Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
  • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
  • A01N25/24—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients to enhance the sticking of the active ingredients
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
  • A01N33/02—Amines; Quaternary ammonium compounds
  • A01N33/12—Quaternary ammonium compounds
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
  • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
  • A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
  • A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
  • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
  • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
  • A61L2/18—Liquid substances
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L9/00—Disinfection, sterilisation or deodorisation of air
  • A61L9/01—Deodorant compositions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L9/00—Disinfection, sterilisation or deodorisation of air
  • A61L9/14—Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances including air-liquid contact processes

Definitions

• the present invention relates to a disinfectant composition capable of imparting a long-term disinfecting effect to various objects to be disinfected.
• Hygiene-consciousness is increasing for telephones, kitchens, living rooms, toilets, bathrooms, washrooms, car interiors, textile products, clothes, and the like.
• the global spread of new coronaviruses and new strains of influenza is also a major factor, and it is possible to easily inactivate not only fungi such as bacteria and molds, but also various viruses, and to make items surrounding the living environment antibacterial. ⁇ It is desired to reduce the risk of infection and secondary infection by making it antiviral.
• benzalkonium chloride As disinfectants for these articles and human hands, many liquid, spray, and sheet disinfectants are on the market. As their active ingredients, ethanol, benzalkonium chloride, cetylpyridinium chloride, phenoxyethanol, silver ions, isopropylmethylphenol, sodium benzoate, etc. are used. Among these, benzalkonium chloride has a high antibacterial effect and is widely used in pharmaceuticals and quasi-drugs (various disinfectants and Non-Patent Document 1). Benzalkonium chloride is also applied to deodorant compositions (Patent Document 1) and acne treatment agents (Patent Document 2).
• an object of the present invention is to provide a disinfectant composition in which the active disinfectant, particularly benzalkonium chloride, has good long-term stability and adhesion to the object to be disinfected.
• the present inventor blended various components with benzalkonium chloride and studied the adhesion of the composition to the disinfection target and the long-term stability of the properties. And by blending a specific amount of a pH buffer and adjusting the pH of the composition to 6.0 to 7.0, the composition dries quickly, and the long-term stability of benzalkonium chloride and adhesion to the disinfection target are improved.
• the inventors have completed the present invention based on the discovery that a disinfectant composition having good properties can be obtained.
• a disinfectant composition containing the following components (A) to (D) and having a pH of 6.0 to 7.0.
• Parabens are one or two selected from methylparaben, ethylparaben, propylparaben and butylparaben
• the disinfectant composition according to [1] which is at least one species.
• the pH buffer is selected from citric acid, malic acid, tartaric acid, triethanolamine, diethanolamine, succinic acid, fumaric acid, maleic acid, trishydroxymethylaminomethane, lactic acid, phosphoric acid, boric acid and salts thereof.
• the disinfectant composition according to any one of [1] to [5] which is a disinfectant composition.
• benzalkonium chloride has good long-term stability, dries quickly on an article to be disinfected (hereinafter also referred to as an article, etc.), has excellent adhesion to the article, etc. It is possible to provide a disinfectant composition that can maintain the disinfectant effect of the above for a long period of time.
• the disinfectant composition of the present invention contains specific amounts of (A) benzalkonium chloride, (B) parabens, (C) ethanol, and (D) a pH buffer.
• Component (A) benzalkonium chloride is known to exert a bactericidal effect against fungi, gram-positive bacteria, and gram-negative bacteria, and its mechanism of action is to denature proteins on the surface of bacterial cell membranes. It is something that loses its activity, and this action functions as a sterilization and disinfection effect. It is also known that benzalkonium chloride detoxifies viruses by acting on their membranes (Ministry of Health, Labor and Welfare website).
• the disinfecting action of benzalkonium chloride is due to such antibacterial action and antiviral action, and the disinfecting action of the present invention includes antibacterial action, disinfection action, antiviral action, and virus removal action.
• the content of component (A) in the disinfectant composition of the present invention is preferably 0.06% by mass or more and 0.2% by mass or less from the viewpoint of disinfecting action, adhesion to articles, etc., and long-term stability. preferable.
• the content of component (A) is more preferably 0.08% by mass or more and 0.2% by mass or less, and still more preferably 0.1% by mass or more and 0.2% by mass or less.
• Component (B) parabens which are usually used as preservatives, contribute not only to the long-term stability of the composition in the present invention, but also to the improvement of adhesion of benzalkonium chloride to articles. .
• parabens are particularly excellent in the effect of benzalkonium chloride on improving adhesion to articles.
• Examples of parabens include methylparaben (methyl paraoxybenzoate), ethylparaben (ethyl paraoxybenzoate), propylparaben (propyl paraoxybenzoate) and butylparaben (butyl paraoxybenzoate), one or Two or more types are used.
• the content of component (B) in the disinfectant composition of the present invention is preferably 0.005% by mass or more and 0.2% by mass or less from the viewpoints of disinfecting action, improvement of adhesion to articles and the like, and long-term stability.
• the content of component (B) is more preferably 0.01% by mass or more and 0.2% by mass or less, and still more preferably 0.05% by mass or more and 0.2% by mass or less.
• the mass ratio (A/B) of the component (A) and the component (B) in the disinfectant composition of the present invention is 0.5 or more and 20 or less from the viewpoint of an excellent effect of improving adhesion to articles and the like. It is preferably 0.5 or more and 10 or less, more preferably 0.5 or more and 5 or less, and even more preferably 0.5 or more and 4 or less.
• Component (C) ethanol not only functions as a solvent for component (A) and component (B), but also maintains long-term stability of the composition, and quickly evaporates after applying the composition to an article, etc., so that the component It has a function of allowing (A) and component (B) to remain attached to the surface of an article or the like.
• the content of the component (C) in the disinfectant composition of the present invention is such that disinfection action, improvement of adhesion to articles, etc., prevention of denaturation of the surface of articles, drying speed, long-term stability of the composition, resistance to irritation From a viewpoint, 5 mass % or more and 30 mass % or less are preferable.
• component (C) exceeds 30% by mass, the quick-drying property of the composition is improved, but the surface of the article to be disinfected may be denatured. Moreover, the content of component (C) is more preferably 5% by mass or more and 25% by mass or less, and even more preferably 5% by mass or more and 20% by mass or less.
• Component (D) pH buffering agent not only functions to adjust the pH of the composition, but also contributes to long-term stability of the composition and improvement of adhesion of component (A).
• pH buffers for component (D) include citric acid, malic acid, tartaric acid, triethanolamine, diethanolamine, succinic acid, fumaric acid, maleic acid, trishydroxymethylaminomethane, lactic acid, phosphoric acid, One or more selected from boric acid and salts thereof can be mentioned.
• component (A) From the viewpoint of the adhesion improvement effect of component (A), one or two or more selected from citric acid, malic acid, tartaric acid, succinic acid, fumaric acid, lactic acid and salts thereof are preferable, and citric acid, malic acid, More preferably, one or more selected from tartaric acid, lactic acid and salts thereof, and more preferably one or more selected from citric acid and salts thereof.
• the salt is preferably an alkali metal salt, more preferably a sodium salt.
• the content of component (D) in the disinfectant composition of the present invention is preferably 0.3 mM or more and less than 10 mM from the viewpoint of improving the long-term stability of the composition and the adhesion of component (A).
• the content of component (D) is more preferably 0.5 mM or more and less than 10 mM, more preferably 1 mM or more and less than 10 mM, and even more preferably 2 mM or more and less than 10 mM.
• the pH of the disinfectant composition of the present invention is preferably 6.0 to 7.0 from the viewpoint of improving the long-term stability of the composition and the adhesion of component (A).
• a more preferable pH is 6.0 to 6.8, and a further preferable pH is more than 6.0 and 6.8 or less. It is preferable to adjust the pH with the component (D).
• the antiseptic composition of the present invention may contain antiseptic and bactericidal components such as cetylpyridinium chloride, phenoxyethanol, silver ions, isopropylmethylphenol and sodium benzoate in addition to the above components.
• antiseptic and bactericidal components such as cetylpyridinium chloride, phenoxyethanol, silver ions, isopropylmethylphenol and sodium benzoate.
• (E) phenoxyethanol is contained from the viewpoint of maintaining the bactericidal and disinfecting action, ensuring the long-term stability of the composition, and ensuring the effect of improving the adhesion of the component (A). preferable.
• the content of phenoxyethanol in the disinfectant composition of the present invention maintains the bactericidal disinfection action, ensures long-term stability of the composition, and ensures the effect of improving the adhesion of component (A), 0.01% by mass or more and 1% by mass is preferable, 0.1% by mass or more and 1% by mass is more preferable, and 0.3% by mass or more and 1% by mass is even more preferable.
• the disinfectant composition of the present invention may contain water, cooling agents such as menthol, plant extracts such as green tea extract and persimmon tannin, and the like.
• glycerin propylene glycol, 1,3-butylene glycol, pentylene glycol, polyhydric alcohols such as sorbitol, anionic polymers such as carboxyvinyl polymer, silicone, glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxy Surfactants such as ethylene isocetyl ether, polyoxyethylene behenyl ether, N-coconut fatty acid acyl-L-arginine ethyl DL-pyrrolidone carboxylate, etc.
• the surfactant is substantially absent.
• substantially does not contain means that the content is less than 0.1% by mass or not contained.
• the disinfectant composition of the present invention exhibits the effects of the present invention because it is a uniform liquid. It is preferably liquid without
• the disinfectant composition of the present invention contains benzalkonium chloride, which is a disinfectant component, is stable for a long period of time, and has excellent adhesion to articles, etc. Therefore, it is suitable for disinfecting various articles. useful as an agent.
• the disinfection action includes antibacterial action, sterilization action, antiviral action, and virus removing action, as described above.
• An article may be an article other than the human body that requires disinfection, and is, for example, an article that exists in a living environment, a business environment of a company, a restaurant environment, a store environment, a medical environment, or the like.
• furniture such as doorknobs, desks, chairs, tables, various tools and appliances, tableware, glasses, mobile phones, kitchens, living rooms, toilets, bathrooms, washrooms, car interiors, textile products, clothing, Examples include medical instruments and surgical instruments.
• the disinfectant composition of the present invention is preferably in a form that can be applied to an article or the like.
• a sheet impregnated with a liquid composition or a spray is preferable, and the composition can be used without waste. It is more preferable to be a propellant from the viewpoint of convenience such as.
• the spray may be either a pump-type spray or an aerosol.
• Examples 1-22 and Comparative Examples 1-18 A homogeneous liquid composition was obtained by mixing the components shown in Tables 1 to 4.
• Adhesion test (benzalkonium chloride adhesion to centrifuge tube) ah. Accurately put 2 mL of each sample into a centrifuge tube, leave it in an upright open state in a constant temperature bath at 80° C., and dry it completely. stomach. After slowly adding 5 mL of purified water to the dried centrifuge tube through the wall surface of the centrifuge tube, the tube is shaken for 1 minute with a shaker. (Shaking speed 100 rpm) hare. After shaking with a shaker, 1 mL of each sample is accurately placed in a volumetric flask, and purified water is added to dilute 50-fold. workman.
• Antibacterial test 1 mL of test sample was dropped on a polyethylene plate and dried, and 0.4 mL of bacterial solution (about 400,000 pieces/mL of Staphylococcus aureus) was placed on it and contacted for 5 minutes. . At the same time, 0.4 mL of the bacterial solution was placed on an unprocessed polyethylene plate. Each bacterial solution was cultured on a medium and the bacterial reduction rate was measured. Bacteria reduction rate ⁇ : 99.9% or more ⁇ : 99.0 or more and less than 99.9% ⁇ : less than 99.0%
• Tables 1 to 4 Evaluation results are shown in Tables 1 to 4. From Tables 1 to 4, (A) benzalkonium chloride 0.06% by mass or more and 0.2% by mass or less, (B) parabens 0.005% by mass or more and 0.2% by mass or less, (C) ethanol 5 A disinfectant composition containing at least 30% by mass and (D) 0.3 mM or more and less than 10 mM of a pH buffer and having a pH of 6.0 to 7.0 has excellent long-term stability and can be used as an article. It can be seen that the adhesion to the surface is excellent.

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• Life Sciences & Earth Sciences (AREA)
• Health & Medical Sciences (AREA)
• General Health & Medical Sciences (AREA)
• Environmental Sciences (AREA)
• Plant Pathology (AREA)
• Engineering & Computer Science (AREA)
• Pest Control & Pesticides (AREA)
• Wood Science & Technology (AREA)
• Zoology (AREA)
• Dentistry (AREA)
• Agronomy & Crop Science (AREA)
• Epidemiology (AREA)
• Toxicology (AREA)
• Animal Behavior & Ethology (AREA)
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• Agricultural Chemicals And Associated Chemicals (AREA)

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Citations (7)

• 2022
  • 2022-12-22 JP JP2023569529A patent/JPWO2023120630A1/ja active Pending
  • 2022-12-22 TW TW111149405A patent/TW202339617A/zh unknown
  • 2022-12-22 WO PCT/JP2022/047310 patent/WO2023120630A1/ja not_active Ceased

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