WO2022246071A2 - Thrombus removal systems and associated methods - Google Patents

Thrombus removal systems and associated methods Download PDF

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Publication number
WO2022246071A2
WO2022246071A2 PCT/US2022/030039 US2022030039W WO2022246071A2 WO 2022246071 A2 WO2022246071 A2 WO 2022246071A2 US 2022030039 W US2022030039 W US 2022030039W WO 2022246071 A2 WO2022246071 A2 WO 2022246071A2
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WO
WIPO (PCT)
Prior art keywords
fluid
thrombus
lumen
ports
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/US2022/030039
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English (en)
French (fr)
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WO2022246071A3 (en
Inventor
Aadel Al-Jadda
Tom Saul
Kevin Muller
Amr Salahieh
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Shifamed Holdings LLC
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Shifamed Holdings LLC
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Publication date
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Priority to JP2023571486A priority Critical patent/JP2024519842A/ja
Priority to EP22805481.3A priority patent/EP4340751A4/en
Priority to US18/562,038 priority patent/US12599397B2/en
Publication of WO2022246071A2 publication Critical patent/WO2022246071A2/en
Publication of WO2022246071A3 publication Critical patent/WO2022246071A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/84—Drainage tubes; Aspiration tips
    • A61M1/85—Drainage tubes; Aspiration tips with gas or fluid supply means, e.g. for supplying rinsing fluids or anticoagulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/84—Drainage tubes; Aspiration tips
    • A61M1/87—Details of the aspiration tip, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0279—Cannula; Nozzles; Tips; their connection means
    • A61M3/0283—Cannula; Nozzles; Tips; their connection means with at least two inner passageways, a first one for irrigating and a second for evacuating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3203—Fluid jet cutting instruments
    • A61B17/32037—Fluid jet cutting instruments for removing obstructions from inner organs or blood vessels, e.g. for atherectomy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A61B2017/00292—Surgical instruments, devices or methods for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22079—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with suction of debris
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A61B2017/2212—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having a closed distal end, e.g. a loop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2217/00—General characteristics of surgical instruments
    • A61B2217/002—Auxiliary appliance
    • A61B2217/005—Auxiliary appliance with suction drainage system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2217/00—General characteristics of surgical instruments
    • A61B2217/002—Auxiliary appliance
    • A61B2217/007—Auxiliary appliance with irrigation system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics

Definitions

  • the present technology generally relates to medical devices and, in particular, to systems including aspiration and fluid delivery mechanisms and associated methods for removing a thrombus from a mammalian blood vessel.
  • Thrombotic material may lead to a blockage in fluid flow within the vasculature of a mammal. Such blockages may occur in varied regions within the body, such as within the pulmonary system, peripheral vasculature, deep vasculature, or brain.
  • Pulmonary embolisms typically arise when a thrombus originating from another part of the body (e.g., a vein in the pelvis or leg) becomes dislodged and travels to the lungs.
  • Anticoagulation therapy is the current standard of care for treating pulmonary embolisms, but may not be effective in some patients.
  • conventional devices for removing thrombotic material may not be capable of navigating the vascular anatomy of the lungs, may not be effective in removing thrombotic material, and/or may lack the ability to provide sensor data or other feedback to the clinician during the thrombectomy procedure.
  • FIGS. 1-lE illustrate various views of a portion of a thrombus removal system including a distal portion of an elongated catheter configured in accordance with an embodiment of the present technology.
  • FIGS. 2A-2E illustrate plan views of various configurations of irrigation ports and fluid streams of a thrombus removal system according to embodiments of the present technology.
  • FIGS. 3A-3H illustrate an elevation view of various configurations of irrigation ports of a thrombus removal system according to embodiments of the present technology.
  • FIGS. 4A-4H illustrate an elevation view of various configurations of irrigation ports and fluid streams of a thrombus removal system according to embodiments of the present technology.
  • FIGS. 5A-5G illustrate various configurations of irrigation ports of a thrombus removal system according to embodiments of the present technology.
  • FIG. 6 is a diagram showing a relationship between jet flow rate and interaction with one or more clots.
  • a thrombus removal system comprising an elongated catheter device including a distal portion configured to be positioned within a blood vessel of a patient, the distal portion comprising an inner wall forming an aspiration lumen, and an outer wall, a manifold formed near a distal end of the fluid lumen, the manifold including at least two fluid ports formed therein and adapted for fluid communication with the fluid lumen to direct respective fluid streams from the at least two fluid ports, a proximal portion configured to be positioned external to the patient, the aspiration lumen extending from the distal portion to the proximal portion, an aspiration mechanism positioned external to the patient and fluidly coupled with the aspiration lumen, the aspiration mechanism configured to reduce a pressure at the distal portion (a) to engage a thrombus therewith and/or (b) to draw the thrombus and/or thrombus fragments proximally, and a fluid delivery mechanism configured to supply fluid through the fluid lumen.
  • the system further includes at least one fluid wall disposed in the space between the inner and outer walls, the at least one fluid wall forming the fluid lumen.
  • the irrigation manifold is formed from the inner wall and the outer wall.
  • the at least two fluid ports are formed within the inner wall of the manifold.
  • the inner wall has a first thickness in a first region within the manifold, and a second thickness proximal to the first region.
  • the first thickness is greater than the second thickness.
  • the first thickness is about twice that of the second thickness.
  • the first thickness ranges from 0.10 mm to 0.60 mm and the second thickness ranges from 0.20 mm to 0.70 mm.
  • the first thickness is selected to provide a generally laminar flow for the respective fluid streams.
  • a cross-sectional dimension of the two or more ports varies along its length.
  • the two or more ports are conical along their lengths.
  • a smallest dimension of the two or more ports is positioned at a distal end of the two or more ports.
  • the respective fluid streams are configured to intersect near at least one intersection region.
  • At least one intersection region is located proximally with respect to at least one of the at least two fluid ports.
  • At least one intersection region is located distally with respect to at least one of the at least two fluid ports.
  • the irrigation manifold is configured to increase a flow rate of the fluid in the fluid lumen. In another embodiment, the irrigation manifold is configured to increase a pressure of the fluid in the fluid lumen.
  • the system further includes a funnel positioned at a distal end of the distal portion, the funnel being configured to engage with the thrombus.
  • the irrigation manifold is disposed proximally of the manifold.
  • the irrigation manifold is integrated into the funnel.
  • a method for removing a thrombus from a blood vessel of a patient comprising introducing a distal portion of an elongate catheter to a thrombus location in a blood vessel, drawing at least a section of the thrombus into the distal portion, and directing fluid toward the thrombus at between 10-15 m/s from at least two different points along respective fluid paths that intersect.
  • directing fluid further comprises directing one of the respective fluid paths proximally. In some embodiments, directing fluid further comprises directing one of the respective fluid paths distally. In other embodiments, directing fluid further comprises directing a first fluid path proximally and a second fluid path distally. In another example, directing fluid further comprises directing a first fluid path proximally and a second fluid path orthogonally with respect to an aspiration flow axis.
  • a method for removing a thrombus from a blood vessel of a patient comprising introducing a distal portion of an elongate catheter to a thrombus location in a blood vessel, drawing at least a section of the thrombus into the distal portion, delivering fluid from a fluid delivery mechanism into a fluid lumen of the elongate catheter, increasing a flow rate of the fluid with an irrigation manifold disposed at a distal end of the fluid lumen, and directing at least two fluid streams with ports disposed in the irrigation manifold.
  • the drawing is by suction applied via an aspiration lumen of the elongate catheter.
  • the at least two fluid streams are directed proximally with the ports. In other embodiments, the at least two fluid streams are directed distally with the ports. In some examples, the at least two fluid streams are directed orthogonally relative to a longitudinal axis of the elongate catheter with the ports. In another embodiment, the at least two fluid streams are directed towards an intersection region.
  • the flow rate of the at least two fluid streams comprises 10-15 m/s. In another embodiment, the flow rate of the at least two fluid streams comprises 12-15 m/s.
  • a system configured in accordance with an embodiment of the present technology can include, for example, an elongated catheter having a distal portion configured to be positioned within a blood vessel of the patient, a proximal portion configured to be external to the patient, a fluid delivery mechanism configured to fragment the thrombus with pressurized fluid, an aspiration mechanism configured to aspirate the fragments of the thrombus, and one or more lumens extending at least partially from the proximal portion to the distal portion.
  • thrombus removal Although some embodiments herein are described in terms of thrombus removal, it will be appreciated that the present technology can be used and/or modified to remove other types of emboli that may occlude a blood vessel, such as fat, tissue, or a foreign substance. Additionally, although some embodiments herein are described in the context of thrombus removal from a pulmonary artery (e.g., pulmonary embolectomy), the technology may be applied to removal of thrombi and/or emboli from other portions of the vasculature (e.g., in neurovascular, coronary, or peripheral applications).
  • pulmonary embolectomy e.g., pulmonary embolectomy
  • thrombus thrombus with a fluid
  • present technology can be adapted for use with other techniques for breaking up a thrombus into smaller fragments or particles (e.g., ultrasonic, mechanical, enzymatic, etc.).
  • the present technology is generally directed to thrombus removal systems.
  • Such systems include an elongated catheter having a distal portion positionable within a blood vessel of the patient (e.g., an artery or vein), a proximal portion positionable outside the patient's body, a fluid delivery mechanism configured to fragment the thrombus with pressurized fluid, an aspiration mechanism configured to aspirate the fragments of the thrombus, and one or more lumens extending at least partially from the proximal portion to the distal portion.
  • the systems herein are configured to engage a thrombus in a patient's blood vessel, break the thrombus into small fragments, and aspirate the fragments out of the patient's body.
  • the pressurized fluid streams function to cut or macerate thrombus, before, during, and/or after at least a portion of the thrombus has entered the aspiration lumen or a funnel of the system. Fragmentation helps to prevent clogging of the aspiration lumen and allows the thrombus removal system to macerate large, firm clots that otherwise could not be aspirated.
  • thrombus and “embolism” are used somewhat interchangeably in various respects. It should be appreciated that while the description may refer to removal of “thrombus,” this should be understood to encompass removal of thrombus fragments and other emboli as provided herein.
  • a fluid delivery mechanism can provide a plurality of fluid streams (e.g., jets) to fluid apertures of the thrombus removal system for macerating, cutting, fragmenting, pulverizing and/or urging thrombus to be removed from a proximal portion of the thrombus removal system.
  • the thrombus removal system can include an aspiration lumen extending at least partially from the proximal portion to the distal portion of the thrombus removal system that is adapted for fluid communication with an aspiration pump (e.g., vacuum source).
  • the aspiration pump may generate a volume of lower pressure within the aspiration lumen near the proximal portion of the thrombus removal system, urging aspiration of thrombus from the distal portion.
  • FIG. 1 illustrates a distal portion 10 of a thrombus removal system according to an embodiment of the present technology.
  • FIG. 1 includes cross-sectional lines A-A, B-B, and C-C, which are illustrated in FIG. 1A, FIG. 1B/1C, and FIG. ID, respectively.
  • FIG. 1A Section A-A illustrates an elevation sectional view of the distal portion.
  • the example section A-A in FIG. 1A depicts a funnel 20 that is positioned at the distal end of the distal portion 10, the funnel adapted to engage with thrombus and/or a tissue (e.g., vessel) wall to aid in thrombus fragmentation and/or removal.
  • tissue e.g., vessel
  • FIG. 1A depicts a double walled thrombus removal device construction having an outer wall/tube 40 and an inner wall/tube 50.
  • An aspiration lumen 55 is formed by the inner wall 50 and is centrally located.
  • a generally annular volume forms at least one fluid lumen 45 between the outer wall 40 and the inner wall 50.
  • the fluid lumen 45 is adapted for fluid communication with a fluid delivery mechanism.
  • One or more apertures (e.g., nozzles, orifices, or ports) 30 are positioned in the thrombus removal system to be in fluid communication with the fluid lumen 45 and an irrigation manifold 25.
  • the ports 30 are adapted to direct (e.g., pressurized) fluid toward thrombus that is engaged with the distal portion 10 of the thrombus removal system.
  • the manifold can be positioned proximal to the funnel. In other embodiments, the manifold can be integrated into the funnel.
  • the thrombus removal system can be sized and configured to access and remove thrombi in various locations or vessels within a patient’s body. It should be understood that while the dimensions of the system may vary depending on the target location, generally the same features and components described herein will be implemented in the thrombus removal system regardless of the application.
  • a thrombus removal system configured to remove pulmonary embolism (PE) from a patient may have an outer wall/tube with a size of approximately 11-13 Fr, or preferably 12 Fr, and an inner wall/tube with a size of 7-9 Fr, or preferably 8 Fr.
  • PE pulmonary embolism
  • a deep vein thrombosis (DVT) device may have an outer wall/tube with a size of approximately 9-11 Fr, or preferably 10 Fr, and an inner wall/tube with a size of 6-9 Fr, or preferably 7.5 Fr.
  • Applications are further provided for ischemic stroke and peripheral embolism applications.
  • Section B-B of FIG. IB illustrates in plan view a portion of the thrombus removal system that is proximal to the funnel and irrigation manifold.
  • Section B-B depicts an outer wall 140, an inner wall 150, an aspiration lumen 155 and a fluid lumen 145.
  • the inner wall 150 forms the aspiration lumen, and the inner wall and outer wall are concentric to another.
  • the fluid lumen 145 is formed in the space between the inner wall and outer wall.
  • the aspiration lumen 155 is generally circular and the fluid lumen 145 is generally annular in shape (e.g., cross-section 70).
  • the inner wall 150 and the outer wall 140 produce variations in cross-sectional shape of the aspiration and fluid lumens 155 and 145.
  • the inner wall 150 can be shaped to form an aspiration lumen 155 that, in cross-section, is generally oval, circular, rectilinear, square, pentagonal, or hexagonal.
  • the inner and outer walls 150 and 140 can be shaped and arranged to form a fluid lumen 145 that, in cross-section, is generally crescent-shaped, diamond shaped, or irregularly shaped. For example, referring to FIG.
  • the region between the inner wall 150 and the outer wall 140 can include one or more wall structures 165 that form respective fluid lumens 145 (e.g., as in cross-section 80).
  • the wall structures 165 can be formed by lamination between the outer and inner walls 140 and 150, or by a multi-lumen extrusion that forms a plurality of the wall structures.
  • Section C-C of FIG. ID illustrates in plan view a portion of the thrombus removal system comprising an irrigation manifold 225.
  • Section C-C depicts an outer wall 240, an inner wall 250, a fluid lumen 245, an aspiration lumen 255, and ports 230 for directing respective fluid streams 210.
  • Detail View 101 of FIG. IE illustrates a section view in elevation of a portion of the irrigation manifold 25 that includes a plurality of ports 230 that are formed within an inner wall 250.
  • the manifold can be positioned at or near a distal end of the fluid lumen(s) formed by the inner and outer walls.
  • a thickness of one or more walls of the thrombus removal system may be varied along its axial length and/or its circumference.
  • inner wall 250 has a first thickness 265 in a region 250 that is proximal to the irrigation manifold 25, and a second thickness 270 in a region 235 that includes the ports 230.
  • the second thickness 270 is greater than the first thickness 265.
  • the first thickness 265 can correspond to a general wall thickness of the inner wall 50 and/or of the outer wall 40, which can be from about 0.10 mm to about 0.60 mm, or any value within the aforementioned range.
  • the second thickness 270 can be from about 0.20 mm to about 0.70 mm, from about 0.70 mm to about 0.90 mm, or from about 0.90 mm to about 1.20 mm.
  • the second thickness 270 can be any value within the aforementioned range.
  • the dimension of the second thickness 270 can be selected to provide a fluid path through the ports 230 that produces a generally laminar flow for a fluid stream that is directed therethrough, when the fluid delivery mechanism supplies fluid via the fluid lumen 245 at a typical operating pressure.
  • Such operating pressure can be from about 10 psi to about 60 psi, from about 60 psi to about 100 psi, or from about 100 psi to about 150 psi.
  • the operating pressure of the fluid delivery mechanism can be any value within the aforementioned range of values.
  • the fluid delivery mechanism is operated in a high pressure mode, having a pressure from about 150 psi to about 250 psi, from about 250 psi to about 350 psi, from about 350 psi to about 425 psi, or from about 425 psi to about 500 psi.
  • the operating pressure of the fluid delivery mechanism in the high pressure mode can be any value within the aforementioned range of values.
  • the manifold is configured to increase a fluid pressure and/or flow rate of the fluid.
  • the manifold When fluid is provided by the fluid delivery mechanism to the fluid lumen(s) at a first pressure and/or a first flow rate, the manifold is configured to increase the pressure of the fluid to a second pressure and/or is configured to increase the flow rate of the fluid to a second flow rate.
  • the second pressure and/or second fluid rate can be higher than the first pressure and/or first flow rate.
  • the manifold can be configured to increase the relatively low operating pressures and/or flow rates generated by the fluid delivery mechanism to the relatively high pressures and/or high flow rates generated by the ports/fluid streams.
  • a profile (cross-sectional dimension) of a port 230 varies along its length (e.g., is non-cylindrical).
  • a variation in the cross-sectional dimension of the port may alter and/or adjust a characteristic of fluid flow along the port 230. For example, a reduction in cross-sectional dimension may accelerate a flow of fluid through the port 230 (for a given volume of fluid).
  • a port 230 may be conical along its length (e.g., tapered), such that its smallest dimension is positioned at the distal end of the port 230, where distal is with respect to a direction of fluid flow.
  • the port 230 is formed to direct the fluid flow along a selected path.
  • FIGS. 2A-2E illustrate various embodiments of arrangements of ports 230 for directing respective fluid streams 210.
  • at least two ports 230 are arranged to produce (e.g., respective) fluid streams 210 that intersect at an intersection region 237 of the thrombus removal system.
  • An intersection region 237 can be a region of increased fluid momentum and/or energy transfer, which increase is with respect to individual fluid streams that are not directed to combine at the intersection. The increased fluid momentum and/or energy transfer at an intersection may advantageously fragment thrombus more efficiently and/or quickly.
  • an intersection region can be formed from at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, or at least 10 fluid streams 210.
  • An intersection region can be generally near a central axis 290 of the thrombus removal system (e.g., 237), or away from the central axis (e.g., 238 and 239 in the embodiment of FIG. 2D).
  • at least two intersection regions e.g., 238 and 239) are formed.
  • one or more ports 230 are arranged to direct a fluid stream 210 along an oblique angle with respect to the central axis of the thrombus removal system.
  • An operating pressure of the fluid delivery mechanism may be selected to approach a targeted fluid velocity for a fluid stream 210 that is delivered from a port 230.
  • the targeted fluid velocity for a fluid stream 210 can be about 5 meters/second (m/s), about 8 m/s, about 10 m/s, about 12 m/s, about 10-15 m/s, or about 12-15 m/s.
  • the targeted fluid velocity for fluid stream 210 can be any value within the range of aforementioned values.
  • at least two ports 230 are adapted to delivery respective fluid streams at different fluid velocities, for a given pressure of the fluid delivery mechanism.
  • At least two ports 230 are adapted to deliver respective fluid streams at the substantially the same fluid velocities, for a given pressure of the fluid delivery mechanism.
  • angular momentum is imparted to a thrombus by application of a) at least one fluid stream 210 that is directed at an oblique angle from a port 230, and/or b) at least two fluid streams 210 that have different fluid velocities.
  • angular momentum produced in a thrombus may impart a (e.g., centrifugal) force that assists in fragmentation and removal of the thrombus.
  • an increased cross-sectional area of the fluid lumen 145 reduces a required operating pressure of the fluid delivery mechanism to achieve a targeted fluid velocity of the fluid streams.
  • ports 330 can be arranged along various axial positions of the thrombus removal system.
  • the thrombus removal system can include a flow axis 305 that is aligned with a general direction (e.g., distal-to-proximal) of flow for fluid that is aspirated therein.
  • a position of a port 330 comprises a) near a base of, b) in a middle portion of, c) in a distal portion of, or d) proximal to, a funnel portion 320 of the thrombus removal system.
  • any of these embodiments can include multiple ports arranged around the funnel or proximal to the funnel.
  • any of the port arrangements illustrated in FIGS. 2A-2E can be implemented a) near a base of, b) in a middle portion of, c) in a distal portion of, or d) proximal to, a funnel portion 320 of the thrombus removal system.
  • at least two ports 330 are aligned along flow axis 305 (e.g., FIG. 3E).
  • At least two ports 330 are arranged at a different axial position along the flow axis 305 (e.g., FIGS. 3F, 3G, 3H). In some embodiments, at least two ports 330 are arranged (e.g., along a perimeter of the thrombus removal system) along a given axial position of the flow axis 305. As with above, any of the port arrangements illustrated in FIGS. 2A-2E can be implemented into the port arrangements illustrated in the embodiments of FIGS. 3F, 3G, and 3H.
  • FIGS. 4A-4H depict various configurations of fluid streams 410 that are directed from respective ports 430.
  • a fluid stream 410 can be directed along a path that is substantially orthogonal (e.g., FIG. 4A), proximal (e.g., FIG. 4C), and/or distal (e.g., FIG. 4B) to the flow axis 405 (which is like to flow axis 305).
  • at least two fluid streams are directed in different directions with respect to the flow axis 405 (e.g., FIG. 4E).
  • At least one fluid stream is directed in a same direction (e.g., distally) with respect to the flow axis 405 and at least another fluid stream is directed in a different direction (e.g., orthogonally or proximally, as shown in FIG. 4D).
  • at least a first fluid stream is directed substantially orthogonally to the flow axis
  • at least a second fluid stream is directed proximally
  • at least a third fluid stream is directed distally with respect to the flow axis 405.
  • An angle a may characterize an angle a fluid stream 410 is directed with respect to an axis that is orthogonal to the flow axis 405 (e.g., as shown in section D-D of FIGS.
  • An intersection region of fluid streams can be within an interior portion of the thrombus removal system, and/or exterior (e.g., distal) to the thrombus removal system.
  • a fluid stream that is directed by a port 430 in a nominal direction is deflected along an altered path (e.g., proximally) by (e.g., suction) pressure generated by the aspiration mechanism during operation.
  • FIGS. 5A-5G illustrate a variety of exit aperture geometries with which ports 530 can be configured in accordance with embodiments of the present technology.
  • Aperture geometries can comprise an oval, circular, cross (“x” shape), “t” shape, rectangle, or square shape.
  • a fluid stream that is delivered from the port 530 can comprise substantially laminar flow (e.g., at the aperture), or a turbulent flow (e.g., that fans or outward).
  • FIG. 5B shows a “x” shaped exit aperture geometry.
  • FIG. 5C shows a “t” shaped exit aperture geometry.
  • FIGS. 5D- 5G show variations of an oval shaped exit aperture geometry. As shown in FIG.
  • the fluid stream can be substantially laminar flow, and in FIG. 5E, the flow can fan outward.
  • FIG. 6 a chart is provided that illustrates the relationship between the exit velocity or flow rate (avg.) of the jet(s) and the mechanism of action with one or more thrombi engaged with the thrombus removal device (i.e., engaged in the funnel or with the aspiration lumen).
  • the jets serve to assist with purging of the thrombus or thrombi into the aspiration lumen (especially when the funnel is occluded or partially occluded by the clot).
  • This purging can include the function of pushing the thrombus into and or through the aspiration lumen and also providing fluid into the funnel and into the aspiration lumen to assist with clot removal.
  • the purging may also assist with breaking up soft, loose material on the surface of the clot but it will not be able to break through harder material.
  • the jet flow rate begins to exceed a cutting threshold 602
  • the jets begin to cut the thrombus or thrombi surface to break the thrombus into small fragments which can then be more easily aspirated into the aspiration lumen of the thrombus removal device. It has also been found that at sufficiently high velocity the jet(s) will pierce the clot surface and penetrate through to the inner part of the clot.
  • the threshold comprises a jet flow rate that ranges from 10-12 m/s. In other embodiments, an ideal cutting or piercing flow rate of the jets range from 10-15 m/s, or alternatively, from 12-15 m/s.

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12053192B2 (en) 2022-09-01 2024-08-06 Endovascular Engineering, Inc. Systems, devices, and methods for aspiration, including expandable structures and rotatable shafts
US12076036B2 (en) 2021-03-01 2024-09-03 Endovascular Engineering, Inc. Thrombectomy systems and devices with aspiration, and methods of use thereof
WO2025050040A1 (en) * 2023-08-30 2025-03-06 Shifamed Holdings, Llc Thrombus removal systems and methods

Family Cites Families (481)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006745A (en) 1975-05-22 1977-02-08 Sorenson Research Co., Inc. Autologous transfusion system and method
US5135482A (en) 1985-12-31 1992-08-04 Arnold Neracher Hydrodynamic device for the elimination of an organic deposit obstructing a vessel of a human body
JPH0197951A (ja) 1987-10-09 1989-04-17 Brother Ind Ltd 画像形成媒体製造装置
GB8730064D0 (en) 1987-12-23 1988-02-03 Veale F C Mucus extractor
DE4018736A1 (de) 1990-06-12 1992-01-02 Wigbert S Prof Dr Med Rau Hochdruck-aspirationskatheter zur wiedereroeffnung von krankhaft verschlossenen gefaessen
US5114581A (en) 1991-01-10 1992-05-19 Ceramem Corporation Back-flushable filtration device and method of forming and using same
US6059825A (en) 1992-03-05 2000-05-09 Angiodynamics, Inc. Clot filter
WO1994016706A1 (en) 1993-01-28 1994-08-04 Neorx Corporation Therapeutic inhibitors of vascular smooth muscle cells
US20080167649A1 (en) 1994-08-12 2008-07-10 Angiodynamics, Inc. Ablation apparatus and method
US5651776A (en) 1995-03-22 1997-07-29 Angiodynamics, Inc. Luer-type connector
US5795322A (en) 1995-04-10 1998-08-18 Cordis Corporation Catheter with filter and thrombus-discharge device
US6689127B1 (en) 1995-08-15 2004-02-10 Rita Medical Systems Multiple antenna ablation apparatus and method with multiple sensor feedback
US5662671A (en) 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US6004339A (en) 1996-11-13 1999-12-21 Angiodynamics Incorporated Balloon catheter with multiple distensibilities
US6315762B1 (en) 1996-11-14 2001-11-13 Angiodynamics, Inc. Contrast medium delivery system and associated method
US5788647A (en) 1997-01-24 1998-08-04 Eggers; Philip E. Method, system and apparatus for evaluating hemodynamic parameters
US6086534A (en) 1997-03-07 2000-07-11 Cardiogenesis Corporation Apparatus and method of myocardial revascularization using ultrasonic pulse-echo distance ranging
US6190352B1 (en) 1997-10-01 2001-02-20 Boston Scientific Corporation Guidewire compatible port and method for inserting same
US6053870A (en) 1997-11-08 2000-04-25 Angiodynamics, Inc. Ultrasonic visible surgical needle
US9586023B2 (en) 1998-02-06 2017-03-07 Boston Scientific Limited Direct stream hydrodynamic catheter system
US6875193B1 (en) 1998-02-06 2005-04-05 Possis Medical, Inc. Rapid exchange fluid jet thrombectomy device and method
AU733053C (en) 1998-02-24 2001-11-29 Boston Scientific Limited High flow rate dialysis catheters and related methods
US6283950B1 (en) 1998-06-11 2001-09-04 Angiodynamics, Inc. Occluding wire assembly
US6074374A (en) 1998-07-31 2000-06-13 Angiodynamics, Inc. Catheter with lumen occluding means
US6306163B1 (en) 1998-08-04 2001-10-23 Advanced Cardiovascular Systems, Inc. Assembly for collecting emboli and method of use
US7780628B1 (en) 1999-01-11 2010-08-24 Angiodynamics, Inc. Apparatus and methods for treating congestive heart disease
US6287333B1 (en) 1999-03-15 2001-09-11 Angiodynamics, Inc. Flexible stent
US6375635B1 (en) 1999-05-18 2002-04-23 Hydrocision, Inc. Fluid jet surgical instruments
AU7720100A (en) 1999-09-27 2001-04-30 Essex Technology, Inc. Rotate-to-advance catheterization system
US6524300B2 (en) 2000-01-03 2003-02-25 Angiodynamics, Inc. Infusion catheter with non-uniform drug delivery density
NL1014095C2 (nl) 2000-01-17 2001-07-18 Cornelis Hendrikus Anna Witten Implantaatklep voor implantatie in een bloedvat.
AU2001279026B2 (en) 2000-07-25 2005-12-22 Angiodynamics, Inc. Apparatus for detecting and treating tumors using localized impedance measurement
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
WO2002026289A1 (en) 2000-09-28 2002-04-04 Beck Robert C Catheter system
US6582447B1 (en) 2000-10-20 2003-06-24 Angiodynamics, Inc. Convertible blood clot filter
US20020058904A1 (en) 2000-11-08 2002-05-16 Robert Boock Thrombus removal device
US20020132076A1 (en) 2000-11-17 2002-09-19 Stevens Robert C. Reinforced catheter device, catheter stock, and methods and apparatus for making same
US7422586B2 (en) 2001-02-28 2008-09-09 Angiodynamics, Inc. Tissue surface treatment apparatus and method
US6997914B2 (en) 2001-04-02 2006-02-14 Horizon Medical Products, Inc. Implantable access port
AU2002322520A1 (en) 2001-07-17 2003-03-03 Kerberos Proximal Solutions Fluid exchange system for controlled and localized irrigation and aspiration
USRE42016E1 (en) 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
DE60210111T2 (de) 2001-09-28 2007-03-29 Rita Medical Systems, Inc., Mountain View Impedanzgesteuerte vorrichtung zur ablation von gewebe
US7347852B2 (en) 2001-11-20 2008-03-25 Angiodynamics, Inc. Catheter retention
US20160317797A1 (en) 2002-04-02 2016-11-03 Angiodynamics, Inc. Implantable Access Port
US6942635B2 (en) 2002-04-04 2005-09-13 Angiodynamics, Inc. Blood treatment catheter and method
US7833215B2 (en) 2002-04-04 2010-11-16 Angiodynamics, Inc. Catheter fluid lock method and device
US7163533B2 (en) 2002-04-04 2007-01-16 Angiodynamics, Inc. Vascular treatment device and method
US9440046B2 (en) 2002-04-04 2016-09-13 Angiodynamics, Inc. Venous insufficiency treatment method
US6881218B2 (en) 2002-05-01 2005-04-19 Angiodynamics, Inc. Blood clot filter
AU2003251566A1 (en) 2002-06-19 2004-01-06 Angiodynamics, Inc. Endovascular treatment device with a protective sleeve
US7033347B2 (en) 2002-12-11 2006-04-25 Angiodynamics, Inc. Endovascular laser treatment device
US7458967B2 (en) 2003-10-31 2008-12-02 Angiodynamics, Inc. Endovascular treatment apparatus and method
US20080287939A1 (en) 2002-07-10 2008-11-20 Appling William M Endovascular thermal treatment device with flexible guide tip and method
AU2003261120A1 (en) 2002-07-10 2004-01-23 Angiodynamics, Inc. Endovascular laser treatment device having a fiber tip spacer
US20080208180A1 (en) 2002-07-10 2008-08-28 Cartier William A Endovascular treatment sheath having a heat insulative tip and method for using the same
WO2008124790A2 (en) 2002-07-10 2008-10-16 Angiodynamics, Inc. Device and method for endovascular treatment for causing closure of a blood vessel
GB0217273D0 (en) 2002-07-25 2002-09-04 Diomed Ltd Laser system
EP1539291A4 (en) 2002-09-20 2010-03-10 Flowmedica Inc METHOD AND DEVICE FOR SELECTIVE INFUSION BY CATHETER INTRA-RENAL
US20050197624A1 (en) 2004-03-04 2005-09-08 Flowmedica, Inc. Sheath for use in peripheral interventions
US7993325B2 (en) 2002-09-20 2011-08-09 Angio Dynamics, Inc. Renal infusion systems and methods
EP1585572A4 (en) 2002-09-20 2010-02-24 Flowmedica Inc METHOD AND APPARATUS FOR ADMINISTERING INTRA-AORTIC SUBSTANCE TO A BRANCHED VESSEL
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
US6733489B2 (en) 2002-09-26 2004-05-11 Angiodynamics, Inc. Vascular orientation marker for determining the orientation of a blood vessel
GB2387544B (en) 2002-10-10 2004-03-17 Microsulis Plc Microwave applicator
US20220105333A1 (en) 2002-10-21 2022-04-07 Angiodynamics, Inc. Implantable medical device for improved placement and adherence in the body
US8574204B2 (en) 2002-10-21 2013-11-05 Angiodynamics, Inc. Implantable medical device for improved placement and adherence in the body
US7455675B2 (en) 2002-11-06 2008-11-25 Angiodynamics, Inc. Device and method for withdrawing a tubular body part
US20040097880A1 (en) 2002-11-19 2004-05-20 Angiodynamics, Inc. Combination thrombolytic infusion catheter and dilator system
US6966886B2 (en) 2002-11-20 2005-11-22 Angiodynamics, Inc. Blood treatment catheter assembly
US20110172644A1 (en) 2002-12-04 2011-07-14 Zanoni Michael S Multi layer coextruded catheter shaft
EP1575641A4 (en) 2002-12-04 2008-02-13 Angiodynamics Inc VENOUS ACCESS CATHETER WITH VARIABLE CHARACTERISTICS
US7988679B2 (en) 2003-03-18 2011-08-02 Navilyst Medical, Inc. Pressure responsive slit valve assembly for a plurality of fluids and uses thereof
US7131981B2 (en) 2003-03-25 2006-11-07 Angiodynamics, Inc. Device and method for converting a balloon catheter into a cutting balloon catheter
EP1635736A2 (en) 2003-06-05 2006-03-22 FlowMedica, Inc. Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens
GB2403148C2 (en) 2003-06-23 2013-02-13 Microsulis Ltd Radiation applicator
US7435236B2 (en) 2003-06-27 2008-10-14 Navilyst Medical, Inc. Pressure actuated valve with improved biasing member
US20050027262A1 (en) 2003-07-31 2005-02-03 Appling William M. Endovascular tumescent infusion apparatus and method
US7252652B2 (en) 2003-08-29 2007-08-07 Boston Scientific Scimed, Inc. Valved catheters including high flow rate catheters
JP5228146B2 (ja) 2003-10-03 2013-07-03 ユーケイ インヴェストメント アソシエイツ リミテッド ライアビリティ カンパニー 中空の解剖学的構造の治療のためのアプリケータ及びシステム
GB2416203B (en) 2004-07-13 2007-03-07 Microsulis Ltd Motion rate sensor
US20160106501A1 (en) 2003-10-31 2016-04-21 Angiodynamics, Inc. Endovascular Treatment Apparatus and Method
US7220269B1 (en) 2003-11-06 2007-05-22 Possis Medical, Inc. Thrombectomy catheter system with occluder and method of using same
US7217256B2 (en) 2003-11-17 2007-05-15 Angiodynamics, Inc. Locking catheter hub
US7481793B2 (en) 2003-12-10 2009-01-27 Boston Scientic Scimed, Inc. Modular steerable sheath catheters
US8366687B2 (en) 2004-01-06 2013-02-05 Angio Dynamics Injection access port with chamfered top hat septum design
US20050165364A1 (en) 2004-01-22 2005-07-28 Dimatteo Kristian Valved catheter to bypass connector
US20050171510A1 (en) 2004-01-29 2005-08-04 Dicarlo Paul Pressure actuated safety valve with spiral flow membrane
US9933079B2 (en) 2004-01-29 2018-04-03 Angiodynamics, Inc. Stacked membrane for pressure actuated valve
US8034035B2 (en) 2004-01-29 2011-10-11 Navilyst Medical, Inc. Pressure activated safety valve with high flow slit
AU2005211992C1 (en) 2004-02-18 2009-05-14 Jozsef Beres Apparatus and method for measuring hemodynamic parameters
US7686825B2 (en) 2004-03-25 2010-03-30 Hauser David L Vascular filter device
US8920402B2 (en) 2004-04-27 2014-12-30 The Spectranetics Corporation Thrombectomy and soft debris removal device
US7722635B2 (en) 2004-06-25 2010-05-25 Angiodynamics, Inc. Blood clot filter
WO2006012244A2 (en) 2004-06-25 2006-02-02 Angiodymamics, Inc. Permanent blood clot filter with capability of being retrieved
US7544202B2 (en) 2004-06-25 2009-06-09 Angiodynamics, Inc. Retrievable blood clot filter
GB2415630C2 (en) 2004-07-02 2007-03-22 Microsulis Ltd Radiation applicator and method of radiating tissue
US7279000B2 (en) 2004-09-29 2007-10-09 Angiodynamics Inc Permanent blood clot filter with capability of being retrieved
CA2596490A1 (en) 2005-02-09 2006-08-17 Angiodynamics, Inc. Reinforced balloon for a catheter
US8328768B2 (en) 2005-02-11 2012-12-11 Angiodynamics, Inc Pressure activated safety valve with improved flow characteristics and durability
US20120226271A1 (en) 2005-03-25 2012-09-06 Peter Callas Vacuum Ablation Apparatus and Method
US7942873B2 (en) 2005-03-25 2011-05-17 Angiodynamics, Inc. Cavity ablation apparatus and method
US7740616B2 (en) 2005-03-29 2010-06-22 Angiodynamics, Inc. Implantable catheter and method of using same
WO2006119503A1 (en) 2005-05-04 2006-11-09 Abbott Laboratories Guidewire apparatus with an expandable portion
US20060270974A1 (en) 2005-05-16 2006-11-30 Kerberos Proximal Solutions, Inc. Methods and systems for filtering aspirated materials
US20060282119A1 (en) 2005-06-10 2006-12-14 Angiodynamics, Inc. Protective device for a suture
USD626231S1 (en) 2005-06-10 2010-10-26 Angio Dynamics, Inc. Surgical button
US8114070B2 (en) 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
US20060293731A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating tumors using electroporation
US20060293725A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating fatty tissue sites using electroporation
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
GB2434314B (en) 2006-01-03 2011-06-15 Microsulis Ltd Microwave applicator with dipole antenna
US8038704B2 (en) 2005-07-27 2011-10-18 Paul S. Sherburne Stent and other objects removal from a body
CN103272325B (zh) 2005-08-11 2016-04-06 泰克尼恩研究和发展基金有限公司 用于在通道内运动的顶端推进装置
US7935077B2 (en) 2005-09-28 2011-05-03 Medrad, Inc. Thrombectomy catheter deployment system
CA2626787A1 (en) 2005-09-30 2007-04-12 Angiodynamics, Inc. Implantable medical device
JP2007117384A (ja) 2005-10-27 2007-05-17 Toshiba Corp 画像診断・治療支援装置及び治療効果判定用画像データ生成方法
US20070156135A1 (en) 2006-01-03 2007-07-05 Boris Rubinsky System and methods for treating atrial fibrillation using electroporation
WO2007081842A2 (en) 2006-01-09 2007-07-19 University Of Virginia Patent Foundation Multi-port catheter system with medium control and measurement systems for therapy and diagnosis delivery
WO2007085025A2 (en) 2006-01-20 2007-07-26 Angiodynamics, Inc. Retrievable blood clot filter
US20070173786A1 (en) 2006-01-25 2007-07-26 Angiodynamics, Inc. Fluid injection system and method using multi-lumen catheters
US7826904B2 (en) 2006-02-07 2010-11-02 Angiodynamics, Inc. Interstitial microwave system and method for thermal treatment of diseases
US20070198035A1 (en) 2006-02-17 2007-08-23 Threlkeld Judson E Method and surgical instrument operable for percutaneous ligation of a vein or vessel
GB0603866D0 (en) 2006-02-27 2006-04-05 Diomed Inc Medical laser device
US7771401B2 (en) 2006-06-08 2010-08-10 Angiodynamics, Inc. Selective renal cannulation and infusion systems and methods
US7947019B2 (en) 2006-08-18 2011-05-24 Angio Dynamics, Inc Catheter retention assembly and method of use
EP1897570A1 (en) 2006-09-08 2008-03-12 Gelanus B.V. Blood recuperation device and method
EP2462881B1 (en) 2006-10-04 2016-08-24 Boston Scientific Limited Interventional catheters
US20080269774A1 (en) 2006-10-26 2008-10-30 Chestnut Medical Technologies, Inc. Intracorporeal Grasping Device
US8317773B2 (en) 2006-11-07 2012-11-27 Angio Dynamics, Inc. Catheter with open faced sloped end portion
US20140276470A1 (en) 2006-11-07 2014-09-18 Raymond Lareau Dialysis Catheters with Fluoropolymer Additives
US8603070B1 (en) 2013-03-15 2013-12-10 Angiodynamics, Inc. Catheters with high-purity fluoropolymer additives
US20080154186A1 (en) 2006-11-07 2008-06-26 Angiodynamics, Inc. Multiple lumen catheter with proximal port
US20080114308A1 (en) 2006-11-13 2008-05-15 Di Palma Giorgio Vascular Access Port with Catheter Connector
US11389171B2 (en) 2006-11-21 2022-07-19 David S. Goldsmith Integrated system for the infixion and retrieval of implants
US20080132885A1 (en) 2006-12-01 2008-06-05 Boris Rubinsky Methods for treating tissue sites using electroporation
US20080132884A1 (en) 2006-12-01 2008-06-05 Boris Rubinsky Systems for treating tissue sites using electroporation
US7914549B2 (en) 2007-01-05 2011-03-29 Hesham Morsi Mechanical embolectomy and suction catheter
US20150038767A1 (en) 2007-01-16 2015-02-05 Radiadyne, Llc Endorectal balloon with gas lumen and stopper
US20080172080A1 (en) 2007-01-16 2008-07-17 Isham John Minimally invasive rectal balloon apparatus
US20090221899A1 (en) 2007-01-16 2009-09-03 Isham John Minimally invasive rectal balloon apparatus with pressure relieving lumen and anal verge dilation collar
US20080300619A1 (en) 2007-01-16 2008-12-04 Isham John Rectal balloon apparatus with radiation sensor and/or markers
US20080183202A1 (en) 2007-01-16 2008-07-31 Isham John Minimally invasive rectal balloon apparatus with pressure relieving lumen
US20140051968A1 (en) 2007-01-16 2014-02-20 Radiadyne, Llc Rectal balloon with sensor cable
EP2120737B1 (en) 2007-02-05 2020-04-01 Boston Scientific Limited Thrombectomy apparatus
WO2008099389A2 (en) 2007-02-12 2008-08-21 Technion Research & Development Foundation Ltd. Inflatable balloon device and applications
US20080208236A1 (en) 2007-02-28 2008-08-28 Angiodynamics, Inc. Dermal marking for use with a medical device
US20090306625A1 (en) 2007-03-09 2009-12-10 Angiodynamics, Inc. Treatment systems and methods for renal-related diseases
US20080294188A1 (en) 2007-05-23 2008-11-27 Angiodynamics, Inc. Implant Holder and Method of Deploying the Implant
USD595892S1 (en) 2007-09-19 2009-07-07 Angiodynamics, Inc. Scalloped implantable injectable port
EP2190517A4 (en) 2007-09-07 2012-08-15 Angiodynamics Inc IMPLANT CONNECTION
US8220121B2 (en) 2007-09-14 2012-07-17 Cook Medical Technologies Llc Device for loading a self-expandable prosthesis into a sheath
AU2008308451A1 (en) 2007-10-05 2009-04-09 Angiodynamics, Inc. Dual reservoir implantable access port
WO2009052506A1 (en) 2007-10-19 2009-04-23 Navilyst Medical, Inc. Recirculation minimizing catheter
US8535306B2 (en) 2007-11-05 2013-09-17 Angiodynamics, Inc. Ablation devices and methods of using the same
WO2009062105A2 (en) 2007-11-08 2009-05-14 Angiodynamics, Inc. Device and method for providing power to lighting elements for use as a visual indicator in a medical probe
US20090131924A1 (en) 2007-11-16 2009-05-21 Meyer Ralph A Endovascular Thermal Treatment Device with Carrier Wire and Method
US20090163926A1 (en) 2007-12-14 2009-06-25 Angiodynamics, Inc. Universal capture assembly
US8613717B2 (en) 2007-12-20 2013-12-24 Angiodynamics, Inc. Systems and methods for removing and fragmenting undesirable material within a circulatory system
US8734374B2 (en) 2007-12-20 2014-05-27 Angiodynamics, Inc. Systems and methods for removing undesirable material within a circulatory system during a surgical procedure
US20170136158A1 (en) 2015-10-16 2017-05-18 Angiodynamics, Inc. Systems and Methods for Removing Undesirable Material Within a Circulatory System
US20130304082A1 (en) 2007-12-20 2013-11-14 Angiodynamics, Inc. Systems and methods for removing undesirable material within a circulaton system utilizing a balloon catheter
US8506512B2 (en) 2007-12-20 2013-08-13 Angio Dynamics Systems and methods for removing undesirable material within a circulatory system utilizing a balloon catheter
US10517617B2 (en) 2007-12-20 2019-12-31 Angiodynamics, Inc. Systems and methods for removing undesirable material within a circulatory system utilizing a balloon catheter
US20110213392A1 (en) 2007-12-20 2011-09-01 Vortex Medical Systems and Methods for Removing Undesirable Material Within a Circulatory System
WO2009082669A1 (en) 2007-12-26 2009-07-02 Medrad, Inc. Rheolytic thrombectomy catheter with self-inflating proximal balloon with drug infusion capabilities
GB2457299B (en) 2008-02-09 2013-04-24 Uk Investments Associates Llc Microwave applicator
US20090248012A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California Irreversible electroporation device and method for attenuating neointimal
US20100004623A1 (en) 2008-03-27 2010-01-07 Angiodynamics, Inc. Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation
US20090259220A1 (en) 2008-04-09 2009-10-15 Angiodynamics, Inc. Treatment Devices and Methods
WO2009131583A1 (en) 2008-04-24 2009-10-29 Angiodynamics, Inc. Catheter with open faced beveled tip
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US20240173063A1 (en) 2008-04-29 2024-05-30 Virginia Tech Intellectual Properties Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
WO2009137800A2 (en) 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
US20190083169A1 (en) 2008-05-09 2019-03-21 Angiodynamics, Inc. Techniques for Controlling an Irreversible Electroporation System
US8257321B2 (en) 2008-05-21 2012-09-04 Navilyst Medical, Inc. Pressure activated valve for high flow rate and pressure venous access applications
US7717900B2 (en) 2008-05-28 2010-05-18 Angio Dynamics, Inc. Locking clamp
US20090306606A1 (en) 2008-06-10 2009-12-10 Angiodynamics, Inc Catheter hub assembly with vascular access port
EP2309934B1 (en) 2008-06-19 2018-11-07 AngioDynamics, Inc. A thrombectomy catheter and a device comprising the same
WO2009155526A2 (en) 2008-06-20 2009-12-23 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
US9681909B2 (en) 2008-06-23 2017-06-20 Angiodynamics, Inc. Treatment devices and methods
US20100076302A1 (en) 2008-09-25 2010-03-25 Jeff Gray Invisible Power Port ID Tattoo
US9510854B2 (en) 2008-10-13 2016-12-06 Boston Scientific Scimed, Inc. Thrombectomy catheter with control box having pressure/vacuum valve for synchronous aspiration and fluid irrigation
US20100114063A1 (en) 2008-11-04 2010-05-06 Angiodynamics, Inc. Catheter injection monitoring device
US20100152725A1 (en) 2008-12-12 2010-06-17 Angiodynamics, Inc. Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
USD603044S1 (en) 2008-12-15 2009-10-27 Angiodynamics, Inc. Catheter tip
US20100168642A1 (en) 2008-12-30 2010-07-01 Angiodynamics, Inc. Multilumen Venous Catheter and Method of Use
US8676290B2 (en) 2010-05-11 2014-03-18 St. Jude Medical, Atrial Fibrillation Division, Inc. Multi-directional catheter control handle
US8753335B2 (en) 2009-01-23 2014-06-17 Angiodynamics, Inc. Therapeutic energy delivery device with rotational mechanism
US8337470B2 (en) 2009-01-28 2012-12-25 Angiodynamics, Inc. Three-way valve for power injection in vascular access devices
US8585950B2 (en) 2009-01-29 2013-11-19 Angiodynamics, Inc. Multilumen catheters and method of manufacturing
WO2010093692A2 (en) 2009-02-10 2010-08-19 Hobbs Eamonn P Irreversible electroporation and tissue regeneration
WO2010093836A2 (en) * 2009-02-11 2010-08-19 Mark Mallaby Neurovascular microcatheter device, system and methods for use thereof
USD644735S1 (en) 2009-02-26 2011-09-06 Angio Dynamics, Inc. Port pocket creation tool
US20100249815A1 (en) 2009-03-25 2010-09-30 Cook Incorporated Everted sheath thrombectomy device
EP2413833A1 (en) 2009-03-31 2012-02-08 AngioDynamics, Inc. System and method for estimating a treatment region for a medical treatment device and for interactively planning a treatment of a patient
US20100256546A1 (en) 2009-04-03 2010-10-07 Davis Scott A Polycarbonate Polyurethane Venous Access Devices Having Enhanced Strength
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US20100256487A1 (en) 2009-04-06 2010-10-07 Angiodynamics, Inc. Micro central line vascular access catheter and method of use
US20100256630A1 (en) 2009-04-07 2010-10-07 Angiodynamics, Inc. Irreversible electroporation (ire) for esophageal disease
WO2010123371A1 (en) 2009-04-24 2010-10-28 Imds R&D Bv Guidewire support system and guidewire
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
WO2010138919A2 (en) 2009-05-28 2010-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US8353858B2 (en) 2009-06-03 2013-01-15 Medrad, Inc. Rapid exchange fluid jet catheter and method
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
US8007468B2 (en) 2009-07-13 2011-08-30 Navilyst Medical, Inc. Method to secure an elastic component in a valve
US20110034886A1 (en) 2009-08-06 2011-02-10 Angiodynamics, Inc. Implantable medical device tool and method of use
US20110040321A1 (en) 2009-08-11 2011-02-17 Angiodynamics, Inc. Retrieval Device and Method of Use
EP2467189A4 (en) 2009-08-20 2013-03-06 Angiodynamics Inc MULTI-ELECTRODE POWER SUPPLY APPARATUS AND METHOD OF APPLICATION THEREFOR
US20110060316A1 (en) 2009-09-04 2011-03-10 Dicarlo Paul Tipped Ribbon Integrated Guidewire
GB2474233A (en) 2009-10-06 2011-04-13 Uk Investments Associates Llc Cooling pump comprising a detachable head portion
US20110105823A1 (en) 2009-10-30 2011-05-05 Angiodynamics, Inc. Medical Template Device and Method for Use in Positioning Therapeutic Probes at a Target Tissue
US20110112527A1 (en) 2009-11-06 2011-05-12 Angiodynamics, Inc. Flexible medical ablation device and method of use
US8496644B2 (en) 2009-12-17 2013-07-30 Angiodynamics, Inc. Drainage catheter tip shape configuration
US8328760B2 (en) 2010-01-11 2012-12-11 Angiodynamics, Inc. Occlusion resistant catheter
US20110190734A1 (en) 2010-02-03 2011-08-04 Richard Graffam Mechanical Advantage For Hub Linear Travel For A Drainage Catheter
US9675406B2 (en) 2010-02-16 2017-06-13 Angiodynamics, Inc. Ablation device with guide sleeves
US20110238057A1 (en) 2010-02-16 2011-09-29 Angiodynamics, Inc. Dual Bracketed Energy Delivery Probe and Method of Use
US8425455B2 (en) 2010-03-30 2013-04-23 Angiodynamics, Inc. Bronchial catheter and method of use
US9126016B2 (en) 2010-05-19 2015-09-08 Nfusion Vascular Systems Llc Augmented delivery catheter and method
US9254173B2 (en) 2010-08-05 2016-02-09 Angio Dynamics, Inc. Microwave applicator
US10039900B2 (en) 2010-09-07 2018-08-07 Angiodynamics, Inc. Fluid delivery and treatment device and method of use
US8858497B2 (en) 2010-09-07 2014-10-14 Angio Dynamics, Inc. Device and method for removing material from a hollow anatomical structure
US8753292B2 (en) 2010-10-01 2014-06-17 Angiodynamics, Inc. Method for locating a catheter tip using audio detection
USD640788S1 (en) 2010-10-01 2011-06-28 Arigio Dynamics, Inc. Dialysis catheter tip
EP2438954B1 (en) 2010-10-08 2016-12-28 Greatbatch Ltd. Bi-directional catheter steering handle
EP2627274B1 (en) 2010-10-13 2022-12-14 AngioDynamics, Inc. System for electrically ablating tissue of a patient
US20120101471A1 (en) 2010-10-22 2012-04-26 Di Palma Giorgio Self-powered infusion device and method of use
EP2646102A4 (en) 2010-12-03 2017-12-06 AngioDynamics, Inc. Devices and methods for removing clots
US20120184942A1 (en) 2011-01-19 2012-07-19 Lareau Raymond J Coaxial stiffener for drainage catheter
US20120193255A1 (en) 2011-01-31 2012-08-02 Lareau Raymond J Medical device and packaging interface
US12076037B2 (en) 2011-03-09 2024-09-03 Neuravi Limited Systems and methods to restore perfusion to a vessel
ES3029850T3 (en) 2011-03-09 2025-06-25 Neuravi Ltd A clot retrieval device for removing occlusive clot from a blood vessel
US11259824B2 (en) 2011-03-09 2022-03-01 Neuravi Limited Clot retrieval device for removing occlusive clot from a blood vessel
US9055964B2 (en) 2011-03-15 2015-06-16 Angio Dynamics, Inc. Device and method for removing material from a hollow anatomical structure
US12245788B2 (en) 2011-03-15 2025-03-11 Angiodynamics, Inc. Device and method for removing material from a hollow anatomical structure
US9050435B2 (en) 2011-03-22 2015-06-09 Angiodynamics, Inc. High flow catheters
US8607428B2 (en) 2011-03-31 2013-12-17 Angiodynamics, Inc. Implantable catheter and method of using same
US20190175939A1 (en) 2011-05-02 2019-06-13 Angiodynamics, Inc. Urinary radiation sensor catheter
CA2874443A1 (en) 2011-05-13 2012-11-22 Vascular Technology Inc. Remotely controlled suction/irrigation for surgery
US20120310230A1 (en) 2011-06-01 2012-12-06 Angiodynamics, Inc. Coaxial dual function probe and method of use
US8852165B2 (en) 2011-06-16 2014-10-07 II Edward G. Mackay Endoluminal drug delivery devices and methods
US8992513B2 (en) 2011-06-30 2015-03-31 Angiodynamics, Inc Endovascular plasma treatment device and method of use
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US12096951B2 (en) 2011-10-05 2024-09-24 Penumbra, Inc. System and method for treating ischemic stroke
US20130150811A1 (en) 2011-12-12 2013-06-13 Angiodynamics, Inc. High-Flow Port Stem
US20150272622A1 (en) 2011-12-22 2015-10-01 Previvo Genetics, Llc Recovery and processing of human embryos formed in vivo
USD736916S1 (en) 2012-01-09 2015-08-18 Angiodynamics, Inc. Dialysis catheter tip
US8663116B2 (en) 2012-01-11 2014-03-04 Angiodynamics, Inc. Methods, assemblies, and devices for positioning a catheter tip using an ultrasonic imaging system
JP5575281B2 (ja) 2012-01-26 2014-08-20 コヴィディエン リミテッド パートナーシップ 血栓摘出カテーテルシステム
US9480497B2 (en) 2012-02-01 2016-11-01 Angiodynamics, Inc. Skin nicking device, method and assembly
WO2013119662A1 (en) 2012-02-06 2013-08-15 Cornell University Catheter based system and method for thrombus removal using time reversal acoustics
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US9707339B2 (en) 2012-03-28 2017-07-18 Angiodynamics, Inc. High flow rate dual reservoir port system
US9713704B2 (en) 2012-03-29 2017-07-25 Bradley D. Chartrand Port reservoir cleaning system and method
US9883878B2 (en) 2012-05-15 2018-02-06 Pulse Therapeutics, Inc. Magnetic-based systems and methods for manipulation of magnetic particles
WO2013190475A2 (en) 2012-06-19 2013-12-27 Baylis Medical Company Inc. Steerable medical device handle
CN102727643B (zh) 2012-06-20 2014-04-02 中国中医科学院广安门医院 一种治疗痔疮及缓解痔切除术后疼痛及水肿的药物及其制备方法
USD677798S1 (en) 2012-06-25 2013-03-12 Angiodynamics, Inc. Medical device package tray
US9050127B2 (en) 2012-06-27 2015-06-09 Boston Scientific Limited Consolidated atherectomy and thrombectomy catheter
US9895524B2 (en) 2012-07-13 2018-02-20 Angiodynamics, Inc. Fluid bypass device for valved catheters
NL2009448C2 (en) 2012-09-11 2014-03-12 Clinical Devices B V Catheter connector.
EP2897536B1 (en) 2012-09-24 2020-08-19 Inari Medical, Inc. Device for treating vascular occlusion
EP2897673B1 (en) 2012-09-24 2020-01-22 Medline Industries, Inc. Power injector device and method of use
US9205242B2 (en) 2012-11-19 2015-12-08 Angiodynamics, Inc. Port septum with integral valve
US8784434B2 (en) 2012-11-20 2014-07-22 Inceptus Medical, Inc. Methods and apparatus for treating embolism
USD748774S1 (en) 2012-12-26 2016-02-02 Angiodynamics, Inc Introducer hub
US9888956B2 (en) 2013-01-22 2018-02-13 Angiodynamics, Inc. Integrated pump and generator device and method of use
US20140303658A1 (en) 2013-02-13 2014-10-09 Bayer Medical Care Inc. Thrombectomy Catheter System
US20140228869A1 (en) 2013-02-13 2014-08-14 Medrad, Inc. Thrombectomy catheter
US9445746B1 (en) 2013-03-14 2016-09-20 Angio Dynamics, Inc. Systems and methods for catheter tip placement using ECG
US10188831B2 (en) 2013-03-14 2019-01-29 Angiodynamics, Inc. Systems and methods for catheter tip placement using ECG
US9440047B1 (en) 2013-03-14 2016-09-13 Angiodynamics, Inc. Systems and methods for catheter tip placement using ECG
US8784402B1 (en) 2013-03-15 2014-07-22 Angiodynamics, Inc. Catheters with fluoropolymer additives
US9206283B1 (en) 2013-03-15 2015-12-08 Angiodynamics, Inc. Thermoplastic polyurethane admixtures
CA2901443A1 (en) 2013-03-15 2014-09-25 Insera Therapeutics, Inc. Vascular treatment devices and methods
US9789229B1 (en) 2013-03-15 2017-10-17 Angio Dynamics Inc. Catheter shaft with enhanced platelet anti-adhesion surfaces
US20160038657A1 (en) 2013-03-15 2016-02-11 Raymond Lareau Medical devices having surface modifiers
US9186491B2 (en) 2013-04-10 2015-11-17 Angiodynamics, Inc. Port catheter locking system and method
US20140364896A1 (en) 2013-06-07 2014-12-11 Abott Cardiovascular Systems, Inc. Device, system, and method for thrombus retrieval
US20150057648A1 (en) 2013-08-20 2015-02-26 Angiodynamics, Inc. Laser Device and Method of Use
US20150068941A1 (en) 2013-09-10 2015-03-12 Angiodynamics, Inc. Containment Clip for Medical Devices
US10238406B2 (en) 2013-10-21 2019-03-26 Inari Medical, Inc. Methods and apparatus for treating embolism
JP6352642B2 (ja) 2013-12-03 2018-07-04 川澄化学工業株式会社 血管内異物除去用カテーテル
US9937325B2 (en) 2014-01-08 2018-04-10 Covidien Lp Catheter system
US11241564B2 (en) 2014-01-09 2022-02-08 Angiodynamics, Inc. High-flow port and infusion needle systems
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
US10285720B2 (en) 2014-03-11 2019-05-14 Neuravi Limited Clot retrieval system for removing occlusive clot from a blood vessel
US9820761B2 (en) 2014-03-21 2017-11-21 Route 92 Medical, Inc. Rapid aspiration thrombectomy system and method
US9433427B2 (en) 2014-04-08 2016-09-06 Incuvate, Llc Systems and methods for management of thrombosis
US20150282734A1 (en) 2014-04-08 2015-10-08 Timothy Schweikert Medical device placement system and a method for its use
US20150305810A1 (en) 2014-04-25 2015-10-29 Angiodynamics, Inc. Microwave based electrosurgical coagulating knife
US9883877B2 (en) 2014-05-19 2018-02-06 Walk Vascular, Llc Systems and methods for removal of blood and thrombotic material
CA2939315C (en) 2014-06-09 2018-09-11 Inceptus Medical, Llc Retraction and aspiration device for treating embolism and associated systems and methods
ES2989493T3 (es) 2014-06-13 2024-11-26 Neuravi Ltd Dispositivos para eliminar las obstrucciones agudas de los vasos sanguíneos
WO2015196156A1 (en) 2014-06-20 2015-12-23 Boston Scientific Limited Thrombectomy catheter system
BR112016031037B1 (pt) 2014-06-30 2023-02-07 Procept Biorobotics Corporation Aparelho para ablação de tecido vascular
US9888968B2 (en) 2014-07-22 2018-02-13 Siemens Healthcare Gmbh Method and system for automated therapy planning for arterial stenosis
US20160030708A1 (en) 2014-07-30 2016-02-04 Angiodynamics, Inc. Rifled catheters and vascular access systems
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
US20160114128A1 (en) 2014-10-24 2016-04-28 Angiodynamics, Inc. Actuating Catheter Luer Devices
US20160114129A1 (en) 2014-10-24 2016-04-28 Angiodynamics, Inc. Actuating catheter luer and hub devices
EP3017775A1 (en) 2014-11-07 2016-05-11 National University of Ireland, Galway A thrombectomy device
US20160135712A1 (en) 2014-11-13 2016-05-19 Angiodynamics, Inc. System and method for determing the position of a catheter
US20160135829A1 (en) 2014-11-13 2016-05-19 Angiodynamics, Inc. Systems and methods for en bloc removal of undesirable material from passageways
US11253278B2 (en) 2014-11-26 2022-02-22 Neuravi Limited Clot retrieval system for removing occlusive clot from a blood vessel
CR20170245A (es) 2014-12-05 2017-09-14 Edwards Lifesciences Corp Cateter dirigible con cable de tracción
ES2577288B8 (es) 2015-01-13 2019-01-10 Anaconda Biomed S L Dispositivo para trombectomía
US20160235974A1 (en) 2015-02-12 2016-08-18 Angiodynamics, Inc. Cancerous metabolic growth inhibitor system
US20160271321A1 (en) 2015-03-17 2016-09-22 Spectrum Health Innovations, LLC Directional sheath and related method of use
HK1254629A1 (zh) 2015-04-10 2019-07-26 安吉戴尼克公司 使用热控电极进行不可逆电穿孔的系统和方法
US20230329777A1 (en) 2015-04-10 2023-10-19 Angiodynamics, Inc. Techniques for controlling an irreversible electroporation system
US20200101326A1 (en) 2015-04-22 2020-04-02 Angiodynamics, Inc. Monolithinc photodetector for dosimeter
US20160346472A1 (en) 2015-05-29 2016-12-01 Angiodynamics, Inc. In-Line Fluid Injection System Comprising a Manifold and Contrast Source Valve for Controlled Injection of Multiple Fluids
US20170035990A1 (en) 2015-08-04 2017-02-09 Kevin Swift Endoluminal fluid delivery device and method
US9999493B2 (en) 2015-08-06 2018-06-19 Kp Medcure, Inc. Axial lengthening thrombus capture system
US10660691B2 (en) 2015-10-07 2020-05-26 Angiodynamics, Inc. Multiple use subassembly with integrated fluid delivery system for use with single or dual-lumen peristaltic tubing
KR102244256B1 (ko) 2015-10-19 2021-04-27 콘메드 코포레이션 액화-가스 분리기
US9700332B2 (en) 2015-10-23 2017-07-11 Inari Medical, Inc. Intravascular treatment of vascular occlusion and associated devices, systems, and methods
US10342571B2 (en) 2015-10-23 2019-07-09 Inari Medical, Inc. Intravascular treatment of vascular occlusion and associated devices, systems, and methods
EP3386380A4 (en) 2015-12-07 2019-07-31 Medici Technologies, LLC MONITORING OBSERVATION MONITORING SYSTEM
EP3389757B1 (en) 2015-12-18 2026-03-04 Inari Medical, Inc. Catheter shaft and associated devices, systems, and methods
CN105559854B (zh) 2016-01-04 2019-01-22 吴娟 一种输尿管软镜碎石术后同轴套管式水循环快速排石装置
WO2017165810A1 (en) 2016-03-25 2017-09-28 Phillip Laby Fluid-actuated sheath displacement and articulation behavior improving systems, devices, and methods for catheters, continuum manipulators, and other uses
US20170333060A1 (en) 2016-05-19 2017-11-23 Justin P. Panian Catheter assembly for blood clots removal
US10835715B2 (en) 2016-08-08 2020-11-17 Angiodynamics Va Llc System and method for locating a catheter tip
US10610678B2 (en) 2016-08-11 2020-04-07 Angiodynamics, Inc. Bi-directional, pressure-actuated medical valve with improved fluid flow control and method of using such
EP3782562A1 (en) 2016-08-17 2021-02-24 Neuravi Limited A clot retrieval system for removing occlusive clot from a blood vessel
WO2018033401A1 (en) 2016-08-17 2018-02-22 Neuravi Limited A clot retrieval system for removing occlusive clot from a blood vessel
US20180050209A1 (en) 2016-08-19 2018-02-22 Advanced Neuromodulation Systems, Inc. Dba St. Jude Medical Neuromodulation Division Lead insertion tool
CN109906058B (zh) 2016-09-06 2022-06-07 尼尔拉维有限公司 用于从血管移除闭塞凝块的凝块取回装置
US10314684B2 (en) 2016-09-07 2019-06-11 Daniel Ezra Walzman Simultaneous rotating separator, irrigator microcatheter for thrombectomy
US11877752B2 (en) 2016-09-07 2024-01-23 Daniel Ezra Walzman Filterless aspiration, irrigating, macerating, rotating microcatheter and method of use
WO2018071691A1 (en) 2016-10-12 2018-04-19 Boston Scientific Scimed, Inc. Thrombectomy catheter
US20180103974A1 (en) 2016-10-14 2018-04-19 Cook Medical Technologies Llc Thrombectomy catheter
USD916281S1 (en) 2016-10-17 2021-04-13 Angiodynamics, Inc. Reinforcement arms and collar for a cannula tip
WO2018080590A1 (en) 2016-10-24 2018-05-03 Inari Medical Devices and methods for treating vascular occlusion
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
WO2018094050A2 (en) 2016-11-18 2018-05-24 The Regents Of The University Of California Renal stone entrapment cage and flushing catheter
US10653860B2 (en) 2016-12-07 2020-05-19 Biosense Webster (Israel) Ltd. Steerable guiding sheath with rack and pinion deflection mechanism
US20180207397A1 (en) * 2017-01-23 2018-07-26 Walk Vascular, Llc Systems and methods for removal of blood and thrombotic material
WO2018137949A1 (en) 2017-01-24 2018-08-02 Koninklijke Philips N.V. Device for determining information relating to a suspected occluding object
CN110475579B (zh) 2017-03-20 2022-10-18 孟休斯医疗有限公司 导向丝-导管组件
US11598328B2 (en) 2017-04-06 2023-03-07 Biosense Webster (Israel) Ltd. Disposable pump chamber for an infusion pump
CA3058764A1 (en) 2017-04-10 2018-10-18 The Regents Of The University Of Michigan Hydrodynamic vortex aspiration catheter
WO2018189593A2 (en) 2017-04-10 2018-10-18 Limflow Gmbh Devices and methods for treating lower extremity vasculature
WO2018204503A1 (en) 2017-05-03 2018-11-08 Z Surgical Llc Minimal-access percutaneous and self-retracting surgical system
US20180344987A1 (en) 2017-06-01 2018-12-06 Angiodynamics, Inc. Splittable Expandable Braided Sheath
EP3654883A1 (en) 2017-07-18 2020-05-27 St. Jude Medical, Cardiology Division, Inc. Flushable loading base
US10912885B2 (en) 2017-08-02 2021-02-09 Angiodynamics, Inc. Device and method for infusing and aspirating fluid
US10429517B1 (en) 2017-08-08 2019-10-01 Angiodynamics, Inc. Manufacture of plastic scintillation dosimeters
USD860941S1 (en) 2017-08-16 2019-09-24 Angiodynamics, Inc. Generator
CN116421876A (zh) 2017-09-06 2023-07-14 伊纳里医疗有限公司 止血阀及其使用方法
US10782425B2 (en) 2017-09-21 2020-09-22 Angiodynamics, Inc. PSD sensors for head and neck
USD879957S1 (en) 2017-10-02 2020-03-31 Angiodynamics, Inc. Distal tip of an atherectomy / thrombectomy catheter with suction port
USD908204S1 (en) 2017-10-16 2021-01-19 Angiodynamics, Inc. Implantable port
US11154314B2 (en) 2018-01-26 2021-10-26 Inari Medical, Inc. Single insertion delivery system for treating embolism and associated systems and methods
WO2019152727A1 (en) * 2018-02-02 2019-08-08 Kalera Medical, Inc. Devices and methods for minimally invasive kidney stone removal by combined aspiration and irrigation
US20230088977A1 (en) 2018-02-20 2023-03-23 Crossliner Inc. Guide catheter extension system for reverse controlled antegrade/retrograde tracking & thrombus removal procedures
US12053207B2 (en) 2018-03-21 2024-08-06 Pacesetter, Inc. Loading tool for a biostimulator
GB2572190A (en) 2018-03-22 2019-09-25 Imperial College Sci Tech & Medicine Angioplasty of calcified arteries
JP2021522885A (ja) 2018-05-01 2021-09-02 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ 血管内部位から閉塞性物質を除去する装置および方法
US20210186547A1 (en) 2018-05-14 2021-06-24 Ghassan S. Kassab Devices, systems, and methods for locally engaging tissue using suction
US11123135B2 (en) 2018-05-30 2021-09-21 Biosense Webster (Israel) Ltd. Enhanced large-diameter balloon catheter
US12097345B2 (en) 2018-06-01 2024-09-24 Penumbra, Inc. Infusion catheter and methods of use
WO2019236239A2 (en) 2018-06-04 2019-12-12 Efremkin Pavel V Devices and methods for intrabody surgery
US10716880B2 (en) 2018-06-15 2020-07-21 Incuvate, Llc Systems and methods for aspiration and monitoring
US11471582B2 (en) 2018-07-06 2022-10-18 Incept, Llc Vacuum transfer tool for extendable catheter
US10470797B1 (en) 2018-07-17 2019-11-12 SlipStream, LLC Systems and methods for vascular access
US10531883B1 (en) 2018-07-20 2020-01-14 Syntheon 2.0, LLC Aspiration thrombectomy system and methods for thrombus removal with aspiration catheter
CN112822979A (zh) 2018-07-23 2021-05-18 Mvi医疗保健公司 用于物理治疗的系统和方法
US12156667B2 (en) 2018-07-24 2024-12-03 Penumbra, Inc. Computer-aided vacuum thrombectomy systems and methods for estimating therapeutic benefit
US12239777B2 (en) 2018-07-24 2025-03-04 Penumbra, Inc. Thrombectomy systems and methods for controlled clot aspiration
US12496076B2 (en) 2018-07-24 2025-12-16 Penumbra, Inc. Computer-aided vacuum thrombectomy systems and methods for processing and visualizing thrombectomy procedure analytics
EP3806757B1 (en) 2018-07-24 2024-10-09 Penumbra, Inc. Apparatus and methods for controlled clot aspiration
US12156666B2 (en) 2018-07-24 2024-12-03 Penumbra, Inc. Computer-aided vacuum thrombectomy systems and methods for controlled clot aspiration
AU2019321256B2 (en) 2018-08-13 2023-06-22 Inari Medical, Inc. System for treating embolism and associated devices and methods
LU100907B1 (en) 2018-08-23 2020-02-24 Metamorphosis Gmbh I G Determination of imaging direction based on a 2d projection image
EP3840630B1 (en) 2018-08-23 2025-09-10 NuVera Medical, Inc. Medical tool positioning devices, systems, and methods of use and manufacture
ES3009676T3 (en) 2018-08-24 2025-03-31 Neuravi Ltd Apparatus for managing acute ischemic events
US20200085453A1 (en) 2018-09-17 2020-03-19 Stryker Corporation Intra-ventricular infusion and evacuation catheter for treatment of intracerebral hemorrhage (ich)
US11406416B2 (en) 2018-10-02 2022-08-09 Neuravi Limited Joint assembly for vasculature obstruction capture device
CA3055856C (en) 2018-10-04 2025-09-02 Sunnybrook Research Institute SYSTEMS AND METHODS FOR TREATMENT OF VASCULAR OCCLUSIONS USING AN ULTRASONIC CATHETER
WO2020076833A1 (en) 2018-10-09 2020-04-16 Limflow Gmbh Devices and methods for catheter alignment
CA3119221A1 (en) 2018-11-13 2020-05-22 Anaconda Biomed, Sl A thrombectomy system and methods of extracting a thrombus from a thrombus site in a blood vessel of a patient
LU101007B1 (en) 2018-11-26 2020-05-26 Metamorphosis Gmbh Artificial-intelligence based reduction support
LU101009B1 (en) 2018-11-26 2020-05-26 Metamorphosis Gmbh Artificial-intelligence-based determination of relative positions of objects in medical images
GB201819164D0 (en) 2018-11-26 2019-01-09 Metamorphosis Gmbh Artificial-intelligence-assisted surgery
EP3890644A4 (en) 2019-02-08 2022-11-16 Auris Health, Inc. MANIPULATION AND CLOT REMOVAL WITH ROBOTIC CONTROL
EP4000540B1 (en) 2019-03-04 2024-02-14 Neuravi Limited Actuated clot retrieval catheter
US20220087554A1 (en) 2019-04-05 2022-03-24 Shifamed Holdings, Llc Delivery devices, systems, and methods of use for positioning and using hemodynamic monitoring systems
US11419392B2 (en) 2019-05-07 2022-08-23 Precision Dynamics Corporation Clasp assembly
US11931522B2 (en) 2019-05-09 2024-03-19 Neuravi Limited Inflation lumen kink protection and balloon profile
US11957855B2 (en) 2019-05-09 2024-04-16 Neuravi Limited Balloon guide catheter with positive venting of residual air
US12274844B2 (en) 2019-06-24 2025-04-15 Covidien Lp Thrombus removal device
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
WO2021016213A1 (en) 2019-07-19 2021-01-28 Elixir Medical Corporation Devices and methods for aspiration of thrombus
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
ES2987037T3 (es) 2019-09-11 2024-11-13 Neuravi Ltd Catéter bucal expansible
CN211068270U (zh) 2019-09-25 2020-07-24 南通市肿瘤医院 一种鼻内镜手术血液收集装置
AU2020353093B2 (en) 2019-09-25 2026-03-26 Thrombolex, Inc. Balloon basket catheter device
US11134859B2 (en) 2019-10-15 2021-10-05 Imperative Care, Inc. Systems and methods for multivariate stroke detection
US11864779B2 (en) 2019-10-16 2024-01-09 Inari Medical, Inc. Systems, devices, and methods for treating vascular occlusions
US11712231B2 (en) 2019-10-29 2023-08-01 Neuravi Limited Proximal locking assembly design for dual stent mechanical thrombectomy device
US20210128183A1 (en) 2019-10-31 2021-05-06 Neuravi Limited Thrombectomy and stenting system
AU2020373046A1 (en) 2019-11-01 2022-05-12 Limflow Gmbh Devices and methods for increasing blood perfusion to a distal extremity
US11839725B2 (en) 2019-11-27 2023-12-12 Neuravi Limited Clot retrieval device with outer sheath and inner catheter
US11779364B2 (en) 2019-11-27 2023-10-10 Neuravi Limited Actuated expandable mouth thrombectomy catheter
US11517340B2 (en) 2019-12-03 2022-12-06 Neuravi Limited Stentriever devices for removing an occlusive clot from a vessel and methods thereof
WO2021127202A1 (en) 2019-12-18 2021-06-24 Inari Medical, Inc. Devices and methods for treating vascular occlusion
US12251119B2 (en) 2019-12-18 2025-03-18 Poseydon Medical, Llc Aspiration systems, devices and methods for treating ischemic stroke
US12144515B2 (en) 2019-12-18 2024-11-19 Poseydon Medical, Llc Aspiration systems, devices and methods for treating ischemic stroke
US12201506B2 (en) 2019-12-18 2025-01-21 Imperative Care, Inc. Rotatable thrombus engagement tool
US12318098B2 (en) 2019-12-18 2025-06-03 Poseydon Medical, Llc Aspiration systems, devices and methods for treating ischemic stroke
JP2023507553A (ja) 2019-12-18 2023-02-24 インパラティブ、ケア、インク． 静脈血栓塞栓症を治療するための方法及びシステム
US11992643B2 (en) 2019-12-20 2024-05-28 Neuravi Limited Neurovascular insertion tool
US20210196292A1 (en) * 2019-12-26 2021-07-01 Neuravi Limited Intravascular Catheter
US20210275110A1 (en) 2019-12-30 2021-09-09 RubyElf, LLC Systems For Synchronizing Different Devices To A Cardiac Cycle And For Generating Pulse Waveforms From Synchronized ECG and PPG Systems
US11648020B2 (en) 2020-02-07 2023-05-16 Angiodynamics, Inc. Device and method for manual aspiration and removal of an undesirable material
EP4114285A4 (en) 2020-03-04 2024-03-06 Shifamed Holdings, LLC THROMBUS REMOVAL SYSTEMS AND ASSOCIATED METHODS
US11944327B2 (en) 2020-03-05 2024-04-02 Neuravi Limited Expandable mouth aspirating clot retrieval catheter
US11883043B2 (en) 2020-03-31 2024-01-30 DePuy Synthes Products, Inc. Catheter funnel extension
CN111528983A (zh) 2020-04-09 2020-08-14 大连大学附属中山医院 胆道镜用水刀碎石冲洗导管
US20220249151A1 (en) 2020-04-13 2022-08-11 Angiodynamics, Inc. Treatment planning and monitoring for ire and h-fire protocols
US20210315639A1 (en) 2020-04-13 2021-10-14 Angiodynamics, Inc. Current Analysis for Patient Customized Irreversible Electroporation Treatment Planning
US11717308B2 (en) 2020-04-17 2023-08-08 Neuravi Limited Clot retrieval device for removing heterogeneous clots from a blood vessel
CN111481262A (zh) 2020-05-29 2020-08-04 上海融脉医疗科技有限公司 一种血栓取出导管结构
CN116234508A (zh) 2020-06-05 2023-06-06 伊纳里医疗有限公司 可再捕获的漏斗导管以及相关联的系统和方法
US20210393277A1 (en) 2020-06-18 2021-12-23 Neuravi Limited Catheter mouth designs
US11737771B2 (en) 2020-06-18 2023-08-29 Neuravi Limited Dual channel thrombectomy device
EP4167892A4 (en) 2020-06-19 2024-10-30 Remedy Robotics, Inc. SYSTEMS AND METHODS FOR GUIDING INTRALUMINAL DEVICES IN THE VASCULAR SYSTEM
EP4181800A4 (en) 2020-07-20 2024-07-24 Elixir Medical Corporation Devices and methods for aspiration of thrombus
US20220031341A1 (en) 2020-07-29 2022-02-03 Neuravi Limited Adhesive-Free Bonded Balloon for a Balloon Guide Catheter With Minimal Outer Profile
US20220039815A1 (en) 2020-08-06 2022-02-10 Inari Medical, Inc. Automatically-locking vacuum syringes, and associated systems and methods
EP4196033A1 (en) 2020-08-11 2023-06-21 Intuitive Surgical Operations, Inc. Systems for planning and performing biopsy procedures and associated methods
US20220054151A1 (en) 2020-08-24 2022-02-24 J. Michael Shifflette Multi-Mode Viscometric Thrombectomy System
US20220061870A1 (en) 2020-08-31 2022-03-03 Covidien Lp Aspiration systems and methods, and expanding-mouth catheters
CA3198851A1 (en) 2020-11-10 2022-05-19 Inari Medical, Inc. Devices for adjustably tensioning sutures, and associated systems and methods
AU2021381331A1 (en) 2020-11-18 2023-05-11 Inari Medical, Inc. Catheters having shaped distal portions, and associated systems and methods
WO2022109034A1 (en) 2020-11-18 2022-05-27 Inari Medical, Inc. Catheters having steerable distal portions, and associated systems and methods
US12582425B2 (en) 2020-12-03 2026-03-24 Covidien Lp Catheter including a radiopaque expandable member
US20240001101A1 (en) 2020-12-04 2024-01-04 Shifamed Holdings, Llc Catheter blood pumps and external fluid control consoles
JP7714655B2 (ja) 2020-12-18 2025-07-29 ボストン サイエンティフィック サイムド，インコーポレイテッド 双方向に操縦可能なカテーテル
US12029442B2 (en) 2021-01-14 2024-07-09 Neuravi Limited Systems and methods for a dual elongated member clot retrieval apparatus
USD972720S1 (en) 2021-02-04 2022-12-13 Angiodynamics, Inc. Port for aspiration device
US12274458B2 (en) 2021-02-15 2025-04-15 Walk Vascular, Llc Systems and methods for removal of blood and thrombotic material
US11986196B2 (en) 2021-02-18 2024-05-21 Boston Scientific Scimed, Inc. Thrombectomy apparatuses and methods
CA3210625A1 (en) 2021-03-01 2022-09-09 Scott J. Baron Aspiration devices for treatment of thrombosis including expandable distal ends and systems and methods thereof
US12390236B2 (en) 2021-03-10 2025-08-19 Covidien Lp Thrombus removal device
USD972723S1 (en) 2021-03-17 2022-12-13 Angiodynamics, Inc. Reinforcement arms and collar for an expandable cannula tip
US12064130B2 (en) 2021-03-18 2024-08-20 Neuravi Limited Vascular obstruction retrieval device having sliding cages pinch mechanism
US12582426B2 (en) 2021-04-17 2026-03-24 Inquis Medical, Inc. Apparatuses for removing obstructive material from body lumens
EP4333743A4 (en) 2021-05-27 2025-05-28 Vascular Development Corp, LLC IMPROVED FUNNEL CATHETER AND NEW METHODS OF USE
AU2022289731A1 (en) 2021-06-10 2023-12-21 Shifamed Holdings, Llc Thrombus removal systems and associated methods
EP4351452A4 (en) 2021-06-10 2025-03-26 Shifamed Holdings, LLC Thrombus removal systems and associated methods
US12032735B2 (en) 2021-06-21 2024-07-09 Penumbra, Inc. Method and apparatus for real-time data communication in full-presence immersive platforms
JP2024524386A (ja) 2021-06-28 2024-07-05 インクイス メディカル，インコーポレーテッド 閉塞性物質の除去を制御するための装置および方法
WO2023288268A1 (en) 2021-07-14 2023-01-19 The University Of Chicago Multi-function catheter and methods for diagnosis and/or treatment of venous thromboembolic disease
US20230030606A1 (en) 2021-07-20 2023-02-02 Angiodynamics, Inc. Device and method of use for aspiration system retrievers
US20240197416A1 (en) 2021-08-12 2024-06-20 Imperative Care, Inc. Hub sensing through a sterile barrier in a robotic catheter assembly
US20240237997A1 (en) 2021-09-03 2024-07-18 Shifamed Holdings, Llc Thrombus removal systems and associated methods
US12305990B2 (en) 2021-09-16 2025-05-20 Penumbra, Inc. Orienting a moving electromagnetic tracking reference frame via external localizing data on an electromagnetic sensor using IMU data
US12184353B2 (en) 2021-09-16 2024-12-31 Penumbra, Inc. Automatically synchronizing a transmitter and receiver in a magnetic tracking system using information from an inertial measurement unit
EP4404852A4 (en) 2021-09-22 2025-06-18 Microvention, Inc. SUCTION THROMBECTOMY SYSTEM
USD1077996S1 (en) 2021-10-18 2025-06-03 Imperative Care, Inc. Inline fluid filter
CA3234832A1 (en) 2021-10-18 2023-04-27 Imperative Care, Inc. Device for clot retrieval
US12011186B2 (en) 2021-10-28 2024-06-18 Neuravi Limited Bevel tip expandable mouth catheter with reinforcing ring
US20230149073A1 (en) 2021-11-15 2023-05-18 Angiodynamics, Inc. Method and device for probe navigation of an ablation system
EP4463083A4 (en) 2022-01-11 2025-12-03 Inari Medical Inc DEVICES FOR REMOVING CLOT MATERIAL FROM INTRAVASCULARLY IMPLANTED DEVICES, AND ASSOCIATED SYSTEMS AND METHODS
AU2023212952A1 (en) 2022-01-31 2024-07-25 Inari Medical, Inc. Aspiration catheters having grooved inner surfaces, and associated systems and methods
EP4472532A4 (en) 2022-02-03 2026-01-28 Shifamed Holdings Llc THROMBUS REMOVAL SYSTEMS AND ASSOCIATED PROCESSES
US20230248380A1 (en) 2022-02-08 2023-08-10 Inari Medical, Inc. Clot treatment systems with dilator locking mechanisms, and associated devices and methods
US20250177692A1 (en) 2022-02-16 2025-06-05 Imperative Care, Inc. Catheter with a preset curve
WO2023168415A1 (en) 2022-03-04 2023-09-07 Covidien Lp Fluid-infusing aspiration system
JP2025509593A (ja) 2022-03-15 2025-04-11 シファメド・ホールディングス・エルエルシー 血栓除去システムおよび関連方法
EP4499176A4 (en) 2022-03-31 2026-03-04 Inari Medical Inc Blood-filtering devices for use with clot treatment systems
CN119451721A (zh) 2022-05-04 2025-02-14 伊纳里医疗有限公司 用于血管进入系统的扩张器，以及相关联的装置和方法
US20250302493A1 (en) 2022-05-10 2025-10-02 Shifamed Holdings, Llc Thrombus removal systems and associated methods

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12076036B2 (en) 2021-03-01 2024-09-03 Endovascular Engineering, Inc. Thrombectomy systems and devices with aspiration, and methods of use thereof
US12053192B2 (en) 2022-09-01 2024-08-06 Endovascular Engineering, Inc. Systems, devices, and methods for aspiration, including expandable structures and rotatable shafts
WO2025050040A1 (en) * 2023-08-30 2025-03-06 Shifamed Holdings, Llc Thrombus removal systems and methods

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