YU16001A - Piroloindoli, piridoindoli i azepinoindoli kao 5-ht2c agonisti - Google Patents

Piroloindoli, piridoindoli i azepinoindoli kao 5-ht2c agonisti

Info

Publication number
YU16001A
YU16001A YU16001A YU16001A YU16001A YU 16001 A YU16001 A YU 16001A YU 16001 A YU16001 A YU 16001A YU 16001 A YU16001 A YU 16001A YU 16001 A YU16001 A YU 16001A
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YU
Yugoslavia
Prior art keywords
alkyl
disorders
hydrogen
independently selected
treatment
Prior art date
Application number
YU16001A
Other languages
English (en)
Inventor
David Reginald Adams
Jonathan Mark Bentley
Jonathan Richard Roffey
Richard John Hamlyn
Suneel Gaur
Matthew Alexander Duncton
James Edward Paul Davidson
Michael John Bickerdike
Ian Anthony Cliffe
Howard Langham Mansell
Original Assignee
Vernalis Research Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis Research Limited filed Critical Vernalis Research Limited
Publication of YU16001A publication Critical patent/YU16001A/sh

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Hemijsko jedinjenje formule (I), gde je n=1, 2 ili 3; R1 i R2 su nezavisno odabrani od vodonika i alkila; R3 je alkil, R4 do R7 su nezavisno odabrani od vodonika, halogena, hidroksi, alkil, aril, alkoksi, ariloksi, alkiltio, alkilsulfoksil, alkilsulfonil, arilsulfoksil, arilsulfonil, amino, monoalkilamino, dialkilamino, nitro, cijano, karboksialdehid, alkilkarbonil, arilkarbonil, aminokarbonil, monoalkilaminokarbonil, dialkilaminokarbonil, alkoksikarbonilamino, aminokarboniloksi, monoalkilaminokarboniloksi, dialkilaminokarboniloksi, monoalkilaminokarbonilamino i dialkilaminokar bonilamino grupe, ili R5 i R6 zajedno obrazuju karbociklicni ili heterociklicni prsten i njegove farmaceutski prihvatljive soli i pro-lekovi, i njegova upotreba za terapiju, narocito za tretiranje oboljenja centralnog nervnog sistema; ostecenja ventralnog nervnog sistema; kardiovaskularnih oboljenja, gastrointestinalnih oboljenja, dijabetes insipidus i poremecaja spavanja, a narocito za tretiranje gojaznosti.
YU16001A 1998-09-01 1999-09-01 Piroloindoli, piridoindoli i azepinoindoli kao 5-ht2c agonisti YU16001A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9819035.8A GB9819035D0 (en) 1998-09-01 1998-09-01 Chemical compounds VII

Publications (1)

Publication Number Publication Date
YU16001A true YU16001A (sh) 2003-10-31

Family

ID=10838167

Family Applications (1)

Application Number Title Priority Date Filing Date
YU16001A YU16001A (sh) 1998-09-01 1999-09-01 Piroloindoli, piridoindoli i azepinoindoli kao 5-ht2c agonisti

Country Status (30)

Country Link
US (1) US6433175B1 (sh)
EP (1) EP1109813B1 (sh)
JP (1) JP2002523508A (sh)
KR (2) KR20070062609A (sh)
CN (1) CN1165537C (sh)
AT (1) ATE273308T1 (sh)
AU (1) AU758084B2 (sh)
BR (1) BR9913477A (sh)
CA (1) CA2341991C (sh)
CZ (1) CZ296275B6 (sh)
DE (1) DE69919364T2 (sh)
DK (1) DK1109813T3 (sh)
ES (1) ES2226430T3 (sh)
GB (1) GB9819035D0 (sh)
HK (1) HK1034967A1 (sh)
HR (1) HRP20010126B1 (sh)
HU (1) HUP0103333A3 (sh)
ID (1) ID28842A (sh)
IL (2) IL141659A0 (sh)
MX (1) MXPA01002101A (sh)
NO (1) NO321527B1 (sh)
NZ (1) NZ510097A (sh)
PL (1) PL346427A1 (sh)
PT (1) PT1109813E (sh)
RU (1) RU2232162C2 (sh)
SI (1) SI1109813T1 (sh)
TR (2) TR200100659T2 (sh)
WO (1) WO2000012510A1 (sh)
YU (1) YU16001A (sh)
ZA (1) ZA200101457B (sh)

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ATE273308T1 (de) 2004-08-15
ZA200101457B (en) 2002-02-21
HK1034967A1 (en) 2001-11-09
AU5637599A (en) 2000-03-21
DE69919364T2 (de) 2005-08-04
NO20010991L (no) 2001-04-23
CZ2001772A3 (cs) 2001-07-11
CN1325399A (zh) 2001-12-05
EP1109813B1 (en) 2004-08-11
HUP0103333A3 (en) 2002-07-29
TR200501110T2 (tr) 2005-07-21
WO2000012510A1 (en) 2000-03-09
US6433175B1 (en) 2002-08-13
CZ296275B6 (cs) 2006-02-15
HUP0103333A2 (hu) 2002-01-28
ES2226430T3 (es) 2005-03-16
ID28842A (id) 2001-07-05
AU758084B2 (en) 2003-03-13
PT1109813E (pt) 2004-11-30
CA2341991A1 (en) 2000-03-09
CA2341991C (en) 2009-04-07
NO321527B1 (no) 2006-05-15
IL141659A0 (en) 2002-03-10
DK1109813T3 (da) 2004-12-20
IL141659A (en) 2007-10-31
GB9819035D0 (en) 1998-10-28
PL346427A1 (en) 2002-02-11
EP1109813A1 (en) 2001-06-27
BR9913477A (pt) 2001-10-09
CN1165537C (zh) 2004-09-08
KR100768595B1 (ko) 2007-10-18
MXPA01002101A (es) 2002-08-20
NZ510097A (en) 2003-06-30
NO20010991D0 (no) 2001-02-27
KR20070062609A (ko) 2007-06-15
HRP20010126B1 (en) 2005-06-30
RU2232162C2 (ru) 2004-07-10
HRP20010126A2 (en) 2002-02-28
KR20010079715A (ko) 2001-08-22
DE69919364D1 (de) 2004-09-16
SI1109813T1 (en) 2005-02-28
TR200100659T2 (tr) 2001-10-22
JP2002523508A (ja) 2002-07-30

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