YU64804A - Inhalator odmerene doze - Google Patents

Inhalator odmerene doze

Info

Publication number
YU64804A
YU64804A YU64804A YUP64804A YU64804A YU 64804 A YU64804 A YU 64804A YU 64804 A YU64804 A YU 64804A YU P64804 A YUP64804 A YU P64804A YU 64804 A YU64804 A YU 64804A
Authority
YU
Yugoslavia
Prior art keywords
actuators
solution formulations
present
metered dose
dose inhaler
Prior art date
Application number
YU64804A
Other languages
English (en)
Inventor
Rebecca Jayne Davies
David Ganderton
David Andrew Lewis
Brian John Meakin
Original Assignee
Chiese Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiese Farmaceutici S.P.A. filed Critical Chiese Farmaceutici S.P.A.
Publication of YU64804A publication Critical patent/YU64804A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

Abstract

Predmetni pronalazak odnosi se na aktuatore (2) inhalatora odmerene doze pod pritiskom (pMDI) sa laserski bušenim prolazima i na proizvode preparata medicinskog rastvora aerosola koji sadrže te aktuatore (2). Posebno se predmetni pronalazak odnosi na optimizaciju izlaznih karakteristika preparata rastvora leka u hidrofluoroalkanima (HFA-ovima) putem upotrebe pMDI-ova sa aktuatorima (2) sa laserski bušenim prolazima specifičnih dimenzija. Štaviše, aktuatori (2) predmetnog pronalaska dozvoljavaju upotrebu formulacija rastvora sa visokim sadržajem etanola i visokom proporocijom etanola u odnosu na aktivne sastojke i na taj način, upotrebu slabo rastvorljivih aktivnih sastojaka u preparatima rastvora i omogućuje upotrebu preparata rastvora koji su gotovo u potpunosti bez slabo isparljivih komponenti.[The present invention relates to pressurized metered dose inhaler (pMDI) actuators (2) with laser drilled orifices and to medicinal aerosol solution formulation products comprising these actuators (2). In particular, the present invention relates to the optimisation of the output characteristics of drug solution formulations in hydrofluoroalkanes (HFAs) by use of pMDIs with actuators (2) with laser drilled orifices of specific dimensions. Moreover, the actuators (2) of the present invention allow the use of solution formulations with a high ethanol content and a high ratio of ethanol to active ingredients and thus, the use of poorly soluble active ingredients in solution formulations and allow the use of solution formulations which are substantially free of low volatility components.
YU64804A 2001-12-21 2002-12-19 Inhalator odmerene doze YU64804A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01130521A EP1321159A1 (en) 2001-12-21 2001-12-21 Pressurized metered dose inhaler (pMDI) actuators with laser drilled orifices

Publications (1)

Publication Number Publication Date
YU64804A true YU64804A (sh) 2006-05-25

Family

ID=8179630

Family Applications (1)

Application Number Title Priority Date Filing Date
YU64804A YU64804A (sh) 2001-12-21 2002-12-19 Inhalator odmerene doze

Country Status (16)

Country Link
US (2) US20050061314A1 (sh)
EP (3) EP1321159A1 (sh)
JP (2) JP2005512691A (sh)
AU (2) AU2002361179B2 (sh)
BR (1) BR0207631A (sh)
CA (1) CA2470857A1 (sh)
EA (1) EA006754B1 (sh)
GE (1) GEP20064002B (sh)
HR (1) HRP20040559A2 (sh)
HU (1) HUP0402487A2 (sh)
NO (1) NO20033722L (sh)
NZ (1) NZ534040A (sh)
PL (1) PL369072A1 (sh)
UA (1) UA75770C2 (sh)
WO (2) WO2003053501A1 (sh)
YU (1) YU64804A (sh)

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Also Published As

Publication number Publication date
JP2005512691A (ja) 2005-05-12
EA200400730A1 (ru) 2005-02-24
WO2003053501A1 (en) 2003-07-03
UA75770C2 (en) 2006-05-15
WO2003055549A1 (en) 2003-07-10
EA006754B1 (ru) 2006-04-28
HUP0402487A2 (hu) 2005-06-28
PL369072A1 (en) 2005-04-18
US20080017191A1 (en) 2008-01-24
AU2002361179B2 (en) 2007-10-25
GEP20064002B (en) 2006-12-25
NO20033722D0 (no) 2003-08-21
HRP20040559A2 (en) 2004-10-31
BR0207631A (pt) 2004-06-01
US20050061314A1 (en) 2005-03-24
AU2002361453A1 (en) 2003-07-15
EP1455873A1 (en) 2004-09-15
NO20033722L (no) 2003-10-20
NZ534040A (en) 2006-03-31
CA2470857A1 (en) 2003-07-03
EP1321159A1 (en) 2003-06-25
EP1455874A1 (en) 2004-09-15
AU2002361179A1 (en) 2003-07-09
JP2005512740A (ja) 2005-05-12

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