WO2023119820A1 - Composition fermentée pour aliments, et procédé d'élevage de bétail - Google Patents

Composition fermentée pour aliments, et procédé d'élevage de bétail Download PDF

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Publication number
WO2023119820A1
WO2023119820A1 PCT/JP2022/038769 JP2022038769W WO2023119820A1 WO 2023119820 A1 WO2023119820 A1 WO 2023119820A1 JP 2022038769 W JP2022038769 W JP 2022038769W WO 2023119820 A1 WO2023119820 A1 WO 2023119820A1
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WIPO (PCT)
Prior art keywords
livestock
vitamin
fermented composition
composition
belonging
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PCT/JP2022/038769
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English (en)
Japanese (ja)
Inventor
良紀 松浦
晋輔 岸田
英人 鳥居
拓三 水津
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万田発酵株式会社
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Publication of WO2023119820A1 publication Critical patent/WO2023119820A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87—Re-use of by-products of food processing for fodder production

Definitions

  • the present invention relates to a fermented composition for livestock feed and a method for raising livestock using the fermented composition.
  • Livestock such as pigs are sometimes fed with antibiotics such as avilamycin, enramycin, virginiamycin and colistin for growth purposes in addition to feeding.
  • antibiotics such as avilamycin, enramycin, virginiamycin and colistin for growth purposes in addition to feeding.
  • the use of antibiotics for growth purposes involves continuous use in the feed. Dosages are generally used that are low relative to the amount of antibiotics used for therapeutic purposes. Usage standards such as dosage are determined for each antibiotic.
  • antibiotics are given to livestock for the purpose of growth is to prevent diarrhea in livestock by suppressing the generation of toxins and putrefactive substances produced by harmful bacteria in the intestines and preventing damage to villi and crypts. It is intended to suppress and promote healthy growth of livestock.
  • the present inventors are earnestly researching the use and effects of fermented compositions obtained by fermenting and aging specific multiple types of raw materials from fruits, grains, seaweeds, and vegetables for a long period of time.
  • the fermented composition increases the production of short-chain fatty acids in the intestines of animals, hypothesized whether it could replace antibiotics given to livestock, and through trial and error and various experiments, the present invention. It has reached
  • the present invention is 1 selected from apples, persimmons, bananas, pineapples, akebi, Actinidia, figs, wild strawberries, strawberries, wild grapes, grapes, mountain vines, peaches, plums, blueberries, and raspberries belonging to fruits.
  • the object is to provide a fermented plant composition for feed (for livestock) containing a fermented composition as a main raw material.
  • the fermented composition may be characterized by increasing specific short chain fatty acids in the gut of livestock.
  • a fermented plant composition for use (for livestock).
  • the present invention provides an antibiotic substitute containing the prebiotic food according to claim 1 or 2, which is characterized by suppressing diarrhea in domestic animals, which uses the fermented composition as a main raw material.
  • One or two fruits selected from apples, persimmons, bananas, pineapples, akebi, actinidia, figs, wild strawberries, strawberries, wild grapes, grapes, wild grapes, peaches, plums, blueberries, raspberries, and loquats.
  • amino acid composition in 100 g, isoleucine: 30-200 mg, Leucine: 50-400 mg, Lysine: 20-200 mg, methionine: 10-150 mg, Cystine: 10-100 mg, Phenylalanine: 30-250 mg, Tyrosine: 20-200 mg, Threonine: 40-200 mg, tryptophan: 1-100 mg, Valine: 30-300 mg, Histidine: 10-200 mg, Arginine: 40-400 mg, Alanine: 50-300 mg, Aspartic acid: 100-600 mg, Glutamic acid: 100-1200 mg, Glycine: 30-300 mg, proline: 40-400 mg, Serine: 30-300 mg.
  • a method of raising livestock by feeding livestock a prebiotic additive for feed containing the fermented composition as a main raw material may also be used.
  • the fermented composition may be characterized by increasing specific short chain fatty acids in the gut of livestock.
  • a livestock breeding method may be adopted in which antibiotics are not administered or the amount used is reduced by feeding livestock with a prebiotic additive for feed, the main raw material of which is the fermented composition.
  • the fermented composition may be characterized by increasing specific short chain fatty acids in the gut of livestock.
  • the administration group of the present fermented composition maintained the same level of weight gain of livestock as compared to the antibiotic administration group, and the blood, the length and weight of the intestinal tract, and the villous tissue showed significant changes. No abnormal findings were observed, and diarrhea symptoms (stool score) were similar.
  • the present inventor focused on the present fermented composition and conducted an experiment to determine whether or not it affects the growth of livestock (especially edible pigs) under livestock conditions in which antibiotics are not administered. .
  • This fermented composition contains apples, persimmons, bananas, pineapples, akebi, actinidia, figs, wild strawberries, strawberries, wild grapes, grapes, wild grapes, peaches, plums, blueberries, raspberries, One or two or more kinds selected from loquat, and one or more kinds selected from citrus navel, hassaku, unshu orange, summer orange, orange, iyokan, kumquat, yuzu, kabosu, pomelo, ponkan, lemon, and lime Two or more kinds, one or more kinds selected from burdock, carrot, garlic, lotus root, and lily bulb belonging to root crops, and brown rice, glutinous rice, white rice, millet, corn, wheat, 1 or 2 or more selected from barley, foxtail millet, and millet; One or two or more selected from kelp, wakame, hijiki, green laver, and kawanori belonging to seaweeds, one or two or more selected from
  • the fermentation and maturation period was 3 years and 3 months or longer.
  • no additives, heat, or water were artificially added, and the fermentation was carried out in a stationary state for three years or more.
  • 1 or 2 types were selected from each type, and 15 types of raw materials were selected and fermented (this fermented composition) was used.
  • the introduced pigs used in this experiment were 23-day-old suckling piglets (crossbreed).
  • rats were fed with a general feed containing antibiotics (control group) and a feed (test group) in which the antibiotic was replaced with FBP (this fermented composition) for comparison.
  • the same mixed feed for piglets was used in both the control group and the test group.
  • 40 ppm of aviramycin was added as an antibiotic to the control group, and no antibiotic was added to the test group.
  • 0.125% of the present fermented composition was added to the test plot, and the present fermented composition was not added to the control plot.
  • the feeding period in this experiment was from 23 days old to 50 days old.
  • the breeding environment was a single cage, and the feeding method was free drinking water and constant feeding.
  • the mixed feed for piglets used a mixed feed suitable for the breeding stage.
  • Avilamycin antibiotic
  • FBP this fermented composition
  • sampling sites and measurement items is "feces, feces score/IgA”, "intravenous blood, blood biochemical analysis”, “cecal venous blood, short chain fatty acid analysis”, “cecal contents, short chain fatty acid analysis”, and “small intestine/large intestine, organ measurement/villus length/crypt depth”.
  • a score of 0 was assigned to a good stool, which was regarded as a stool.
  • Soft stool was scored as 1, diarrheal stool as score 2, watery stool as score 3, and more water-soluble diarrhea as score 4. The higher the score, the worse the stool.
  • FIG. 1 (left) is a graph showing the growth performance of edible pigs.
  • control group the body weight of edible pigs bred with a general feed containing antibiotics (control group) and a feed in which the antibiotic was replaced with FBP (this fermented composition) (test group) was measured and graphed. bottom.
  • the vertical axis is weight (kg), and the horizontal axis is age after birth (days). Both the control group and the test group showed similar weight gain over time.
  • the feed conversion rate is calculated as [feed intake (or consumption) (kg) / livestock product production (kg)].
  • the feed conversion rate is a unitless number.
  • the feed conversion rate increases as the postnatal age increases, reaching a peak at the 37th to 44th day postnatal age, and tends to decrease slightly at the 44th to 55th postnatal age.
  • the feed conversion rate showed almost the same values in the control plot and the test plot.
  • the feed conversion rate is the amount of feed consumed (or consumed) required for production of 1 kg of livestock product. This indicates that the higher the efficiency, the better.
  • Figure 2 shows data obtained by observing the intestinal environment at specific times in the control and test plots.
  • the left graph shows fecal scores at specific age periods.
  • the fecal score evaluation method is as described above.
  • the fecal score was good in both the control group and the test group, and the intestinal environment was stable during the period.
  • Right graph shows fecal IgA scores at specific ages (23 days, 31 days, 50 days). No change in resting intestinal immunity was observed.
  • the fecal IgA concentration correlates with the immune status in the intestinal tract.
  • the fecal IgA concentration is high due to infectious diseases, and conversely, if the fecal IgA concentration is extremely low, the risk of infectious diseases increases. Since the values were low and stable in both groups, it is thought that this indicates that the intestinal environment was relatively stable.
  • Fig. 3 is a graph showing short-chain fatty acid concentrations in cecal contents and cecal venous blood in the control and test groups. Acetic acid, propionic acid, and n-butyric acid were measured as short-chain fatty acids. Both the cecal contents and the venous blood showed no significant change in the composition ratio of overall short-chain fatty acids with FBP feeding in both the control group and the test group, but the short-chain fatty acid concentration was high in the test group. A trend was observed.
  • the intestinal mucosa plays an intestinal barrier function to prevent invasion of pathogens.
  • Butyric acid and propionic acid have the function of maintaining the intestinal mucosa and enhancing the intestinal barrier function.
  • butyric acid is the most important energy source for intestinal epithelial cells, and has been reported to promote the metabolism of the intestinal epithelium and the peristaltic movement of the intestinal tract.
  • Fig. 4 is a table showing the shape of the gastrointestinal tract and blood biochemical examination of edible pigs.
  • Anatomy such as small intestine (length, weight), large intestine (length, weight), digestive absorption (villus height ( ⁇ m), crypt depth ( ⁇ m), villus/crypt depth) in control and test groups
  • villus height ⁇ m
  • crypt depth ⁇ m
  • villus/crypt depth a table showing the shape of the gastrointestinal tract and blood biochemical examination of edible pigs.
  • Fig. 5 is an explanatory diagram of the effect mechanism of the present fermented composition on edible pigs.
  • harmful bacteria proliferate in the digestive tract due to stress or disease on the living body, and these harmful bacteria produce toxins and putrefactive substances that damage the inside of the digestive tract. Specifically, it damages the villi and crypts responsible for digestive and absorption functions, resulting in diarrhea.
  • antibiotics were given to livestock during breeding to remove the so-called harmful bacteria in the digestive tract, prevent diarrhea, etc., and promote growth.
  • harmful bacteria there were some bacteria that were resistant to antibiotics.
  • the fermented composition according to the present invention could be used as an antibiotic substitute material for raising livestock because the same effect can be obtained even when antibiotics are not given. That is, it is believed that the fermented composition increases useful bacteria in the gastrointestinal tract of livestock, promotes the production of short-chain fatty acids from these useful bacteria, promotes the utilization of nutrients, and can achieve a favorable intestinal environment. . Since the same effect can be obtained even when antibiotics are not given, the fermented composition according to the present invention was able to be used as an antibiotic substitute material for raising livestock.

Abstract

[Problème] Fournir un matériau de composition végétale fermentée qui peut être utilisé en tant que substitut d'un antibiotique dans l'élevage du bétail. [Solution] Un matériau de substitution d'un antibiotique destiné à être utilisé dans l'élevage du bétail, ledit matériau de substitution comprenant, en tant qu'ingrédient principal, une composition fermentée obtenue par fermentation et maturation de deux matériaux ou plus choisis parmi les fruits, les agrumes, la racine de bardane et la carotte appartenant aux cultures de racines, les céréales, les graines de sésame, les algues et les sucres, et ayant la caractéristique d'augmenter des acides gras à chaîne courte spécifiques dans les intestins.
PCT/JP2022/038769 2021-12-24 2022-10-18 Composition fermentée pour aliments, et procédé d'élevage de bétail WO2023119820A1 (fr)

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JP2021-211087 2021-12-24
JP2021211087 2021-12-24

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WO2023119820A1 true WO2023119820A1 (fr) 2023-06-29

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Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0787899A (ja) * 1993-09-22 1995-04-04 Hokueiken Corp:Kk 養豚飼料用添加剤
WO1998001042A1 (fr) * 1996-07-10 1998-01-15 Manda Fermentation Co., Ltd. Composition fermentaire, procede d'elaboration et utilisation
JP2001269125A (ja) * 2000-03-29 2001-10-02 Nihon Nosan Kogyo Kk 豚用飼料
JP2003238400A (ja) * 2002-02-12 2003-08-27 Nippon Zenyaku Kogyo Kk 抗コクシジウム組成物及びそれを含有する飼料
JP2005065671A (ja) * 2003-08-26 2005-03-17 Gouda:Kk 醗酵飼料
JP2007084504A (ja) * 2005-09-26 2007-04-05 Sanwa Shiyurui Kk 大麦を発酵に付したものを有効成分とする血管新生阻害の作用を有する組成物
JP2014011994A (ja) * 2012-06-07 2014-01-23 Takara Bio Inc 醸造粕を含む培地で培養した担子菌を含む組成物
WO2015197623A1 (fr) * 2014-06-26 2015-12-30 Novozymes A/S Bio-disponibilité améliorée des protéines de tourteau de palmiste à l'aide de conditions de presse continue plus douces et de traitement enzymatique
JP2019182763A (ja) * 2018-04-05 2019-10-24 株式会社ダイワ 組成物、およびそれを含む食品および飼料
JP2020043838A (ja) * 2018-09-21 2020-03-26 天草梅肉ポーク株式会社 家畜用飼料添加物及びその製造方法

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0787899A (ja) * 1993-09-22 1995-04-04 Hokueiken Corp:Kk 養豚飼料用添加剤
WO1998001042A1 (fr) * 1996-07-10 1998-01-15 Manda Fermentation Co., Ltd. Composition fermentaire, procede d'elaboration et utilisation
JP2001269125A (ja) * 2000-03-29 2001-10-02 Nihon Nosan Kogyo Kk 豚用飼料
JP2003238400A (ja) * 2002-02-12 2003-08-27 Nippon Zenyaku Kogyo Kk 抗コクシジウム組成物及びそれを含有する飼料
JP2005065671A (ja) * 2003-08-26 2005-03-17 Gouda:Kk 醗酵飼料
JP2007084504A (ja) * 2005-09-26 2007-04-05 Sanwa Shiyurui Kk 大麦を発酵に付したものを有効成分とする血管新生阻害の作用を有する組成物
JP2014011994A (ja) * 2012-06-07 2014-01-23 Takara Bio Inc 醸造粕を含む培地で培養した担子菌を含む組成物
WO2015197623A1 (fr) * 2014-06-26 2015-12-30 Novozymes A/S Bio-disponibilité améliorée des protéines de tourteau de palmiste à l'aide de conditions de presse continue plus douces et de traitement enzymatique
JP2019182763A (ja) * 2018-04-05 2019-10-24 株式会社ダイワ 組成物、およびそれを含む食品および飼料
JP2020043838A (ja) * 2018-09-21 2020-03-26 天草梅肉ポーク株式会社 家畜用飼料添加物及びその製造方法

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