YU14502A - Farmaceutska kombinacija etinilestradiola i drospirenona za primenu kao kontraceptivnog sredstva - Google Patents

Farmaceutska kombinacija etinilestradiola i drospirenona za primenu kao kontraceptivnog sredstva

Info

Publication number
YU14502A
YU14502A YU14502A YUP14502A YU14502A YU 14502 A YU14502 A YU 14502A YU 14502 A YU14502 A YU 14502A YU P14502 A YUP14502 A YU P14502A YU 14502 A YU14502 A YU 14502A
Authority
YU
Yugoslavia
Prior art keywords
ethinylestradiol
daily dosage
drospirenone
active agent
composition
Prior art date
Application number
YU14502A
Other languages
English (en)
Inventor
Wolfgang Heil
Jurgen Hilman
Ralph Lipp
Renate Heithecker
Original Assignee
Schering Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26153359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU14502(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag. filed Critical Schering Ag.
Publication of YU14502A publication Critical patent/YU14502A/sh
Publication of RS50262B publication Critical patent/RS50262B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Farmaceutska kompozicija koja sadrzi, kao prvo aktivno sredstvo, 6ß, 7ß; 15ß,16ß-dimetilen-3-okso-17α-pregn-4-en-21,17,-karbolakton (drospirenon) u kolicini koja odgovara jednoj dnevnoj dozi, nakon davanja kompozicije, od oko 2 mg do oko 4 mg, i, kao drugo aktivno sredstvo, 17α-etinilestradiol (etinilestra-diol) u kolicini koja odgovara dnevnoj dozi od oko 0,01 mg do oko 0,05 mg, zajedno sa jednim ili vise farmaceutski prihvatljivih nosaca ili neutralnih dodataka. Kod jednog posebnog izvodenja, kompozicija se sastoji od vise odvojeno pakovanih i pojedinacno odvojivih dnevnih doznih jedinica postavljenih u jednu jedinicu pakovanja i namenjenih za oralno davanje u trajanju od najamnje 21 dan zaredom, pri cemu pomenute dnevne dozne jedinice sadrze svaka jednu kombinaciju drospirenona i etinilestradiola. Kompozicija moze dalje sadrzati 7 ili manje dnevnih doznih jedinica koje ne sadrze nikakvo aktivno sredstvo ili sadrze sam etinilestradiol.
YU14502A 1999-08-31 2000-08-31 Farmaceutska kombinacija etinilestradiola i drospirenona za primenu kao kontraceptivnog sredstva RS50262B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38627499A 1999-08-31 1999-08-31
EP99202826 1999-08-31

Publications (2)

Publication Number Publication Date
YU14502A true YU14502A (sh) 2006-01-16
RS50262B RS50262B (sr) 2009-07-15

Family

ID=26153359

Country Status (26)

Country Link
EP (4) EP1598069B1 (sh)
JP (2) JP4354667B2 (sh)
KR (2) KR101019361B1 (sh)
AT (3) ATE420648T1 (sh)
AU (4) AU780330B2 (sh)
BG (1) BG66114B1 (sh)
BR (1) BR0014159A (sh)
CY (3) CY1108990T1 (sh)
CZ (1) CZ300514B6 (sh)
DE (5) DE60042089D1 (sh)
DK (3) DK1380301T3 (sh)
EE (1) EE05128B1 (sh)
ES (3) ES2319750T3 (sh)
HK (3) HK1047247B (sh)
HR (1) HRP20070188B1 (sh)
HU (1) HU227207B1 (sh)
IL (1) IL148339A0 (sh)
ME (2) ME00329B (sh)
NO (1) NO326860B1 (sh)
NZ (1) NZ517845A (sh)
PL (1) PL199028B1 (sh)
PT (3) PT1598069E (sh)
RS (3) RS20090134A (sh)
SI (3) SI1214076T1 (sh)
TW (1) TWI276436B (sh)
WO (1) WO2001015701A1 (sh)

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US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
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Also Published As

Publication number Publication date
AU780330B2 (en) 2005-03-17
CZ2002615A3 (cs) 2002-08-14
EP1214076A1 (en) 2002-06-19
EP2044941A1 (en) 2009-04-08
DE122009000007I2 (de) 2011-07-21
PT1214076E (pt) 2004-04-30
ATE420648T1 (de) 2009-01-15
EP1598069B1 (en) 2009-04-22
CY1108990T1 (el) 2014-02-12
BG66114B1 (bg) 2011-05-31
CZ300514B6 (cs) 2009-06-03
EP1598069A3 (en) 2006-04-05
AU2009200247B2 (en) 2010-07-01
CY2009015I1 (el) 2014-02-12
TWI276436B (en) 2007-03-21
WO2001015701A1 (en) 2001-03-08
AU2005202046A1 (en) 2005-06-09
EP1380301B1 (en) 2009-01-14
EE05128B1 (et) 2009-02-16
DK1380301T3 (da) 2009-04-20
DE122009000007I1 (de) 2009-05-07
ME00329B (me) 2011-05-10
PT1598069E (pt) 2009-07-20
MEP36008A (en) 2011-02-10
AU2005202046B9 (en) 2008-12-11
HUP0202500A2 (en) 2002-10-28
RS20090134A (en) 2009-11-10
DE60042089D1 (de) 2009-06-04
ATE254464T1 (de) 2003-12-15
HK1047247B (zh) 2004-07-23
KR20070067248A (ko) 2007-06-27
RS50262B2 (sr) 2018-10-31
SI1214076T1 (en) 2004-06-30
DE60006692D1 (de) 2003-12-24
BR0014159A (pt) 2002-05-07
HK1061968A1 (en) 2004-10-15
AU2009200247A1 (en) 2009-02-19
RS50262B (sr) 2009-07-15
KR100857344B1 (ko) 2008-09-05
EP1598069A2 (en) 2005-11-23
DE60006692T2 (de) 2004-09-23
HUP0202500A3 (en) 2004-04-28
HK1047247A1 (en) 2003-02-14
DK1214076T3 (da) 2004-02-23
NZ517845A (en) 2004-12-24
HRP20070188B1 (hr) 2015-06-19
JP2009143959A (ja) 2009-07-02
DE122009000006I1 (de) 2009-05-07
HK1082432A1 (en) 2006-06-09
NO326860B1 (no) 2009-03-02
SI1380301T1 (sl) 2009-06-30
DE60041421D1 (de) 2009-03-05
KR101019361B1 (ko) 2011-03-07
CY1109252T1 (el) 2014-07-02
PL199028B1 (pl) 2008-08-29
CY2009015I2 (el) 2014-02-12
SI1598069T1 (sl) 2009-10-31
NO20020801D0 (no) 2002-02-19
DK1598069T3 (da) 2009-07-06
PT1380301E (pt) 2009-03-30
ES2319750T3 (es) 2009-05-12
HRP20070188A2 (en) 2007-07-31
AU2005202046B2 (en) 2008-11-20
PL354406A1 (en) 2004-01-12
AU2010226924A1 (en) 2010-10-28
EE200200110A (et) 2003-06-16
ES2325589T3 (es) 2009-09-09
EP1380301A1 (en) 2004-01-14
HU227207B1 (en) 2010-11-29
JP2003508441A (ja) 2003-03-04
ATE429231T1 (de) 2009-05-15
EP1214076B1 (en) 2003-11-19
NO20020801L (no) 2002-04-26
DE122009000006I2 (de) 2012-03-22
ES2211580T3 (es) 2004-07-16
KR20020040798A (ko) 2002-05-30
IL148339A0 (en) 2002-09-12
AU6589500A (en) 2001-03-26
JP4354667B2 (ja) 2009-10-28

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