CY2009015I2 - Φαρμακευτικος συνδυασμος αιθινυλεστραδιολης και δροπιρενονης για χρηση ως αντισυλληπτικο - Google Patents

Φαρμακευτικος συνδυασμος αιθινυλεστραδιολης και δροπιρενονης για χρηση ως αντισυλληπτικο

Info

Publication number
CY2009015I2
CY2009015I2 CY2009015C CY2009015C CY2009015I2 CY 2009015 I2 CY2009015 I2 CY 2009015I2 CY 2009015 C CY2009015 C CY 2009015C CY 2009015 C CY2009015 C CY 2009015C CY 2009015 I2 CY2009015 I2 CY 2009015I2
Authority
CY
Cyprus
Prior art keywords
dropirenone
ethinylestradiol
pharmaceutical combination
contraceptive use
contraceptive
Prior art date
Application number
CY2009015C
Other languages
English (en)
Other versions
CY2009015I1 (el
Original Assignee
Bayer Schering Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26153359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2009015(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Aktiengesellschaft filed Critical Bayer Schering Pharma Aktiengesellschaft
Publication of CY2009015I1 publication Critical patent/CY2009015I1/el
Publication of CY2009015I2 publication Critical patent/CY2009015I2/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28Antiandrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CY2009015C 1999-08-31 2009-09-25 Φαρμακευτικος συνδυασμος αιθινυλεστραδιολης και δροπιρενονης για χρηση ως αντισυλληπτικο CY2009015I2 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38627499A 1999-08-31 1999-08-31
EP99202826 1999-08-31
EP00953387A EP1214076B1 (en) 1999-08-31 2000-08-31 Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive
EP03017743A EP1380301B1 (en) 1999-08-31 2000-08-31 Pharmaceutical combination of ethinylestradiol and dropirenone for use as a contraceptive

Publications (2)

Publication Number Publication Date
CY2009015I1 CY2009015I1 (el) 2014-02-12
CY2009015I2 true CY2009015I2 (el) 2014-02-12

Family

ID=26153359

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20091100446T CY1108990T1 (el) 1999-08-31 2009-04-14 Φαρμακευτικος συνδυασμος αιθινυλεστραδιολης και δροπιρενονης για χρηση ως αντισυλληπτικο
CY20091100784T CY1109252T1 (el) 1999-08-31 2009-07-22 Φαρμακευτικος συνδυασμος αιθινυλοιστραδιολης και δροσπιρενονης για χρηση ως αντισυλληπτικο
CY2009015C CY2009015I2 (el) 1999-08-31 2009-09-25 Φαρμακευτικος συνδυασμος αιθινυλεστραδιολης και δροπιρενονης για χρηση ως αντισυλληπτικο

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CY20091100446T CY1108990T1 (el) 1999-08-31 2009-04-14 Φαρμακευτικος συνδυασμος αιθινυλεστραδιολης και δροπιρενονης για χρηση ως αντισυλληπτικο
CY20091100784T CY1109252T1 (el) 1999-08-31 2009-07-22 Φαρμακευτικος συνδυασμος αιθινυλοιστραδιολης και δροσπιρενονης για χρηση ως αντισυλληπτικο

Country Status (26)

Country Link
EP (4) EP1598069B1 (el)
JP (2) JP4354667B2 (el)
KR (2) KR100857344B1 (el)
AT (3) ATE420648T1 (el)
AU (4) AU780330B2 (el)
BG (1) BG66114B1 (el)
BR (1) BR0014159A (el)
CY (3) CY1108990T1 (el)
CZ (1) CZ300514B6 (el)
DE (5) DE60041421D1 (el)
DK (3) DK1598069T3 (el)
EE (1) EE05128B1 (el)
ES (3) ES2319750T3 (el)
HK (3) HK1047247B (el)
HR (1) HRP20070188B1 (el)
HU (1) HU227207B1 (el)
IL (1) IL148339A0 (el)
ME (2) MEP36008A (el)
NO (1) NO326860B1 (el)
NZ (1) NZ517845A (el)
PL (1) PL199028B1 (el)
PT (3) PT1214076E (el)
RS (3) RS50262B2 (el)
SI (3) SI1380301T1 (el)
TW (1) TWI276436B (el)
WO (1) WO2001015701A1 (el)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1598069B1 (en) * 1999-08-31 2009-04-22 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive
PT1611892E (pt) * 2000-01-18 2009-11-20 Bayer Schering Pharma Ag Composições farmacêuticas compreendendo drospirenona
JO2334B1 (en) * 2000-01-18 2006-06-28 باير شيرنغ فارما اكتنجيسيلشافت Drospirenone for hormone replacement therapy
AU2002222387A1 (en) * 2000-12-20 2002-07-01 Schering Aktiengesellschaft Cyclodextrin-drospirenone inclusion complexes
EP1216713A1 (en) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions of estrogen-cyclodextrin complexes
RU2373940C2 (ru) * 2002-04-26 2009-11-27 "Байер Шеринг Фарма Акциенгезельшафт" Лечение гипертензии у женщин, подвергающихся гормонзаместительной терапии
US7786101B2 (en) 2002-11-05 2010-08-31 Bayer Schering Pharma Ag Cardiovascular protection using anti-aldosteronic progestins
SI1748756T1 (sl) * 2004-03-10 2009-10-31 Bayer Schering Pharma Ag Sestavki, ki obsegajo molekularno dispergiran drospirenon
MY142989A (en) 2004-03-10 2011-02-14 Bayer Schering Pharma Ag Stabilised supersaturated solids of lipophilic drugs
MY151322A (en) * 2004-04-30 2014-05-15 Bayer Ip Gmbh Management of breakthrough bleeding in extended hormonal contraceptive regimens
EP1625849A1 (en) * 2004-08-09 2006-02-15 Liconsa, Liberacion Controlada de Sustancias Activas, S.A. Pharmaceutical composition comprising drospirenone and ethynylestradiol
US8216611B2 (en) * 2005-03-30 2012-07-10 Mylan Pharmaceuticals Ulc Combined-step process for pharmaceutical compositions
UY29527A1 (es) 2005-05-13 2006-12-29 Schering Ag Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato.
EP1767194A1 (de) * 2005-06-09 2007-03-28 Helm AG Verfahren zur Herstellung von Adsorbaten des Drospirenons
US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
CN101489563A (zh) * 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
WO2008031631A2 (en) * 2006-09-16 2008-03-20 Bayer Schering Pharma Aktiengesellschaft Oral modified release formulations
EP1900359A1 (en) * 2006-09-16 2008-03-19 KAIROSmed GmbH Oral modified release formulations containing drospirenon and 8-prenylnaringenin for use in female contraception
WO2008122439A2 (en) * 2007-04-05 2008-10-16 Bayer Schering Pharma Aktiengesellschaft Dr0spiren0ne/17beta-estradi0l regimen, pharmaceutical combination product and kit for performing this regimen
HUP0700826A3 (en) 2007-12-20 2010-03-29 Richter Gedeon Nyrt Coated tablet containing drospirenone and process for producing the same
WO2009112231A2 (en) * 2008-03-10 2009-09-17 Schuermann Rolf New drospirenone/17beta-estradil regimen, pharmaceutical combination product and kit for performing this regimen
TW200946542A (en) * 2008-03-10 2009-11-16 Vladimir Hanes New drospirenone/17β-estradiol regimen, pharmaceutical combination product and kit for performing this regimen
WO2009138224A1 (en) * 2008-05-14 2009-11-19 Helm Ag Pharmaceutical composition comprising drospirenone
DE102008037025C5 (de) 2008-08-08 2016-07-07 Jesalis Pharma Gmbh Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform
EP2398461A1 (en) * 2009-02-18 2011-12-28 Bayer Pharma Aktiengesellschaft Formulation comprising drospirenone for subcutaneous or intramuscular administration
UY32836A (es) 2009-08-12 2011-03-31 Bayer Schering Pharma Ag Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato
AU2011240102B2 (en) * 2010-04-15 2015-07-23 Bayer Intellectual Property Gmbh Very low-dosed solid oral dosage forms for HRT
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
IT202100008834A1 (it) 2021-04-08 2022-10-08 Ind Chimica Srl Processo per la preparazione di drospirenone come polvere fine tramite duplice cambio di forma cristallina
WO2023152658A1 (en) 2022-02-10 2023-08-17 Lupin Limited Slow release drospirenone tablet composition
WO2023165988A1 (en) * 2022-03-01 2023-09-07 Chemo Research, S.L. Chewable oral contraceptive

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DE3916112A1 (de) 1989-05-16 1990-11-22 Schering Ag Dihydrospirorenon als antiandrogen
DE4227989A1 (de) 1992-08-21 1994-06-09 Schering Ag Mittel zur transdermalen Applikation enthaltend 3-Keto-desogestrel
DK95093D0 (da) * 1993-08-20 1993-08-20 Novo Nordisk As Farmaceutisk formulering indeholdende et hormon
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DE4411585A1 (de) * 1994-03-30 1995-10-05 Schering Ag Pharmazeutisches Kombinationspräparat zur hormonalen Kontrazeption
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NZ293606A (en) * 1994-09-22 1998-06-26 Akzo Nobel Nv Preparation of pharmaceutical dosage units of a steroidal progestogen by mixing with water and granulating the solution
DE19525017A1 (de) * 1995-06-28 1997-01-02 Schering Ag Pharmazeutisches Kombinatonspräparat, Kit und Methode zur hormonalen Kontrazeption
US5897539A (en) * 1995-09-28 1999-04-27 Schering Aktiengesellschaft Hormone replacement therapy method and hormone dispenser
DE19540253C2 (de) * 1995-10-28 1998-06-04 Jenapharm Gmbh Mehrphasenpräparat zur Kontrazeption auf der Basis natürlicher Estrogene
DK0917466T3 (da) * 1996-07-26 2004-12-20 Wyeth Corp Oralt antikonceptionsmiddel
AU3888697A (en) * 1996-07-26 1998-02-20 American Home Products Corporation Progestin/estrogen oral contraceptive
BR9710566A (pt) * 1996-07-26 1999-08-17 American Home Prod M-todo anticoncepcional monof sico e um kit compreendendo uma combina-Æo de uma progestina e estrog-nio
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
DE19651000A1 (de) 1996-12-01 1998-06-04 Schering Ag Oxyiminopregnancarbolactone
EP1598069B1 (en) * 1999-08-31 2009-04-22 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive
PT1611892E (pt) * 2000-01-18 2009-11-20 Bayer Schering Pharma Ag Composições farmacêuticas compreendendo drospirenona

Also Published As

Publication number Publication date
HK1061968A1 (en) 2004-10-15
ATE254464T1 (de) 2003-12-15
HK1082432A1 (en) 2006-06-09
EE05128B1 (et) 2009-02-16
NO20020801L (no) 2002-04-26
EP1214076A1 (en) 2002-06-19
AU2010226924A1 (en) 2010-10-28
BG66114B1 (bg) 2011-05-31
ME00329B (me) 2011-05-10
HUP0202500A3 (en) 2004-04-28
AU2009200247B2 (en) 2010-07-01
EP1214076B1 (en) 2003-11-19
AU2005202046B9 (en) 2008-12-11
HUP0202500A2 (en) 2002-10-28
AU2009200247A1 (en) 2009-02-19
JP2009143959A (ja) 2009-07-02
DE122009000007I1 (de) 2009-05-07
HRP20070188B1 (hr) 2015-06-19
BR0014159A (pt) 2002-05-07
EP1598069A2 (en) 2005-11-23
RS50262B2 (sr) 2018-10-31
KR20020040798A (ko) 2002-05-30
AU6589500A (en) 2001-03-26
RS20090134A (en) 2009-11-10
NO20020801D0 (no) 2002-02-19
KR100857344B1 (ko) 2008-09-05
PL199028B1 (pl) 2008-08-29
DK1598069T3 (da) 2009-07-06
NZ517845A (en) 2004-12-24
AU2005202046A1 (en) 2005-06-09
DE122009000007I2 (de) 2011-07-21
ES2211580T3 (es) 2004-07-16
JP2003508441A (ja) 2003-03-04
PT1598069E (pt) 2009-07-20
DE60041421D1 (de) 2009-03-05
JP4354667B2 (ja) 2009-10-28
ES2319750T3 (es) 2009-05-12
CY2009015I1 (el) 2014-02-12
KR101019361B1 (ko) 2011-03-07
AU780330B2 (en) 2005-03-17
TWI276436B (en) 2007-03-21
EP2044941A1 (en) 2009-04-08
DE122009000006I1 (de) 2009-05-07
EP1598069A3 (en) 2006-04-05
EP1598069B1 (en) 2009-04-22
NO326860B1 (no) 2009-03-02
SI1214076T1 (en) 2004-06-30
EP1380301A1 (en) 2004-01-14
CZ2002615A3 (cs) 2002-08-14
AU2005202046B2 (en) 2008-11-20
HU227207B1 (en) 2010-11-29
DE60006692T2 (de) 2004-09-23
DE60006692D1 (de) 2003-12-24
ATE429231T1 (de) 2009-05-15
CY1109252T1 (el) 2014-07-02
PT1214076E (pt) 2004-04-30
MEP36008A (en) 2011-02-10
DE60042089D1 (de) 2009-06-04
ES2325589T3 (es) 2009-09-09
ATE420648T1 (de) 2009-01-15
SI1598069T1 (sl) 2009-10-31
CZ300514B6 (cs) 2009-06-03
PL354406A1 (en) 2004-01-12
EP1380301B1 (en) 2009-01-14
HK1047247A1 (en) 2003-02-14
DK1380301T3 (da) 2009-04-20
KR20070067248A (ko) 2007-06-27
HRP20070188A2 (en) 2007-07-31
HK1047247B (zh) 2004-07-23
PT1380301E (pt) 2009-03-30
IL148339A0 (en) 2002-09-12
DK1214076T3 (da) 2004-02-23
RS50262B (sr) 2009-07-15
WO2001015701A1 (en) 2001-03-08
SI1380301T1 (sl) 2009-06-30
DE122009000006I2 (de) 2012-03-22
YU14502A (sh) 2006-01-16
CY1108990T1 (el) 2014-02-12
EE200200110A (et) 2003-06-16

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