ZA200005563B - SPLA2 inhibitor compounds for treatment of disease. - Google Patents
SPLA2 inhibitor compounds for treatment of disease. Download PDFInfo
- Publication number
- ZA200005563B ZA200005563B ZA200005563A ZA200005563A ZA200005563B ZA 200005563 B ZA200005563 B ZA 200005563B ZA 200005563 A ZA200005563 A ZA 200005563A ZA 200005563 A ZA200005563 A ZA 200005563A ZA 200005563 B ZA200005563 B ZA 200005563B
- Authority
- ZA
- South Africa
- Prior art keywords
- amino
- acid
- indol
- dioxoethyl
- group
- Prior art date
Links
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- 238000011282 treatment Methods 0.000 title claims description 42
- 239000003112 inhibitor Substances 0.000 title claims description 41
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- 239000000203 mixture Substances 0.000 claims description 70
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- 238000000034 method Methods 0.000 claims description 48
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- 239000000126 substance Substances 0.000 claims description 25
- 238000009472 formulation Methods 0.000 claims description 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 17
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8387498P | 1998-05-01 | 1998-05-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200005563B true ZA200005563B (en) | 2002-01-10 |
Family
ID=22181224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200005563A ZA200005563B (en) | 1998-05-01 | 2000-10-10 | SPLA2 inhibitor compounds for treatment of disease. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6340699B1 (ko) |
| EP (1) | EP1084108A4 (ko) |
| JP (1) | JP2002513783A (ko) |
| KR (1) | KR20010043190A (ko) |
| CN (1) | CN1299348A (ko) |
| AU (1) | AU3656299A (ko) |
| BR (1) | BR9910095A (ko) |
| CA (1) | CA2330856A1 (ko) |
| CZ (1) | CZ20004052A3 (ko) |
| EA (1) | EA200001140A1 (ko) |
| HR (1) | HRP20000739A2 (ko) |
| HU (1) | HUP0102243A2 (ko) |
| ID (1) | ID27153A (ko) |
| IL (1) | IL139019A0 (ko) |
| NO (1) | NO20005479L (ko) |
| PL (1) | PL343708A1 (ko) |
| SK (1) | SK16342000A3 (ko) |
| TR (1) | TR200003194T2 (ko) |
| WO (1) | WO1999057100A1 (ko) |
| ZA (1) | ZA200005563B (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
| WO2001055108A2 (en) * | 2000-01-25 | 2001-08-02 | Eli Lilly And Company | Use of spl a2 inhibitors for the treatment of inflammation |
| JPWO2002000621A1 (ja) | 2000-06-29 | 2004-04-22 | 塩野義製薬株式会社 | Ｘ型ｓＰＬＡ２阻害作用を有する化合物 |
| AU2002224531B2 (en) * | 2000-07-24 | 2005-08-25 | Dow Global Technologies Inc. | Thermoplastic superabsorbent polymer blend compositions and their preparation |
| CA2627353A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Indole compounds having c4-acidic substituents and use thereof as phospholipase-a2 inhibitors |
| CA2720275A1 (en) * | 2008-04-01 | 2009-10-08 | Astellas Pharma Inc. | Indolinone compound |
| NZ789295A (en) | 2009-04-29 | 2024-02-23 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| US9290752B2 (en) | 2013-03-13 | 2016-03-22 | Sunny Delight Beverages Co. | Process for enhancing the amylase inhibitory efficacy from phaseolus vulgaris extracts |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356919A (en) | 1991-05-30 | 1994-10-18 | G. D. Searle & Co. | Leukotriene B4 synthesis inhibitors |
| DE4218096A1 (de) | 1992-06-02 | 1993-12-09 | Boehringer Mannheim Gmbh | Spiro-oxetane, Verfahren zu ihrer Herstellung und Arzneimittel |
| DE4323409A1 (de) | 1993-07-13 | 1995-01-19 | Boehringer Mannheim Gmbh | Verwendung von Cumarinen und Carbostyrilen als PLA¶2¶-Inhibitoren, neue Cumarine und Carbostyrile, Verfahren zu ihrer Herstellung und Arzneimittel |
| CZ82295A3 (en) | 1994-04-01 | 1995-12-13 | Lilly Co Eli | Derivative of 1h-indole-3-glyoxylamide and a pharmaceutical composition containing thereof |
| WO1995033462A1 (en) * | 1994-06-02 | 1995-12-14 | Smithkline Beecham Corporation | Anti-inflammatory compounds |
| NZ298145A (en) * | 1994-12-29 | 1998-08-26 | Yamanouchi Pharma Co Ltd | Monoclonal antibodies having inhibitory effect on type ii phospholipase a2, proteins forming part thereof, cells producing them, dna encoding them, recombinant vector comprising the dna and medicament |
| TR199900956T2 (xx) | 1996-10-30 | 1999-07-21 | Eli Lilly And Company | S�bstit�e edilmi� trisiklik bile�imler. |
| EA003876B1 (ru) * | 1998-02-25 | 2003-10-30 | Дженетикс Инститьют, Ллс | Ингибиторы фосфолипазных ферментов |
-
1999
- 1999-04-20 ID IDW20002214A patent/ID27153A/id unknown
- 1999-04-20 CZ CZ20004052A patent/CZ20004052A3/cs unknown
- 1999-04-20 SK SK1634-2000A patent/SK16342000A3/sk unknown
- 1999-04-20 TR TR2000/03194T patent/TR200003194T2/xx unknown
- 1999-04-20 EP EP99918711A patent/EP1084108A4/en not_active Withdrawn
- 1999-04-20 WO PCT/US1999/008654 patent/WO1999057100A1/en not_active Application Discontinuation
- 1999-04-20 KR KR1020007012113A patent/KR20010043190A/ko not_active Application Discontinuation
- 1999-04-20 US US09/673,675 patent/US6340699B1/en not_active Expired - Fee Related
- 1999-04-20 CA CA002330856A patent/CA2330856A1/en not_active Abandoned
- 1999-04-20 JP JP2000547070A patent/JP2002513783A/ja not_active Withdrawn
- 1999-04-20 PL PL99343708A patent/PL343708A1/xx unknown
- 1999-04-20 HU HU0102243A patent/HUP0102243A2/hu unknown
- 1999-04-20 AU AU36562/99A patent/AU3656299A/en not_active Abandoned
- 1999-04-20 EA EA200001140A patent/EA200001140A1/ru unknown
- 1999-04-20 BR BR9910095-9A patent/BR9910095A/pt not_active Application Discontinuation
- 1999-04-20 CN CN99805675A patent/CN1299348A/zh active Pending
- 1999-04-20 IL IL13901999A patent/IL139019A0/xx unknown
-
2000
- 2000-10-10 ZA ZA200005563A patent/ZA200005563B/en unknown
- 2000-10-31 NO NO20005479A patent/NO20005479L/no not_active Application Discontinuation
- 2000-10-31 HR HR20000739A patent/HRP20000739A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL343708A1 (en) | 2001-08-27 |
| CZ20004052A3 (cs) | 2002-05-15 |
| BR9910095A (pt) | 2000-12-26 |
| WO1999057100A1 (en) | 1999-11-11 |
| SK16342000A3 (sk) | 2002-04-04 |
| EP1084108A4 (en) | 2005-01-12 |
| KR20010043190A (ko) | 2001-05-25 |
| AU3656299A (en) | 1999-11-23 |
| HUP0102243A2 (hu) | 2001-10-28 |
| NO20005479D0 (no) | 2000-10-31 |
| CA2330856A1 (en) | 1999-11-11 |
| EP1084108A1 (en) | 2001-03-21 |
| NO20005479L (no) | 2000-12-20 |
| ID27153A (id) | 2001-03-08 |
| TR200003194T2 (tr) | 2001-03-21 |
| EA200001140A1 (ru) | 2001-04-23 |
| HRP20000739A2 (en) | 2001-10-31 |
| IL139019A0 (en) | 2001-11-25 |
| US6340699B1 (en) | 2002-01-22 |
| CN1299348A (zh) | 2001-06-13 |
| JP2002513783A (ja) | 2002-05-14 |
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