WO2023280120A1 - 一种包含内部微流道的打印头 - Google Patents

一种包含内部微流道的打印头 Download PDF

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Publication number
WO2023280120A1
WO2023280120A1 PCT/CN2022/103715 CN2022103715W WO2023280120A1 WO 2023280120 A1 WO2023280120 A1 WO 2023280120A1 CN 2022103715 W CN2022103715 W CN 2022103715W WO 2023280120 A1 WO2023280120 A1 WO 2023280120A1
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Prior art keywords
liquid
printing
channel
liquid inlet
chip
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PCT/CN2022/103715
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English (en)
French (fr)
Inventor
张异
关一民
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上海傲睿科技有限公司
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Priority to EP22836871.8A priority Critical patent/EP4368370A1/en
Publication of WO2023280120A1 publication Critical patent/WO2023280120A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B29C64/205—Means for applying layers
    • B29C64/209—Heads; Nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B29C64/112—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41J—TYPEWRITERS; SELECTIVE PRINTING MECHANISMS, i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; CORRECTION OF TYPOGRAPHICAL ERRORS
    • B41J2/00—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed
    • B41J2/005—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by bringing liquid or particles selectively into contact with a printing material
    • B41J2/01—Ink jet

Definitions

  • the invention relates to the technical field of bioprinting devices, in particular to a printing head containing internal microfluidic channels.
  • Bio 3D printing refers to the printing of biological materials (including natural biological materials, synthetic biological materials or cell solutions) into a designed three-dimensional structure through the principles and methods of 3D printing.
  • Bio-3D printing technology is different from ordinary 3D printing technology.
  • the produced biological tissues or organs also have certain biological functions, which provide conditions for the further growth of cells and tissues. It is precisely because of the above characteristics that 3D bioprinting technology faces many specific technical problems in the development.
  • the technology of using cells as printing materials is called cell 3D printing technology. People use cells and biocompatible materials to make bio-ink, move the nozzle and eject the bio-ink, and control the flow of the nozzle through the program. Move, print the bio-ink according to the preset target, so as to print the shape according to the three-dimensional digital model of the object.
  • the printers used for bioprinting in the prior art include extrusion and non-contact printers.
  • the print head uses an open print head design. As shown in Figure 1, the liquid inlet on the print head is an open type.
  • the liquid port is convenient to use a pipette gun to add liquid to the open liquid inlet, but the problem caused by the open print head is that the cell solution settles over time due to the action of gravity. When the cell solution settles, it is necessary to manually remove the settled cells. The solution is sucked away.
  • This kind of operation has high requirements for the operator, is labor-intensive and time-consuming, and because the size of the open liquid inlet inside the print head is small, it is difficult for the pipette gun to completely suck up all the liquid, making the cell solution susceptible to contamination.
  • the object of the present invention is to provide a print head containing internal microfluidic channels, which is used to solve the problem of cell solution settling over time due to gravity when the open print head is used in the prior art. It is not easy to discharge, resulting in the problem that the cell solution is easily polluted.
  • the present invention provides a print head comprising an internal microfluidic channel, the print head comprising:
  • a printing base includes a liquid inlet channel, a liquid outlet channel and a storage tank, and the liquid inlet channel and the liquid outlet channel communicate with the storage tank;
  • Printing chip the printing chip is packaged on the surface of the printing base, and the printing chip is connected with the storage tank to form an internal micro flow channel, and the accommodation space of the internal micro flow channel is equal to that of the printing head The filling volume of printing liquid at one time.
  • the printing base further includes a waste liquid tank connected to the liquid outlet channel, and the waste liquid tank and the printing chip are arranged on opposite sides of the printing base.
  • the liquid inlet channel is located outside the waste liquid tank, and the liquid outlet channel is located inside the waste liquid tank.
  • the accommodating space of the internal micro-channel is 10 ⁇ L-30 ⁇ L.
  • the printing chip is in the shape of a rectangular sheet, and the printing chip includes a first surface and a second surface opposite to each other, the first surface is provided with a chip liquid inlet along the length direction, and the chip liquid inlet is connected to the chip liquid inlet.
  • the internal micro-channels are connected; the second surface is provided with a plurality of nozzle holes, and the plurality of nozzle holes are arranged in a row at equal intervals along the length direction, and the plurality of nozzle holes are all connected to the printing chip.
  • the openings are connected, and the printing liquid in the internal micro-channel enters the nozzle hole through the liquid inlet of the chip.
  • the printing chip is a thermal bubble jet printing chip.
  • the liquid inlet channel has a circular liquid inlet with a diameter of 0.5 mm to 1.5 mm.
  • the liquid inlet channel is connected to a pipette gun for manual liquid addition, or the liquid inlet channel is connected to a liquid supply pipeline, and the liquid supply pipeline is electrically connected to a controller, and the controller is used to The liquid supply pipeline is controlled to automatically add liquid to the liquid inlet channel.
  • the liquid inlet channel has a funnel-shaped liquid inlet with an upper part in the shape of a cylinder and a lower part in the shape of a cone.
  • the liquid inlet channel is connected with a pipette gun for manual liquid addition.
  • the print head containing internal microfluidic channels of the present invention has the following beneficial effects:
  • the printing head in the present invention forms an internal micro-channel by connecting the printing chip with the storage tank, and the accommodation space of the internal micro-channel is equal to the filling amount of printing liquid of the printing head at one time, so that when the liquid discharge operation is performed, the old printing The liquid is pushed out at one time, which greatly reduces the probability of printing liquid being contaminated, and solves the problem that the printing liquid is difficult to discharge from the printing base, and the setting of the internal micro-channel structure with a small accommodating space will not cause printing liquid. Waste, can greatly save the use cost of printing liquid.
  • the liquid inlet channel is connected with the pipette gun or the liquid supply pipeline for manual or automatic liquid addition, thereby forming a one-way flow path between the liquid inlet channel and the liquid outlet channel.
  • the liquid inlet channel with a smaller cross-sectional area A one-way flow path is formed between the liquid outlet channel and the pressure in the one-way flow path is high and the flow rate is fast, so that the liquid discharge rate can be improved; at the same time, it solves the problem of the print head using an open liquid inlet in the prior art, and the cell
  • the solution settles over time due to the action of gravity, and using a pipette gun to manually absorb the settled cell solution is labor-intensive and time-consuming, and the size of the open liquid inlet is small, so it is difficult to completely absorb all the liquid, making the cell solution easy to be absorbed. pollution problem.
  • FIG. 1 is a schematic diagram of a three-dimensional structure of a printed substrate in the prior art.
  • FIG. 2 is a schematic diagram of the three-dimensional structure of the printed substrate in Example 1 of the present invention.
  • FIG. 3 is a schematic cross-sectional structure diagram along the A-A direction in FIG. 2 .
  • FIG. 4 is a schematic front view of the printed substrate in Example 1 of the present invention.
  • FIG. 5 is a schematic top view of the printed substrate in Embodiment 1 of the present invention.
  • FIG. 6 is a schematic bottom view of the printed substrate in Embodiment 1 of the present invention.
  • FIG. 7 is a schematic diagram of the three-dimensional structure of the first viewing angle of the chip in the present invention.
  • FIG. 8 is a schematic diagram of the three-dimensional structure of the second viewing angle of the chip in the present invention.
  • FIG. 9 is a schematic diagram of the three-dimensional structure of the printed substrate in Embodiment 2 of the present invention.
  • FIG. 10 is a schematic cross-sectional structure diagram along the B-B direction in FIG. 9 .
  • FIG. 11 is a schematic front view of the printed substrate in Embodiment 2 of the present invention.
  • this embodiment provides a print head containing internal microfluidic channels, the print head at least includes:
  • the printing base includes a liquid inlet channel 100 , a liquid outlet channel 200 and a storage tank 300 , and the liquid inlet channel 100 and the liquid outlet channel 200 communicate with the storage tank 300 .
  • Printing chip 500 the printing chip 500 is packaged on the surface of the printing base, and the printing chip 500 is connected with the storage tank 300 to form an internal micro-channel, and the accommodation space of the internal micro-channel is equal to the printing liquid filling volume of the printing head at one time.
  • the printing chip 500 connected to the storage tank 300 can form an internal microfluidic channel with the printing base, Therefore, the internal micro-channel can be used to store the printing liquid, so that when the printing head first adds printing liquid and the printer performs printing work for a certain period of time, the printing liquid in the printing head begins to settle (such as cells in the cell fluid), when the printing liquid
  • the printing liquid in the printing head begins to settle (such as cells in the cell fluid)
  • the printing liquid inlet channel 100 through a liquid adding device such as a pipette gun, new printing liquid can be added to the internal micro-channel, and since the accommodation space of the internal micro-channel is equal to the print head once Liquid filling amount, so that after the new printing liquid is filled into the internal micro-channel, the old printing liquid will be pushed out from the liquid outlet channel 200 to discharge the waste liquid.
  • This embodiment can solve the problem that the printing liquid, especially the cell solution, settles over time due to the action of gravity, and it is
  • the printing base further includes a waste liquid tank 400 connected to the liquid outlet channel 200 , and the waste liquid tank 400 and the printing chip 500 are respectively arranged on opposite sides of the printing base.
  • the waste liquid tank 400 is arranged on the surface of the printing base, that is, the waste liquid tank 400 and the printing chip 500 are respectively arranged on the opposite sides of the printing base, and the waste liquid tank 400 is used to accommodate the liquid outlet channel 200.
  • the discharged waste liquid facilitates the treatment of the waste liquid, but it is not limited thereto, and the liquid outlet channel 200 can also be directly connected to the drain pipe to collect the waste liquid, etc., which will not be repeated here.
  • the liquid inlet channel 100 is located outside the waste liquid tank 400 , and the liquid outlet channel 200 is located inside the waste liquid tank 400 .
  • the liquid inlet channel 100 is kept away from the waste liquid tank 400 to avoid contamination of the liquid inlet channel 100 .
  • the liquid inlet end surface of the liquid inlet channel 100 is not lower than the liquid outlet end surface of the liquid outlet channel 200, and the liquid inlet channel 100 and the liquid outlet channel 200 are in the horizontal direction on the same horizontal line.
  • the liquid outlet end surface of the liquid outlet channel 200 is not higher than the notch end of the waste liquid tank 400, and the liquid inlet end surface of the liquid outlet channel 200 is flush with the bottom of the storage tank 400; The bottom of the tank is flush, so that the liquid inlet channel 100 with a higher liquid inlet end surface can avoid pollution caused by liquid backflow, but the positional relationship between the liquid outlet channel 200 and the liquid inlet channel 100 is not limited thereto.
  • the accommodation space of the internal micro-channel is 10 ⁇ L-30 ⁇ L (such as 10 ⁇ L, 15 ⁇ L, 20 ⁇ L, 25 ⁇ L, 30 ⁇ L).
  • 10 ⁇ L-30 ⁇ L such as 10 ⁇ L, 15 ⁇ L, 20 ⁇ L, 25 ⁇ L, 30 ⁇ L.
  • printing liquids such as cell solutions
  • the cell solution is prone to sedimentation due to its own gravity. If a large amount of cell solution is added at one time, it will cause waste of printing liquid.
  • 10 ⁇ L to 30 ⁇ L of printing liquid is the printing liquid filling volume of the printing head at one time. Therefore, the internal microflow The setting of channels can greatly save the cost of printing liquid.
  • the printing chip 500 is in the shape of a rectangular sheet.
  • the printing chip 500 includes a first surface and a second surface oppositely arranged.
  • the liquid port 600, the chip liquid inlet 600 communicates with the internal micro flow channel;
  • the second surface is provided with a plurality of nozzle holes 700, and the plurality of nozzle holes 700 are arranged in a row at equal intervals along the length direction, and the plurality of nozzle holes 700 are all connected to the chip
  • the liquid inlets 600 are connected, and the printing liquid in the internal micro-channel enters the nozzle holes 700 through the chip liquid inlets 600 .
  • the specific shape of the printing chip 500 is not overly limited here.
  • the printing chip 500 is a thermal bubble jet printing chip.
  • the printing chip 500 in this embodiment is a thermal bubble inkjet printing chip made of silicon wafers.
  • the thermal bubble inkjet printing head adopts thermal foam printing technology, and the ink is heated to generate bubbles and sprayed onto the printing medium. It belongs to high temperature and high pressure printing technology.
  • the ink inside the nozzle reaches a relative balance with the external atmospheric pressure under the action of surface tension, and is in a stable state; when the nozzle receives the printing signal, the heating element (such as a thin film resistor) inside the nozzle The temperature rises rapidly, so that the temperature of the ink near the heating element rises sharply and vaporizes, forming countless tiny bubbles, and the small bubbles gather and become larger to form a vapor film.
  • the printing signal disappears, the residual heat of the heating element further expands the bubble, and the pressure generated inside pushes the ink out of the nozzle, and the temperature of the heating element begins to drop.
  • the boundary between the bubble and the ink begins to cool down. Since the front end of the ink has been extruded from the nozzle, and the rear end is reduced due to the contraction of the ink, the nozzle generates a negative pressure, and then the ink is discharged. Suction back into the spray head. When the bubbles in the nozzle disappear, the negative pressure continues to act, the ink droplet is completely separated from the nozzle, and the remaining ink is sucked back into the nozzle. Then the surface tension will generate outward suction, pulling new ink to supplement the ink ejection area to prepare for the next printing cycle.
  • the print chip 500 and the print base form a closed accommodation space, so that the liquid can be fed through the liquid inlet of the liquid inlet channel 100, and the liquid can be discharged from the liquid outlet of the liquid outlet channel 200. Drain.
  • the liquid inlet channel 100 is a circular liquid inlet with a diameter of 0.5mm ⁇ 1.5mm (such as 0.5mm, 0.8mm, 1.0mm, 1.2mm, 1.5mm).
  • the liquid inlet channel 100 is connected to a pipette gun (not marked) for manual liquid addition, or the liquid inlet channel 100 is connected to a liquid supply pipeline (not marked), and the liquid supply pipeline is electrically
  • a controller (not marked) is connected, and the controller is used to control the liquid supply pipeline to automatically add liquid to the liquid inlet channel 100 .
  • FIG. 2 it is a schematic diagram of the three-dimensional structure of the print head substrate.
  • the liquid inlet pipe 100 is a circular liquid inlet, and the circumference of the circular liquid inlet is threaded.
  • the sealing performance is relatively good.
  • the pipette gun is manually filled or the liquid supply line is automatically filled, the pressure increases, and a one-way flow path is formed between the liquid inlet channel 100 and the liquid outlet channel 200. Permanently discharge the original old printing liquid.
  • this embodiment also provides a kind of printing head that contains internal micro flow channel, the difference between this embodiment and embodiment 1 mainly lies in: the shape of the liquid inlet of the liquid inlet channel 110 Different, for the specific structure of the print head, please refer to Embodiment 1, which will not be repeated here, and only the differences from Embodiment 1 will be introduced below.
  • the liquid inlet channel 110 has a funnel-shaped liquid inlet with an upper part in the shape of a cylinder and a lower part in the shape of a cone.
  • the liquid inlet channel 110 is connected with a pipette gun (not marked) for manual liquid addition.
  • the liquid inlet of the liquid inlet channel 110 is located at the port at the bottom of the funnel in the lower part of the tapered shape, that is, the liquid inlet of the liquid inlet channel 110 is lower than the liquid outlet of the liquid outlet channel 200 , and the liquid inlet channel 110 and the liquid outlet channel 200 are on the same horizontal line in the horizontal direction.
  • This setting makes it easier for the tip of the pipette to be aligned with the liquid inlet port, so that the connection between the liquid inlet channel 110 and the pipette is better sealed.
  • the liquid inlet pipe A one-way flow path is formed between 110 and the liquid outlet pipe 200.
  • the printer starts to perform printing work. After a certain period of time, the printing liquid (such as cell solution) in the print head begins to settle, unable to When the printing conditions are satisfied, when new printing liquid is added again, the old printing liquid is pushed out from the liquid outlet channel 200 at one time and directly enters the waste liquid tank 400 .
  • the printing liquid such as cell solution
  • the print head in the present invention forms an internal micro-channel by connecting the printing chip with the storage tank, and the accommodation space of the internal micro-channel is equal to the printing liquid filling volume of the print head at one time, so that the discharge operation At the same time, the old printing liquid is pushed out at one time, which greatly reduces the probability of printing liquid being contaminated, solves the problem that the printing liquid is difficult to discharge from the printing base, and has an internal micro-channel structure with a small accommodating space. It will cause waste of printing liquid, which can greatly save the use cost of printing liquid.
  • the liquid inlet channel is connected with the pipette gun or the liquid supply pipeline for manual or automatic liquid addition, thereby forming a one-way flow path between the liquid inlet channel and the liquid outlet channel.
  • the liquid inlet channel with a smaller cross-sectional area A one-way flow path is formed between the liquid outlet channel and the pressure in the one-way flow path is high and the flow rate is fast, so that the liquid discharge rate can be improved; at the same time, it solves the problem of the print head using an open liquid inlet in the prior art, and the cell
  • the solution settles over time due to the action of gravity, and using a pipette gun to manually absorb the settled cell solution is labor-intensive and time-consuming, and the size of the open liquid inlet is small, so it is difficult to completely absorb all the liquid, making the cell solution easy to be absorbed. pollution problem. Therefore, the present invention effectively overcomes various shortcomings in the prior art and has high industrial application value.

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Optics & Photonics (AREA)
  • Ink Jet (AREA)
  • Particle Formation And Scattering Control In Inkjet Printers (AREA)

Abstract

提供了一种包含内部微流道的打印头，该打印头包括：打印基座和打印芯片，打印基座包括进液通道（100）、出液通道（200）及存储槽（300），进液通道（100）及出液通道（200）与存储槽（300）相贯通；打印芯片（500）封装于打印基座的表面，且打印芯片（500）与存储槽（300）相连通构成内部微流道，且内部微流道的容纳空间等于打印头一次的打印液体装填量。打印头通过内部微流道，使得旧的打印液体一次性的被推出，大大减小了打印液体被污染的概率，解决打印液体难以排出的问题，以及具有较小容纳空间的内部微流道的设置，大大节约了打印液体的使用成本；具有较小横截面积的进液通道与出液通道之间形成单向流路，由于单向流路内的压力大，流速快，从而可提高排液速率。

Description

一种包含内部微流道的打印头 技术领域
本发明涉及生物打印装置技术领域，特别是涉及一种包含内部微流道的打印头。
背景技术
生物3D打印是指通过3D打印的原理和方法，将生物材料(包括天然生物材料、合成生物材料或细胞溶液)打印成为设计的三维结构体，生物3D打印技术区别于普通的3D打印技术，其生产的生物组织或器官还具有一定的生物学功能，为细胞和组织的进一步生长提供条件，正是由于上述特性，生物3D打印技术在发展中，面临着很多特定的技术问题。其中，在生物3D打印领域，将细胞作为打印材料的技术称为细胞3D打印技术，人们利用细胞和生物相容性材料制成生物墨汁，移动喷头并将生物墨汁喷出，通过程序控制喷头的移动，将生物墨汁按照预设的目标打印，以按照物体的三维数字模型打印成型。
现有技术中用于生物打印的打印机，包括挤出式和非接触式的打印机，打印头使用开放式打印头的设计，如附图1所示，打印头上的进液口为开放式进液口，方便使用移液枪向开放式进液口内加液，但是开放式打印头带来的问题是，细胞溶液因重力作用随时间而发生沉降，当细胞溶液沉降后需要手动把沉降的细胞溶液吸走，这样的操作对操作人员的要求很高，费工费时，并且由于打印头内部的开放式进液口的尺寸很小，移液枪很难完全吸走全部的液体，使得细胞溶液易被污染。
因此，需要提供一种针对上述现有技术不足的改进技术方案。
发明内容
鉴于以上所述现有技术的缺点，本发明的目的在于提供一种包含内部微流道的打印头，用于解决现有技术中采用开放式打印头，细胞溶液因重力作用随时间发生沉降后不易排出，导致细胞溶液易被污染的问题。
为实现上述目的及其他相关目的，本发明提供一种包含内部微流道的打印头，所述打印头包括：
打印基座，所述打印基座包括进液通道、出液通道及存储槽，所述进液通道及出液通道与所述存储槽相贯通；
打印芯片，所述打印芯片封装于所述打印基座的表面，且所述打印芯片与所述存储槽相连通构成内部微流道，且所述内部微流道的容纳空间等于所述打印头一次的打印液体装填量。
优选地，所述打印基座还包括与所述出液通道相连接的废液槽，所述废液槽与所述打印芯片设于所述打印基座的相对两面。
优选地，所述进液通道位于所述废液槽外部，所述出液通道位于所述废液槽的内部。
优选地，所述内部微流道的容纳空间为10μL～30μL。
优选地，所述打印芯片呈长方形片状，所述打印芯片包括相对设置的第一表面和第二表面，所述第一表面沿长度方向开设有芯片进液口，所述芯片进液口与所述内部微流道连通；所述第二表面设置有多个喷孔，多个所述喷孔沿长度方向等间距排列成一排，且多个所述喷孔均与所述打印芯片进液口相连通，所述内部微流道内的打印液体通过所述芯片进液口进入所述喷孔中。
优选地，所述打印芯片为热泡喷墨打印芯片。
优选地，所述进液通道具有直径0.5mm～1.5mm的圆形进液口。
优选地，所述进液通道与移液枪相连接以进行手动加液，或所述进液通道与供液管路连接，所述供液管路电性连接控制器，所述控制器用于控制所述供液管路自动向所述进液通道加液。
优选地，所述进液通道具有上部呈圆柱体状且下部呈锥形状的漏斗形进液口。
优选地，所述进液通道与移液枪相连接以进行手动加液。
如上所述，本发明的包含内部微流道的打印头，具有以下有益效果：
本发明中的打印头通过将打印芯片与存储槽相连通构成内部微流道，且内部微流道的容纳空间等于打印头一次的打印液体装填量，使得在进行排液操作时，旧的打印液体一次性的被推出，大大减小了打印液体被污染的概率，解决打印液体难以排出打印基座的问题，且具有较小容纳空间的内部微流道结构的设置，不会造成打印液体的浪费，能够大大的节约打印液体的使用成本。
本发明中进液通道与移液枪或供液管路连接用以手动或自动加液，从而在进液通道和出液通道之间形成单向流路，当第一次加入打印液体后，打印机开始执行打印工作，当超过一定时间后，打印头内的打印液体(比如细胞溶液)开始沉降，无法满足打印条件，当再次加入新的打印液体时，具有较小横截面积的进液通道与出液通道之间形成单向流路，由于单向流路内的压力大，流速快，从而可提高排液速率；同时解决了现有技术中采用开放式进液口的打印头，细胞溶液因重力作用随时间发生沉降以及采用移液枪人工将发生沉降的细胞溶液吸走，费工费时，且开放式进液口的尺寸小，很难完全吸走全部液体，使得细胞溶液易被污染的问题。
附图说明
图1显示为现有技术中打印基体的立体结构示意图。
图2显示为本发明实施例1中打印基体的立体结构示意图。
图3显示为图2中沿A-A方向的剖视结构示意图。
图4显示为本发明实施例1中打印基体的主视结构示意图。
图5显示为本发明实施例1中打印基体的俯视结构示意图。
图6显示为本发明实施例1中打印基体的仰视结构示意图。
图7显示为本发明中芯片第一视角的立体结构示意图。
图8显示为本发明中芯片第二视角的立体结构示意图。
图9显示为本发明实施例2中打印基体的立体结构示意图。
图10显示为图9中沿B-B方向的剖视结构示意图。
图11显示为本发明实施例2中打印基体的主视结构示意图。
元件标号说明
100a                   开放式进液口
100、110               进液通道
200                    出液通道
300                    存储槽
400                    废液槽
500                    打印芯片
600                    芯片进液口
700                    喷孔
具体实施方式
以下由特定的具体实施例说明本发明的实施方式，熟悉此技术的人士可由本说明书所揭露的内容轻易地了解本发明的其他优点及功效。
请参阅图2至图11。须知，本说明书所附图式所绘示的结构、比例、大小等，均仅用以配合说明书所揭示的内容，以供熟悉此技术的人士了解与阅读，并非用以限定本发明可实施的限定条件，故不具技术上的实质意义，任何结构的修饰、比例关系的改变或大小的调整，在不影响本发明所能产生的功效及所能达成的目的下，均应仍落在本发明所揭示的技术内容 得能涵盖的范围内。同时，本说明书中所引用的如“上”、“下”、“左”、“右”、“中间”及“一”等的用语，亦仅为便于叙述的明了，而非用以限定本发明可实施的范围，其相对关系的改变或调整，在无实质变更技术内容下，当亦视为本发明可实施的范畴。
实施例1
请查阅图2至图8，本实施例提供一种包含内部微流道的打印头，该打印头至少包括：
打印基座，打印基座包括进液通道100、出液通道200及存储槽300，进液通道100及出液通道200与存储槽300相贯通。
打印芯片500，打印芯片500封装于打印基座的表面，且打印芯片500与存储槽300相连通构成内部微流道，且内部微流道的容纳空间等于打印头一次的打印液体装填量。
具体的，通过设置于打印基座中的进液通道100、出液通道200及存储槽300，可使得与存储槽300相连通的打印芯片500可与打印基座之间构成内部微流道，从而内部微流道可用于存储打印液体，从而当打印头第一次加入打印液体及打印机执行打印工作一定时间后，打印头内的打印液体开始沉降(如细胞液中的细胞)，当打印液体无法满足打印条件时，通过加液设备如移液枪等与进液通道100连接后，可向内部微流道加入新的打印液体，且由于内部微流道的容纳空间等于打印头一次的打印液体装填量，从而在新的打印液体装填进内部微流道后，旧的打印液体则会从出液通道200处被推出，从而排出废液。本实施例可解决打印液体特别是细胞溶液因重力作用随时间而沉降，难以排出打印基座的问题，从而可提高打印质量。
在本发明具体实施例中，打印基座还包括与出液通道200相连接的废液槽400，废液槽400与打印芯片500分别设于打印基座的相对两面。
具体的，如图5，废液槽400设于打印基座的表面，即废液槽400及打印芯片500分别设于打印基座的相对两面，废液槽400用以容纳自出液通道200排出的废液，从而便于对废液进行处理，但并非局限于此，也可将出液通道200直接连接排液管，以进行废液的收集等，此处不作赘述。
在本发明具体实施例中，进液通道100位于废液槽400外部，出液通道200位于废液槽400的内部。使得进液通道100远离废液槽400，避免污染进液通道100。
具体的，如图2～图4所示，本实施例中，进液通道100的进液端面不低于出液通道200的出液端面，且进液通道100和出液通道200在水平方向上处于同一条水平线上。出液通道200的出液端面不高于废液槽400的槽口端，出液通道200的进液端面与存储槽400的槽底齐平；进液通道200的出液端面与存储槽400的槽底齐平，从而具有较高进液端面的进液通 道100可避免由于液体回流造成的污染，但出液通道200及进液通道100的位置关系并非局限于此。
在本发明具体实施例中，内部微流道的容纳空间为10μL～30μL(比如10μL、15μL、20μL、25μL、30μL)。具体的，由于存储槽400的深度较小，存储槽400与打印芯片500相连通构成的内部微流道内仅能够储存约10μL～30μL的打印液体，通常打印液体(比如细胞溶液)都是比较昂贵的，细胞溶液因自身重力作用易发生沉降，若一次性加入较多的细胞溶液，造成打印液体的浪费，10μL～30μL的打印液体也就是打印头一次的打印液体装填量，因此，内部微流道的设置能够大大的节约打印液体的使用成本。
在本发明具体实施例中，如图7、图8所示，打印芯片500呈长方形片状，打印芯片500包括相对设置的第一表面和第二表面，第一表面沿长度方向开设有芯片进液口600，芯片进液口600与内部微流道连通；第二表面设置有多个喷孔700，多个喷孔700沿长度方向等间距排列成一排，且多个喷孔700均与芯片进液口600相连通，内部微流道内的打印液体通过芯片进液口600进入喷孔700中。关于打印芯片500的具体形貌此处不作过分限制。
在本发明具体实施例中，打印芯片500为热泡喷墨打印芯片。
具体的，本实施例中的打印芯片500为硅片材质的热泡喷墨打印芯片，热泡喷墨打印头是采用热发泡打印技术，通过加热喷头，使墨水产生气泡，喷到打印介质上，属于高温高压打印技术。其工作原理是：在正常情况下喷头内部的墨水在表面张力的作用下与外界大气压达成相对的平衡，处于稳定状态；当喷头接收到打印信号后，喷头内部的加热元件(例如薄膜电阻器)迅速升温，使加热元件附近的墨水温度急剧上升并汽化，形成无数微小气泡，小气泡聚集变大形成蒸汽膜。当打印信号消失后，加热元件持续的余热使气泡进一步膨胀，内部产生的压力将墨水从喷嘴处挤出，同时加热元件的温度开始下降。随着加热元件表面温度的降低，气泡和墨水分界处开始冷却，由于墨水前端已从喷嘴处挤出，而后端又由于墨水收缩而使喷头内部压力减小，喷嘴处产生负压，再将墨水吸回到喷头内。当喷头内气泡消失后，负压力继续作用，墨滴与喷嘴完全分立，剩余墨水被吸回到喷头内。接着表面张力会产生向外的吸力，拉引新的墨水补充到墨水喷出区准备下一次的循环喷印。从而在对打印头进行废液排除的操作时，打印芯片500与打印基座形成闭合的容纳空间，使得可通过进液通道100的进液口进行进液，从出液通道200出液口进行排液。
在本发明具体实施例中，进液通道100为直径0.5mm～1.5mm(比如0.5mm、0.8mm、1.0mm、1.2mm、1.5mm)的圆形进液口。
在本发明具体实施例中，进液通道100与移液枪(未标识)相连接以进行手动加液，或 进液通道100与供液管路(未标识)连接，供液管路电性连接控制器(未标识)，通过控制器用于控制供液管路自动向进液通道100加液。
具体的，如图2所示为打印头基体的立体结构示意图，进液管道100为圆形进液口，圆形进液口的周向有螺纹，移液枪或供液管路与进液通道100对接时，密封性能比较好，当移液枪手动加液或供液管路自动加液时，压力增大，在进液通道100与出液通道200之间形成单向流路，一次性的排出原有旧的打印液体。
实施例2
请查阅图7至图11，本实施例还提供一种包含内部微流道的打印头，本实施例与实施例1的不同之处主要在于：进液通道110的进液口的形貌的不同，关于打印头的具体结构可参阅实施例1，此处不作赘述，以下仅对与实施例1中的不同之处进行介绍。
在本发明具体实施例中，进液通道110具有上部呈圆柱体状且下部呈锥形状的漏斗形进液口。
在本发明具体实施例中，进液通道110与移液枪(未标识)相连接以进行手动加液。
具体的，如图10、图11所示，进液通道110进液口位于下部呈锥形状的漏斗底端的端口处，即进液通道110的进液口低于出液通道200的出液口，且进液通道110和出液通道200在水平方向上处于同一条水平线上。如此设置使得移液枪的枪头更容易对准进液端口，使进液通道110与移液枪之间的连接密封性更好，当使用移液枪进行手动加液时，在进液管道110与出液管道200之间形成单向流路，当第一次加入打印液体后，打印机开始执行打印工作，当超过一定时间后，打印头内的打印液体(比如细胞溶液)开始沉降，无法满足打印条件，当再次加入新的打印液体时，旧的打印液体自出液通道200一次性的被推出直接进入废液槽400内。
综上所述，本发明中的打印头通过将打印芯片与存储槽相连通构成内部微流道，且内部微流道的容纳空间等于打印头一次的打印液体装填量，使得在进行排液操作时，旧的打印液体一次性的被推出，大大减小了打印液体被污染的概率，解决打印液体难以排出打印基座的问题，且具有较小容纳空间的内部微流道结构的设置，不会造成打印液体的浪费，能够大大的节约打印液体的使用成本。
本发明中进液通道与移液枪或供液管路连接用以手动或自动加液，从而在进液通道和出液通道之间形成单向流路，当第一次加入打印液体后，打印机开始执行打印工作，当超过一定时间后，打印头内的打印液体(比如细胞溶液)开始沉降，无法满足打印条件，当再次加 入新的打印液体时，具有较小横截面积的进液通道与出液通道之间形成单向流路，由于单向流路内的压力大，流速快，从而可提高排液速率；同时解决了现有技术中采用开放式进液口的打印头，细胞溶液因重力作用随时间发生沉降以及采用移液枪人工将发生沉降的细胞溶液吸走，费工费时，且开放式进液口的尺寸小，很难完全吸走全部液体，使得细胞溶液易被污染的问题。所以，本发明有效克服了现有技术中的种种缺点而具高度产业利用价值。
上述实施例仅例示性说明本发明的原理及其功效，而非用于限制本发明。任何熟悉此技术的人士皆可在不违背本发明的精神及范畴下，对上述实施例进行修饰或改变。因此，举凡所属技术领域中具有通常知识者在未脱离本发明所揭示的精神与技术思想下所完成的一切等效修饰或改变，仍应由本发明的权利要求所涵盖。

Claims (10)

  1. 一种包含内部微流道的打印头，其特征在于，所述打印头包括：
    打印基座，所述打印基座包括进液通道、出液通道及存储槽，所述进液通道及出液通道与所述存储槽相贯通；
    打印芯片，所述打印芯片封装于所述打印基座的表面，且所述打印芯片与所述存储槽相连通构成内部微流道，且所述内部微流道的容纳空间等于所述打印头一次的打印液体装填量。
  2. 根据权利要求1所述的包含内部微流道的打印头，其特征在于，所述打印基座还包括与所述出液通道相连接的废液槽，所述废液槽与所述打印芯片分别设于所述打印基座的相对两面。
  3. 根据权利要求2所述的包含内部微流道的打印头，其特征在于，所述进液通道位于所述废液槽外部，所述出液通道位于所述废液槽的内部。
  4. 根据权利要求1所述的包含内部微流道的打印头，其特征在于，所述内部微流道的容纳空间为10μL～30μL。
  5. 根据权利要求1所述的包含内部微流道的打印头，其特征在于，所述打印芯片呈长方形片状，所述打印芯片包括相对设置的第一表面和第二表面，所述第一表面沿长度方向开设有芯片进液口，所述芯片进液口与所述内部微流道连通；所述第二表面设置有多个喷孔，多个所述喷孔沿长度方向等间距排列成一排，且多个所述喷孔均与所述打印芯片进液口相连通，所述内部微流道内的打印液体通过所述芯片进液口进入所述喷孔中。
  6. 根据权利要求1所述的包含内部微流道的打印头，其特征在于，所述打印芯片为热泡喷墨打印芯片。
  7. 根据权利要求1所述的包含内部微流道的打印头，其特征在于，所述进液通道具有直径0.5mm～1.5mm的圆形进液口。
  8. 根据权利要求7所述的包含内部微流道的打印头，其特征在于，所述进液通道与移液枪相连接以进行手动加液，或所述进液通道与供液管路连接，所述供液管路电性连接控制器，所述控制器用于控制所述供液管路自动向所述进液通道加液。
  9. 根据权利要求1～6任一所述的包含内部微流道的打印头，其特征在于，所述进液通道具有上部呈圆柱体状且下部呈锥形状的漏斗形进液口。
  10. 根据权利要求9所述的包含内部微流道的打印头，其特征在于，所述进液通道与移液枪相连接以进行手动加液。
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