ID=26798150

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200101829A ZA200101829B (en) 1998-09-22 2001-03-05 Immunogenic liposome compositions.

Country Status (31)

Country Link
EP (1) EP1115382B1 (ko)
JP (1) JP2002526436A (ko)
KR (1) KR100592825B1 (ko)
CN (1) CN1555254A (ko)
AP (1) AP2010A (ko)
AT (1) ATE468108T1 (ko)
AU (1) AU766772B2 (ko)
BG (1) BG65675B1 (ko)
BR (1) BR9914004A (ko)
CA (1) CA2344173C (ko)
CY (1) CY1110718T1 (ko)
CZ (1) CZ20011013A3 (ko)
DE (1) DE69942393D1 (ko)
DK (1) DK1115382T3 (ko)
EA (1) EA004797B1 (ko)
EE (1) EE200100168A (ko)
ES (1) ES2345695T3 (ko)
GE (1) GEP20053444B (ko)
HK (1) HK1039064A1 (ko)
HU (1) HUP0105391A3 (ko)
ID (1) ID29082A (ko)
IL (2) IL141675A0 (ko)
MX (1) MXPA01002973A (ko)
NO (1) NO330685B1 (ko)
NZ (2) NZ528055A (ko)
OA (1) OA11657A (ko)
PL (1) PL206260B1 (ko)
SK (1) SK287670B6 (ko)
UA (1) UA75327C2 (ko)
WO (1) WO2000016746A2 (ko)
ZA (1) ZA200101829B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200726479A (en) 2005-04-12 2007-07-16 Univ Duke Method of inducing neutralizing antibodies to human immunodeficiency virus
CA2764424C (en) 2009-06-04 2019-12-31 National Institute Of Advanced Industrial Science And Technology Vaccine for mycoplasma infection
EA034702B1 (ru) 2011-04-26 2020-03-10 Молекулар Экспресс, Инк. Липосомные композиции
US10076567B2 (en) 2013-09-27 2018-09-18 Duke University MPER-liposome conjugates and uses thereof
AU2018250226A1 (en) * 2017-04-04 2019-10-10 Barinthus Biotherapeutics North America, Inc. Peptide-based vaccines, methods of manufacturing, and uses thereof for inducing an immune response
KR20240033309A (ko) * 2022-09-05 2024-03-12 주식회사 차백신연구소 에멀전 제형의 면역증강제 조성물 및 이의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8405493D0 (sv) * 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
US5374548A (en) * 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
SE462375B (sv) * 1985-10-15 1990-06-18 Morgaardshammar Ab Centro Traadblock
DE3776966D1 (de) 1986-05-20 1992-04-09 Wako Pure Chem Ind Ltd Funktionelle gruppen tragende liposome und verfahren zu deren herstellung.
FR2754543B1 (fr) 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires

Also Published As

Publication number Publication date
EA200100269A1 (ru) 2001-12-24
UA75327C2 (en) 2006-04-17
EP1115382A2 (en) 2001-07-18
PL206260B1 (pl) 2010-07-30
SK287670B6 (sk) 2011-05-06
HUP0105391A3 (en) 2006-02-28
CA2344173A1 (en) 2000-03-30
MXPA01002973A (es) 2003-03-27
IL141675A (en) 2007-06-17
NO20011406L (no) 2001-04-24
CZ20011013A3 (cs) 2002-03-13
HK1039064A1 (en) 2002-04-12
KR20010075261A (ko) 2001-08-09
ID29082A (id) 2001-07-26
IL141675A0 (en) 2002-03-10
BG65675B1 (bg) 2009-06-30
NZ510442A (en) 2003-10-31
DE69942393D1 (de) 2010-07-01
WO2000016746A2 (en) 2000-03-30
ES2345695T3 (es) 2010-09-29
WO2000016746A8 (en) 2000-08-10
WO2000016746A3 (en) 2000-11-23
EA004797B1 (ru) 2004-08-26
WO2000016746A9 (en) 2000-09-21
BR9914004A (pt) 2001-07-24
ATE468108T1 (de) 2010-06-15
AU766772B2 (en) 2003-10-23
NO330685B1 (no) 2011-06-06
JP2002526436A (ja) 2002-08-20
SK3222001A3 (en) 2001-09-11
PL348604A1 (en) 2002-06-03
BG105372A (en) 2001-10-31
AU6035199A (en) 2000-04-10
DK1115382T3 (da) 2010-09-06
CA2344173C (en) 2010-02-23
AP2010A (en) 2009-06-29
CN1555254A (zh) 2004-12-15
CY1110718T1 (el) 2015-06-10
HUP0105391A2 (hu) 2002-05-29
NO20011406D0 (no) 2001-03-20
AP2001002096A0 (en) 2001-03-31
GEP20053444B (en) 2005-02-25
OA11657A (en) 2004-12-08
EP1115382B1 (en) 2010-05-19
EE200100168A (et) 2002-06-17
NZ528055A (en) 2005-01-28
KR100592825B1 (ko) 2006-06-23

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