YU48291B - Postupak za izradu anti-ulkusnih agenasa - Google Patents

Postupak za izradu anti-ulkusnih agenasa

Info

Publication number
YU48291B
YU48291B YU89492A YU89492A YU48291B YU 48291 B YU48291 B YU 48291B YU 89492 A YU89492 A YU 89492A YU 89492 A YU89492 A YU 89492A YU 48291 B YU48291 B YU 48291B
Authority
YU
Yugoslavia
Prior art keywords
ulcus
agencies
procedure
making
bridge
Prior art date
Application number
YU89492A
Other languages
English (en)
Other versions
YU89492A (sh
Inventor
R.S. Hoerner
J.J. Friedman
J.S. Amato
T. Meng-Han Liv
I. Shinkai
L.M. Weinstock
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of YU89492A publication Critical patent/YU89492A/sh
Publication of YU48291B publication Critical patent/YU48291B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

POSTUPAK ZA IZRADU ANTI-ULKUSNIH AGENASA - Postupak za izradu jedinjenja formule I:u kojoj su R1 i R3 nezavisno odabrani od: (a) vodonika, (b) C1-C8-alkila (c) C3-C8-cikloalkila, (d) C2-C8-fluoralkila, i (e) C1-C8-alkiloksi; R2 je odabran od: a) vodonika, (b) C1-C8-alkila (c) C3-C8-cikloalkila, (d) C2-C8-fluoralkila, (e) C1-C8 alkiloksi, i (f) -O-(CH2)n-R6; R4 i R5 su nezavisno odabrani od: (a) vodonika, (b) -C1-C8-alkila,(c) C3-C8-cikloalkila, (d) -CH2-C3-C8-cikloalkila, (e) C1-C8-alkiloksi, (f) CF3, (g) C2-C8 fluoralkila, i (h) -C(O)O-C1-C8-alkila; R6 je odabran od (a) -O-(CH2)-R7, (b) -N-pirolidinonila (c) -N-sulcinimidila, d) e) f) g) OR10, h i) R7 je odabran od: (a) hidroksi, (b) C1-C8-alkiloksi, (c) arila, (d) heteroarila, (e) -O-arila, (f) C1-C8-aralkiloksi, (g) -O-(CH2)s-OR10, h) -halogena, i (i) -C(O)O-R10 R8 je odabran od: (a) C1-C8-alkila, (b) C3-C8-cikloalkila, (c) C1-C8-aralkila, (d) -C(O)O-C1-C8-alkila, (e) piridila, f) furanila, i g) R9 je odabran od: (a) acetoksi, (b) C1-C8 alkila, i (c) C1-C8-cikloalkila; R10 je odabran od: (a) vodonika, (b) C1-C8-alkila, (c) C3-C8-cikloalkila, i (d) arila; R11 i R12 su nezavisno odabrani od: a) vodonika, i (b) C1-C8-alkiloksi; X je O, S, ili NR10; Y je CH ili N; n, p i s su nezavisno 1 do 5; i r je O do 2; naznačen time, što sadrži stupanj a) obrade smeše jedinjenja formule II: u kojoj su supstituenti R1, R2 R3, R4 i R5 kako su definisani ovde gore, u rastvaraču; sa magnezijum monoperoksiftalatom, u količini dovoljnoj da se jedinjenje formule II prevede u jedinjenje formule I. Prijava sadrži još 9 zavisnih zahteva.
YU89492A 1991-09-20 1992-10-07 Postupak za izradu anti-ulkusnih agenasa YU48291B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76456491A 1991-09-20 1991-09-20
US77787391A 1991-10-15 1991-10-15

Publications (2)

Publication Number Publication Date
YU89492A YU89492A (sh) 1995-10-03
YU48291B true YU48291B (sh) 1998-05-15

Family

ID=27117485

Family Applications (1)

Application Number Title Priority Date Filing Date
YU89492A YU48291B (sh) 1991-09-20 1992-10-07 Postupak za izradu anti-ulkusnih agenasa

Country Status (18)

Country Link
US (1) US5391752A (sh)
EP (1) EP0533264B1 (sh)
JP (1) JPH0720956B2 (sh)
KR (1) KR100242622B1 (sh)
CN (1) CN1048729C (sh)
AT (1) ATE186535T1 (sh)
AU (1) AU649355B2 (sh)
CA (1) CA2078517C (sh)
DE (1) DE69230278T2 (sh)
DK (1) DK0533264T3 (sh)
ES (1) ES2143468T3 (sh)
GR (1) GR3032619T3 (sh)
IL (1) IL103156A (sh)
MX (1) MX9205333A (sh)
NZ (1) NZ244301A (sh)
PT (1) PT533264E (sh)
WO (1) WO1993006097A1 (sh)
YU (1) YU48291B (sh)

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WO1993024480A1 (en) * 1992-06-01 1993-12-09 Yoshitomi Pharmaceutical Industries, Ltd. Pyridine compound and medicinal use thereof
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US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
CN1053444C (zh) * 1996-03-20 2000-06-14 常州市第四制药厂 奥美拉唑的一种精制方法
SE508669C2 (sv) * 1996-04-26 1998-10-26 Astra Ab Nytt förfarande
SK283805B6 (sk) * 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
SE9704183D0 (sv) 1997-11-14 1997-11-14 Astra Ab New process
US6191148B1 (en) 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
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US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6780880B1 (en) * 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
CN100347167C (zh) * 2001-02-02 2007-11-07 特瓦制药工业有限公司 取代的2－(2－吡啶基甲基)亚磺酰基－1h－苯并咪唑化合物的生产方法
KR100783020B1 (ko) * 2001-03-23 2007-12-07 동아제약주식회사 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법
KR100914175B1 (ko) * 2001-07-16 2009-08-27 얀센 파마슈티카 엔.브이. 벤즈이미다졸-타입 화합물의 개선된 제조 방법
CA2472103A1 (en) * 2002-01-25 2003-08-07 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
CA2493618A1 (en) * 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
US7507829B2 (en) 2002-12-19 2009-03-24 Teva Pharmaceuticals Industries, Ltd Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
DE602004020730D1 (de) * 2003-01-15 2009-06-04 Cipla Ltd Pharmazeutisches verfahren und damit hergestellte verbindungen
CA2517005A1 (en) * 2003-02-20 2004-09-02 Santarus, Inc. A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
CA2518999A1 (en) * 2003-03-12 2004-09-23 Teva Pharmaceutical Industries Ltd Crystalline and amorphous solids of pantoprazole and processes for their preparation
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US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20050031700A1 (en) * 2003-07-18 2005-02-10 Sanatarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
AR045062A1 (es) * 2003-07-18 2005-10-12 Santarus Inc Formulaciones farmaceuticas para inhibir la secrecion de acido y metodos para preparar y utilizarlas
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
EP1742946A1 (en) * 2004-04-28 2007-01-17 Altana Pharma AG Dialkoxy-imidazopyridines derivatives
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
JP5457632B2 (ja) * 2004-06-24 2014-04-02 アストラゼネカ・アクチエボラーグ エソメプラゾールのナトリウム塩の製造に使用するための結晶の改変型の作成方法
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Also Published As

Publication number Publication date
YU89492A (sh) 1995-10-03
PT533264E (pt) 2000-05-31
EP0533264A1 (en) 1993-03-24
EP0533264B1 (en) 1999-11-10
KR930006021A (ko) 1993-04-20
DK0533264T3 (da) 2000-05-15
IL103156A (en) 1997-02-18
ES2143468T3 (es) 2000-05-16
DE69230278T2 (de) 2001-04-05
NZ244301A (en) 1994-08-26
AU649355B2 (en) 1994-05-19
IL103156A0 (en) 1993-02-21
CN1071169A (zh) 1993-04-21
KR100242622B1 (ko) 2000-03-02
CN1048729C (zh) 2000-01-26
CA2078517A1 (en) 1993-03-21
AU2520792A (en) 1993-03-25
CA2078517C (en) 2003-11-04
ATE186535T1 (de) 1999-11-15
US5391752A (en) 1995-02-21
DE69230278D1 (de) 1999-12-16
JPH05213936A (ja) 1993-08-24
WO1993006097A1 (en) 1993-04-01
MX9205333A (es) 1993-07-01
JPH0720956B2 (ja) 1995-03-08
GR3032619T3 (en) 2000-05-31

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