HUP0105391A2 - Immunogén lipószómakészítmények - Google Patents

Immunogén lipószómakészítmények

Info

Publication number
HUP0105391A2
HUP0105391A2 HU0105391A HUP0105391A HUP0105391A2 HU P0105391 A2 HUP0105391 A2 HU P0105391A2 HU 0105391 A HU0105391 A HU 0105391A HU P0105391 A HUP0105391 A HU P0105391A HU P0105391 A2 HUP0105391 A2 HU P0105391A2
Authority
HU
Hungary
Prior art keywords
preparation
liposome compositions
immunogenic liposome
immunogenic
antigenic
Prior art date
Application number
HU0105391A
Other languages
English (en)
Inventor
Jill Adler-Moore
Donald V. Cramer
William A. Ernst
Gary Fujii
L. Jeanne Perry
Original Assignee
Molecular Express, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Express, Inc. filed Critical Molecular Express, Inc.
Publication of HUP0105391A2 publication Critical patent/HUP0105391A2/hu
Publication of HUP0105391A3 publication Critical patent/HUP0105391A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány tárgya egy immunogén liposzómakészítmény, melyvezikulumképző lipideket valamint egy vagy több antigéndeterminánst ésegy hidrofób domént tartalmazó antigénszerkezetet tartalmaz. Akészítmény egy vagy több adjuvánst is tartalmazhat. A találmánytovábbá a fenti készítmény előállítási eljárásaira, valamint aliposzómakészítményt tartalmazó vakcinákra is vonatkozik. Ó
HU0105391A 1998-09-22 1999-09-22 Immunogenic liposome compositions HUP0105391A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10135198P 1998-09-22 1998-09-22
US40072399A 1999-09-21 1999-09-21

Publications (2)

Publication Number Publication Date
HUP0105391A2 true HUP0105391A2 (hu) 2002-05-29
HUP0105391A3 HUP0105391A3 (en) 2006-02-28

Family

ID=26798150

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105391A HUP0105391A3 (en) 1998-09-22 1999-09-22 Immunogenic liposome compositions

Country Status (31)

Country Link
EP (1) EP1115382B1 (hu)
JP (1) JP2002526436A (hu)
KR (1) KR100592825B1 (hu)
CN (1) CN1555254A (hu)
AP (1) AP2010A (hu)
AT (1) ATE468108T1 (hu)
AU (1) AU766772B2 (hu)
BG (1) BG65675B1 (hu)
BR (1) BR9914004A (hu)
CA (1) CA2344173C (hu)
CY (1) CY1110718T1 (hu)
CZ (1) CZ20011013A3 (hu)
DE (1) DE69942393D1 (hu)
DK (1) DK1115382T3 (hu)
EA (1) EA004797B1 (hu)
EE (1) EE200100168A (hu)
ES (1) ES2345695T3 (hu)
GE (1) GEP20053444B (hu)
HK (1) HK1039064A1 (hu)
HU (1) HUP0105391A3 (hu)
ID (1) ID29082A (hu)
IL (2) IL141675A0 (hu)
MX (1) MXPA01002973A (hu)
NO (1) NO330685B1 (hu)
NZ (2) NZ528055A (hu)
OA (1) OA11657A (hu)
PL (1) PL206260B1 (hu)
SK (1) SK287670B6 (hu)
UA (1) UA75327C2 (hu)
WO (1) WO2000016746A2 (hu)
ZA (1) ZA200101829B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200726479A (en) 2005-04-12 2007-07-16 Univ Duke Method of inducing neutralizing antibodies to human immunodeficiency virus
CA2764424C (en) 2009-06-04 2019-12-31 National Institute Of Advanced Industrial Science And Technology Vaccine for mycoplasma infection
EA034702B1 (ru) 2011-04-26 2020-03-10 Молекулар Экспресс, Инк. Липосомные композиции
US10076567B2 (en) 2013-09-27 2018-09-18 Duke University MPER-liposome conjugates and uses thereof
AU2018250226A1 (en) * 2017-04-04 2019-10-10 Barinthus Biotherapeutics North America, Inc. Peptide-based vaccines, methods of manufacturing, and uses thereof for inducing an immune response
KR20240033309A (ko) * 2022-09-05 2024-03-12 주식회사 차백신연구소 에멀전 제형의 면역증강제 조성물 및 이의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8405493D0 (sv) * 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
US5374548A (en) * 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
SE462375B (sv) * 1985-10-15 1990-06-18 Morgaardshammar Ab Centro Traadblock
DE3776966D1 (de) 1986-05-20 1992-04-09 Wako Pure Chem Ind Ltd Funktionelle gruppen tragende liposome und verfahren zu deren herstellung.
FR2754543B1 (fr) 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires

Also Published As

Publication number Publication date
EA200100269A1 (ru) 2001-12-24
UA75327C2 (en) 2006-04-17
EP1115382A2 (en) 2001-07-18
PL206260B1 (pl) 2010-07-30
SK287670B6 (sk) 2011-05-06
HUP0105391A3 (en) 2006-02-28
CA2344173A1 (en) 2000-03-30
MXPA01002973A (es) 2003-03-27
IL141675A (en) 2007-06-17
NO20011406L (no) 2001-04-24
CZ20011013A3 (cs) 2002-03-13
HK1039064A1 (en) 2002-04-12
KR20010075261A (ko) 2001-08-09
ID29082A (id) 2001-07-26
IL141675A0 (en) 2002-03-10
BG65675B1 (bg) 2009-06-30
NZ510442A (en) 2003-10-31
DE69942393D1 (de) 2010-07-01
WO2000016746A2 (en) 2000-03-30
ZA200101829B (en) 2002-06-05
ES2345695T3 (es) 2010-09-29
WO2000016746A8 (en) 2000-08-10
WO2000016746A3 (en) 2000-11-23
EA004797B1 (ru) 2004-08-26
WO2000016746A9 (en) 2000-09-21
BR9914004A (pt) 2001-07-24
ATE468108T1 (de) 2010-06-15
AU766772B2 (en) 2003-10-23
NO330685B1 (no) 2011-06-06
JP2002526436A (ja) 2002-08-20
SK3222001A3 (en) 2001-09-11
PL348604A1 (en) 2002-06-03
BG105372A (en) 2001-10-31
AU6035199A (en) 2000-04-10
DK1115382T3 (da) 2010-09-06
CA2344173C (en) 2010-02-23
AP2010A (en) 2009-06-29
CN1555254A (zh) 2004-12-15
CY1110718T1 (el) 2015-06-10
NO20011406D0 (no) 2001-03-20
AP2001002096A0 (en) 2001-03-31
GEP20053444B (en) 2005-02-25
OA11657A (en) 2004-12-08
EP1115382B1 (en) 2010-05-19
EE200100168A (et) 2002-06-17
NZ528055A (en) 2005-01-28
KR100592825B1 (ko) 2006-06-23

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished