WO2023077291A1 - Composition de réparation de barrière, produit de soins de la peau et procédé de préparation et utilisation associés dans la préparation d'une lingette humide - Google Patents

Composition de réparation de barrière, produit de soins de la peau et procédé de préparation et utilisation associés dans la préparation d'une lingette humide Download PDF

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WO2023077291A1
WO2023077291A1 PCT/CN2021/128346 CN2021128346W WO2023077291A1 WO 2023077291 A1 WO2023077291 A1 WO 2023077291A1 CN 2021128346 W CN2021128346 W CN 2021128346W WO 2023077291 A1 WO2023077291 A1 WO 2023077291A1
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parts
skin
barrier
skin care
combination
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PCT/CN2021/128346
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English (en)
Chinese (zh)
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刘桐
刘宇轩
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珠海德贡实业有限公司
Lah贸易有限责任公司
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Priority to CN202180003553.0A priority Critical patent/CN114173751B/zh
Priority to PCT/CN2021/128346 priority patent/WO2023077291A1/fr
Publication of WO2023077291A1 publication Critical patent/WO2023077291A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

Definitions

  • the application belongs to the technical field of daily chemicals, and in particular relates to a barrier repair composition, a skin care product, a preparation method thereof, and an application in the preparation of wet wipes.
  • the skin covers the surface of the human body and is the largest organ of the human body. It has the functions of barrier, absorption, excretion, and temperature regulation, among which the barrier function is the foundation.
  • the barrier function of the skin mainly means that the skin can protect the subcutaneous organs and tissues of the human body from harmful factors such as mechanical, physical, and chemical factors in the external environment.
  • a healthy skin barrier can effectively prevent the loss of various nutrients, electrolytes, and water in the tissue.
  • Barrier repair is mainly through the adjustment of three major balances: the balance of metabolism, the balance of water and oil, and the balance of microecology.
  • the surface of human skin carries more than 1,000 kinds of microorganisms, about 80% of which are bacteria; bacteria that settle on the surface of the skin can usually be divided into resident flora and transient flora, and the resident flora colonizes the skin in an orderly manner
  • a layer of biological barrier is formed, so that pathogenic bacteria and foreign bacteria cannot gain a foothold in the skin.
  • the micro-ecological balance maintains the resident bacteria of the skin in a suitable state, prevents the loss of transepidermal water evaporation, and enhances the skin's resistance to pathogenic diseases.
  • the ability and moisturizing ability of bacteria and foreign bacteria have become a crucial means.
  • amniotic fluid environment of the mother provides a mild and safe living environment for the baby. Simulating the composition and concentration of the amniotic fluid to build a safe and effective system to build the biological barrier of the skin and strengthen the physical barrier of the skin has become a new skin care direction.
  • CN105919819A discloses a napkin care wet tissue for infants and young children based on polyionized water, which includes polyionized water and an acidic chelating agent.
  • the buttock care wet tissue has a good cleaning and sterilization effect, but it is easy to cause excessive cleaning and sterilization, and the skin feel is poor, and it is easy to cause damage to the fragile skin of infants and young children.
  • CN104173207A discloses a skin barrier repairing preparation and a preparation method thereof.
  • the skin barrier repairing preparation includes deionized water, sucrose stearate, vitamin E, butylene glycol, glycerin, sodium hyaluronate and the like.
  • the skin barrier repair composition has a good effect of regulating the lipid content of the skin, but has a single function, has no bactericidal effect, and cannot maintain the micro-ecological balance of the skin; and the preparation process of the natural extract is complicated.
  • CN109172432A discloses a moisturizing and repairing composition, which comprises Cladosiphon Novae-Caledoniae (CLADOSIPHON NOVAE-CALEDONIAE) extract and lactobacillus/soybean milk fermentation product filtrate; the moisturizing repairing composition has good moisturizing effect, It can effectively adjust the water-oil balance of the skin, thereby repairing the skin barrier, but it has a single function and has no effect on regulating the skin flora, and a large amount of absolute ethanol is used in the preparation process, so the safety needs to be considered.
  • CLADOSIPHON NOVAE-CALEDONIAE Cladosiphon Novae-Caledoniae
  • CN105769713A discloses a baby skin care softening lotion, a baby skin care soft wet tissue and a preparation process thereof, the baby skin care lotion contains 0.01wt%-5wt% of nursing ingredients and 0.001wt%-0.3wt% of bactericidal ingredients ; wherein, the nursing ingredients are composed of vitamin E, licorice extract, and olive extract, and the weight ratio of the vitamin E, licorice extract, and olive extract is 0.01-0.5%:0.1-3%:0.1- 3%.
  • the baby skin care lotion has a bactericidal effect, the addition of a bactericide may cause damage to the baby's skin; and the effect is single, unable to establish a biological barrier and maintain the micro-ecological balance of the skin.
  • CN104887568A discloses a pure plant wet wipe, which is composed of a fully degradable non-woven fabric and a wet wipe liquid, which includes water, xylitol, licorice extract, aloe vera and vitamin E.
  • a pure plant wet wipe has no harm to human skin, it cannot promote the growth of beneficial bacteria on the skin surface of infants and young children, and cannot build a microbial barrier; and it cannot supplement the lipid components between keratinocytes, nourish the skin, and build a physical barrier for the skin.
  • CN105663018A discloses a cosmetic composition
  • a cosmetic composition comprising water, 4-tert-butylcyclohexanol, plankton extract, aloe extract and zucchini seed extract.
  • the main function of the cosmetic composition is to remove the stratum corneum, and the purpose is to maintain the metabolic balance of the stratum corneum, thereby repairing the skin barrier.
  • the present application provides a barrier repairing composition, a skin care product, a preparation method thereof, and an application in preparing wet wipes.
  • the barrier repairing composition provided by this application is safe and non-irritating. By promoting the growth of beneficial bacteria and inhibiting the growth of harmful microorganisms, the microbial barrier on the skin surface is established; by supplementing nutrition and moisture to the skin, the physical barrier of the skin is enhanced.
  • the present application provides a barrier repair composition
  • the preparation raw materials of the barrier repair composition include by weight parts:
  • the inorganic salts include calcium salts, magnesium salts, potassium salts, sodium salts and manganese salts.
  • the barrier function of the skin mainly means that the skin can protect the subcutaneous organs and tissues of the human body from harmful factors such as mechanical, physical, and chemical factors in the external environment.
  • a healthy skin barrier can effectively prevent the loss of various nutrients, electrolytes, and water in the tissue.
  • Human skin needs to resist various harmful substances or ultraviolet rays in the daily environment, and the skin barrier is gradually damaged, so barrier repair is an important direction of skin care.
  • Barrier repair is mainly through the adjustment of three major balances: the balance of newborn and fading, the balance of water and oil, and the balance of microecology.
  • water, inorganic salts, glucose, protein and folic acid cooperate synergistically, while ensuring safety and reliability, it can effectively promote the growth of probiotics on the skin surface, promote the establishment of micro-ecological balance on the skin surface, inhibit The growth of harmful microorganisms builds the microbial barrier of the skin; it also nourishes the skin, balances oil, promotes the absorption of water and nutrients, and makes the skin elastic.
  • water is used as a solvent, mild and non-irritating; inorganic salts can clean the skin, balance the water-oil balance of the skin, and can inhibit the growth of harmful microorganisms; glucose can enhance skin resistance, activate skin cells, promote collagen synthesis, and enhance Skin elasticity, in addition, it can also play the role of anti-allergic and sunscreen, can enhance the skin's ability to resist ultraviolet rays, can also increase the renewal speed of the cuticle of the skin, and promote wound healing; protein can enhance the immune function of the skin and promote beneficial bacteria on the skin
  • the growth of the skin can regulate skin moisture and acid-base, and can balance oil, improve skin condition, and can enhance the function of the lymphatic system, improve the anti-allergic ability of sensitive skin, and can also chelate with divalent metal ions in the inner layer of the skin Reaction, prevent excessive divalent metal ions from cross-linking with collagen in the skin, maintain enough collagen fibers and elastic fibers, make the skin smooth, delicate and elastic, and prevent wrinkles; folic acid
  • the parts by weight of the inorganic salt are 0.01-9 parts, such as 0.01 parts, 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, etc.
  • the parts by weight of the glucose are 0.1-1 parts, such as 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts , 0.8 parts, 0.9 parts, 1 part, etc.
  • the parts by weight of the protein are 0.5-2 parts, such as 0.5 parts, 0.7 parts, 0.9 parts, 1.1 parts, 1.3 parts, 1.5 parts, 1.7 parts , 2 copies, etc.
  • the weight part of the folic acid is 0.0001-0.5 parts, for example, it can be 0.0001 parts, 0.01 parts, 0.05 parts, 0.09 parts, 0.1 parts, 0.2 parts, 0.3 parts , 0.4 parts, 0.5 parts, etc.
  • the weight part of the polyol is 0.01-0.5 parts, such as 0.01 parts, 0.05 parts, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts portion etc.
  • the parts by weight of the water are 800-1200 parts, such as 800 parts, 850 parts, 900 parts, 950 parts, 1000 parts, 1050 parts, 1100 parts, 1150 parts , 1200 copies, etc.
  • the weight ratio of the calcium salt, magnesium salt, potassium salt, sodium salt and manganese salt is (0.01-0.2):(0.01-0.1):(0.2-0.6): (4-8):(0.01-0.1), such as 0.01:0.01:0.2:4:0.01, 0.01:0.05:0.3:5:0.05, 0.05:0.08:0.5:7:0.1, 0.1:0.09:0.4 :6:0.04, 0.2:0.1:0.6:8:0.1, etc.
  • the concentration of the inorganic salt in the composition can be made to be similar to the concentration of the inorganic salt in the amniotic fluid, thereby better caring for the skin.
  • the calcium salt includes any one or a combination of at least two of calcium carbonate, calcium chloride, calcium sulfate or calcium phosphate.
  • the magnesium salt includes any one or a combination of at least two of magnesium sulfate, magnesium chloride, magnesium carbonate or magnesium phosphate.
  • the potassium salt includes any one or a combination of at least two of potassium chloride, potassium carbonate, potassium sulfate or potassium phosphate.
  • the sodium salt includes any one or a combination of at least two of sodium chloride, sodium carbonate, sodium sulfate or sodium phosphate.
  • the manganese salt includes any one or a combination of at least two of manganese chloride, manganese carbonate, manganese sulfate or manganese phosphate.
  • the protein includes any one or a combination of at least two of casein, glycoprotein, lipoprotein, trypsin or pancreatic casein, preferably casein.
  • casein is a protein containing phosphorus and calcium. Casein can cooperate with inorganic salts, glucose and folic acid to promote the growth of beneficial bacteria, resist external harmful microorganisms, and jointly build a microbial barrier on the skin surface.
  • the polyhydric alcohol includes any one or a combination of at least two of glycerin, 1,3-butanediol or 1,3-propanediol.
  • polyols can absorb water from the environment and supplement the skin, and at the same time have a certain effect of inhibiting the growth of harmful microorganisms.
  • the raw materials for the preparation of the barrier repair composition further include any one or a combination of at least two of Bacillus/soybean fermentation product extract and/or sodium hyaluronate.
  • the Bacillus/soybean fermentation extract uses soybeans as raw materials to cultivate Bacillus and extract the metabolites of Bacillus.
  • Soybean fermentation products are rich in nutrients, which can nourish the skin, promote metabolism, and condition the skin; hyaluronic acid Sodium is an inherent biological substance of the skin.
  • Exogenous sodium hyaluronate can supplement the endogenous sodium hyaluronate of the skin.
  • Sodium hyaluronate can penetrate into the epidermis of the skin to promote the supply of skin nutrients and the excretion of waste, and Sodium hyaluronate has a strong moisturizing effect.
  • sodium hyaluronate can promote the proliferation and differentiation of epidermal cells, as well as scavenge oxygen free radicals, which can promote the regeneration of injured skin.
  • the parts by weight of the Bacillus/soybean fermentation product extract are 0.001-0.05 parts, such as 0.001 parts, 0.005 parts, 0.007 parts, 0.01 parts, 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, etc. .
  • the weight part of the sodium hyaluronate is 0.001-0.05 parts, such as 0.001 parts, 0.005 parts, 0.007 parts, 0.01 parts, 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, etc.
  • the molecular weight of the sodium hyaluronate is 1800000-2200000Da, such as 1800000Da, 1900000Da, 2000000Da, 2100000Da, 22000000Da, etc.
  • the preparation raw materials of the barrier repair composition include by weight parts:
  • the water, glucose, inorganic salts, protein, folic acid, polyols, Bacillus/soybean fermentation product extract and sodium hyaluronate in the barrier repair composition cooperate synergistically, under the condition of ensuring safety and non-irritation , can further promote the skin's absorption of moisture and nutrients, making the skin supple, smooth and elastic, and can strengthen the skin's ability to resist external damage, inhibit the invasion of harmful microorganisms, promote the growth of probiotics, and maintain the ecological balance of the skin surface .
  • the weight part of the calcium salt is 0.01-0.2 parts, such as 0.01 parts, 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, etc.
  • the weight part of the magnesium salt is 0.01-0.1 part, such as 0.01 part, 0.03 part, 0.05 part, 0.07 part, 0.1 part and so on.
  • the weight part of the potassium salt is 0.2-0.6 parts, such as 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, etc.
  • the weight part of the sodium salt is 4-8 parts, such as 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, etc.
  • the manganese salt may be in parts by weight of 0.01-0.1 part, for example, 0.01 part, 0.03 part, 0.05 part, 0.07 part, 0.1 part, etc.
  • the present application provides a skin care product.
  • the preparation raw materials of the skin care product include: oil, ceramide, polyquaternium salt, the barrier repair composition as described in the first aspect, and water.
  • the barrier repairing composition is used in combination with oil, ceramide and polyquaternium salts, which can maintain the ecological balance of the skin surface, promote the growth of beneficial bacteria, and inhibit the growth of harmful bacteria while ensuring safety and non-irritation.
  • the growth of microorganisms builds a biological barrier; it can also supplement the lipid components between cuticles to enhance the physical barrier of the skin care products described in this application.
  • oil can not only clean the skin, but also has the effect of moisturizing, moisturizing and whitening, and can give the skin a certain degree of elasticity and luster; ceramide can promote the metabolism of skin cells, repair the skin barrier, and effectively relieve acne, and to a certain extent It can accelerate the disappearance of acne marks; in addition, ceramide also has the effect of moisturizing and locking water, which can effectively improve the phenomenon of dry and peeling skin, thereby slowing down the appearance of fine lines; polyquaternium salt has good wettability, Soft and film-forming, can form a film on the skin surface, making the skin supple and smooth.
  • the raw materials for the preparation of skin care products described in this application include by parts by weight:
  • the weight fraction of the oil is 1-5 parts, for example, it can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, etc.
  • the weight part of the ceramide is 0.1-0.5 parts, such as 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, etc.
  • the parts by weight of the polyquaternium salt are 0.1-1 part, such as 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part parts, 0.9 parts, 1 part, etc.
  • the parts by weight of the barrier repair composition are 30-40 parts, such as 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts parts, 38 parts, 39 parts, 40 parts, etc.
  • the parts by weight of the water are 50-75 parts, such as 50 parts, 52 parts, 54 parts, 56 parts, 58 parts, 60 parts, 62 parts, 64 parts, 66 parts parts, 68 parts, 70 parts, 73 parts, 75 parts, etc.
  • the oil includes any one of PEG-7 olive oil ester, hydrolyzed jojoba ester, PEG-10 wild soybean sterol or laureth-12/White Pond Seed Oil or A combination of at least two, preferably a combination of PEG-7 Olivate and Laureth-12/White Pond Seed Oil.
  • PEG-7 olive oil ester and laureth-12/white pond flower seed oil are used together to synergize. While replenishing skin moisture, it can also enhance the skin's antioxidant capacity. In addition, it can also Provides a refreshing skin feel.
  • PEG-7 olive oil ester is a derivative of olive oil, and the skin feels refreshing and supple;
  • laureth-12/white pond flower seed oil is a derivative of white pond flower seed oil, which contains a large amount of anti-oxidant Long-chain fatty acids, and the exfoliating hormone in the white pond flower seed oil can prevent water loss and regenerate the skin.
  • the white pond flower seed oil can adjust the exudation of water and compounds by changing the keratin tissue, reabsorb water and regenerate the cells in the epidermis Hydrates to lock moisture in the epidermis of the skin.
  • the weight ratio of the PEG-7 olive oil ester and laureth-12/white pond flower seed oil is 1:(0.8-1.2), such as 1:0.8, 1:0.9, 1:1 , 1:1.1, 1:1.2, etc.
  • the polyquaternium salt includes any one or a combination of at least two of polyquaternium-10, polyquaternium-4 or polyquaternium-57.
  • polyquaternium-57 can provide slippery skin feel while having good moisturizing properties.
  • the preparation raw materials of the skin care product further include any one or a combination of at least two of preservatives, flavoring agents or dispersants.
  • the preservative includes any one or a combination of at least two of 1,2-hexanediol, sodium benzoate, phenoxyethanol or hydroxyacetophenone, preferably a combination of sodium benzoate and phenoxyethanol.
  • the combined use of sodium benzoate and phenoxyethanol can effectively control the production of more bacteria in skin care products and avoid the deterioration of skin care products; it can also penetrate the cell membrane and enter the cell body to play a role in sterilization and antibacterial. It is a relatively safe preservative.
  • the weight ratio of sodium benzoate to phenoxyethanol is 1:(0.8-1.2), for example, it can be 1:0.8, 1:0.9, 1:1, 1:1.1, 1:1.2, etc.
  • the weight part of the preservative is 0.3-1 part, such as 0.3 part, 0.5 part, 0.7 part, 0.9 part, 1 part, etc.
  • the flavoring agent includes any one or a combination of at least two of vetiver essential oil, lemon essential oil or lavender essential oil.
  • the parts by weight of the flavoring agent are 0.005-0.05 parts, such as 0.005 parts, 0.009 parts, 0.011 parts, 0.017 parts, 0.02 parts, 0.027 parts, 0.03 parts, 0.036 parts, 0.04 parts, 0.044 parts , 0.05 copies, etc.
  • the dispersant includes PEG-40 hydrogenated castor oil, PPG-26 butane-26/PEG-40 hydrogenated castor oil, PEG-35 castor oil/PEG-50 hydrogenated castor oil/nonylphenol polyether -12. Any one or a combination of at least two of PEG-50 hydrogenated castor oil/nonylphenol polyether-25, preferably PEG-40 hydrogenated castor oil;
  • PPG-26 buteth-26/PEG-40 hydrogenated castor oil means the combination of PPG-26 buteth-26 and PEG-40 hydrogenated castor oil;
  • Alcohol-26/PEG-40 hydrogenated castor oil, PEG-35 castor oil/PEG-50 hydrogenated castor oil/nonylphenol polyether-12, PEG-50 hydrogenated castor oil/nonylphenol polyether-25 are all Conventional products available commercially.
  • the weight fraction of the dispersant is 0.01-0.05 parts, such as 0.01 parts, 0.011 parts, 0.017 parts, 0.02 parts, 0.027 parts, 0.03 parts, 0.036 parts, 0.04 parts, 0.044 parts, 0.05 parts, etc.
  • the present application provides a method for preparing a skin care product as described in the second aspect, the method for preparing a skin care product includes the following steps:
  • step (2) The water phase obtained in step (1), oil, ceramide, polyquaternium salt and barrier repair composition are mixed, homogenized, and filtered to obtain the skin care product.
  • the heating temperature is 80-90°C; for example, it can be 80°C, 81°C, 82°C, 83°C, 84°C, 85 °C, 86°C, 87°C, 88°C, 89°C, 90°C, etc.
  • the incubation time is 20-40min, such as 20min, 22min, 24min, 26min, 28min, 30min, 32min, 34min, 36min, 38min, 40min, etc.
  • the mixing further includes any one or a combination of at least two of preservatives, flavoring agents or dispersants.
  • the mixing temperature is 25-45°C, such as 25°C, 27°C, 29°C, 31°C, 33°C, 35°C, 37°C, 39°C, 41°C, 43°C, 45°C, etc.; the time is 10-30min, such as 10min, 12min, 14min, 16min, 18min, 20min, 22min, 24min, 26min, 28min, 30min, etc.
  • the homogeneous temperature is 25-45°C, such as 25°C, 27°C, 30°C, 33°C, 35°C, 37°C, 40°C, 42°C, 45°C etc.; the time is 3-8 minutes, for example, it can be 3 minutes, 5 minutes, 6 minutes, 7 minutes, 8 minutes, etc.
  • the filter cloth is 500-1000 mesh, such as 500 mesh, 600 mesh, 700 mesh, 800 mesh, 900 mesh, 1000 mesh, etc.
  • the present application provides a barrier repair composition as described in the first aspect, or an application of the skin care product as described in the second aspect in the preparation of wet wipes.
  • the barrier repair composition described in the application can promote the growth of probiotics on the surface of human skin, inhibit the growth of harmful microorganisms, thereby promoting the establishment of micro-ecological balance on the surface of the skin, thereby establishing a microbial barrier on the surface of the skin;
  • the barrier repair composition described in this application can enhance the physical barrier of the skin by supplementing nutrition and moisture to the skin;
  • Fig. 1 is a schematic diagram of the effect of the barrier repair composition provided by Examples 1-16 and Comparative Examples 1-10 on the growth of Escherichia coli.
  • Fig. 2 is a schematic diagram of the effect of the barrier repair composition provided by Examples 1-16 and Comparative Examples 1-10 on the growth of Lactobacillus.
  • Fig. 3 is a schematic diagram of the effect of the barrier repair composition provided by Examples 1-16 and Comparative Examples 1-10 on the growth of Lactobacillus acidophilus.
  • Fig. 4 is a schematic diagram of the influence of the skin care products provided by Application Examples 1-9 and Comparative Examples 1-3 on the average water loss.
  • Part source of components is as follows in the following examples:
  • This embodiment provides a barrier repair composition
  • the preparation raw materials of the barrier repair composition include the following composition in parts by weight:
  • the preparation method of the barrier repair composition comprises the following steps: heating the deionized water to 82°C according to the formula amount, then cooling down to 37°C, and mixing with calcium carbonate, magnesium sulfate, potassium chloride, sodium chloride, manganese sulfate, glucose , casein, folic acid, polyol, bacillus/soybean fermentation product extract and sodium hyaluronate are mixed to obtain the barrier repair composition.
  • This embodiment provides a barrier repair composition
  • the preparation raw materials of the barrier repair composition include the following composition in parts by weight:
  • the preparation method of the barrier repair composition comprises the following steps: heating the deionized water to 82°C according to the formula amount, then cooling down to 37°C, and mixing with calcium carbonate, magnesium sulfate, potassium chloride, sodium chloride, manganese sulfate, glucose , casein, folic acid, polyol, bacillus/soybean fermentation product extract and sodium hyaluronate are mixed to obtain the barrier repair composition.
  • This embodiment provides a barrier repair composition
  • the preparation raw materials of the barrier repair composition include the following composition in parts by weight:
  • the preparation method of the barrier repair composition comprises the following steps: heating the deionized water to 82°C according to the formula amount, then cooling down to 37°C, and mixing with calcium carbonate, magnesium sulfate, potassium chloride, sodium chloride, manganese sulfate, glucose , casein, folic acid, polyol, bacillus/soybean fermentation product extract and sodium hyaluronate are mixed to obtain the barrier repair composition.
  • This embodiment provides a barrier repair composition
  • the preparation raw materials of the barrier repair composition include the following composition in parts by weight:
  • the preparation method of the barrier repair composition comprises the following steps: heating the deionized water to 82°C according to the formula amount, then cooling down to 37°C, and mixing with calcium carbonate, magnesium sulfate, potassium chloride, sodium chloride, manganese sulfate, glucose , casein, folic acid, polyol, bacillus/soybean fermentation product extract and sodium hyaluronate are mixed to obtain the barrier repair composition.
  • This embodiment provides a barrier repair composition
  • the preparation raw materials of the barrier repair composition include the following composition in parts by weight:
  • the preparation method of the barrier repair composition comprises the following steps: heating the deionized water to 82°C according to the formula amount, then cooling down to 37°C, and mixing with calcium carbonate, magnesium sulfate, potassium chloride, sodium chloride, manganese sulfate, glucose , casein, folic acid, polyol, bacillus/soybean fermentation product extract and sodium hyaluronate are mixed to obtain the barrier repair composition.
  • Embodiments 6-10 provide 5 kinds of barrier repair compositions, and the only difference from Embodiment 1 is that the examples of calcium salts, magnesium salts, potassium salts, sodium salts and manganese salts with higher parts by weight are provided respectively.
  • the preparation method is the same as in Example 1; the raw materials for the preparation of the barrier repair composition described in each embodiment are composed of the following components in parts by weight:
  • Embodiments 11-15 provide 5 kinds of barrier repair compositions, and the only difference from Embodiment 1 is that they provide examples with low parts by weight of any one of calcium salt, magnesium salt, potassium salt, sodium salt and manganese salt , the preparation method is the same as in Example 1; the raw materials for the preparation of the barrier repair composition described in each embodiment are composed of the following components in parts by weight:
  • Example 16 provides a barrier repair composition, the only difference from Example 1 is that casein is replaced by glycoprotein of the same weight, and other components and preparation methods are the same as in Example 1.
  • Comparative Examples 1-5 provide 5 kinds of barrier repair compositions, the only difference from Preparation Example 1 is that there is no example of any one of calcium salt, magnesium salt, potassium salt, sodium salt and manganese salt, and the preparation method is the same as that of Preparation Example 1;
  • the raw materials for the preparation of the barrier repair composition described in each comparative example consist of the following components in parts by weight:
  • Comparative Examples 6-10 provide 4 kinds of barrier repair compositions, the only difference from Preparation Example 1 is that they lack inorganic salts (calcium salts, magnesium salts, potassium salts, sodium salts and manganese salts), glucose, protein, folic acid and multiple An example of any one of the alcohols, other components and preparation methods are the same as Preparation Example 1; the preparation raw materials of the barrier repair composition described in each comparative example are composed of the following components in parts by weight:
  • Test samples barrier repair compositions provided by Examples 1-16 and Comparative Examples 1-10
  • Test method Escherichia coli, Lactobacillus and Lactobacillus acidophilus were inoculated into the agar nutrient medium containing 5% of the barrier repair composition provided by the test sample at a ratio of 1:1:1 of viable bacteria (for the formula, see “Disinfection Technology Specification "(2002 version)), after culturing for 24 hours according to the standard method, the number of colonies of each bacterial population was counted.
  • By co-cultivating skin resident bacteria and pathogenic bacteria that cause micro-ecological balance damage in the same environment simulating the actual situation of skin flora under the condition of drug administration to patients, and illustrating the composition of the present application for the changes in the abundance of different flora.
  • the pharmacological effect of up-regulating the resident flora and down-regulating the pathogenic flora; change value the proportion of the number of strains after cultivation - the proportion of the number of strains before cultivation;
  • the barrier repair composition provided by the present application reduced the proportion of E. coli strains by 3.23-4.89%, and the proportion of Lactobacillus strains increased by 5.05-10.63%.
  • the proportion of the number of lactobacillus strains has increased by 4.28-8.09%;
  • the barrier repair composition provided by the preferred technical solution has reduced the proportion of Escherichia coli strains by 3.23-4.89%, and the proportion of the number of lactic acid bacteria strains has increased 8.64-10.63%, and the proportion of Lactobacillus acidophilus strains increased by 6.54-8.09%.
  • the barrier repair composition provided in Example 1-16 can effectively promote probiotics (Lactobacillus, Lactobacillus acidophilus ), inhibit the growth of harmful bacteria (Escherichia coli), indicating that in the barrier repair composition provided by the application, glucose, inorganic salts, protein, folic acid, polyol, bacillus/soybean fermentation product extract and sodium hyaluronate Synergistically, under the condition of ensuring safety and non-irritation, it can inhibit the growth of harmful microorganisms, promote the growth of probiotics, maintain the ecological balance of the skin surface, and thus build a microbial barrier on the skin surface.
  • probiotics Lactobacillus acidophilus
  • harmful bacteria Esscherichia coli
  • Example 1 From the comparison of Example 1 and Comparative Examples 1-5, it can be seen that the type of inorganic salt has a great influence on the efficacy of the barrier repair composition to regulate the balance of skin flora.
  • the barrier repair composition When lacking any one of calcium salt, magnesium salt, potassium salt, sodium salt and manganese salt, it is not conducive to the barrier repair composition to play a role in maintaining the balance of skin surface flora, indicating that the components in the inorganic salt cooperate with each other, Synergy.
  • Example 1 From the comparison of Example 1 and Examples 6-15, it can be seen that the weight parts of calcium salt, magnesium salt, potassium salt, sodium salt and manganese salt in the inorganic salt will affect the function of the barrier repair composition to build the microbial barrier on the skin surface.
  • concentration of various salts When the concentration of various salts is high or low, it is not conducive to promoting the growth of probiotics. This may be because only when the concentrations of calcium salts, magnesium salts, potassium salts, sodium salts and manganese salts in the barrier repairing composition are similar to those in amniotic fluid, the skin surface can be constructed under the synergistic effect of glucose, folic acid and protein. microbial barrier.
  • Example 1 From the comparison of Example 1 and Example 16, it can be seen that the choice of protein will affect the efficacy of the barrier repair composition, and the growth of lactic acid bacteria is inhibited when casein is replaced by glycoprotein of the same weight.
  • Example 1 Through the comparison of Example 1 and Comparative Examples 6-10, it can be seen that when any component in inorganic salts, glucose, folic acid, protein and polyols is lacking, the efficacy of the barrier repair composition will be seriously affected, and the probiotics will be seriously affected.
  • the growth of bacteria will affect the effect of inhibiting the growth of harmful bacteria to a certain extent; it shows that only when inorganic salts, folic acid, protein, glucose and polyols cooperate with each other and synergize, can they achieve the ideal effect of regulating the balance of skin flora.
  • Test samples barrier repair compositions provided by Examples 1-16 and Comparative Examples 1-10
  • Test method Inoculate the glycerol tube of Bifidobacterium infantis into BS medium at a ratio of 1:100, place it in an incubator for static anaerobic cultivation, and the cultivation temperature is 37°C; the next day, press the activated seeds Inoculate it into the barrier repair composition medium provided by the test sample at a ratio of 1:50, place it in an incubator for static anaerobic culture, and set the culture medium of the control group as normal saline; after 48 hours of culture, the Bifidobacterium infantis grows Stop the culture after reaching the plateau stage, take an appropriate amount of medium for OD600 detection (OD600 value can indirectly reflect the growth of microorganisms); take 100 ⁇ L of medium, spread the bacterial liquid on the BS solid medium in the ultra-clean workbench, and apply After the cloth is finished, put it into the anaerobic bag, put it into the anaerobic bag, seal the outlet of the anaerobic bag, and put the anaerobic bag in the
  • the barrier repair composition (Example 1-16) provided by the present application promotes the OD600 value between 0.074-0.121, the number of Bifidobacterium infantis between 130-200CFU/mL, and the pH value between 4.52- Between 4.89; the barrier repair composition provided by the preferred technical scheme (embodiment 1-5) promotes the OD600 value between 0.104-0.121, the number of Bifidobacterium infantis is between 180-200CFU/mL, and the pH value is between 4.52-4.78 between.
  • the barrier repair composition mentioned in Example 1-16 can significantly promote the growth of Bifidobacterium infantis;
  • inorganic salts, folic acid, glucose and protein can cooperate with each other to effectively promote the growth of Bifidobacterium infantis.
  • Example 1 Through the comparison of Example 1 and Comparative Examples 6-10, it can be known that the lack of any component in inorganic salts, glucose, protein, folic acid and polyols will seriously affect the effect of the barrier repair composition on promoting the growth of Bifidobacterium infantis; Especially in the absence of inorganic salts, the barrier repair composition failed to promote the growth of Bifidobacterium infantis.
  • Test samples barrier repair compositions provided by Examples 1-16 and Comparative Examples 1-10
  • Test method Inoculate Lactobacillus glycerol tubes into MRS medium at a ratio of 1:100, place them in an incubator at a temperature of 37°C; the next day, inoculate activated seeds at a ratio of 1:50 to the test sample
  • the culture medium of the barrier repair composition provided, it is placed in an incubator for culture, and the culture medium of the control group is set as physiological saline.
  • OD600 value can indirectly reflect the growth of microorganisms, the higher the OD600, the better the growth of microorganisms);
  • the barrier repair composition (Example 1-16) provided by the present application is used as a culture medium for Lactobacillus, the OD600 value is between 0.199-0.270 at 6h, and the OD600 value at 24h is 0.498-0.531 Between, the OD600 value is between 0.509-0.619 at 30h, and the OD600 value is between 0.559-0.710 at 48h; , the OD600 value is between 0.224-0.270 at 6h, 0.508-0.531 at 24h, 0.579-0.619 at 30h, and 0.663-0.710 at 48h.
  • the lactobacilli in the samples of the barrier repair composition provided in Examples 1-16 as culture medium were higher than those in the blank control group, indicating that the barrier repair composition provided by the present application can promote probiotics. growth of Lactobacillus.
  • the barrier repair composition provided in Examples 1-16 can significantly promote the growth of Lactobacillus; it shows that in the barrier repair composition provided by the present application, inorganic salts, folic acid , glucose, protein and polyols can cooperate with each other to effectively promote the growth of Lactobacillus.
  • the preparation raw material of described skin care product comprises the following composition by weight part:
  • the preparation method of the skin care product comprises the following steps: according to the amount of the formula, heating the water to 85°C, keeping it warm for 30 minutes, then cooling down to 40°C, adding PEG-7 olive oil ester, laureth-12/white pool flower seed Oil, ceramide, polyquaternium-57, barrier repair composition, sodium benzoate, phenoxyethanol, vetiver essential oil and PEG-40 hydrogenated castor oil, mixed for 20 minutes, then homogenized at 40 ° C for 5 minutes, and finally adopted 800 The objective filter cloth is filtered to obtain the skin care product.
  • the preparation raw material of described skin care product comprises the following composition by weight part:
  • the preparation method of the skin care product comprises the following steps: heating the water to 82°C, keeping it warm for 32 minutes, then cooling down to 35°C, adding PEG-7 olive oil ester, laureth-12/white pond flower seed oil, and ceramide , polyquaternium-57, barrier repair composition, sodium benzoate, phenoxyethanol, vetiver essential oil and PEG-40 hydrogenated castor oil, mixed for 22 minutes, then homogenized at 35°C for 6 minutes, and finally filtered with 800-mesh filter cloth , to obtain the skin care product.
  • the preparation raw material of described skin care product comprises the following composition by weight part:
  • the preparation method of the skin care product comprises the following steps: heating the water to 87°C, keeping it warm for 33 minutes, then cooling down to 37°C, adding PEG-7 olive oil ester, laureth-12/white pond flower seed oil, and ceramide , polyquaternium-57, barrier repair composition, sodium benzoate, phenoxyethanol, vetiver essential oil and PEG-40 hydrogenated castor oil, mixed for 20 minutes, then homogenized at 37°C for 4.5 minutes, and finally filtered with 800-mesh filter cloth , to obtain the skin care product.
  • the preparation raw material of described skin care product comprises the following composition by weight part:
  • the preparation method of the skin care product comprises the following steps: heating the water to 88°C, keeping it warm for 29 minutes, then cooling down to 42°C, adding PEG-7 olive oil ester, laureth-12/white pond flower seed oil, and ceramide , polyquaternium-57, barrier repair composition, sodium benzoate, phenoxyethanol, vetiver essential oil and PEG-40 hydrogenated castor oil, mixed for 20 minutes, then homogenized at 42°C for 5 minutes, and finally filtered with 800-mesh filter cloth , to obtain the skin care product.
  • the preparation raw material of described skin care product comprises the following composition by weight part:
  • the preparation method of the skin care product comprises the following steps: heating the water to 82°C, keeping it warm for 26 minutes, then cooling down to 38°C, adding PEG-7 olive oil ester, laureth-12/white pond flower seed oil, and ceramide , polyquaternium-57, barrier repair composition, sodium benzoate, phenoxyethanol, vetiver essential oil and PEG-40 hydrogenated castor oil, mixed for 30 minutes, then homogenized at 38°C for 7 minutes, and finally filtered with 800-mesh filter cloth , to obtain the skin care product.
  • This application example provides a skin care product, the only difference from application example 1 is that the weight part of the barrier repair composition is reduced to 20 parts, and other components and preparation methods are the same as application example 1.
  • This application example provides a skin care product, the only difference from application example 1 is that the weight part of the barrier repair composition is increased to 50 parts, and the other components and preparation methods are the same as application example 1.
  • Application examples 8-9 provide two kinds of skin care products, the only difference from application example 1 is that they lack any examples of PEG-7 olive oil ester or laureth-12/white pond flower seed oil respectively, and the preparation method is the same Application example 1; the preparation raw materials of the barrier repair composition described in each application example are composed of the following components in parts by weight:
  • Comparative application examples 1-3 provide three skin care products, the only difference from application example 1 is that there is no example of any one of oil, ceramide or barrier repair composition, and the other components and preparation methods are the same as application example 1 , the preparation raw materials of the skin care products described in each comparative application example are composed of the following ingredients in parts by weight:
  • Test sample the skin care products provided by Application Examples 1-9 and Comparative Application Examples 1-3
  • Test method 120 volunteers with dry forearm skin between the ages of 18 and 30 were selected as subjects. The subjects were divided into 12 groups, with 10 people in each group. The inclusion condition was that the moisture content of the inner forearm was less than 45; Before using the product, mark the test area for the subject; use the sample in different areas, the product volume is (2.0 ⁇ 0.1) uL/cm 2 , the test site is the forearm internal test; the test index is the transcutaneous water loss value (TEWL value) , Test time points: before use, two weeks and four weeks after use.
  • TEWL value transcutaneous water loss value
  • change value 1 average transdermal water loss value after two weeks of use - average transdermal water loss value before use
  • change value 2 average transdermal water loss value after four weeks of use - Average transcutaneous water loss value before use
  • Test sample skin care products provided by application examples 1-18 and comparative application examples 1-12
  • Test method According to the standard of "SN/T 2329-2009 Cosmetic Eye Irritation/Corrosion Test on Chicken Embryo Allantoic Membrane", take 0.3mL of skin care products provided by the test sample and drop directly on the surface of the chicken embryo allantoic membrane , Observe and record the chorioallantoic membrane toxicity effect indicators (such as bleeding, coagulation and blood vessel melting) after 5 minutes of action. These indicators reflect the changes in the morphological structure, color and permeability of blood vessels and vascular network, as well as the phenomenon of chorioallantoic membrane protein denaturation and the degree of damage. These are then combined to obtain a score for evaluating the eye irritation of the test substance.
  • chorioallantoic membrane toxicity effect indicators such as bleeding, coagulation and blood vessel melting
  • Stimulus score method For tests conducted using the reaction time method, the calculation formula for calculating the stimulus score (IS) is:
  • secH bleeding time
  • secL vascular melting time
  • secC coagulation time
  • Test sample the skin care products provided by Application Examples 1-9 and Comparative Application Examples 1-3
  • Test method Firstly, 24 hours before the test, the two eyes of the experimental animals were routinely checked. During the test, the lower eyelid of one side of the eye of the experimental animal was gently opened, 0.1 mL of the test sample was sucked and dropped into the conjunctival sac, and the eyes were passively closed for 1 second. Treated as self-control; 1h, 24h, 48h, 72h, 4d, 7d, 14d and 21d after the end of the test, the eyes were checked and scored, if there was no irritation within 72h, or the eyes completely recovered on the 7th or 14th day, Trials may be terminated early. The cornea was examined with 2% sodium fluorescein when necessary.
  • the irritation response score was calculated. According to the irritation response score and recovery time evaluation, the eye irritation response was graded according to Table 7.

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Abstract

La présente demande concerne une composition de réparation de barrière, un produit de soins de la peau et un procédé de préparation et une utilisation associés dans la préparation d'une lingette humide. La composition de réparation de barrière comprend les matières premières suivantes, en parties en poids : 0,01 à 9 parties de sels inorganiques, 0,1 à 1 partie de glucose, 0,5 à 2 parties de protéine, 0,0001 à 0,05 partie d'acide folique, 0,01 à 0,5 partie d'un polyol et 800 à 1200 parties d'eau, les sels inorganiques comprenant un sel de calcium, un sel de magnésium, un sel de potassium, un sel de sodium et un sel de manganèse. Le produit de soins de la peau comprend les matières premières suivantes : des lipides, de la céramide, du polyquaternium, la composition de réparation de barrière mentionnée ci-dessus et de l'eau. La composition de réparation de barrière selon la présente demande est sûre et non irritante. Au moyen de la composition de réparation de barrière, une barrière microbienne est établie sur la surface de la peau par promotion de l'établissement d'un équilibre microécologique sur la surface de la peau, et la barrière physique de la peau est améliorée par apport nutritif et d'humidité à la peau.
PCT/CN2021/128346 2021-11-03 2021-11-03 Composition de réparation de barrière, produit de soins de la peau et procédé de préparation et utilisation associés dans la préparation d'une lingette humide WO2023077291A1 (fr)

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PCT/CN2021/128346 WO2023077291A1 (fr) 2021-11-03 2021-11-03 Composition de réparation de barrière, produit de soins de la peau et procédé de préparation et utilisation associés dans la préparation d'une lingette humide

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CN112426393A (zh) * 2020-12-04 2021-03-02 维尼健康（深圳）股份有限公司 一种婴儿专用全棉湿巾
CN113476346A (zh) * 2021-06-16 2021-10-08 西安德诺海思医疗科技有限公司 一种皮肤屏障修复组合物

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CN111514173A (zh) * 2019-02-01 2020-08-11 宝龄富锦生技股份有限公司 修复皮肤屏障的组合物及其用途
CN112426393A (zh) * 2020-12-04 2021-03-02 维尼健康（深圳）股份有限公司 一种婴儿专用全棉湿巾
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