ATE227134T1 - Chitosan-impfstoff-zusammensetzungen zur intranasalen verabreichung und anwendungen - Google Patents
Chitosan-impfstoff-zusammensetzungen zur intranasalen verabreichung und anwendungenInfo
- Publication number
- ATE227134T1 ATE227134T1 AT96941743T AT96941743T ATE227134T1 AT E227134 T1 ATE227134 T1 AT E227134T1 AT 96941743 T AT96941743 T AT 96941743T AT 96941743 T AT96941743 T AT 96941743T AT E227134 T1 ATE227134 T1 AT E227134T1
- Authority
- AT
- Austria
- Prior art keywords
- chitosan
- intranasal administration
- vaccine compositions
- compositions
- antigens
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 229920001661 Chitosan Polymers 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9525083.3A GB9525083D0 (en) | 1995-12-07 | 1995-12-07 | Vaccine compositions |
| PCT/GB1996/003019 WO1997020576A1 (en) | 1995-12-07 | 1996-12-09 | Vaccine compositions for intranasal administration comprising chitosan and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE227134T1 true ATE227134T1 (de) | 2002-11-15 |
Family
ID=10785093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96941743T ATE227134T1 (de) | 1995-12-07 | 1996-12-09 | Chitosan-impfstoff-zusammensetzungen zur intranasalen verabreichung und anwendungen |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6391318B1 (de) |
| EP (1) | EP0865297B1 (de) |
| JP (1) | JP4063876B2 (de) |
| AT (1) | ATE227134T1 (de) |
| CA (1) | CA2237529C (de) |
| DE (1) | DE69624726T2 (de) |
| DK (1) | DK0865297T3 (de) |
| ES (1) | ES2186809T3 (de) |
| GB (2) | GB9525083D0 (de) |
| NO (1) | NO323084B1 (de) |
| NZ (1) | NZ323973A (de) |
| PT (1) | PT865297E (de) |
| WO (1) | WO1997020576A1 (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9419979D0 (en) * | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
| US5993852A (en) * | 1997-08-29 | 1999-11-30 | Pharmaderm Laboratories Ltd. | Biphasic lipid vesicle composition for transdermal administration of an immunogen |
| GB9725084D0 (en) * | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
| US7022683B1 (en) | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
| ATE403436T1 (de) * | 1999-03-24 | 2008-08-15 | Secr Defence | Polykationische karbohydrate als immunostimulierende mittel in impstoffen |
| GB9914412D0 (en) * | 1999-06-22 | 1999-08-18 | Worrall Eric E | Method for the preservation of viruses,bacteria and biomolecules |
| US20030206958A1 (en) * | 2000-12-22 | 2003-11-06 | Cattaneo Maurizio V. | Chitosan biopolymer for the topical delivery of active agents |
| AU2001276831A1 (en) | 2000-06-22 | 2002-01-02 | Rxkinetix, Inc. | Delivery vehicle composition and methods for delivering antigens and other drugs |
| WO2002034287A2 (en) * | 2000-10-27 | 2002-05-02 | Pharmexa A/S | Therapeutic vaccine formulations containing chitosan |
| US6777000B2 (en) * | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
| US7494669B2 (en) * | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
| ES2295391T3 (es) | 2001-08-16 | 2008-04-16 | Cmp Therapeutics Limited | Microparticulas de quitina y sus usos medicos. |
| CN100333792C (zh) | 2001-09-28 | 2007-08-29 | 南佛罗里达大学 | Rsv基因表达疫苗 |
| WO2003043574A2 (en) * | 2001-11-19 | 2003-05-30 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
| DE60328481D1 (de) * | 2002-05-14 | 2009-09-03 | Novartis Vaccines & Diagnostic | Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält |
| MXPA04011248A (es) * | 2002-05-14 | 2005-02-17 | Chiron Srl | Vacunas mucosales en combinacion para la meningitis bacteriana. |
| GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
| WO2004003145A2 (en) * | 2002-06-28 | 2004-01-08 | Nastech Pharmaceutical Company Inc. | Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds |
| JP2006516609A (ja) * | 2003-01-30 | 2006-07-06 | カイロン ソチエタ ア レスポンサビリタ リミタータ | 粘膜髄膜炎菌性ワクチン |
| JP4675317B2 (ja) * | 2003-01-30 | 2011-04-20 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | アジュバント化インフルエンザワクチン |
| WO2004074314A2 (en) | 2003-02-14 | 2004-09-02 | University Of South Florida | Chistosan-microparticles for ifn gene delivery |
| US8796235B2 (en) * | 2003-02-21 | 2014-08-05 | University Of South Florida | Methods for attenuating dengue virus infection |
| CA2523870A1 (en) * | 2003-04-30 | 2004-11-18 | Nastech Pharmaceutical Company Inc. | Claudins' underexpression as markers of tumor metastasis |
| JP2006525354A (ja) * | 2003-05-01 | 2006-11-09 | アルキメデス・ディヴェロップメント・リミテッド | Lh−rhアナログロイプロイドの経鼻投与 |
| ES2425221T3 (es) * | 2003-05-30 | 2013-10-14 | Amylin Pharmaceuticals, Llc | Nuevos métodos y composiciones para suministro por vía transmucosa potenciado de péptidos y proteínas |
| GB0315632D0 (en) * | 2003-07-04 | 2003-08-13 | West Pharm Serv Drug Res Ltd | Pharmaceutical formulations |
| US20070238676A1 (en) * | 2003-12-04 | 2007-10-11 | Mohapatra Shyam S | Polynucleotides for Reducing Respiratory Syncytial Virus Gene Expression |
| US7968122B2 (en) * | 2003-12-10 | 2011-06-28 | Adventrx Pharmaceuticals, Inc. | Anti-viral pharmaceutical compositions |
| US20050129679A1 (en) * | 2003-12-15 | 2005-06-16 | Nastech Pharmaceutical Company Inc. | Method for opening tight junctions |
| US7740883B2 (en) * | 2004-03-28 | 2010-06-22 | University Of Debrecen | Nanoparticles from chitosan |
| EP1742612A2 (de) * | 2004-05-06 | 2007-01-17 | Ivrea Pharmaceuticals, Inc. | Partikel zur wirkstofffreisetzung |
| US20090069226A1 (en) * | 2004-05-28 | 2009-03-12 | Amylin Pharmaceuticals, Inc. | Transmucosal delivery of peptides and proteins |
| US20050283004A1 (en) * | 2004-06-18 | 2005-12-22 | Hopax Chemicals Manufacturing Co., Ltd. | Alkylsulfonated polyaminosaccharides |
| JPWO2006030730A1 (ja) * | 2004-09-15 | 2008-05-15 | 大塚製薬株式会社 | 経粘膜用組成物、及び経粘膜吸収の向上方法 |
| WO2007086923A2 (en) * | 2005-05-23 | 2007-08-02 | University Of South Florida | Controlled and sustained gene transfer mediated by thiol-modified polymers |
| US20070031512A1 (en) * | 2005-08-03 | 2007-02-08 | Amcol International Corporation | Virus-interacting layered phyllosilicates and methods of inactivating viruses |
| US20080184618A1 (en) * | 2005-08-03 | 2008-08-07 | Amcol International | Virus-Interacting Layered Phyllosilicates and Methods of Use |
| US20100272769A1 (en) * | 2005-08-03 | 2010-10-28 | Amcol International | Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use |
| US8536324B2 (en) * | 2005-10-21 | 2013-09-17 | University Of South Florida | Method of drug delivery by carbon nanotube-chitosan nanocomplexes |
| CA2628313A1 (en) * | 2005-11-04 | 2007-05-31 | Bio Syntech Canada Inc. | Composition and method for efficient delivery of nucleic acids to cells using chitosan |
| PT1965787E (pt) | 2005-11-30 | 2013-07-05 | Endo Pharmaceuticals Inc | Tratamento de xerostomia com um antioxidante que contém enxofre |
| US8846102B2 (en) * | 2006-03-30 | 2014-09-30 | Engene, Inc. | Non-viral compositions and methods for transfecting gut cells in vivo |
| JP2009541281A (ja) | 2006-06-20 | 2009-11-26 | シーエムピー セラピューティクス リミテッド | キチンマイクロ粒子を含む組成物およびそれらの医学的使用 |
| HUE032422T2 (en) * | 2006-09-29 | 2017-09-28 | Takeda Vaccines Inc | Norovirus vaccine preparations |
| EP2112923A1 (de) | 2007-01-22 | 2009-11-04 | Targacept Inc. | Intranasale, orale und sublinguale verabreichung von metanikotin-analogen |
| US20080182819A1 (en) * | 2007-01-29 | 2008-07-31 | Act Iii Licensing, Llc | Chitosan compositions and methods for using chitosan compositions in the treatment of health disorders |
| EP2167069B1 (de) | 2007-05-23 | 2011-10-26 | Amcol International Corporation | Mit cholesterin interagierende phyllosilikate und verfahren zur reduktion von hypercholesterinämie bei einem säuger |
| US20100266636A1 (en) * | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| SG10201601660YA (en) * | 2007-09-18 | 2016-04-28 | Takeda Vaccines Inc | Method of conferring a protective immune response to norovirus |
| US8741313B2 (en) * | 2008-01-11 | 2014-06-03 | Emory University | Polypeptide vaccine and vaccination strategy against mycobacterium |
| AU2009219204B2 (en) | 2008-02-27 | 2013-01-17 | Amcol International Corporation | Methods of treating cardiovascular disorders associated with atherosclerosis |
| AU2009279456B2 (en) | 2008-08-08 | 2015-02-05 | Takeda Vaccines, Inc. | Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity |
| WO2010119112A1 (en) * | 2009-04-15 | 2010-10-21 | Ceva Sante Animale | Recombinant avian herpes virus vectors and vaccine for immunizing waterfowl species |
| EA029470B1 (ru) | 2011-07-11 | 2018-03-30 | Такеда Вэксинс, Инк. | Способ стимулирования формирования защитного иммунитета против норовируса |
| CA2871786C (en) | 2012-04-24 | 2021-11-16 | Ohio State Innovation Foundation | Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome |
| US10279028B2 (en) | 2012-04-24 | 2019-05-07 | Ohio State Innovation Foundation | Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome |
| CN108715607B (zh) * | 2018-04-12 | 2021-12-10 | 华南农业大学 | 重组霍乱毒素b亚基蛋白、pedv灭活疫苗及制备与应用 |
| CN109172817B (zh) * | 2018-08-16 | 2021-10-26 | 华中农业大学 | 猪流行性腹泻病毒减毒活疫苗壳聚糖微球的制备方法及其应用 |
| EP3698773A1 (de) | 2019-02-21 | 2020-08-26 | Università degli Studi di Parma | Zusammensetzung und herstellung von pulvern mit nanoadjuvanzien zur mukosalen impfung |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1261264A (en) * | 1984-11-29 | 1989-09-26 | Shigeo Suzuki | Immunopotentiating agents and method |
| US4950740A (en) * | 1987-03-17 | 1990-08-21 | Cetus Corporation | Recombinant diphtheria vaccines |
| US5554388A (en) * | 1989-02-25 | 1996-09-10 | Danbiosyst Uk Limited | Systemic drug delivery compositions comprising a polycationi substance |
| GB8904370D0 (en) * | 1989-02-25 | 1989-04-12 | Cosmas Damian Ltd | Liquid delivery compositions |
| GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
| AU688603B2 (en) | 1994-09-23 | 1998-03-12 | Zonagen, Inc. | Chitosan induced immunopotentiation |
| US5912000A (en) * | 1994-09-23 | 1999-06-15 | Zonagen, Inc. | Chitosan induced immunopotentiation |
| GB9419979D0 (en) * | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
| EP0857059A1 (de) * | 1995-06-26 | 1998-08-12 | Research Triangle Pharmaceuticals Ltd. | Neuartige adjuvanszusammensetzung und sie enthaltende impfstoffformulierung |
| GB9522351D0 (en) * | 1995-11-01 | 1996-01-03 | Medeva Holdings Bv | Vaccine compositions |
-
1995
- 1995-12-07 GB GBGB9525083.3A patent/GB9525083D0/en active Pending
-
1996
- 1996-12-09 NZ NZ323973A patent/NZ323973A/xx not_active IP Right Cessation
- 1996-12-09 DE DE69624726T patent/DE69624726T2/de not_active Expired - Lifetime
- 1996-12-09 ES ES96941743T patent/ES2186809T3/es not_active Expired - Lifetime
- 1996-12-09 DK DK96941743T patent/DK0865297T3/da active
- 1996-12-09 EP EP96941743A patent/EP0865297B1/de not_active Expired - Lifetime
- 1996-12-09 AT AT96941743T patent/ATE227134T1/de active
- 1996-12-09 PT PT96941743T patent/PT865297E/pt unknown
- 1996-12-09 CA CA002237529A patent/CA2237529C/en not_active Expired - Fee Related
- 1996-12-09 WO PCT/GB1996/003019 patent/WO1997020576A1/en not_active Ceased
- 1996-12-09 GB GB9811810A patent/GB2322801B/en not_active Expired - Fee Related
- 1996-12-09 JP JP52109497A patent/JP4063876B2/ja not_active Expired - Fee Related
-
1998
- 1998-06-01 US US09/088,185 patent/US6391318B1/en not_active Expired - Lifetime
- 1998-06-02 NO NO19982497A patent/NO323084B1/no not_active IP Right Cessation
-
2002
- 2002-05-08 US US10/141,312 patent/US7323183B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK0865297T3 (da) | 2003-03-03 |
| WO1997020576A1 (en) | 1997-06-12 |
| NO982497D0 (no) | 1998-06-02 |
| US6391318B1 (en) | 2002-05-21 |
| DE69624726D1 (de) | 2002-12-12 |
| GB2322801B (en) | 2000-01-19 |
| AU705452B2 (en) | 1999-05-20 |
| AU1102597A (en) | 1997-06-27 |
| ES2186809T3 (es) | 2003-05-16 |
| JP4063876B2 (ja) | 2008-03-19 |
| EP0865297A1 (de) | 1998-09-23 |
| NO323084B1 (no) | 2006-12-27 |
| US20030039665A1 (en) | 2003-02-27 |
| GB9811810D0 (en) | 1998-07-29 |
| DE69624726T2 (de) | 2003-09-18 |
| EP0865297B1 (de) | 2002-11-06 |
| GB9525083D0 (en) | 1996-02-07 |
| GB2322801A (en) | 1998-09-09 |
| JP2000501412A (ja) | 2000-02-08 |
| NO982497L (no) | 1998-06-02 |
| NZ323973A (en) | 2004-12-24 |
| PT865297E (pt) | 2003-03-31 |
| CA2237529C (en) | 2008-10-14 |
| CA2237529A1 (en) | 1997-06-12 |
| US7323183B2 (en) | 2008-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0865297 Country of ref document: EP |
|
| EEFA | Change of the company name |