YU220890A - Imunostimulatorni 6-aril-5,6-dihidroimidazo-/ 2,1-b/tiazol derivati - Google Patents
Imunostimulatorni 6-aril-5,6-dihidroimidazo-/ 2,1-b/tiazol derivatiInfo
- Publication number
- YU220890A YU220890A YU220890A YU220890A YU220890A YU 220890 A YU220890 A YU 220890A YU 220890 A YU220890 A YU 220890A YU 220890 A YU220890 A YU 220890A YU 220890 A YU220890 A YU 220890A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- aryl
- 6alkyl
- immunostimulator
- dihydroimidazo
- derivatives
- Prior art date
Links
- 150000007979 thiazole derivatives Chemical class 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- -1 nitro, amino Chemical group 0.000 abstract 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004658 aryl carbonyl amino group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
IMUNOSTIMULATORNI 6-ARIL-5,6-DIHIDROIMIDAZO-/ 2,1-B/TIAZOL DERIVATI. Pronalazak se odnosi na nove 6-aril-5,6-dihroimidazolo/2,11-b/ triazol derivate opšte formule I: gde Ar je fenil supstituisan sa nekim od supsetituenata iz grupe koju čine, halo, hidroksi, C1-6alkoksi, merkapto, C1-6alkiltio, C1-6alkil, nitro, amino, mono i di (C1-6alkil)-amino, C1-6alkilkarbonilamino, aričkarbonilamino, C1-6alkilsulfonilamino, trifluorometil, ciano, aminokarbonil, piridinil, tienil, furanil, R1 i R2 svaki nezavisno su C1-20alkil, (C3-7cikloalkil)C1-6alkil, C3-7cikloalkil, aril ili (aril)C1-6alkil i jedan od R1 i R2 može biti vodonik ili zajedno mogu da grade C3-6alkandili radikal, kao i na postupak za dobivanje ovih derivata.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HRP-2208/90A HRP930481A2 (en) | 1989-11-24 | 1993-03-23 | IMMUNOSIMULATING 6-ARYL-5,6-DIHYDROIMIDAZO/2,1-b/THIAZOLE DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44084289A | 1989-11-24 | 1989-11-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU220890A true YU220890A (sh) | 1992-12-21 |
| YU47955B YU47955B (sh) | 1996-07-24 |
Family
ID=23750399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU220890A YU47955B (sh) | 1989-11-24 | 1990-11-20 | Imunostimulatorni 6-aril-5,6-dihidromidazo (2,1-b) tiazol derivati i postupak za njihovo dobijanje |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0430334B1 (sh) |
| JP (1) | JPH03170487A (sh) |
| KR (1) | KR910009714A (sh) |
| CN (1) | CN1032754C (sh) |
| AT (1) | ATE127795T1 (sh) |
| AU (1) | AU630766B2 (sh) |
| BG (1) | BG60587B1 (sh) |
| CA (1) | CA2028756A1 (sh) |
| CZ (1) | CZ281422B6 (sh) |
| DE (1) | DE69022370T2 (sh) |
| FI (1) | FI93459C (sh) |
| HU (1) | HU206361B (sh) |
| IE (1) | IE67656B1 (sh) |
| IL (1) | IL96435A (sh) |
| MY (1) | MY131024A (sh) |
| NO (1) | NO300065B1 (sh) |
| NZ (1) | NZ236026A (sh) |
| PL (1) | PL165413B1 (sh) |
| PT (1) | PT95978B (sh) |
| RO (1) | RO108869B1 (sh) |
| RU (1) | RU2051153C1 (sh) |
| YU (1) | YU47955B (sh) |
| ZA (1) | ZA909445B (sh) |
| ZM (1) | ZM5390A1 (sh) |
| ZW (1) | ZW17890A1 (sh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0524055A1 (fr) * | 1991-07-19 | 1993-01-20 | Synthelabo | Dérivés d'imidazo[2,1-b]benzothiazole-3-acétamide, leur préparation et leur application en thérapeutique |
| US6165253A (en) * | 1994-05-23 | 2000-12-26 | New Jersey Institute Of Technology | Apparatus for removal of volatile organic compounds from gaseous mixtures |
| EP1797880A3 (en) * | 1999-01-29 | 2010-04-28 | Board Of Trustees Of The University Of Illinois | P53 inhibitors and their use for the treatment of cancer, hyperthermia, hypoxia, a burn, trauma to the central nervous system, a seizure, acute inflammation, tissue ageing, preservation of organs for transplant and preparation of a host for bone marrow transplant |
| DE60037394T2 (de) | 1999-01-29 | 2009-01-02 | The Board Of Trustees For The University Of Illinois, Urbana | VERWENDUNG VON p53 INHIBITOREN ZUR BEHANDLUNG VON NEBENERSCHEINUNGEN BEI DER KREBSTHERAPIE |
| CA2580126C (en) | 2004-09-28 | 2014-08-26 | Quark Biotech, Inc. | Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases |
| US7825099B2 (en) | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
| US7910566B2 (en) | 2006-03-09 | 2011-03-22 | Quark Pharmaceuticals Inc. | Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA |
| ES2474176T3 (es) | 2007-06-27 | 2014-07-08 | Quark Pharmaceuticals, Inc. | Composiciones y métodos para inhibir la expresión de genes pro-apopt�ticos |
| CN104557979A (zh) * | 2013-10-23 | 2015-04-29 | 丹阳恒安化学科技研究所有限公司 | 盐酸左旋咪唑的制备方法 |
| RU2763739C1 (ru) * | 2021-06-28 | 2021-12-30 | Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) | (Z)-9-ароил-8-гидрокси-6-(2-гидроксифенил)-2-(((Z)-2-оксоиндолин-3-илиден)гидразоно)-1-тиа-3,6-диазаспиро[4.4]нон-8-ен-4,7-дионы, обладающие противомикробной активностью |
| WO2023093700A1 (zh) * | 2021-11-29 | 2023-06-01 | 中国海洋大学 | 咪唑并噻唑衍生物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU409983B2 (en) * | 1965-07-19 | 1970-12-31 | Imperial Chemical Industries Of Australia New Zealand Limited | Process for the manufacture of thia zolidines and thiazolidines produced thereby |
| GB1444743A (en) * | 1973-09-20 | 1976-08-04 | Pfizer Ltd | 7-substituted imidazo-1,1-b-thiazolium and 9-substituted thiazolo-3,2-a-benzimidazolium derivatives having hypogly caemic and/or growth promotant properties |
| US4340738A (en) * | 1979-06-21 | 1982-07-20 | Janssen Pharmaceutica, N.V. | 2,3-Dihydro-imidazo[2,1-b]benzothiazoles |
-
1990
- 1990-10-29 CA CA002028756A patent/CA2028756A1/en not_active Abandoned
- 1990-11-09 NZ NZ236026A patent/NZ236026A/xx unknown
- 1990-11-15 AT AT90203031T patent/ATE127795T1/de active
- 1990-11-15 DE DE69022370T patent/DE69022370T2/de not_active Expired - Fee Related
- 1990-11-15 EP EP90203031A patent/EP0430334B1/en not_active Expired - Lifetime
- 1990-11-17 JP JP2310193A patent/JPH03170487A/ja active Pending
- 1990-11-20 YU YU220890A patent/YU47955B/sh unknown
- 1990-11-21 AU AU66809/90A patent/AU630766B2/en not_active Ceased
- 1990-11-21 MY MYPI90002052A patent/MY131024A/en unknown
- 1990-11-22 BG BG93298A patent/BG60587B1/bg unknown
- 1990-11-22 CZ CS905803A patent/CZ281422B6/cs unknown
- 1990-11-22 IL IL9643590A patent/IL96435A/en not_active IP Right Cessation
- 1990-11-23 HU HU907633A patent/HU206361B/hu not_active IP Right Cessation
- 1990-11-23 KR KR1019900019029A patent/KR910009714A/ko not_active Application Discontinuation
- 1990-11-23 PT PT95978A patent/PT95978B/pt not_active IP Right Cessation
- 1990-11-23 ZW ZW178/90A patent/ZW17890A1/xx unknown
- 1990-11-23 PL PL90287907A patent/PL165413B1/pl unknown
- 1990-11-23 IE IE424190A patent/IE67656B1/en not_active IP Right Cessation
- 1990-11-23 ZM ZM53/90A patent/ZM5390A1/xx unknown
- 1990-11-23 ZA ZA909445A patent/ZA909445B/xx unknown
- 1990-11-23 FI FI905788A patent/FI93459C/fi not_active IP Right Cessation
- 1990-11-23 RO RO146390A patent/RO108869B1/ro unknown
- 1990-11-23 RU SU904831684A patent/RU2051153C1/ru active
- 1990-11-23 NO NO905086A patent/NO300065B1/no unknown
- 1990-11-24 CN CN90109407A patent/CN1032754C/zh not_active Expired - Fee Related
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