EA200400730A1 - Ингалятор контролируемой дозы - Google Patents

Ингалятор контролируемой дозы

Info

Publication number
EA200400730A1
EA200400730A1 EA200400730A EA200400730A EA200400730A1 EA 200400730 A1 EA200400730 A1 EA 200400730A1 EA 200400730 A EA200400730 A EA 200400730A EA 200400730 A EA200400730 A EA 200400730A EA 200400730 A1 EA200400730 A1 EA 200400730A1
Authority
EA
Eurasian Patent Office
Prior art keywords
actuators
allow
pmdi
laser
active ingredients
Prior art date
Application number
EA200400730A
Other languages
English (en)
Other versions
EA006754B1 (ru
Inventor
Ребекка Джэйн Дэвис
Дэвид Гэндертон
Дэвид Эндрю Льюис
Брайан Джон Миакин
Original Assignee
Кьези Фармасьютичи С. П. А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кьези Фармасьютичи С. П. А. filed Critical Кьези Фармасьютичи С. П. А.
Publication of EA200400730A1 publication Critical patent/EA200400730A1/ru
Publication of EA006754B1 publication Critical patent/EA006754B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

Abstract

В изобретении описаны исполнительные механизмы (2) для вытеснительного ингалятора контролируемой дозы (pMDI) с просверленными лазером отверстиями и системы для распыления раствора лекарственного аэрозоля, которые содержат такие исполнительные механизмы (2). В частности, описана оптимизация выходных характеристик лекарственных растворов в гидрофторалканах (HFAs) за счет использования pMDI, имеющих исполнительные механизмы (2) с просверленными лазером отверстиями специфических размеров. Более того, исполнительные механизмы (2) в соответствии с настоящим изобретением позволяют использовать составы растворов с высоким содержанием этилового спирта и с высоким отношением этилового спирта к активным ингредиентам и, следовательно, позволяют использовать плохо растворимые активные ингредиенты в составах растворов, а также позволяют использовать составы растворов, которые, главным образом, не содержат компонентов с низкой летучестью.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400730A 2001-12-21 2002-12-19 Ингалятор контролируемой дозы EA006754B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01130521A EP1321159A1 (en) 2001-12-21 2001-12-21 Pressurized metered dose inhaler (pMDI) actuators with laser drilled orifices
PCT/EP2002/014588 WO2003053501A1 (en) 2001-12-21 2002-12-19 Metered dose inhaler

Publications (2)

Publication Number Publication Date
EA200400730A1 true EA200400730A1 (ru) 2005-02-24
EA006754B1 EA006754B1 (ru) 2006-04-28

Family

ID=8179630

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400730A EA006754B1 (ru) 2001-12-21 2002-12-19 Ингалятор контролируемой дозы

Country Status (16)

Country Link
US (2) US20050061314A1 (ru)
EP (3) EP1321159A1 (ru)
JP (2) JP2005512691A (ru)
AU (2) AU2002361179B2 (ru)
BR (1) BR0207631A (ru)
CA (1) CA2470857A1 (ru)
EA (1) EA006754B1 (ru)
GE (1) GEP20064002B (ru)
HR (1) HRP20040559A2 (ru)
HU (1) HUP0402487A2 (ru)
NO (1) NO20033722L (ru)
NZ (1) NZ534040A (ru)
PL (1) PL369072A1 (ru)
UA (1) UA75770C2 (ru)
WO (2) WO2003053501A1 (ru)
YU (1) YU64804A (ru)

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Also Published As

Publication number Publication date
EA006754B1 (ru) 2006-04-28
NO20033722L (no) 2003-10-20
JP2005512740A (ja) 2005-05-12
UA75770C2 (en) 2006-05-15
NZ534040A (en) 2006-03-31
WO2003053501A1 (en) 2003-07-03
EP1455874A1 (en) 2004-09-15
WO2003055549A1 (en) 2003-07-10
JP2005512691A (ja) 2005-05-12
BR0207631A (pt) 2004-06-01
HRP20040559A2 (en) 2004-10-31
NO20033722D0 (no) 2003-08-21
PL369072A1 (en) 2005-04-18
US20050061314A1 (en) 2005-03-24
CA2470857A1 (en) 2003-07-03
AU2002361179B2 (en) 2007-10-25
YU64804A (sh) 2006-05-25
EP1455873A1 (en) 2004-09-15
GEP20064002B (en) 2006-12-25
HUP0402487A2 (hu) 2005-06-28
EP1321159A1 (en) 2003-06-25
US20080017191A1 (en) 2008-01-24
AU2002361179A1 (en) 2003-07-09
AU2002361453A1 (en) 2003-07-15

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU