ZA200004670B - Transdermal therapeutic system containing pergolide. - Google Patents
Transdermal therapeutic system containing pergolide. Download PDFInfo
- Publication number
- ZA200004670B ZA200004670B ZA200004670A ZA200004670A ZA200004670B ZA 200004670 B ZA200004670 B ZA 200004670B ZA 200004670 A ZA200004670 A ZA 200004670A ZA 200004670 A ZA200004670 A ZA 200004670A ZA 200004670 B ZA200004670 B ZA 200004670B
- Authority
- ZA
- South Africa
- Prior art keywords
- pergolide
- tts
- skin
- active substance
- meth
- Prior art date
Links
- 229960004851 pergolide Drugs 0.000 title claims abstract description 48
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 title claims abstract description 48
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 15
- 239000011159 matrix material Substances 0.000 claims abstract description 46
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229920001577 copolymer Polymers 0.000 claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 claims abstract description 17
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 6
- 125000003277 amino group Chemical group 0.000 claims abstract description 5
- 125000000656 azaniumyl group Chemical group [H][N+]([H])([H])[*] 0.000 claims abstract description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 5
- 239000013543 active substance Substances 0.000 claims description 77
- 229920000642 polymer Polymers 0.000 claims description 21
- 239000011888 foil Substances 0.000 claims description 14
- 239000011505 plaster Substances 0.000 claims description 14
- 239000003623 enhancer Substances 0.000 claims description 10
- 239000004902 Softening Agent Substances 0.000 claims description 7
- 230000035515 penetration Effects 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- UWCVGPLTGZWHGS-ZORIOUSZSA-N pergolide mesylate Chemical compound CS(O)(=O)=O.C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 UWCVGPLTGZWHGS-ZORIOUSZSA-N 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000003961 penetration enhancing agent Substances 0.000 claims description 3
- 229940026235 propylene glycol monolaurate Drugs 0.000 claims description 3
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 2
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical class CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims description 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical class CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 2
- 229960001511 pergolide mesylate Drugs 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 11
- 239000002904 solvent Substances 0.000 abstract description 10
- 210000003491 skin Anatomy 0.000 description 30
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- 239000002609 medium Substances 0.000 description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 7
- -1 polypropylene Polymers 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 5
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- 229950002475 mesilate Drugs 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
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- JQVDAXLFBXTEQA-UHFFFAOYSA-N dibutylamine Chemical compound CCCCNCCCC JQVDAXLFBXTEQA-UHFFFAOYSA-N 0.000 description 4
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000013461 design Methods 0.000 description 3
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- BQBYBPAPSIWHCE-UHFFFAOYSA-N 5-(dimethylamino)-2-methylpent-2-enoic acid Chemical compound CN(C)CCC=C(C)C(O)=O BQBYBPAPSIWHCE-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920003149 Eudragit® E 100 Polymers 0.000 description 1
- 229920003159 Eudragit® RS 100 Polymers 0.000 description 1
- 208000004547 Hallucinations Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Natural products CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
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- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
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- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
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- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 1
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- 229960002433 cysteine Drugs 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 229960001305 cysteine hydrochloride Drugs 0.000 description 1
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- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 229960004452 methionine Drugs 0.000 description 1
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- 238000002156 mixing Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 229940100640 transdermal system Drugs 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
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- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- IELOKBJPULMYRW-UHFFFAOYSA-N α-tocopherol succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19821788A DE19821788C1 (de) | 1998-05-15 | 1998-05-15 | Transdermales Therapeutisches System (TTS) Pergolid enthaltend |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200004670B true ZA200004670B (en) | 2000-11-22 |
Family
ID=7867847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200004670A ZA200004670B (en) | 1998-05-15 | 2000-09-06 | Transdermal therapeutic system containing pergolide. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6461636B1 (pt) |
| EP (1) | EP1077688B1 (pt) |
| JP (1) | JP4556039B2 (pt) |
| KR (1) | KR100507266B1 (pt) |
| CN (1) | CN1190189C (pt) |
| AT (1) | ATE210432T1 (pt) |
| AU (1) | AU743229C (pt) |
| BR (1) | BR9910404B1 (pt) |
| CA (1) | CA2327187C (pt) |
| DE (2) | DE19821788C1 (pt) |
| DK (1) | DK1077688T3 (pt) |
| ES (1) | ES2167116T3 (pt) |
| HK (1) | HK1037541A1 (pt) |
| IL (1) | IL138005A (pt) |
| MX (1) | MXPA00011253A (pt) |
| NO (1) | NO329042B1 (pt) |
| PL (1) | PL192213B1 (pt) |
| PT (1) | PT1077688E (pt) |
| WO (1) | WO1999059558A1 (pt) |
| ZA (1) | ZA200004670B (pt) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
| DE10033855A1 (de) * | 2000-07-12 | 2002-01-31 | Hexal Ag | Matrixkontrolliertes transdermales System mit Sulfonsäuresalz eines ACE-Hemmers |
| DE10053397A1 (de) * | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| DE10066158B4 (de) * | 2000-08-24 | 2007-08-09 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung des Restless-Legs-Syndroms |
| DE10341317B4 (de) * | 2003-09-03 | 2008-10-23 | Axxonis Pharma Ag | Transdermales therapeutisches System (TTS) zur Verabreichung von Ergolinverbindungen ausgenommen Pergolid |
| DE10064453A1 (de) * | 2000-12-16 | 2002-07-04 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
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|---|---|---|---|---|
| CA2075517C (en) * | 1992-04-01 | 1997-03-11 | John Wick | Transdermal patch incorporating a polymer film incorporated with an active agent |
| DE4310012A1 (de) * | 1993-03-27 | 1994-09-29 | Roehm Gmbh | Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung |
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| CA2259353C (en) * | 1996-07-02 | 2006-09-05 | Hexal Ag | Plaster for the transdermal application of pergolide |
| DE19728517C2 (de) * | 1997-07-04 | 1999-11-11 | Sanol Arznei Schwarz Gmbh | TTS zur Verabreichung von Sexualsteroidhormonen und Verfahren zu seiner Herstellung |
-
1998
- 1998-05-15 DE DE19821788A patent/DE19821788C1/de not_active Expired - Fee Related
-
1999
- 1999-05-12 WO PCT/EP1999/003278 patent/WO1999059558A1/de active IP Right Grant
- 1999-05-12 EP EP99923585A patent/EP1077688B1/de not_active Expired - Lifetime
- 1999-05-12 DE DE59900548T patent/DE59900548D1/de not_active Expired - Lifetime
- 1999-05-12 ES ES99923585T patent/ES2167116T3/es not_active Expired - Lifetime
- 1999-05-12 CA CA002327187A patent/CA2327187C/en not_active Expired - Fee Related
- 1999-05-12 CN CNB998062014A patent/CN1190189C/zh not_active Expired - Fee Related
- 1999-05-12 PT PT99923585T patent/PT1077688E/pt unknown
- 1999-05-12 IL IL13800599A patent/IL138005A/xx not_active IP Right Cessation
- 1999-05-12 AT AT99923585T patent/ATE210432T1/de not_active IP Right Cessation
- 1999-05-12 US US09/673,069 patent/US6461636B1/en not_active Expired - Fee Related
- 1999-05-12 AU AU40407/99A patent/AU743229C/en not_active Ceased
- 1999-05-12 KR KR10-2000-7011389A patent/KR100507266B1/ko not_active IP Right Cessation
- 1999-05-12 JP JP2000549223A patent/JP4556039B2/ja not_active Expired - Fee Related
- 1999-05-12 MX MXPA00011253A patent/MXPA00011253A/es not_active IP Right Cessation
- 1999-05-12 BR BRPI9910404-0A patent/BR9910404B1/pt not_active IP Right Cessation
- 1999-05-12 PL PL344160A patent/PL192213B1/pl not_active IP Right Cessation
- 1999-05-12 DK DK99923585T patent/DK1077688T3/da active
-
2000
- 2000-09-06 ZA ZA200004670A patent/ZA200004670B/en unknown
- 2000-09-27 NO NO20004859A patent/NO329042B1/no not_active IP Right Cessation
-
2001
- 2001-12-07 HK HK01108600A patent/HK1037541A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1301152A (zh) | 2001-06-27 |
| DE59900548D1 (de) | 2002-01-24 |
| AU4040799A (en) | 1999-12-06 |
| JP2002515424A (ja) | 2002-05-28 |
| NO20004859D0 (no) | 2000-09-27 |
| EP1077688B1 (de) | 2001-12-12 |
| ES2167116T3 (es) | 2002-05-01 |
| EP1077688A1 (de) | 2001-02-28 |
| PT1077688E (pt) | 2002-05-31 |
| IL138005A (en) | 2005-07-25 |
| PL192213B1 (pl) | 2006-09-29 |
| KR20010042685A (ko) | 2001-05-25 |
| WO1999059558A1 (de) | 1999-11-25 |
| US6461636B1 (en) | 2002-10-08 |
| DE19821788C1 (de) | 1999-12-02 |
| CN1190189C (zh) | 2005-02-23 |
| IL138005A0 (en) | 2001-10-31 |
| NO329042B1 (no) | 2010-08-02 |
| PL344160A1 (en) | 2001-10-08 |
| NO20004859L (no) | 2000-09-27 |
| CA2327187A1 (en) | 1999-11-25 |
| HK1037541A1 (en) | 2002-02-15 |
| BR9910404B1 (pt) | 2009-12-01 |
| MXPA00011253A (es) | 2003-05-19 |
| AU743229B2 (en) | 2002-01-24 |
| ATE210432T1 (de) | 2001-12-15 |
| BR9910404A (pt) | 2001-01-09 |
| CA2327187C (en) | 2005-12-27 |
| KR100507266B1 (ko) | 2005-08-10 |
| AU743229C (en) | 2003-03-20 |
| JP4556039B2 (ja) | 2010-10-06 |
| DK1077688T3 (da) | 2002-04-02 |
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