WO2022085353A1 - 自動分析装置 - Google Patents
自動分析装置 Download PDFInfo
- Publication number
- WO2022085353A1 WO2022085353A1 PCT/JP2021/034719 JP2021034719W WO2022085353A1 WO 2022085353 A1 WO2022085353 A1 WO 2022085353A1 JP 2021034719 W JP2021034719 W JP 2021034719W WO 2022085353 A1 WO2022085353 A1 WO 2022085353A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- container
- reaction vessel
- gripping
- automatic analyzer
- pieces
- Prior art date
Links
- 238000004458 analytical method Methods 0.000 title abstract description 13
- 230000007246 mechanism Effects 0.000 claims abstract description 58
- 238000000926 separation method Methods 0.000 claims abstract description 8
- 239000002699 waste material Substances 0.000 claims description 35
- 238000003860 storage Methods 0.000 claims description 9
- 230000004308 accommodation Effects 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 description 54
- 230000007723 transport mechanism Effects 0.000 description 23
- 238000001514 detection method Methods 0.000 description 11
- 238000003556 assay Methods 0.000 description 6
- 210000000078 claw Anatomy 0.000 description 5
- 230000007704 transition Effects 0.000 description 4
- 230000032258 transport Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000007885 magnetic separation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 239000011324 bead Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00277—Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/046—General conveyor features
- G01N2035/0465—Loading or unloading the conveyor
Definitions
- the present invention relates to an automated analyzer.
- an automatic analyzer that biochemically or immunologically analyzes a sample such as blood or urine has been known.
- the analysis is generally performed by reacting a sample with a reagent, and the reaction occurring between the reagent and the sample is detected optically and electrically.
- the reaction between the reagent and the sample is generally carried out using a disposable reaction vessel in order to prevent contamination with other reagents or the sample. Then, the used reaction vessel after the analysis is completed is conveyed by the reaction vessel transport mechanism and discarded from a predetermined disposal port.
- Patent Document 1 discloses that the sample dispensing tip is discarded in the sample dispensing tip / reaction vessel disposal hole.
- the reaction vessel put into the reaction vessel disposal hole passes through the disposal cylinder and is accumulated in the storage part such as the disposal box.
- the waste hole which is the open end of the upper end of the waste cylinder
- the reaction vessel tilts, the bottom surface of the reaction vessel comes into contact with the side surface of the waste cylinder, and the step (flange) of the reaction vessel is the waste cylinder. If it comes in contact with the upper end of the reaction vessel, the reaction vessel may not be disposed of properly. If the inner diameter of the waste cylinder is increased, the reaction vessel will be disposed of smoothly, but the space inside the automated analyzer will be restricted.
- An object of the present invention is to provide an automatic analyzer that smoothly disposes of a used reaction vessel while suppressing space restrictions.
- the automatic analyzer of the present invention horizontally holds a storage unit for accommodating a used container, a hollow waste cylinder for guiding the container vertically to the storage unit, and a plurality of gripping pieces. It is provided with a container gripping mechanism that grips the container by bringing it close to the direction and drops the container by separating a plurality of gripping pieces in the horizontal direction, and a control unit that controls the container gripping mechanism, and discards the container.
- the disposal port at the upper end of the cylinder is formed by a container guide portion that guides the container and a grip piece separating portion that forms a space in which the plurality of gripping pieces are separated.
- FIG. 1 The plan view which shows the whole structure of the automatic analyzer which concerns on Example 1.
- FIG. 2 The front view of the main part of the automatic analyzer which concerns on Example 1.
- FIG. As a comparative example it is a figure which shows the movement of the reaction vessel when there is no protrusion or notch in the reaction vessel disposal port.
- FIG. The flowchart which shows the disposal operation of the reaction vessel in Example 1.
- FIG. 1 is a plan view showing the overall configuration of the automatic analyzer of this embodiment.
- the automated analyzer 100 in this embodiment is an apparatus that reacts a sample with a reagent and measures the reacted reaction solution.
- the automatic analyzer 100 includes a reagent cooler 1, a reagent container 3, a sample dispensing nozzle 303, a reaction table 305, a reaction vessel transport mechanism 306, a sample dispensing chip / reaction vessel holding member 307, and a reagent disk. 2, a reagent dispensing nozzle 314, a processing unit 315, a detection unit 316, a rack transfer line 317, and a control device 319 are provided.
- the rack transport line 317 is a line for transporting a rack 301 on which a plurality of sample containers 302 containing a sample can be placed to a sample dispensing position or the like.
- the sample dispensing nozzle 303 is a nozzle for sucking the sample contained in the sample container 302 and discharging it to the reaction container 304.
- the reaction table 305 is a disk for carrying out the reaction between the sample and the reagent at a constant temperature, and the temperature is maintained at a predetermined temperature by a heater (not shown) to promote the reaction between the sample and the reagent.
- a plurality of reaction vessels 304 are held in the reaction table 305, and serve as a place for mixing and reacting the sample and the reagent.
- the reaction vessel transport mechanism 306 transports the reaction vessel 304.
- the sample dispensing tip / reaction vessel holding member 307 stores the disposable sample dispensing tip and the reaction vessel 304 used for sample dispensing.
- the reagent disk 2 is a disk for storing the reagent container 3, and is kept cold by the reagent cold storage 1 in order to stably store the reagent.
- the reagent container 3 can be accessed by a user or a reagent container transport mechanism (not shown) by opening the opening / closing lid 5 arranged on the lid 4. Further, a part of the lid 4 is provided with a reagent suction hole 6 which is a through hole for reagent suction.
- the reagent dispensing nozzle 314 is a nozzle for sucking the reagent stored in the reagent container 3 in the reagent disk 2 through the reagent suction hole 6 and discharging it to the reaction container 304.
- each reagent container 3 in this reagent disk 2 contains various assay reagents (first reagent) used for analysis of a sample.
- the processing unit 315 performs processing before analysis of the sample by the detection unit 316.
- the detection unit 316 performs detection using the liquid in which the reaction has been completed in the reaction vessel 304.
- the control device 319 controls various operations of each of the above-mentioned members, and also performs an arithmetic process for obtaining the concentration of a predetermined component in the sample from the detection result performed by the detection unit 316.
- the control device 319 is provided with a control unit 318 that executes control of the reaction vessel transport mechanism 306.
- the user Prior to the analysis, the user installs consumables such as the reagent container 3 and the sample dispensing chip and the reaction vessel 304 necessary for the analysis on the reagent disk 2 and the sample dispensing chip / reaction vessel holding member 307 in the analyzer, respectively. I will do it.
- consumables such as the reagent container 3 and the sample dispensing chip and the reaction vessel 304 necessary for the analysis on the reagent disk 2 and the sample dispensing chip / reaction vessel holding member 307 in the analyzer, respectively. I will do it.
- the user puts the rack 301 into the automatic analyzer with the sample such as blood or urine to be analyzed put in the sample container 302.
- the unused reaction vessel 304 and the sample dispensing chip are transported to the reaction table 305 and the sample dispensing chip mounting position 321 by the first transfer mechanism 308 of the analyzer.
- the reagent dispensing nozzle 314 is attached so as to be able to rotate and move up and down, and after rotating and moving above the reagent suction hole 6 provided in the lid 4 of the reagent cold storage 1, it descends and sucks the reagent. It passes through the reagent 6. After that, the tip of the reagent dispensing nozzle 314 that has passed through the reagent suction hole 6 is inserted into the reagent in the predetermined reagent container 3, and a predetermined amount of reagent is sucked. Then, after the reagent dispensing nozzle 314 is raised, it rotates and moves above a predetermined position of the reaction table 305, and discharges the reagent into the reaction vessel 304 installed in the reaction table 305.
- the sample dispensing nozzle 303 attaches the sample dispensing chip, and the sample is dispensed from the sample container 302 to the reaction container 304.
- the reaction between the sample and the assay reagent begins.
- the reaction referred to here means, for example, binding a sample to a luminescent labeled substance by an antigen-antibody reaction using a luminescent labeled antibody that reacts only with a specific antigen of the sample as an assay reagent.
- the sample and the assay reagent are stirred by sucking and discharging the mixture of the sample and the assay reagent in the sample dispensing chip. After this operation is completed, the used sample dispensing tip is discarded in the sample dispensing tip disposal port 320.
- reaction vessel 304 placed on the reaction table 305 for a predetermined time is conveyed to the processing unit 315 by the reaction vessel transfer mechanism 306.
- magnetic separation and stirring of the sample are performed as pre-detection processing of the sample.
- reaction vessel 304 is transported to the reaction table 305 again by the reaction vessel transport mechanism 306.
- the reaction vessel 304 that has passed a predetermined time while being placed on the reaction table 305 is guided to the detection unit 316 by the second transfer mechanism 309.
- the detection unit 316 detects the signal from the reaction solution, notifies the user of the analysis result, and records the analysis result in the storage device.
- reaction vessel 304 is conveyed to the reaction vessel disposal port 322 by the second transfer mechanism 309 and the reaction vessel transfer mechanism 306 and discarded.
- a storage unit 323 for storing the discarded reaction vessel 304 and the sample dispensing tip is provided below the reaction vessel disposal port 322 and the sample dispensing tip disposal port 320.
- FIG. 2 is a front view of a main part of the automatic analyzer
- FIG. 3 is a view taken along the line A of FIG. 2.
- the reaction vessel transport mechanism 306 is arranged in the temperature control chamber 332 temperature-controlled by a temperature control device (not shown) using a Pelche element or the like, and has a container gripping mechanism for gripping the reaction vessel 304 and a container gripping mechanism. It consists of a vertical movement mechanism that moves the mechanism in the vertical direction.
- the main body case of the reaction vessel transport mechanism 306 is connected to a belt (not shown), and the belt is rotated by a motor (not shown) along the horizontal rail 324 fixed to the wall surface of the temperature control chamber 332. It can be moved horizontally.
- the container gripping mechanism is a solenoid 326 that brings the first gripping piece 325a and the second gripping piece 325b abutting on the side surface of the reaction vessel 304 and the first gripping piece 325a and the second gripping piece 325b close to each other or separated from each other. And has.
- This container gripping mechanism grips the reaction vessel 304 by bringing the first gripping piece 325a and the second gripping piece 325b close to each other in the horizontal direction, and separates the first gripping piece 325a and the second gripping piece 325b in the horizontal direction. Drop the reaction vessel 304 with.
- the container gripping mechanism may be driven by a motor or an air cylinder instead of the solenoid 326.
- the vertical movement mechanism is fixed to the motor 327, the pinion gear 328 connected to the shaft of the motor 327, the rack portion 329 that converts the rotational motion into a linear motion by meshing with the pinion gear 328, and the solenoid 326 fixed to the rack portion 329. It is provided with a support portion 330 for supporting the support portion 330 and a vertical rail 331 for guiding the vertical movement of the support portion 330. Further, the motor 327 and the vertical rail 331 are fixed to the main body case of the reaction vessel transport mechanism 306, and the rack portion 329 and the support portion 330 move up and down relative to the main body case.
- the vertical movement mechanism may be driven by a solenoid or an air cylinder instead of the motor 327.
- the control unit 318 raises and lowers the first gripping piece 325a and the second gripping piece 325b together with the container gripping mechanism by controlling the rotation of the motor 327. Further, the control unit 318 opens the first grip piece 325a and the second grip piece 325b by energizing the solenoid 326, and turns off the energization of the solenoid 326 to open the first grip piece 325a and the second grip piece 325a by spring force. The grip piece 325b is closed.
- a hollow waste cylinder 333 extending in the vertical direction and guiding the reaction vessel 304 to the accommodating portion 323 is connected to the bottom surface of the temperature control chamber 332. Therefore, the reaction vessel 304 thrown in from the open end (reaction vessel disposal port 322) at the upper end of the waste cylinder 333 falls by gravity while being guided by the inner surface of the waste cylinder 333, and the used reaction vessel 304 is used. Is accommodated in the accommodating portion 323.
- FIG. 4A and 4B are views showing the structures of the reaction vessel waste port 322, the first gripping piece 325a, and the second gripping piece 325b, where FIG. 4A is a front view and FIG. It is a plan view seen from.
- FIG. 4A the upper open end of the waste cylinder 333 projects upward from the bottom surface of the temperature control chamber 332 and has a plurality of protrusions 333c. Further, as shown in FIG. 4 (b), it corresponds to a locus (see the arrow in FIG.
- a flange portion having a larger outer diameter than the lower side is formed on the upper side of the reaction vessel 304, and a step is present at the lower end of the flange portion. Therefore, a claw is provided at the lower end of the first grip piece 325a so that the claw can lock the flange portion of the reaction vessel 304.
- the second grip piece 325b is not provided with a claw, it has a curved contact surface, and by pressing this contact surface against the side surface of the flange portion of the reaction vessel 304, the first grip piece 325a In conjunction with, the reaction vessel 304 is gripped.
- the reaction vessel 304 is likely to fall when the first grip piece 325a and the second grip piece 325b are separated from each other.
- the separation locus is as shown in FIG. 4 (b). It becomes an arc shape.
- FIG. 5 is a diagram showing the movement of the reaction vessel 304 when the reaction vessel waste port 322 has no protrusion or notch, where (a) is a front view and (b) is B in (a). -B'is a plan view seen from above, (c) is a left side view, and (d) is a plan view of BB' of (c) seen from above.
- FIG. 5A when the first grip piece 325a and the second grip piece 325b are separated from each other, the lower end of the first grip piece 325a is higher than the upper end of the waste cylinder 333, so that the reaction vessel 304 The collar of the waste cylinder 333 is also higher than the upper end of the waste cylinder 333.
- the reaction vessel 304 when the reaction vessel 304 is out of balance when the container gripping mechanism is separated, for example, when the reaction vessel 304 is tilted in a state of being tilted backward as shown in FIG. 5 (c), the side surface of the reaction vessel 304 such as the flange portion. May hit the upper end of the waste cylinder 333, and the bottom surface of the reaction vessel 304 may hit the side surface of the waste cylinder 333. In such a case, the reaction vessel 304 may not smoothly fall to the accommodating portion 323, and the operation by the operator may be required.
- FIG. 6A and 6B are views showing the movement of the reaction vessel 304 in this embodiment, where FIG. 6A is a front view, FIG. 6B is a plan view of BB'of FIG. 6A viewed from above, and FIG. Is a left side view, and (d) is a plan view of (c) BB'as viewed from above.
- the notch 333a and the notch 333b are formed on the separation trajectories of the first grip piece 325a and the second grip piece 325b, respectively. Therefore, as shown in FIG.
- the control unit 318 lowers the lower ends of the first gripping piece 325a and the second gripping piece 325b to a position lower than the upper end of the protrusion 333c, and then lowers the container gripping mechanism. Can be separated. Therefore, even if the reaction vessel 304 is out of balance when the container gripping mechanism is separated, and the reaction vessel 304 is tilted in a state of being tilted backward as shown in FIG. 6 (c), the flange portion of the reaction vessel 304 is projected. It does not hit the upper end of 333c.
- the control unit 318 separates the container gripping mechanism at a position where the upper end of the reaction vessel 304 is lower than the upper end of the protrusion 333c, the upper end side surface of the reaction vessel 304 is the side surface of the protrusion 333c even when the reaction vessel 304 is tilted. The reaction vessel 304 will fall more smoothly because it only comes into contact with.
- the protrusion 333c of the present embodiment comes into contact with the side surface of the reaction vessel 304 and functions as a container guide portion that guides the reaction vessel 304 downward while restricting the movement of the reaction vessel 304.
- the protrusion 333c has an inclination in which the inner diameter expands toward the upper side, there is an advantage that the reaction vessel 304 can be easily charged.
- the reaction vessel 304 may be caught on an inclination or the air in the temperature control chamber 332 may leak out to reduce the temperature control effect. Therefore, it is desirable that the inner diameter of the upper end of the protrusion 333c is 100 to 110% of the inner diameter of the lower end of the protrusion 333c.
- the notches 333a and 333b function as gripping piece separating portions that form a space in which the first gripping piece 325a and the second gripping piece 325b are separated for dropping the reaction vessel 304.
- the reaction vessel 304 fits into the notches 333a and 333b, the reaction vessel 304 is greatly tilted, and the reaction vessel 304 is tilted. It may not fall smoothly. Therefore, it is desirable that the gap between the separation locus of the first gripping piece 325a and the second gripping piece 325b and the circumferential end of the protrusion 333c is smaller than the outer diameter of the reaction vessel 304.
- FIG. 7 is a flowchart showing the disposal operation of the reaction vessel 304 in this embodiment
- FIG. 8 is a diagram showing the transition of the states of the reaction vessel transport mechanism 306 and the reaction vessel 304.
- the control unit 318 controls the rotation of a motor (not shown) and horizontally moves the reaction vessel transport mechanism 306 to transport the reaction vessel 304 into the vertical projection of the reaction vessel disposal port 322 (step S101).
- the state 1 of 8 is assumed.
- the control unit 318 controls the rotation of the motor 327 constituting the vertical movement mechanism, lowers the container gripping mechanism (step S102), and shifts to the state 2 of FIG.
- control unit 318 separates the first gripping piece 325a and the second gripping piece 325b by energizing the solenoid 326 of the container gripping mechanism (step S103), and the reaction vessel 304 is as shown in the state 3 of FIG. Fall.
- control unit 318 controls the rotation of the motor 327 to raise the container gripping mechanism (step S104), and shifts to the state 4 of FIG. 8 to prepare for the next transfer of the reaction vessel 304. ..
- the waste port at the upper end of the waste cylinder 333 is formed by the container guide portion and the gripping piece separating portion, and even when the reaction vessel 304 is most tilted, the reaction vessel 304 is formed. Only the top or bottom surface contacts the side surface of the waste cylinder 333. Therefore, when the used reaction vessel 304 is put into the waste port, it smoothly falls in the waste cylinder 333. Further, in this embodiment, a part of the waste cylinder 333 (projection 333c) travels upward from the bottom surface of the temperature control chamber 332, but it is automatic as compared with the case where the inner diameter of the waste cylinder 333 is uniformly increased. There are few space restrictions in the analyzer, and the amount of heat entering the temperature control chamber 332 through the waste cylinder 333 can be suppressed.
- FIG. 9 is a flowchart showing the disposal operation of the reaction vessel 304 in this embodiment.
- control unit 318 first controls the rotation of the motor (not shown) and horizontally moves the reaction vessel transport mechanism 306 to move the reaction vessel horizontally.
- the 304 is transported into the vertical projection of the reaction vessel disposal port 322 (step S201).
- control unit 318 controls the rotation of the motor 327 constituting the vertical movement mechanism, and lowers the container gripping mechanism (step S202).
- the control unit 318 separates the first gripping piece 325a and the second gripping piece 325b by energizing the solenoid 326 of the container gripping mechanism (step S203).
- the separated first gripping piece 325a and the second gripping piece 325b close the inner diameter side of the gripping piece separated portion (notch 333a, 333b).
- the positions of the inner diameter side ends of the first grip piece 325a and the second grip piece 325b when separated are set to be on the inner diameter side of the container guide portion (projection 333c).
- the first gripping piece 325a or the second gripping piece 325b guides the reaction vessel 304 and smoothes the reaction vessel 304. It is possible to drop it into.
- the container gripping mechanism is raised at the same time as the container gripping mechanism is separated, but in the present embodiment, the container gripping mechanism is raised after a predetermined time has elapsed after the container gripping mechanism is separated. .. That is, the control unit 318 separates the first grip piece 325a and the second grip piece 325b, stops the vertical movement mechanism for a predetermined time, and then drives the vertical movement mechanism to drive the first grip piece 325a and the second grip piece 325a and the second grip piece 325a.
- the grip piece 325b is raised (step S204).
- the predetermined time is calculated in advance as the time from when the reaction vessel 304 drops due to the separation of the container gripping mechanism until the height of the upper end of the reaction vessel 304 becomes lower than the lower end of the first gripping piece 325a. Is used.
- the timing for the control unit 318 to raise the container gripping mechanism is not triggered by the passage of a predetermined time, but by detecting that the reaction vessel 304 has passed a predetermined height by a sensor separately provided. Is also good.
- FIG. 10A and 10B are views showing the movement of the reaction vessel 304 in this embodiment, where FIG. 10A is a front view, FIG. 10B is a plan view of BB'of FIG. 10A viewed from above, and FIG. Is a left side view, and (d) is a plan view of (c) BB'as viewed from above.
- the first gripping piece 325a guides the reaction vessel 304 to fall for a while even after the container gripping mechanism is separated. Therefore, as shown in FIG. 10A, even if the reaction vessel 304 is tilted to the left, the reaction vessel 304 can be smoothly dropped.
- FIG. 11 is a flowchart showing the disposal operation of the reaction vessel 304 in this embodiment
- FIG. 12 is a diagram showing the transition of the states of the reaction vessel transport mechanism 306 and the reaction vessel 304.
- the control unit 318 first moves the reaction vessel transport mechanism 306 horizontally to move the reaction vessel 304 to the reaction vessel disposal port 322. (Step S301), and the state 1 in FIG. 12 is set. Next, the control unit 318 controls the motor 327 that constitutes the vertical movement mechanism, and lowers the container gripping mechanism (step S302).
- the lower end of the reaction vessel 304 is lower than the lower end of the gripping piece separating portion (notch 333a, 333b), and the lower end of the first gripping piece 325a is the gripping piece separating portion.
- the portion is higher than the upper end, the first grip piece 325a and the second grip piece 325b are separated from each other (step S303).
- the control unit 318 further continues the descent of the container gripping mechanism (step S304).
- the control unit 318 stops the rotation of the motor 327. Then, the lowering of the container gripping mechanism is stopped (step S305). Subsequently, the control unit 318 turns the container gripping mechanism upward immediately after the container gripping mechanism is stopped to prepare for the next transfer of the reaction vessel 304 (step S306).
- the time required to dispose of the reaction vessel 304 can be shortened as compared with Examples 1 and 2. Further, since the first gripping piece 325a and the second gripping piece 325b separated during the descent descend in parallel with the fall of the reaction vessel 304, even if the reaction vessel 304 tilts to the left or right, the first grip piece 325a and the second gripping piece 325b descend. The 1 grip piece 325a or the 2nd grip piece 325b suppresses further tilting of the reaction vessel 304. It is desirable that the descending speed of the container gripping mechanism is equal to or higher than the falling speed of the reaction vessel 304.
- notches 333a and 333b are formed as the gripping piece separating portion in the above embodiment, but the dimensions may be larger than the gripping piece separating locus by expanding only this portion in the radial direction.
- the first grip piece 325a and the second grip piece 325b have an asymmetrical shape, but the second grip piece 325b is also provided with a claw and has a shape symmetrical with the first grip piece 325a. It doesn't matter.
- the number of gripping pieces may be three or more instead of two.
- a cushioning material is attached to the inner peripheral surface of the waste cylinder 333 to alleviate the impact force when the reaction vessel 304 is dropped into the reaction vessel disposal port 322, thereby suppressing the inclination of the reaction vessel 304 due to rebound and reacting. It is also possible to drop the container 304 smoothly.
- This cushioning material may project upward of the temperature control chamber 332 instead of the protrusion 333c of the above-described embodiment.
- Reagent cooler 1 ... Reagent cooler, 2 ... Reagent disk, 3 ... Reagent container, 4 ... Lid, 5 ... Open / close lid, 6 ... Reagent suction hole, 100 ... Automatic analyzer, 301 ... Rack, 302 ... Specimen container, 303 ... Specimen Dispensing nozzle, 304 ... Reaction vessel, 305 ... Reaction table, 306 ... Reaction vessel transport mechanism, 307 ... Sample dispensing chip / reaction vessel holding member, 308 ... First transport mechanism, 309 ... Second transport mechanism, 314 ... Reagent dispensing nozzle, 315 ... Processing unit, 316 ... Detection unit, 317 ... Rack transfer line, 318 ...
- Control unit 319 ... Control device, 320 ... Specimen dispensing chip disposal port, 321 ... Specimen dispensing chip mounting position, 322 ... Reaction vessel disposal port, 323 ... Storage unit, 324 ... Horizontal rail, 325a ... First grip piece, 325b ... Second grip piece, 326 ... solenoid, 327 ... Motor, 328 ... Pinion gear, 329 ... Rack part, 330 ... Support part, 331 ... Vertical rail, 332 ... Temperature control chamber, 333 ... Waste cylinder, 333a ... Notch, 333b ... Notch, 333c ... Protrusion
Landscapes
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Robotics (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
まず、図1を用いて、本実施例の自動分析装置の全体構成の概略について説明する。図1は、本実施例の自動分析装置の全体構成を示す平面図である。
実施例2では、反応容器304を廃棄するときの反応容器搬送機構306の動作が、実施例1と異なる。図9は、本実施例における反応容器304の廃棄動作を示すフローチャートである。
実施例3では、反応容器304を廃棄するときの反応容器搬送機構306の動作が、実施例1,2と異なる。図11は、本実施例における反応容器304の廃棄動作を示すフローチャートであり、図12は、反応容器搬送機構306と反応容器304の状態の推移を示す図である。
Claims (8)
- 使用済の容器を収容する収容部と、
前記容器を前記収容部まで鉛直方向に案内する中空の廃棄筒と、
複数の把持片を水平方向に近接させることで前記容器を把持し、複数の把持片を水平方向に離間させることで前記容器を落下させる容器把持機構と、
前記容器把持機構を制御する制御部と、を備え、
前記廃棄筒の上端の廃棄口は、前記容器を案内する容器案内部と、複数の前記把持片が離間する空間を形成する把持片離間部と、で形成される、自動分析装置。 - 請求項1に記載の自動分析装置において、
前記制御部は、前記容器の上端が前記廃棄口より低い位置にあるときに、複数の前記把持片を離間して前記容器を落下させる、自動分析装置。 - 請求項1に記載の自動分析装置において、
前記把持片離間部は、前記廃棄筒の上端に形成された切欠きである、自動分析装置。 - 請求項1に記載の自動分析装置において、
前記容器が落下するとき、複数の前記把持片が前記把持片離間部の内径側を塞ぎ、複数の前記把持片が前記容器を案内する、自動分析装置。 - 請求項4に記載の自動分析装置において、
前記容器が落下するとき、複数の前記把持片の内径側端は、前記容器案内部より内径側にある、自動分析装置。 - 請求項1に記載の自動分析装置において、
複数の把持片を鉛直方向に移動させる上下移動機構を有し、
前記制御部は、複数の前記把持片を離間させた後、前記容器の上端が複数の前記把持片のうち最下端よりも低いときに、前記上下移動機構を駆動させて複数の前記把持片を上昇させる、自動分析装置。 - 請求項6に記載の自動分析装置において、
前記制御部は、複数の前記把持片を離間させた後、前記上下移動機構を所定時間停止させてから、前記上下移動機構を駆動させて複数の前記把持片を上昇させる、自動分析装置。 - 請求項1に記載の自動分析装置において、
複数の把持片を鉛直方向に移動させる上下移動機構を有し、
前記制御部は、前記上下移動機構により複数の前記把持片が下降中であって、前記容器の下端が前記把持片離間部の下端よりも低く、複数の前記把持片のうち最下端が前記把持片離間部の上端より高い位置にあるときに、複数の前記把持片を離間して前記容器を落下させた後、前記上下移動機構により複数の前記把持片をさらに下降させて、前記把持片離間部の内径側を塞ぐ、自動分析装置。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18/026,865 US20240027484A1 (en) | 2020-10-20 | 2021-09-22 | Automatic Analyzer |
EP21882494.4A EP4235187A1 (en) | 2020-10-20 | 2021-09-22 | Automatic analysis device |
CN202180063884.3A CN116194782A (zh) | 2020-10-20 | 2021-09-22 | 自动分析装置 |
JP2022557311A JP7423814B2 (ja) | 2020-10-20 | 2021-09-22 | 自動分析装置 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020-175746 | 2020-10-20 | ||
JP2020175746 | 2020-10-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2022085353A1 true WO2022085353A1 (ja) | 2022-04-28 |
Family
ID=81289806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2021/034719 WO2022085353A1 (ja) | 2020-10-20 | 2021-09-22 | 自動分析装置 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20240027484A1 (ja) |
EP (1) | EP4235187A1 (ja) |
JP (1) | JP7423814B2 (ja) |
CN (1) | CN116194782A (ja) |
WO (1) | WO2022085353A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024062752A1 (ja) * | 2022-09-21 | 2024-03-28 | 株式会社日立ハイテク | 自動分析装置 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008026051A (ja) * | 2006-07-19 | 2008-02-07 | Furuno Electric Co Ltd | 生化学自動分析装置 |
JP2008309686A (ja) * | 2007-06-15 | 2008-12-25 | Sysmex Corp | 試料分析装置および試料分析方法 |
JP2014233765A (ja) * | 2013-05-30 | 2014-12-15 | 富士レビオ株式会社 | 把持機構 |
JP2016224048A (ja) * | 2015-05-28 | 2016-12-28 | シーメンス ヘルスケア ダイアグノスティクス プロダクツ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 廃棄物処分システム |
-
2021
- 2021-09-22 JP JP2022557311A patent/JP7423814B2/ja active Active
- 2021-09-22 CN CN202180063884.3A patent/CN116194782A/zh active Pending
- 2021-09-22 EP EP21882494.4A patent/EP4235187A1/en active Pending
- 2021-09-22 US US18/026,865 patent/US20240027484A1/en active Pending
- 2021-09-22 WO PCT/JP2021/034719 patent/WO2022085353A1/ja active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008026051A (ja) * | 2006-07-19 | 2008-02-07 | Furuno Electric Co Ltd | 生化学自動分析装置 |
JP2008309686A (ja) * | 2007-06-15 | 2008-12-25 | Sysmex Corp | 試料分析装置および試料分析方法 |
JP2014233765A (ja) * | 2013-05-30 | 2014-12-15 | 富士レビオ株式会社 | 把持機構 |
JP2016224048A (ja) * | 2015-05-28 | 2016-12-28 | シーメンス ヘルスケア ダイアグノスティクス プロダクツ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 廃棄物処分システム |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024062752A1 (ja) * | 2022-09-21 | 2024-03-28 | 株式会社日立ハイテク | 自動分析装置 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2022085353A1 (ja) | 2022-04-28 |
CN116194782A (zh) | 2023-05-30 |
JP7423814B2 (ja) | 2024-01-29 |
US20240027484A1 (en) | 2024-01-25 |
EP4235187A1 (en) | 2023-08-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6726242B2 (ja) | 遠心分離機、および反応容器ユニットに遠心力を作用させるための方法 | |
JP6837362B2 (ja) | 自動分析装置 | |
CN101324631B (zh) | 试样分析仪及试样分析方法 | |
JP4861762B2 (ja) | 自動分析装置 | |
JP2008096115A (ja) | キュベット | |
EP1832880A2 (en) | Parts supply device, sample analyzing device, parts supply method | |
JP4902205B2 (ja) | 分析装置および分析方法 | |
CN111033262A (zh) | 自动分析装置 | |
JP5100277B2 (ja) | ピペットチップ供給装置および検体分析装置 | |
US9738451B2 (en) | Container supply unit and automated analyzer | |
US20200393474A1 (en) | Bf separator, sample analyzer, and bf separation method | |
JP2002286726A (ja) | デイスポーザブルな反応容器を用いる分析装置 | |
WO2022085353A1 (ja) | 自動分析装置 | |
US20090081081A1 (en) | Pipette tip supplier and sample analyzer | |
JP2008020360A (ja) | 自動分析装置及び試薬容器 | |
CN219266306U (zh) | 一种免疫层分析仪 | |
WO2017104524A1 (ja) | 容器供給ユニット及び自動分析装置 | |
JPH11183484A (ja) | 自動分析装置 | |
JP4827579B2 (ja) | ピペットチップ自動供給装置および検体分析装置 | |
JP2003083986A (ja) | 自動分析装置におけるディスポーザブルパーツの廃棄処理装置 | |
JP6004398B2 (ja) | 自動分析装置 | |
WO2014002954A1 (ja) | 攪拌機構及び攪拌方法 | |
JPS5951359A (ja) | 生化学自動分析装置における試薬供給装置 | |
JP5507630B2 (ja) | ピペットチップ供給装置および検体分析装置 | |
JP6454518B2 (ja) | 分析装置および分析方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 21882494 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 18026865 Country of ref document: US |
|
ENP | Entry into the national phase |
Ref document number: 2022557311 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2021882494 Country of ref document: EP Effective date: 20230522 |