EA200100269A1 - Иммуногенные липосомные композиции - Google Patents

Иммуногенные липосомные композиции

Info

Publication number
EA200100269A1
EA200100269A1 EA200100269A EA200100269A EA200100269A1 EA 200100269 A1 EA200100269 A1 EA 200100269A1 EA 200100269 A EA200100269 A EA 200100269A EA 200100269 A EA200100269 A EA 200100269A EA 200100269 A1 EA200100269 A1 EA 200100269A1
Authority
EA
Eurasian Patent Office
Prior art keywords
immunogenic
liposomic
compositions
liposomic compositions
antigenic
Prior art date
Application number
EA200100269A
Other languages
English (en)
Other versions
EA004797B1 (ru
Inventor
Гэрри Фудзии
Доналд В. Креймер
Уильям А. Эрнст
Джилл Адлер-Мур
Л. Джинн Перри
Original Assignee
Молекьюлар Экспресс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Молекьюлар Экспресс, Инк. filed Critical Молекьюлар Экспресс, Инк.
Publication of EA200100269A1 publication Critical patent/EA200100269A1/ru
Publication of EA004797B1 publication Critical patent/EA004797B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

Данное изобретение относится к иммуногенной липосомной композиции, включающей пузырекобразующие липиды и антигенную конструкцию, включающую одну или несколько антигенных детерминант и гидрофобную область.Отчет о международном поиске был опубликован 2000.11.23.
EA200100269A 1998-09-22 1999-09-22 Иммуногенные липосомные композиции EA004797B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10135198P 1998-09-22 1998-09-22
US40072399A 1999-09-21 1999-09-21
PCT/US1999/020880 WO2000016746A2 (en) 1998-09-22 1999-09-22 Immunogenic liposome compositions

Publications (2)

Publication Number Publication Date
EA200100269A1 true EA200100269A1 (ru) 2001-12-24
EA004797B1 EA004797B1 (ru) 2004-08-26

Family

ID=26798150

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100269A EA004797B1 (ru) 1998-09-22 1999-09-22 Иммуногенные липосомные композиции

Country Status (31)

Country Link
EP (1) EP1115382B1 (ru)
JP (1) JP2002526436A (ru)
KR (1) KR100592825B1 (ru)
CN (1) CN1555254A (ru)
AP (1) AP2010A (ru)
AT (1) ATE468108T1 (ru)
AU (1) AU766772B2 (ru)
BG (1) BG65675B1 (ru)
BR (1) BR9914004A (ru)
CA (1) CA2344173C (ru)
CY (1) CY1110718T1 (ru)
CZ (1) CZ20011013A3 (ru)
DE (1) DE69942393D1 (ru)
DK (1) DK1115382T3 (ru)
EA (1) EA004797B1 (ru)
EE (1) EE200100168A (ru)
ES (1) ES2345695T3 (ru)
GE (1) GEP20053444B (ru)
HK (1) HK1039064A1 (ru)
HU (1) HUP0105391A3 (ru)
ID (1) ID29082A (ru)
IL (2) IL141675A0 (ru)
MX (1) MXPA01002973A (ru)
NO (1) NO330685B1 (ru)
NZ (2) NZ510442A (ru)
OA (1) OA11657A (ru)
PL (1) PL206260B1 (ru)
SK (1) SK287670B6 (ru)
UA (1) UA75327C2 (ru)
WO (1) WO2000016746A2 (ru)
ZA (1) ZA200101829B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1868651A4 (en) * 2005-04-12 2010-10-06 Univ Duke METHOD FOR INDUCING ANTIBODIES THAT NEUTRALIZE THE HUMAN IMMUNODEFICIENCY VIRUS
CN102448488B (zh) 2009-06-04 2014-10-15 独立行政法人产业技术综合研究所 支原体感染症用疫苗
US20140287022A1 (en) * 2011-04-26 2014-09-25 Molecular Express, Inc. Liposomal formulations
US10076567B2 (en) 2013-09-27 2018-09-18 Duke University MPER-liposome conjugates and uses thereof
IL302880A (en) * 2017-04-04 2023-07-01 Avidea Tech Inc Peptide-based ingredients, production methods, and their uses for inducing an immune response
KR20240033309A (ko) * 2022-09-05 2024-03-12 주식회사 차백신연구소 에멀전 제형의 면역증강제 조성물 및 이의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8405493D0 (sv) * 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
US5374548A (en) * 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
SE462375B (sv) * 1985-10-15 1990-06-18 Morgaardshammar Ab Centro Traadblock
ES2032776T3 (es) * 1986-05-20 1993-03-01 Wako Pure Chemical Industries, Ltd. Nuevos liposomas funcionalizados y un procedimiento para su produccion.
FR2754543B1 (fr) * 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires

Also Published As

Publication number Publication date
BG65675B1 (bg) 2009-06-30
EA004797B1 (ru) 2004-08-26
JP2002526436A (ja) 2002-08-20
CY1110718T1 (el) 2015-06-10
EE200100168A (et) 2002-06-17
SK3222001A3 (en) 2001-09-11
WO2000016746A8 (en) 2000-08-10
ZA200101829B (en) 2002-06-05
BG105372A (en) 2001-10-31
ID29082A (id) 2001-07-26
NZ528055A (en) 2005-01-28
UA75327C2 (en) 2006-04-17
AU766772B2 (en) 2003-10-23
KR20010075261A (ko) 2001-08-09
EP1115382A2 (en) 2001-07-18
HK1039064A1 (en) 2002-04-12
IL141675A0 (en) 2002-03-10
HUP0105391A2 (hu) 2002-05-29
BR9914004A (pt) 2001-07-24
NO20011406D0 (no) 2001-03-20
OA11657A (en) 2004-12-08
NO20011406L (no) 2001-04-24
EP1115382B1 (en) 2010-05-19
SK287670B6 (sk) 2011-05-06
DE69942393D1 (de) 2010-07-01
WO2000016746A3 (en) 2000-11-23
WO2000016746A2 (en) 2000-03-30
ES2345695T3 (es) 2010-09-29
GEP20053444B (en) 2005-02-25
MXPA01002973A (es) 2003-03-27
PL206260B1 (pl) 2010-07-30
NZ510442A (en) 2003-10-31
AP2001002096A0 (en) 2001-03-31
HUP0105391A3 (en) 2006-02-28
WO2000016746A9 (en) 2000-09-21
IL141675A (en) 2007-06-17
KR100592825B1 (ko) 2006-06-23
ATE468108T1 (de) 2010-06-15
NO330685B1 (no) 2011-06-06
CA2344173C (en) 2010-02-23
AP2010A (en) 2009-06-29
CN1555254A (zh) 2004-12-15
PL348604A1 (en) 2002-06-03
DK1115382T3 (da) 2010-09-06
CZ20011013A3 (cs) 2002-03-13
AU6035199A (en) 2000-04-10
CA2344173A1 (en) 2000-03-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU