ZA200007757B - New heterocyclically substituted amides, their production and their use. - Google Patents
New heterocyclically substituted amides, their production and their use. Download PDFInfo
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- ZA200007757B ZA200007757B ZA200007757A ZA200007757A ZA200007757B ZA 200007757 B ZA200007757 B ZA 200007757B ZA 200007757 A ZA200007757 A ZA 200007757A ZA 200007757 A ZA200007757 A ZA 200007757A ZA 200007757 B ZA200007757 B ZA 200007757B
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- South Africa
- Prior art keywords
- alkyl
- formula
- phenyl
- branched
- substituted
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- 150000001408 amides Chemical class 0.000 title claims description 31
- 150000001875 compounds Chemical class 0.000 claims description 17
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 239000003112 inhibitor Substances 0.000 claims description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
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- 108010005843 Cysteine Proteases Proteins 0.000 claims description 9
- 125000004076 pyridyl group Chemical group 0.000 claims description 8
- -1 quinazyl Chemical group 0.000 claims description 8
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- 230000006378 damage Effects 0.000 claims description 5
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- 108010084457 Cathepsins Proteins 0.000 claims description 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 4
- 125000001041 indolyl group Chemical group 0.000 claims description 4
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- 125000001624 naphthyl group Chemical group 0.000 claims description 4
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- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 125000002541 furyl group Chemical group 0.000 claims description 2
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- 125000005495 pyridazyl group Chemical group 0.000 claims description 2
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- 125000005493 quinolyl group Chemical group 0.000 claims description 2
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- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823245 | 1998-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200007757B true ZA200007757B (en) | 2002-01-21 |
Family
ID=7868806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200007757A ZA200007757B (en) | 1998-05-25 | 2000-12-21 | New heterocyclically substituted amides, their production and their use. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6482832B1 (ja) |
| EP (2) | EP1080074B1 (ja) |
| JP (2) | JP4700192B2 (ja) |
| KR (1) | KR20010043799A (ja) |
| CN (1) | CN1303372A (ja) |
| AT (2) | ATE524440T1 (ja) |
| AU (1) | AU4500399A (ja) |
| BR (1) | BR9910701A (ja) |
| CA (1) | CA2333008C (ja) |
| CZ (1) | CZ20004381A3 (ja) |
| DE (1) | DE59913973D1 (ja) |
| ES (2) | ES2277439T3 (ja) |
| HU (1) | HUP0102146A3 (ja) |
| IL (1) | IL139357A0 (ja) |
| NO (1) | NO20005929L (ja) |
| WO (1) | WO1999061423A1 (ja) |
| ZA (1) | ZA200007757B (ja) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2220061T3 (es) * | 1998-04-20 | 2004-12-01 | ABBOTT GMBH & CO. KG | Nuevas amidas substituidas, su obtencion y aplicacion. |
| DE10114762A1 (de) * | 2001-03-26 | 2002-10-02 | Knoll Gmbh | Verwendung von Cysteinprotease-Inhibitoren |
| US6831087B2 (en) * | 2001-11-09 | 2004-12-14 | Hoffmann-La Roche Inc. | Pyridine substituted isoquinoline derivatives |
| JP2005515254A (ja) | 2002-01-17 | 2005-05-26 | スミスクライン ビーチャム コーポレーション | カテプシンｋ阻害剤として有用なシクロアルキルケトアミド誘導体 |
| CA2505098A1 (en) * | 2002-11-12 | 2004-05-27 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease |
| DE10331980A1 (de) * | 2003-07-14 | 2005-02-17 | Aventis Pharma Deutschland Gmbh | Verwendung von Calpain zur Identifizierung von schmerzmodulierenden Verbindungen |
| WO2005023188A2 (en) * | 2003-09-03 | 2005-03-17 | Smithkline Beecham Corporation | Compounds and methods |
| WO2008080969A1 (en) * | 2006-12-29 | 2008-07-10 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
| TWI453019B (zh) | 2007-12-28 | 2014-09-21 | Abbvie Deutschland | 甲醯胺化合物 |
| TWI519530B (zh) | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途 |
| US8236798B2 (en) | 2009-05-07 | 2012-08-07 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
| US9051304B2 (en) | 2009-12-22 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
| US8598211B2 (en) | 2009-12-22 | 2013-12-03 | Abbvie Inc. | Carboxamide compounds and their use as calpain inhibitors IV |
| CN103599588B (zh) | 2010-04-30 | 2017-04-26 | 雅培心脏血管系统股份有限公司 | 呈现迅速膨胀和收缩的改进型球囊导管 |
| CA2819087A1 (en) | 2010-12-09 | 2012-06-14 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors v |
| SG11201406345XA (en) | 2012-04-03 | 2014-11-27 | Abbvie Deutschland | Carboxamide compounds and their use as calpain inhibitors v |
| WO2013157562A1 (ja) | 2012-04-17 | 2013-10-24 | アステラス製薬株式会社 | 含窒素二環式芳香族へテロ環化合物 |
| EP3426674A4 (en) | 2016-03-09 | 2019-08-14 | Blade Therapeutics, Inc. | CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| WO2018009417A1 (en) | 2016-07-05 | 2018-01-11 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| WO2018064119A1 (en) | 2016-09-28 | 2018-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| CN115057856B (zh) * | 2022-06-08 | 2024-04-02 | 澳门科技大学 | 3,5-二取代-7氮杂吲哚衍生物及其合成方法与应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0499237A (ja) * | 1990-08-08 | 1992-03-31 | Kubota Corp | 金属マトリックス繊維強化複合材料 |
| JPH06504061A (ja) * | 1990-12-28 | 1994-05-12 | コーテックス ファーマシューティカルズ インコーポレイテッド | 神経変性の治療および予防におけるカルパイン阻害剤の使用 |
| WO1992012140A1 (en) * | 1990-12-28 | 1992-07-23 | Georgia Tech Research Corporation | Peptides ketoamides, ketoacids, and ketoesters |
| CA2071621C (en) * | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Aldehyde derivatives |
| CA2138124A1 (en) * | 1992-06-24 | 1994-01-06 | David D. Eveleth, Jr. | Use of calpain inhibitors in the inhibition and treatment of medical conditions associated with increased calpain activity |
| US5541290A (en) * | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
| JP3216458B2 (ja) * | 1994-12-28 | 2001-10-09 | 富士レビオ株式会社 | アミド誘導体 |
| TR199901305T2 (xx) * | 1996-12-11 | 1999-08-23 | Basf Aktiengesellschaft | Calpain-�nleyicileri olarak ketonbenzamidler |
| ES2220061T3 (es) * | 1998-04-20 | 2004-12-01 | ABBOTT GMBH & CO. KG | Nuevas amidas substituidas, su obtencion y aplicacion. |
| DE19817459A1 (de) * | 1998-04-20 | 1999-10-21 | Basf Ag | Neue heterozyklische substituierte Amide, Herstellung und Anwendung |
-
1999
- 1999-05-25 EP EP99927749A patent/EP1080074B1/de not_active Expired - Lifetime
- 1999-05-25 EP EP06023149A patent/EP1757584B1/de not_active Expired - Lifetime
- 1999-05-25 CZ CZ20004381A patent/CZ20004381A3/cs unknown
- 1999-05-25 CN CN99806590A patent/CN1303372A/zh active Pending
- 1999-05-25 ES ES99927749T patent/ES2277439T3/es not_active Expired - Lifetime
- 1999-05-25 BR BR9910701-5A patent/BR9910701A/pt not_active IP Right Cessation
- 1999-05-25 AU AU45003/99A patent/AU4500399A/en not_active Abandoned
- 1999-05-25 ES ES06023149T patent/ES2373564T3/es not_active Expired - Lifetime
- 1999-05-25 CA CA002333008A patent/CA2333008C/en not_active Expired - Fee Related
- 1999-05-25 JP JP2000550829A patent/JP4700192B2/ja not_active Expired - Fee Related
- 1999-05-25 HU HU0102146A patent/HUP0102146A3/hu unknown
- 1999-05-25 AT AT06023149T patent/ATE524440T1/de active
- 1999-05-25 DE DE59913973T patent/DE59913973D1/de not_active Expired - Lifetime
- 1999-05-25 KR KR1020007013225A patent/KR20010043799A/ko not_active Application Discontinuation
- 1999-05-25 AT AT99927749T patent/ATE344794T1/de not_active IP Right Cessation
- 1999-05-25 US US09/700,453 patent/US6482832B1/en not_active Expired - Lifetime
- 1999-05-25 IL IL13935799A patent/IL139357A0/xx unknown
- 1999-05-25 WO PCT/EP1999/003549 patent/WO1999061423A1/de active IP Right Grant
-
2000
- 2000-11-23 NO NO20005929A patent/NO20005929L/no not_active Application Discontinuation
- 2000-12-21 ZA ZA200007757A patent/ZA200007757B/en unknown
-
2010
- 2010-11-08 JP JP2010250318A patent/JP2011063604A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2333008A1 (en) | 1999-12-02 |
| ES2373564T3 (es) | 2012-02-06 |
| DE59913973D1 (de) | 2006-12-21 |
| HUP0102146A2 (hu) | 2001-11-28 |
| HUP0102146A3 (en) | 2003-01-28 |
| JP2011063604A (ja) | 2011-03-31 |
| EP1080074A1 (de) | 2001-03-07 |
| ATE524440T1 (de) | 2011-09-15 |
| AU4500399A (en) | 1999-12-13 |
| EP1757584A1 (de) | 2007-02-28 |
| KR20010043799A (ko) | 2001-05-25 |
| CA2333008C (en) | 2008-07-29 |
| NO20005929D0 (no) | 2000-11-23 |
| JP4700192B2 (ja) | 2011-06-15 |
| NO20005929L (no) | 2000-11-23 |
| CZ20004381A3 (cs) | 2001-09-12 |
| ES2277439T3 (es) | 2007-07-01 |
| IL139357A0 (en) | 2001-11-25 |
| US6482832B1 (en) | 2002-11-19 |
| WO1999061423A1 (de) | 1999-12-02 |
| ATE344794T1 (de) | 2006-11-15 |
| CN1303372A (zh) | 2001-07-11 |
| EP1080074B1 (de) | 2006-11-08 |
| JP2002516311A (ja) | 2002-06-04 |
| BR9910701A (pt) | 2001-01-30 |
| EP1757584B1 (de) | 2011-09-14 |
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