YU1396A - 2,9-disupstituisani purin-6-oni, postupak za njihovo pripremanje i njihova primena u lekovima - Google Patents

2,9-disupstituisani purin-6-oni, postupak za njihovo pripremanje i njihova primena u lekovima

Info

Publication number
YU1396A
YU1396A YU1396A YU1396A YU1396A YU 1396 A YU1396 A YU 1396A YU 1396 A YU1396 A YU 1396A YU 1396 A YU1396 A YU 1396A YU 1396 A YU1396 A YU 1396A
Authority
YU
Yugoslavia
Prior art keywords
ones
medicaments
preparation
application
disubstituted purine
Prior art date
Application number
YU1396A
Other languages
English (en)
Inventor
Ulrich Niewohner
Erwin Bishoff
Helmuth Schutz
Elisabeth Perzobron
Matthias Schramm
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of YU1396A publication Critical patent/YU1396A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

2,9-disupstituisani purin-6-oni, formule I, u kojoj A, R1, R2, R3, R4 imaju značenja data u 1. patentnom zahtevu, pripremaju se kada se u prvom stupnju aciluju odgovarajuće supstituisani aminoimidazoli, pa se zatim ciklizuju u purin. Novi 2,9-disupstituisani purin-6-oni mogu da se upotrebe kao delotvorne supstance u lekovima, naročito za lečenje zapaljivih procesa, tromboembolijskih, srčanih i oboljenja krvotoka, i oboljenja urogenitalnog sistema.
YU1396A 1995-01-19 1996-01-12 2,9-disupstituisani purin-6-oni, postupak za njihovo pripremanje i njihova primena u lekovima YU1396A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19501482A DE19501482A1 (de) 1995-01-19 1995-01-19 2,9-disubstituierte Purin-6-one

Publications (1)

Publication Number Publication Date
YU1396A true YU1396A (sh) 1999-03-04

Family

ID=7751830

Family Applications (1)

Application Number Title Priority Date Filing Date
YU1396A YU1396A (sh) 1995-01-19 1996-01-12 2,9-disupstituisani purin-6-oni, postupak za njihovo pripremanje i njihova primena u lekovima

Country Status (31)

Country Link
US (1) US5861404A (sh)
EP (1) EP0722944A1 (sh)
JP (1) JPH08231545A (sh)
KR (1) KR960029334A (sh)
CN (1) CN1135485A (sh)
AR (1) AR002953A1 (sh)
AU (1) AU4097996A (sh)
BG (1) BG61728B1 (sh)
BR (1) BR9600147A (sh)
CA (1) CA2167353A1 (sh)
CO (1) CO4700523A1 (sh)
CZ (1) CZ16696A3 (sh)
DE (1) DE19501482A1 (sh)
EE (1) EE9600018A (sh)
FI (1) FI960225A (sh)
HR (1) HRP960007A2 (sh)
HU (1) HUP9600106A3 (sh)
IL (1) IL116769A (sh)
MA (1) MA23778A1 (sh)
NO (1) NO960223L (sh)
NZ (1) NZ280830A (sh)
PE (1) PE64996A1 (sh)
PL (1) PL312354A1 (sh)
SG (1) SG50401A1 (sh)
SK (1) SK8096A3 (sh)
SV (1) SV1996000006A (sh)
TN (2) TNSN96006A1 (sh)
TR (1) TR199600028A2 (sh)
TW (1) TW314519B (sh)
YU (1) YU1396A (sh)
ZA (1) ZA96398B (sh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19529102A1 (de) * 1995-08-08 1997-02-13 Kummer Horst Dieter Verwendung von PDE-Inhibitoren bei der Behandlung von Harnblasenerkrankungen
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
EP0999211A4 (en) * 1997-07-15 2001-09-19 Japan Energy Corp PURINE DERIVATIVES AND THEIR MEDICINAL APPLICATION
EP1043324B1 (en) 1997-11-12 2004-06-16 Mitsubishi Chemical Corporation Purine derivatives and medicine containing the same as the active ingredient
AU1688599A (en) * 1998-01-05 1999-07-26 Eisai Co. Ltd. Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes
US6268372B1 (en) 1998-09-11 2001-07-31 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
US6124303A (en) * 1998-09-11 2000-09-26 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 9-substituted 2-(2-N-aloxyphenyl) purin-6-ones
CA2373015A1 (en) * 1999-05-11 2000-11-16 Mitsubishi Chemical Corporation Purine derivative dihydrate, drugs containing the same as the active ingredient and intermediate in the production thereof
GB9924020D0 (en) 1999-10-11 1999-12-15 Pfizer Ltd Pharmaceutically active compounds
CN1264574C (zh) * 2000-09-06 2006-07-19 田边制药株式会社 口服制剂
CA2437754C (en) * 2001-02-15 2010-05-18 Tanabe Seiyaku Co., Ltd. Tablets quickly disintegrated in oral cavity
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
US7276529B2 (en) 2002-03-20 2007-10-02 Celgene Corporation Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7208516B2 (en) 2002-03-20 2007-04-24 Celgene Corporation Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
CN102742513A (zh) * 2012-07-17 2012-10-24 南京熊猫机电制造有限公司 一种喂食栏装置
ES2749433T3 (es) 2014-06-23 2020-03-20 Celgene Corp Apremilast para el tratamiento de una enfermedad hepática o una anomalía de la función hepática
SG11202110742TA (en) 2019-04-02 2021-10-28 Aligos Therapeutics Inc Compounds targeting prmt5

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451478A (en) * 1982-03-12 1984-05-29 Newport Pharmaceuticals International, Inc. Imidazole compounds
IL76546A (en) * 1984-10-12 1988-12-30 Warner Lambert Co 9-(heteroarylalkyl)-6-purine(thi)one derivatives,their preparation and pharmaceutical compositions containing them
GB9213623D0 (en) * 1992-06-26 1992-08-12 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
SV1996000006A (es) 1996-10-29
TNSN96007A1 (fr) 2005-03-15
US5861404A (en) 1999-01-19
CA2167353A1 (en) 1996-07-20
SG50401A1 (en) 1998-07-20
CZ16696A3 (en) 1996-08-14
AU4097996A (en) 1996-07-25
HRP960007A2 (en) 1998-02-28
BG61728B1 (bg) 1998-04-30
DE19501482A1 (de) 1996-07-25
AR002953A1 (es) 1998-05-27
FI960225A0 (fi) 1996-01-17
IL116769A0 (en) 1996-05-14
PL312354A1 (en) 1996-07-22
NZ280830A (en) 1998-04-27
HUP9600106A3 (en) 1998-04-28
NO960223D0 (no) 1996-01-18
CN1135485A (zh) 1996-11-13
EP0722944A1 (de) 1996-07-24
CO4700523A1 (es) 1998-12-29
IL116769A (en) 1998-12-06
JPH08231545A (ja) 1996-09-10
KR960029334A (ko) 1996-08-17
MA23778A1 (fr) 1996-10-01
HU9600106D0 (en) 1996-03-28
NO960223L (no) 1996-07-22
TW314519B (sh) 1997-09-01
PE64996A1 (es) 1997-03-09
TR199600028A2 (tr) 1996-08-21
SK8096A3 (en) 1996-08-07
BR9600147A (pt) 1998-01-06
HUP9600106A2 (en) 1997-05-28
BG100292A (bg) 1996-07-31
FI960225A (fi) 1996-07-20
ZA96398B (en) 1996-08-28
TNSN96006A1 (fr) 2005-03-15
EE9600018A (et) 1996-08-15

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