ATE186535T1 - Verfahren zur herstellung von omeprazol - Google Patents
Verfahren zur herstellung von omeprazolInfo
- Publication number
- ATE186535T1 ATE186535T1 AT92202792T AT92202792T ATE186535T1 AT E186535 T1 ATE186535 T1 AT E186535T1 AT 92202792 T AT92202792 T AT 92202792T AT 92202792 T AT92202792 T AT 92202792T AT E186535 T1 ATE186535 T1 AT E186535T1
- Authority
- AT
- Austria
- Prior art keywords
- bridge
- moiety
- reaction
- substituted
- omeprazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76456491A | 1991-09-20 | 1991-09-20 | |
US77787391A | 1991-10-15 | 1991-10-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE186535T1 true ATE186535T1 (de) | 1999-11-15 |
Family
ID=27117485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92202792T ATE186535T1 (de) | 1991-09-20 | 1992-09-12 | Verfahren zur herstellung von omeprazol |
Country Status (18)
Country | Link |
---|---|
US (1) | US5391752A (de) |
EP (1) | EP0533264B1 (de) |
JP (1) | JPH0720956B2 (de) |
KR (1) | KR100242622B1 (de) |
CN (1) | CN1048729C (de) |
AT (1) | ATE186535T1 (de) |
AU (1) | AU649355B2 (de) |
CA (1) | CA2078517C (de) |
DE (1) | DE69230278T2 (de) |
DK (1) | DK0533264T3 (de) |
ES (1) | ES2143468T3 (de) |
GR (1) | GR3032619T3 (de) |
IL (1) | IL103156A (de) |
MX (1) | MX9205333A (de) |
NZ (1) | NZ244301A (de) |
PT (1) | PT533264E (de) |
WO (1) | WO1993006097A1 (de) |
YU (1) | YU48291B (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9002043D0 (sv) * | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
US5504082A (en) * | 1992-06-01 | 1996-04-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridine compound and pharmaceutical compostions |
KR950701921A (ko) * | 1992-06-01 | 1995-05-17 | 고야 다다시 | 피리딘 화합물 및 이의 제약학적 용도(pyridine compound and medicinal use thereof) |
SE521100C2 (sv) * | 1995-12-15 | 2003-09-30 | Astra Ab | Förfarande för framställning av en bensimidazolförening |
US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
CN1053444C (zh) * | 1996-03-20 | 2000-06-14 | 常州市第四制药厂 | 奥美拉唑的一种精制方法 |
SE508669C2 (sv) * | 1996-04-26 | 1998-10-26 | Astra Ab | Nytt förfarande |
SK283805B6 (sk) * | 1996-09-09 | 2004-02-03 | Slovakofarma, A. S. | Spôsob prípravy omeprazolu |
SE9704183D0 (sv) | 1997-11-14 | 1997-11-14 | Astra Ab | New process |
US6166213A (en) * | 1998-08-11 | 2000-12-26 | Merck & Co., Inc. | Omeprazole process and compositions thereof |
US6191148B1 (en) | 1998-08-11 | 2001-02-20 | Merck & Co., Inc. | Omerazole process and compositions thereof |
US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
DE19951960C2 (de) * | 1999-10-28 | 2002-06-27 | Gruenenthal Gmbh | Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate |
CN1781918A (zh) * | 2001-02-02 | 2006-06-07 | 特瓦制药工业有限公司 | 制备硫酯化合物的方法 |
KR100783020B1 (ko) * | 2001-03-23 | 2007-12-07 | 동아제약주식회사 | 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법 |
CA2450433C (en) * | 2001-07-16 | 2010-05-25 | Janssen Pharmaceutica N.V. | Improved process for preparing benzimidazole-type compounds |
EP1469839A2 (de) * | 2002-01-25 | 2004-10-27 | Santarus, Inc. | Transmukosale verabreichung von protonenpumpeninhibitoren |
US7211590B2 (en) * | 2002-08-01 | 2007-05-01 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
SE0203092D0 (en) * | 2002-10-18 | 2002-10-18 | Astrazeneca Ab | Method for the synthesis of a benzimidazole compound |
US7507829B2 (en) | 2002-12-19 | 2009-03-24 | Teva Pharmaceuticals Industries, Ltd | Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates |
EP1587805B1 (de) * | 2003-01-15 | 2009-04-22 | Cipla Limited | Pharmazeutisches verfahren und damit hergestellte verbindungen |
JP2006518751A (ja) * | 2003-02-20 | 2006-08-17 | サンタラス インコーポレイティッド | 胃酸の急速かつ持続的な抑制のための新規製剤、オメプラゾール制酸剤複合体−即時放出物 |
EP1601667A2 (de) * | 2003-03-12 | 2005-12-07 | Teva Pharmaceutical Industries Limited | Kristalline und amorphe festformen von pantoprazol und vervahren zu ihrer herstellung |
EP1615913A2 (de) | 2003-06-10 | 2006-01-18 | Teva Pharmaceutical Industries Limited | Verfahren zur herstellung von (pyridinyl)methyl]sulfinyl-substituierte benzimidazoles und neue chlorierte derivate von pantoprazole |
US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
CA2531564C (en) * | 2003-07-18 | 2016-01-19 | Santarus, Inc. | Pharmaceutical composition for inhibiting acid secretion |
TWI337877B (en) * | 2003-07-18 | 2011-03-01 | Santarus Inc | Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders |
US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
CN1946722A (zh) * | 2004-04-28 | 2007-04-11 | 奥坦纳医药公司 | 二烷氧基咪唑并吡啶衍生物 |
US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
CA2570795C (en) * | 2004-06-24 | 2013-05-28 | Astrazeneca Ab | Process for the preparation of crystal modifications for use in the preparation of esomeprazole sodium salt |
GB0525710D0 (en) * | 2005-12-17 | 2006-01-25 | Pliva Hrvatska D O O | An improved process for preparing of substituted 2-benzimidazolesulfoxide compounds |
WO2008017020A2 (en) * | 2006-08-03 | 2008-02-07 | Dr. Reddy's Laboratories Limited | Process for preparing proton pump inhibitors |
US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
EP2114919A2 (de) | 2007-01-31 | 2009-11-11 | Krka Tovarna Zdravil, D.D., Novo Mesto | Verfahren zur herstellung von optisch reinem omeprazol durch salzbildung mit einem chiralen amin oder behandlung mit einem enantiomer umwandelnden enzym und chromatographische auftrennung |
WO2010134099A1 (en) | 2009-05-21 | 2010-11-25 | Cadila Healthcare Limited | One pot process for preparing omeprazole and related compounds |
WO2013108068A1 (en) | 2012-01-21 | 2013-07-25 | Jubilant Life Sciences Limited | Process for the preparation of 2-pyridinylmethylsulfinyl benzimidazoles, their analogs and optically active enantiomers |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4483781A (en) * | 1983-09-02 | 1984-11-20 | The Procter & Gamble Company | Magnesium salts of peroxycarboxylic acids |
JPS6150978A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
JPS61178919A (ja) * | 1985-02-04 | 1986-08-11 | Banyu Pharmaceut Co Ltd | ベンズイミダゾ−ル誘導体およびそれを含有する医薬 |
JPS62201884A (ja) * | 1986-02-28 | 1987-09-05 | Tokyo Tanabe Co Ltd | ベンズイミダゾール誘導体及びその製造法 |
JPH0643426B2 (ja) * | 1986-07-25 | 1994-06-08 | 東京田辺製薬株式会社 | イミダゾ〔4,5−b〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤 |
FI864046A (fi) * | 1986-10-07 | 1988-04-08 | Farmos Oy | Foerfarande foer framstaellning av en terapeutiskt aktiv foerening. |
FI90544C (fi) * | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
DE3722810A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung |
DK171989B1 (da) * | 1987-08-04 | 1997-09-08 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler |
AU2817989A (en) * | 1987-12-11 | 1989-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel benzimidazole derivatives |
SE8804628D0 (sv) * | 1988-12-22 | 1988-12-22 | Ab Haessle | New compounds |
SE8804629D0 (sv) * | 1988-12-22 | 1988-12-22 | Ab Haessle | New therapeutically active compounds |
FR2660313B1 (fr) * | 1990-04-02 | 1992-07-03 | Fournier Ind & Sante | Nouveau sulfonyl-phenyl-betha-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique. |
-
1992
- 1992-09-11 NZ NZ244301A patent/NZ244301A/xx not_active IP Right Cessation
- 1992-09-11 WO PCT/US1992/007712 patent/WO1993006097A1/en active Search and Examination
- 1992-09-12 AT AT92202792T patent/ATE186535T1/de not_active IP Right Cessation
- 1992-09-12 DK DK92202792T patent/DK0533264T3/da active
- 1992-09-12 PT PT92202792T patent/PT533264E/pt unknown
- 1992-09-12 ES ES92202792T patent/ES2143468T3/es not_active Expired - Lifetime
- 1992-09-12 DE DE69230278T patent/DE69230278T2/de not_active Expired - Fee Related
- 1992-09-12 EP EP92202792A patent/EP0533264B1/de not_active Expired - Lifetime
- 1992-09-14 IL IL10315692A patent/IL103156A/xx not_active IP Right Cessation
- 1992-09-14 JP JP4244822A patent/JPH0720956B2/ja not_active Expired - Fee Related
- 1992-09-17 CA CA002078517A patent/CA2078517C/en not_active Expired - Fee Related
- 1992-09-18 AU AU25207/92A patent/AU649355B2/en not_active Ceased
- 1992-09-18 MX MX9205333A patent/MX9205333A/es not_active IP Right Cessation
- 1992-09-18 KR KR1019920016990A patent/KR100242622B1/ko not_active IP Right Cessation
- 1992-09-19 CN CN92110899A patent/CN1048729C/zh not_active Expired - Fee Related
- 1992-10-07 YU YU89492A patent/YU48291B/sh unknown
-
1993
- 1993-02-22 US US08/022,804 patent/US5391752A/en not_active Expired - Lifetime
-
2000
- 2000-02-09 GR GR20000400318T patent/GR3032619T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2078517A1 (en) | 1993-03-21 |
JPH0720956B2 (ja) | 1995-03-08 |
US5391752A (en) | 1995-02-21 |
AU649355B2 (en) | 1994-05-19 |
DE69230278T2 (de) | 2001-04-05 |
CN1071169A (zh) | 1993-04-21 |
IL103156A0 (en) | 1993-02-21 |
WO1993006097A1 (en) | 1993-04-01 |
EP0533264A1 (de) | 1993-03-24 |
MX9205333A (es) | 1993-07-01 |
KR100242622B1 (ko) | 2000-03-02 |
NZ244301A (en) | 1994-08-26 |
AU2520792A (en) | 1993-03-25 |
DE69230278D1 (de) | 1999-12-16 |
YU89492A (sh) | 1995-10-03 |
IL103156A (en) | 1997-02-18 |
KR930006021A (ko) | 1993-04-20 |
PT533264E (pt) | 2000-05-31 |
EP0533264B1 (de) | 1999-11-10 |
YU48291B (sh) | 1998-05-15 |
JPH05213936A (ja) | 1993-08-24 |
ES2143468T3 (es) | 2000-05-16 |
CA2078517C (en) | 2003-11-04 |
GR3032619T3 (en) | 2000-05-31 |
DK0533264T3 (da) | 2000-05-15 |
CN1048729C (zh) | 2000-01-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEIH | Change in the person of patent owner | ||
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |